{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:38:05Z","timestamp":1778636285545,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Clinical Research Center"},{"name":"Shizuoka Cancer Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The nutritional status of patients with esophageal squamous cell carcinoma (ESCC) harboring dysphagia is often poor. The efficacy and safety of enteral nutrition (EN) versus total parenteral nutrition (TPN) have not been addressed in patients with ESCC requiring nutritional support during definitive chemoradiotherapy (dCRT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a retrospective analysis of 51 locally advanced unresectable ESCC patients with dysphagia receiving EN (n = 28) or TPN (n = 23) during dCRT between 2009 and 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patient characteristics in EN vs. TPN were as follows: median age (range), 67 (34 to 82) vs. 66 (57 to 83); ECOG performance status 0\/1\/2, 11\/15\/2 vs. 7\/14\/2; dysphagia score 2\/3\/4, 11\/15\/2 vs. 14\/8\/1; and primary tumor location Ce\/Ut\/Mt\/Lt\/Ae, 4\/6\/14\/3\/1 vs. 2\/2\/16\/1\/2. Median changes in serum albumin level one month after dCRT were +8.8% (\u221236 to 40) in EN and \u221212% (\u221264 to 29) in TPN (P = 0.00377). Weight, body mass index, and skeletal muscle area were not significantly different between the groups. Median durations of hospitalization were 50 days (18 to 72) in EN and 63 days (36 to 164) in TPN (P = 0.00302). Adverse events during dCRT in EN vs. TPN were as follows: catheter-related infection, 0 vs. 6 (27%); aspiration pneumonia, 3 (11%) vs. 2 (9%); mediastinitis, 3 (11%) vs. 1 (5%); grade \u22653 neutropenia, 6 (21%) vs. 14 (64%) (P = 0.00287); and febrile neutropenia, 0 vs. 6 (27%) (P = 0.00561).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>EN may be advantageous for improving serum albumin level, and reducing hematological toxicity and duration of hospitalization compared with TPN during dCRT in ESCC patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyz089","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T11:40:16Z","timestamp":1559648416000},"page":"910-918","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of enteral nutrition with total parenteral nutrition for patients with locally advanced unresectable esophageal cancer harboring dysphagia in definitive chemoradiotherapy"],"prefix":"10.1093","volume":"49","author":[{"given":"Mitsuhiro","family":"Furuta","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Yokota","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Tsushima","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Todaka","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Machida","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hamauchi","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Fukutomi","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadayuki","family":"Kawai","sequence":"first","affiliation":[{"name":"Clinical Research Center, Shizuoka Cancer Center, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Kawabata","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Shizuoka Cancer Center, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Onozawa","sequence":"first","affiliation":[{"name":"Clinical Research Center, Shizuoka Cancer Center, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Yasui","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Oncology, Shizuoka Cancer Center Shizuoka, 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Risk factors for esophageal fistula associated with chemoradiotherapy for locally advanced unresectable esophageal cancer: A supplementary analysis of JCOG0303","volume":"95","author":"Tsushima","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2020041007352221000_hyz089C22","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0003-4975(10)63600-4","article-title":"Management of malignant esophagorespiratory fistula","volume":"25","author":"Lolley","year":"1978","journal-title":"Ann Thorac Surg"},{"key":"2020041007352221000_hyz089C23","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J Clin Oncol"},{"key":"2020041007352221000_hyz089C24","first-page":"1659","volume-title":"Hospital Epidemiology and Infection Control","author":"Horan","year":"2004","edition":"3rd edn."},{"key":"2020041007352221000_hyz089C25","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s00277-010-1005-2","article-title":"Central venous catheter-associated bloodstream infection and colonisation of insertion site and catheter tip. What are the rates and risk factors in haematology patients?","volume":"89","author":"Luft","year":"2010","journal-title":"Ann Hematol"},{"key":"2020041007352221000_hyz089C26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s00595-015-1236-x","article-title":"Extended Clavien-Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria","volume":"46","author":"Katayama","year":"2016","journal-title":"Surg Today"},{"key":"2020041007352221000_hyz089C27","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"2020041007352221000_hyz089C28","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1245\/s10434-011-1754-8","article-title":"Elevated preoperative neutrophil:lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer","volume":"18","author":"Sharaiha","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"2020041007352221000_hyz089C29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"2020041007352221000_hyz089C30","first-page":"1","article-title":"Enteral Nutrition Support Does Not Improve PNI in Radiotherapy Patients with Locally Advanced Esophageal Cancer","volume":"20","author":"Ye","year":"2019","journal-title":"Nutr Cancer"},{"key":"2020041007352221000_hyz089C31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dote\/doy016","article-title":"Nutrition therapy in esophageal cancer-Consensus statement of the Gastroenterological Society of Taiwan","volume":"31","author":"Chen","year":"2018","journal-title":"Dis Esophagus"},{"key":"2020041007352221000_hyz089C32","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.clnu.2011.11.002","article-title":"Randomized study of clinical effect of enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer","volume":"31","author":"Miyata","year":"2012","journal-title":"Clin Nutr"},{"key":"2020041007352221000_hyz089C33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.clnu.2015.03.001","article-title":"Diagnostic criteria for malnutrition - 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