{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:55:55Z","timestamp":1753876555757,"version":"3.41.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Obesity increases the risk for many diseases, including some malignancies. We found that in diffuse large B-cell lymphoma, the most common form of non-Hodgkin\u2019s lymphoma, patients with higher body mass index had significantly longer overall survival. Patients with peripheral T-cell lymphoma usually have worse outcomes than those with diffuse large B-cell lymphoma. Nonetheless, the association between body mass index at diagnosis and survival in patients with peripheral T-cell lymphoma remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 411 peripheral T-cell lymphoma patients from January 2010 to July 2017. Patients were stratified by body mass index into low body mass index (&lt;24.0\u00a0kg\/m2) and high body mass index (\u226524.0\u00a0kg\/m2) groups. We mainly used Cox modelling and the Kaplan\u2013Meier method to evaluate survival and other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analysis demonstrated that body mass index, international prognostic index and triglyceride level were independent prognostic factors of overall survival. Interestingly, patients with high body mass index had significantly longer overall survival (P\u00a0&lt;\u00a00.01), with 69% of patients alive at 3\u00a0years versus 43% in the low body mass index group. Cox analysis showed reduced mortality in the high body mass index group compared with the low body mass index group (hazard ratio\u00a0=\u00a00.511, 95% CI, 0.309\u20130.846, P\u00a0=\u00a00.009). In addition, patients with high body mass index and low international prognostic index had the longest overall survival (P\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High body mass index at the time of diagnosis was associated with improved overall survival in Chinese peripheral T-cell lymphoma patients.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jjco\/hyz144","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T11:45:18Z","timestamp":1566560718000},"source":"Crossref","is-referenced-by-count":1,"title":["Body mass index at diagnosis is associated with survival outcome in peripheral T-cell lymphoma: a study of Chinese population"],"prefix":"10.1093","author":[{"given":"Shanshan","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danlei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiujin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0966-5581","authenticated-orcid":false,"given":"Wanzhuo","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"2019101506285014500_ref1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1467-789X.2011.00944.x","article-title":"Secular trends in the prevalence of general and abdominal obesity among Chinese adults, 1993\u20132009","volume":"13","author":"Xi","year":"2012","journal-title":"Obes Rev"},{"key":"2019101506285014500_ref2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0140-6736(09)60318-4","article-title":"Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies","volume":"373","author":"Whitlock","year":"2009","journal-title":"Lancet"},{"key":"2019101506285014500_ref3","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.3109\/10428194.2012.742523","article-title":"Body mass index, height and risk of lymphoid neoplasms in a large United States cohort","volume":"54","author":"Patel","year":"2013","journal-title":"Leuk Lymphoma"},{"key":"2019101506285014500_ref4","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/jnci\/djj442","article-title":"Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer","volume":"98","author":"Dignam","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"2019101506285014500_ref5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1200\/JCO.2010.29.7614","article-title":"Effect of obesity on prognosis after early-stage breast cancer","volume":"29","author":"Ewertz","year":"2011","journal-title":"J Clin Oncol"},{"key":"2019101506285014500_ref6","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1007\/s10552-010-9618-2","article-title":"Obesity is associated with improved survival in patients with organ-confined clear-cell kidney cancer","volume":"21","author":"Waalkes","year":"2010","journal-title":"Cancer Causes Control"},{"key":"2019101506285014500_ref7","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1016\/j.jss.2011.04.061","article-title":"Obesity and weight loss at presentation of lung cancer are associated with opposite effects on survival","volume":"170","author":"Yang","year":"2011","journal-title":"J Surg Res"},{"key":"2019101506285014500_ref8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/annonc\/mdi145","article-title":"Risk profile and outcome in Hodgkin\u2019s lymphoma: is obesity beneficial?","volume":"16","author":"Landgren","year":"2005","journal-title":"Ann Oncol"},{"key":"2019101506285014500_ref9","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1200\/JCO.2011.39.2100","article-title":"Increased body mass index is associated with improved survival in United States veterans with diffuse large B-cell lymphoma","volume":"30","author":"Carson","year":"2012","journal-title":"J Clin Oncol"},{"key":"2019101506285014500_ref10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/annonc\/mdt481","article-title":"Increased body mass index is associated with improved overall survival in diffuse large B-cell lymphoma","volume":"25","author":"Weiss","year":"2014","journal-title":"Ann Oncol"},{"key":"2019101506285014500_ref11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/annonc\/mdt594","article-title":"The role of body mass index in survival outcome for lymphoma patients: US intergroup experience","volume":"25","author":"Hong","year":"2014","journal-title":"Ann Oncol"},{"key":"2019101506285014500_ref12","first-page":"83","article-title":"Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2014study on optimal cut-off points of body mass index and waist circumference in Chinese adults","volume":"15","author":"Zhou","year":"2002","journal-title":"Biomed Environ Sci"},{"key":"2019101506285014500_ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2016.12.132","article-title":"Effect of aerobic exercise on the atherogenic index of plasma in middle-aged Chinese men with various body weights","volume":"230","author":"Shen","year":"2017","journal-title":"Int J Cardiol"},{"key":"2019101506285014500_ref14","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJM199309303291402","article-title":"A predictive model for aggressive non-Hodgkin\u2019s lymphoma","volume":"329","year":"1993","journal-title":"N Engl J 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