{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:45:53Z","timestamp":1780580753647,"version":"3.54.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1093\/jjco\/hyw208","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T13:27:19Z","timestamp":1485782839000},"page":"306-312","source":"Crossref","is-referenced-by-count":12,"title":["Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2"],"prefix":"10.1093","volume":"47","author":[{"given":"Akira","family":"Yokoyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Shiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"key\n\t\t\t\t20170324052527_hyw208C1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1176\/ajp.152.8.1219","article-title":"Alcohol and aldehyde dehydrogenase polymorphism and the risk for alcoholism","volume":"152","year":"1995","journal-title":"Am J Psychiatry"},{"key":"key\n\t\t\t\t20170324052527_hyw208C2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1086\/302540","article-title":"Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism","volume":"65","year":"1999","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20170324052527_hyw208C3","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/hmg\/ddm357","article-title":"Major genetic components underlying alcoholism in Korean population","volume":"17","year":"2008","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170324052527_hyw208C4","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1001\/jama.1986.03380110080031","article-title":"Alcohol and immune defense","volume":"256","year":"1986","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170324052527_hyw208C5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1055\/s-2008-1040574","article-title":"Hematologic complications of alcohol abuse","volume":"7","year":"1987","journal-title":"Semen Liver Dis"},{"key":"key\n\t\t\t\t20170324052527_hyw208C6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000205888","article-title":"Alcohol-induced bone marrow damage. A bone marrow study in alcohol-dependent individuals","volume":"78","year":"1987","journal-title":"Acta Haemat"},{"key":"key\n\t\t\t\t20170324052527_hyw208C7","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/acer.12372","article-title":"Philip J. Brooks, et al. Macrocytosis, macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men","volume":"38","year":"2014","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20170324052527_hyw208C8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/acer.12983","article-title":"Blood leukocyte counts and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men","volume":"40","year":"2016","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20170324052527_hyw208C9","first-page":"e50","article-title":"The alcohol flushing response: an unrecognized risk factor of esophageal cancer from alcohol consumption","volume":"6","year":"2009","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t20170324052527_hyw208C10","volume-title":"Alcohol Beverage Consumption and Ethyl Carbamate (Urethane)","author":"International Agency for Research on Cancer","year":"2010"},{"key":"key\n\t\t\t\t20170324052527_hyw208C11","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1053\/j.gastro.2009.07.070","article-title":"Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk","volume":"137","year":"2009","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170324052527_hyw208C12","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1136\/gut.2009.205724","article-title":"Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and\/or ALDH2 risk alleles","volume":"59","year":"2010","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170324052527_hyw208C13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/carcin\/22.3.433","article-title":"Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics","volume":"22","year":"2001","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170324052527_hyw208C14","volume-title":"Japanese Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus","author":"The Japan Esophageal Society","year":"2012"},{"key":"key\n\t\t\t\t20170324052527_hyw208C15","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994","edition":"4th edn"},{"key":"key\n\t\t\t\t20170324052527_hyw208C16","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1001\/jama.286.23.2940","article-title":"Persistent macrocytosis following abstinence from chronic alcohol use","volume":"286","year":"2001","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170324052527_hyw208C17","first-page":"13","article-title":"Genetic polymorphism of alcohol and aldehyde dehydrogenase and the effects on alcohol metabolism","volume":"28","year":"1993","journal-title":"Arukoru Kenkyuto Yakabutsu Ison"},{"key":"key\n\t\t\t\t20170324052527_hyw208C18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/FPC.0000000000000096","article-title":"ALDH2*2 but not ADH1B*2 is a causative variant gene allele for Asian alcohol flushing after a low-dose challenge: correlation of the pharmacokinetic and pharmacodynamic findings","volume":"24","year":"2014","journal-title":"Pharmacogenet Genomics"},{"key":"key\n\t\t\t\t20170324052527_hyw208C19","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/BF02267057","article-title":"The contribution of polymorphism in the alcohol dehydrogenase \u03b2 subunit to alcohol sensitivity in a Japanese population","volume":"97","year":"1996","journal-title":"Hum Genet"},{"key":"key\n\t\t\t\t20170324052527_hyw208C20","first-page":"1227","article-title":"Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men","volume":"12","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t20170324052527_hyw208C21","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1158\/1055-9965.EPI-05-0911","article-title":"Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: analysis of 2,299 Japanese subjects","volume":"15","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t20170324052527_hyw208C22","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1111\/j.1349-7006.2010.01709.x","article-title":"Past and current tendency for facial flushing after a small dose of alcohol is a marker for increased risk of upper aerodigestive tract cancer","volume":"101","year":"2010","journal-title":"Cancer Sci"},{"key":"key\n\t\t\t\t20170324052527_hyw208C23","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1530-0277.2011.01458.x","article-title":"ALDH2 and ADH1B interactions in retrospective reports of low-dose reactions and initial sensitivity to alcohol in Asian American college students","volume":"35","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20170324052527_hyw208C24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1265\/jjh.70.134","article-title":"Associations between ALDH2 and ADH1B Genotypes and ethanol-induced cutaneous erythema in young Japanese women","volume":"70","year":"2015","journal-title":"Nihon Eiseigaku Zasshi"},{"key":"key\n\t\t\t\t20170324052527_hyw208C25","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1530-0277.2010.01202.x","article-title":"Polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men","volume":"34","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20170324052527_hyw208C26","first-page":"352","article-title":"Combination of ADH1B*2\/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics","volume":"103","year":"2012","journal-title":"Cancer Sci"},{"key":"key\n\t\t\t\t20170324052527_hyw208C27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.mrgentox.2010.05.013","article-title":"Effects of alcohol drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay","volume":"701","year":"2010","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170324052527_hyw208C28","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1097\/01.ALC.0000085589.47243.8D","article-title":"Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers","volume":"27","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20170324052527_hyw208C29","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/01.ALC.0000158842.24218.03","article-title":"Epidemiological evidence that acetaldehyde plays a significant role in the development of decreased serum folate concentration and elevated mean corpuscular volume in alcohol drinkers","volume":"29","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20170324052527_hyw208C30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1056\/NEJM198209303071402","article-title":"Suppression of haematopoietic progenitor-cell proliferation by ethanol and acetaldehyde","volume":"307","year":"1982","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170324052527_hyw208C31","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/acer.12069","article-title":"Alcohol dehydrogenase-1B genotype (rs1229984) is a strong determinant of the relationship between body weight and alcohol intake in Japanese alcoholic men","volume":"37","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"key\n\t\t\t\t20170324052527_hyw208C32","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1182\/blood.V79.9.2273.2273","article-title":"Ineffective hematopoiesis in folate-deficient mice","volume":"79","year":"1992","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170324052527_hyw208C33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.me.33.020182.002021","article-title":"The effects of alcohol on folate metabolism","volume":"33","year":"1982","journal-title":"Annu Rev Med"},{"key":"key\n\t\t\t\t20170324052527_hyw208C34","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1365-2141.2006.06367.x","article-title":"Differential cell division history between neutrophils and macrophages in their development from granulocyte-macrophage progenitors","volume":"135","year":"2006","journal-title":"Br J Haematol"},{"key":"key\n\t\t\t\t20170324052527_hyw208C35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12199-008-0047-8","article-title":"Low lymphocyte count in underweight Japanese women","volume":"13","year":"2008","journal-title":"Environ Health Prev Med"},{"key":"key\n\t\t\t\t20170324052527_hyw208C36","first-page":"135","article-title":"Present status of esophageal cancer and its treatment in Japan","volume":"10","year":"2004","journal-title":"Ann Thorac Cardiovasc Surg"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/47\/4\/306\/11078674\/hyw208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T21:39:55Z","timestamp":1749937195000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article-lookup\/doi\/10.1093\/jjco\/hyw208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,1,31]]},"published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyw208","relation":{},"ISSN":["0368-2811","1465-3621"],"issn-type":[{"value":"0368-2811","type":"print"},{"value":"1465-3621","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}