{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T22:51:08Z","timestamp":1794264668068,"version":"4.9.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Saitama Medical University Research Center for Genomic Medicine","award":["S1311002"],"award-info":[{"award-number":["S1311002"]}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP18kk0205004"],"award-info":[{"award-number":["JP18kk0205004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of Lynch syndrome and the use of universal tumor screening to identify Lynch syndrome among unselected patients with upper urinary tract urothelial carcinoma, which is associated with Lynch syndrome, have not been closely investigated yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 166 tumors from 164 upper urinary tract urothelial carcinoma patients were tested for microsatellite instability and expression of mismatch repair proteins (MLH1, MHS2, MSH6 and PMS2) by immunohistochemistry. Genetic testing was performed for patients suspected of having Lynch syndrome. Clinicopathological factors, including familial and personal cancer history associated with mismatch repair deficiency, were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of high-level microsatellite instability and loss of at least one mismatch repair protein was 2.4% (4\/164); the microsatellite instability and immunohistochemistry results showed complete concordance. Of these four patients, three were genetically proven to have Lynch syndrome, while the remaining one was highly suggestive for Lynch syndrome based on their personal cancer history. Univariate analysis showed that age&amp;lt;70\u00a0years (P\u00a0=\u00a00.04), ureter as the tumor location (P\u00a0=\u00a00.052), previous history\/synchronous diagnosis of colorectal cancer (P\u00a0&amp;lt;\u00a00.01) and fulfillment of the criteria per the revised Bethesda guideline (P\u00a0&amp;lt;\u00a00.01) tended to be or were significantly associated with high-level microsatellite instability\/mismatch repair loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of Lynch syndrome among unselected upper urinary tract urothelial carcinoma patients was at least 1.8% in our study population. The screening efficacies of the microsatellite instability test and immunohistochemistry appear equivalent. Universal tumor screening may be a valid approach; however, selective screening methods that consider factors associated with mismatch repair loss\/high-level microsatellite instability tumors require further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jjco\/hyz140","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T11:28:52Z","timestamp":1565954932000},"page":"80-88","source":"Crossref","is-referenced-by-count":30,"title":["Prevalence of Lynch syndrome among patients with upper urinary tract carcinoma in a Japanese hospital-based population"],"prefix":"10.1093","volume":"50","author":[{"given":"Tetsuya","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Diagnosis and Therapeutics of Intractable Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Diagnosis and Therapeutics of Intractable Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gou","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiko","family":"Tachikawa","sequence":"additional","affiliation":[{"name":"Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwamu","family":"Akagi","sequence":"additional","affiliation":[{"name":"Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Urology, Saitama Medical Center, Saitama Medical University, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Urology, Saitama Medical Center, Saitama Medical University, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Morozumi","sequence":"additional","affiliation":[{"name":"Department of Urology, Saitama Medical Center, Saitama Medical University, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Tamaru","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saitama Medical Center, Saitama Medical University, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2020012404264491600_ref1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/humu.21446","article-title":"Recurrence and variability of germline EPCAM deletions in Lynch syndrome","volume":"32","author":"Kuiper","year":"2011","journal-title":"Hum Mutat"},{"key":"2020012404264491600_ref2","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1200\/JCO.2008.17.5950","article-title":"Feasibility of screening for Lynch syndrome among patients with colorectal cancer","volume":"26","author":"Hampel","year":"2008","journal-title":"J Clin Oncol"},{"key":"2020012404264491600_ref3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00345-012-0946-6","article-title":"Distinct patterns and behaviour of urothelial carcinoma with respect to anatomical location: how molecular biomarkers can augment clinicopathological predictors in upper urinary tract tumours","volume":"31","author":"Yates","year":"2013","journal-title":"World J Urol"},{"key":"2020012404264491600_ref4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0959-8049(02)00584-1","article-title":"Defective mismatch-repair in patients with multiple primary tumours including colorectal cancer","volume":"39","author":"Ericson","year":"2003","journal-title":"Eur J Cancer"},{"key":"2020012404264491600_ref5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1399-0004.2008.01125.x","article-title":"Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutations","volume":"75","author":"Barrow","year":"2009","journal-title":"Clin Genet"},{"key":"2020012404264491600_ref6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ijc.23508","article-title":"The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome","volume":"123","author":"Watson","year":"2008","journal-title":"Int J Cancer"},{"key":"2020012404264491600_ref7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L","article-title":"Cancer risk in mutation carriers of DNA-mismatch-repair genes","volume":"81","author":"Aarnio","year":"1999","journal-title":"Int J Cancer"},{"key":"2020012404264491600_ref8","first-page":"1635","article-title":"The tumor spectrum in HNPCC","volume":"14","author":"Watson","year":"1994","journal-title":"Anticancer Res."},{"key":"2020012404264491600_ref9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0022-5347(01)62926-4","article-title":"Urinary tract cancer and hereditary nonpolyposis colorectal cancer: risks and screening options","volume":"160","author":"Sijmons","year":"1998","journal-title":"J Urol"},{"key":"2020012404264491600_ref10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1158\/1940-6207.CAPR-11-0288","article-title":"Identification of cancer patients with Lynch syndrome: clinically significant discordances and problems in tissue-based mismatch repair testing","volume":"5","author":"Bartley","year":"2012","journal-title":"Cancer Prev Res (Phila)"},{"key":"2020012404264491600_ref11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/gutjnl-2011-300041","article-title":"Comparison between universal molecular screening for Lynch syndrome and revised Bethesda guidelines in a large population-based cohort of patients with colorectal cancer","volume":"61","author":"P\u00e9rez-Carbonell","year":"2012","journal-title":"Gut"},{"key":"2020012404264491600_ref12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1158\/1940-6207.CAPR-16-0219","article-title":"Clinical challenges associated with universal screening for Lynch syndrome associated endometrial cancer","volume":"10","author":"Bruegl","year":"2017","journal-title":"Cancer Prev Res (Phila)"},{"key":"2020012404264491600_ref13","volume-title":"AJCC Cancer Staging Manual","author":"Edge","year":"2010","edition":"7th"},{"key":"2020012404264491600_ref14","volume-title":"Tumors of the Urinary System and Male Genital Organs (World Health Organization Classification of Tumors)","author":"Eble","year":"2004"},{"key":"2020012404264491600_ref15","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3748\/wjg.v21.i4.1275","article-title":"Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer","volume":"21","author":"Kadowaki","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2020012404264491600_ref16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/jjco\/hyw178","article-title":"Prevalence of Lynch syndrome and Lynch-like syndrome among patients with colorectal cancer in a Japanese hospital-based population","volume":"47","author":"Chika","year":"2017","journal-title":"Jpn J Clin Oncol"},{"key":"2020012404264491600_ref17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10689-016-9872-x","article-title":"Rapid detection of germline mutations for hereditary gastrointestinal polyposis\/cancers using HaloPlex target enrichment and high-throughput sequencing technologies","volume":"15","author":"Kohda","year":"2016","journal-title":"Fam Cancer"},{"key":"2020012404264491600_ref18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/jjco\/hyz031","article-title":"The single-base-pair deletion, MSH2 c.2635-3delC affecting intron 15 splicing can be a cause of Lynch syndrome","volume":"49","author":"Ito","year":"2019","journal-title":"Jpn J Clin Oncol"},{"key":"2020012404264491600_ref19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djh034","article-title":"Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability","volume":"96","author":"Umar","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"2020012404264491600_ref20","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1097\/PAS.0000000000001141","article-title":"Universal Lynch syndrome screening should be performed in all upper tract urothelial carcinomas","volume":"42","author":"Ju","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"2020012404264491600_ref21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.juro.2017.08.002","article-title":"Universal point of care testing for Lynch syndrome in patients with upper tract urothelial carcinoma","volume":"199","author":"Metcalfe","year":"2018","journal-title":"J Urol"},{"key":"2020012404264491600_ref22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/iju.13481","article-title":"Clinicopathological characteristics of patients with upper urinary tract urothelial cancer with loss of immunohistochemical expression of the DNA mismatch repair proteins in universal screening","volume":"25","author":"Urakami","year":"2018","journal-title":"Int J Urol"},{"key":"2020012404264491600_ref23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2407-5-23","article-title":"Low frequency of defective mismatch repair in a population-based series of upper urothelial carcinoma","volume":"5","author":"Ericson","year":"2005","journal-title":"BMC Cancer."},{"key":"2020012404264491600_ref24","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.acuro.2014.03.010","article-title":"DNA repair genes and prognosis in sporadic forms of urothelial carcinoma of the upper urinary tract","volume":"38","author":"Garc\u00eda-Tello","year":"2014","journal-title":"Actas Urol Esp"},{"key":"2020012404264491600_ref25","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/cam4.1025","article-title":"Screening for mismatch repair deficiency in colorectal cancer: data from three academic medical centers","volume":"6","author":"O'Kane","year":"2017","journal-title":"Cancer Med"},{"key":"2020012404264491600_ref26","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1002\/cncr.31534","article-title":"Universal screening of both endometrial and colon cancers increases the detection of Lynch syndrome","volume":"124","author":"Adar","year":"2018","journal-title":"Cancer"},{"key":"2020012404264491600_ref27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/PGP.0000000000000312","article-title":"Universal screening for mismatch-repair deficiency in endometrial cancers to identify patients with Lynch syndrome and Lynch-like syndrome","volume":"36","author":"Watkins","year":"2017","journal-title":"Int J Gynecol Pathol"},{"key":"2020012404264491600_ref28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/PAS.0000000000000544","article-title":"Clinicopathologic comparison of Lynch syndrome-associated and \"Lynch-like\" endometrial carcinomas identified on universal screening using mismatch repair protein immunohistochemistry","volume":"40","author":"Mills","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"2020012404264491600_ref29","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1200\/JCO.2012.46.8454","article-title":"Population-based molecular screening for Lynch syndrome: implications for personalized medicine","volume":"31","author":"Ward","year":"2013","journal-title":"J Clin Oncol."},{"key":"2020012404264491600_ref30","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.urology.2015.08.018","article-title":"Urinary tract cancer in Lynch syndrome; increased risk in carriers of MSH2 mutations","volume":"86","author":"Joost","year":"2015","journal-title":"Urology"},{"key":"2020012404264491600_ref31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10689-012-9526-6","article-title":"Uroepithelial and kidney carcinoma in Lynch syndrome","volume":"11","author":"Aarnio","year":"2012","journal-title":"Fam Cancer."},{"key":"2020012404264491600_ref32","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1200\/JCO.2012.43.2278","article-title":"Risks of less common cancers in proven mutation carriers with Lynch syndrome","volume":"30","author":"Engel","year":"2012","journal-title":"J Clin Oncol"},{"key":"2020012404264491600_ref33","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/S0022-5347(05)66409-9","article-title":"Genetic analysis of hMLH1 in transitional cell carcinoma of the urinary tract: promoter methylation or mutation","volume":"165","author":"Furihata","year":"2001","journal-title":"J Urol"},{"key":"2020012404264491600_ref34","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1097\/01.MP.0000024263.25043.0C","article-title":"Upper tract urothelial carcinoma: a clinicopathologic study including microsatellite instability analysis","volume":"15","author":"Blaszyk","year":"2002","journal-title":"Mod Pathol"},{"key":"2020012404264491600_ref35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2353\/jmoldx.2006.050092","article-title":"Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers","volume":"8","author":"Murphy","year":"2006","journal-title":"J Mol Diagn"},{"key":"2020012404264491600_ref36","doi-asserted-by":"crossref","first-page":"e9393","DOI":"10.1371\/journal.pone.0009393","article-title":"An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers","volume":"5","author":"Goel","year":"2010","journal-title":"PLoS One"},{"key":"2020012404264491600_ref37","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1200\/JCO.20.4.1043","article-title":"Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors","volume":"20","author":"Lindor","year":"2002","journal-title":"J Clin Oncol"},{"key":"2020012404264491600_ref38","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ygyno.2012.01.049","article-title":"Prospective evaluation of molecular screening for Lynch syndrome in patients with endometrial cancer \u226470 years","volume":"125","author":"Leenen","year":"2012","journal-title":"Gynecol Oncol"},{"key":"2020012404264491600_ref39","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1001\/jama.2012.13088","article-title":"Identification of Lynch syndrome among patients with colorectal cancer","volume":"308","author":"Moreira","year":"2012","journal-title":"JAMA"},{"key":"2020012404264491600_ref40","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/path.3963","article-title":"Yield of routine molecular analyses in colorectal cancer patients \u226470 years to detect underlying Lynch syndrome","volume":"226","author":"van Lier","year":"2012","journal-title":"J Pathol"},{"key":"2020012404264491600_ref41","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1002\/cncr.28933","article-title":"Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing","volume":"120","author":"Ferguson","year":"2014","journal-title":"Cancer"},{"key":"2020012404264491600_ref42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1200\/JCO.2013.51.2129","article-title":"Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing","volume":"32","author":"Buchanan","year":"2014","journal-title":"J Clin Oncol"},{"key":"2020012404264491600_ref43","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.eururo.2008.08.008","article-title":"Upper urinary tract urothelial cell carcinomas and other urological malignancies involved in the hereditary nonpolyposis colorectal cancer (Lynch syndrome) tumor spectrum","volume":"54","author":"Roupr\u00eat","year":"2008","journal-title":"Eur Urol"},{"key":"2020012404264491600_ref44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/MOU.0000000000000340","article-title":"Lynch syndrome in upper tract urothelial carcinoma: significance, screening, and surveillance","volume":"27","author":"Pradere","year":"2017","journal-title":"Curr Opin Urol"},{"key":"2020012404264491600_ref45","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1464-410X.2010.09443.x","article-title":"Towards a rational strategy for the surveillance of patients with Lynch syndrome (hereditary non-polyposis colon cancer) for upper tract transitional cell carcinoma","volume":"106","author":"Acher","year":"2010","journal-title":"BJU Int."},{"key":"2020012404264491600_ref46","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.juro.2010.12.102","article-title":"Upper urinary tract carcinoma in Lynch syndrome cases","volume":"185","author":"Crockett","year":"2011","journal-title":"J Urol"},{"key":"2020012404264491600_ref47","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/modpathol.2016.171","article-title":"Upper tract urothelial carcinomas: frequency of association with mismatch repair protein loss and Lynch syndrome","volume":"30","author":"Harper","year":"2017","journal-title":"Mod Pathol"},{"key":"2020012404264491600_ref48","doi-asserted-by":"crossref","first-page":"e583","DOI":"10.1111\/j.1464-410X.2012.11298.x","article-title":"A proportion of hereditary upper urinary tract urothelial carcinomas are misclassified as sporadic according to multi-institutional database analysis: proposal of patient-specific risk identification tool","volume":"110","author":"Audenet","year":"2012","journal-title":"BJU Int"},{"key":"2020012404264491600_ref49","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1056\/NEJMoa1613683","article-title":"Pembrolizumab as second-line therapy for advanced urothelial carcinoma","volume":"376","author":"Bellmunt","year":"2017","journal-title":"N Engl J Med"},{"key":"2020012404264491600_ref50","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1200\/JCO.2018.36.15_suppl.3514","article-title":"KEYNOTE-164: pembrolizumab for patients with advanced microsatellite instability high (MSI-H) colorectal cancer","volume":"36","author":"Le","year":"2018","journal-title":"J Clin Oncol"},{"key":"2020012404264491600_ref51","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1200\/JCO.2017.35.15_suppl.5514","article-title":"Pembrolizumab for previously treated advanced cervical squamous cell cancer: preliminary results from the phase 2 KEYNOTE-158 study","volume":"35","author":"Jan","year":"2017","journal-title":"J Clin Oncol"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/50\/1\/80\/31952846\/hyz140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/50\/1\/80\/31952846\/hyz140.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T20:05:28Z","timestamp":1664136328000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/50\/1\/80\/5610092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,10,30]]},"published-print":{"date-parts":[[2020,1,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyz140","relation":{},"ISSN":["1465-3621"],"issn-type":[{"value":"1465-3621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,10,30]]}}}