{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:09:58Z","timestamp":1783130998621,"version":"3.54.6"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A number of major modifications were made to the classification of head and neck carcinomas in the eighth edition of the American Joint Committee on Cancer, Cancer Staging Manual and Union for International Cancer Control TNM classification of Malignant Tumors. These modifications were aimed at improving the prognosis prediction accuracy of the system. In this article, we review the new edition of the TNM classification system. Among the several changes in the new system, a separate algorithm for p16-positive oropharyngeal carcinoma was included, as were new chapters on \u2018Head and Neck Skin Carcinoma\u2019 and \u2018Unknown Primary Carcinoma\u2014Cervical Nodes.\u2019 Changes to Tumor (T) classification were made by introducing the depth of invasion of oral carcinoma, whereas changes to Node (N) classification were made by adding extra-nodal extension. It is believed that these changes will help improve the accuracy of the system in the prediction of prognosis. However, it is necessary to verify their validity through further clinical research.<\/jats:p>","DOI":"10.1093\/jjco\/hyz052","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T12:26:41Z","timestamp":1557145601000},"page":"589-595","source":"Crossref","is-referenced-by-count":31,"title":["A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition)"],"prefix":"10.1093","volume":"49","author":[{"name":"Head and Neck Cancer Study Group (HNCSG)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1119-028X","authenticated-orcid":false,"given":"Nobuya","family":"Monden","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Asakage","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology\/Hematology, Kobe University Hospital\/Cancer Center, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery, Miyagi Cancer Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Hanai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kodaira","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Aichi Cancer Center Hospital, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadamoto","family":"Zenda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center Hospital East"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Jichi Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-3106","authenticated-orcid":false,"given":"Makoto","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Medical Oncology, National Cancer Center Hospital East"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Yokota","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center Hospital East"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemichi","family":"Iwae","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Hyogo Cancer Center, Hyogo, 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