{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:51:42Z","timestamp":1789563102538,"version":"build-2803163510"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the impact of lymphadenectomy (LND) on survival of clinically apparent early-stage malignant ovarian germ cell tumors (MOGCTs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively analyzed the survival of patients who were diagnosed with the three most common histopathology types of malignant ovarian germ cell tumors (yolk sac tumor, dysgerminoma and immature teratoma) and with clinical stage I and II disease, and treated at Sun Yat-sen University Cancer Center between 1 January 1970 and 30 September 2018.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 227 stage I, 28 stage II and one stage IIIA cases after surgery. One hundred and twenty-six patients underwent lymphadenectomy and 130 did not. Only one lymph node metastasis (0.8%) was found in the lymphadenectomy group. Two hundred and twenty-four out of 256 patients (87.5%) received postoperative chemotherapy. There were five relapses (4.0%) in the lymphadenectomy group and four (3.1%) in the non-lymphadenectomy group. Median follow-up was 68\u00a0months (range, 1\u2013388). The 10-year disease-free survival rate in the lymphadenectomy group and non-lymphadenectomy group were 88.2 and 96.4%, respectively (P\u00a0=\u00a00.412); the 10-year overall survival rate in the two groups were 95.7 and 98.2%; respectively (P\u00a0=\u00a00.798). The results showed that lymphadenectomy did not improve patient survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Lymphadenectomy may have little impact on survival in patients with clinically apparent early-stage malignant ovarian germ cell tumors and may be omitted in the surgical treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyz180","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T21:21:31Z","timestamp":1572556891000},"page":"282-287","source":"Crossref","is-referenced-by-count":12,"title":["The impact of lymphadenectomy on prognosis and survival of clinically apparent early-stage malignant ovarian germ cell tumors"],"prefix":"10.1093","volume":"50","author":[{"given":"Beijiao","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"},{"name":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"2020030903372912000_ref1","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1097\/IGC.0000000000000223","article-title":"Gynecologic cancer intergroup (GCIG) consensus review for ovarian germ cell tumors","volume":"24","author":"Brown","year":"2014","journal-title":"Int J Gynecol Cancer"},{"key":"2020030903372912000_ref2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ygyno.2010.12.351","article-title":"Multidisciplinary management of malignant ovarian germ cell tumours","volume":"121","author":"Parkinson","year":"2011","journal-title":"Gynecol Oncol"},{"key":"2020030903372912000_ref3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ygyno.2015.03.054","article-title":"Outcomes of pediatric and adolescent girls with malignant ovarian germ cell tumors","volume":"137","author":"Park","year":"2015","journal-title":"Gynecol Oncol"},{"key":"2020030903372912000_ref4","author":"National Comprehensive Cancer Network clinical practice guidelines of ovarian cancer"},{"key":"2020030903372912000_ref5","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.bpobgyn.2015.04.010","article-title":"Does debulking of enlarged positive lymph nodes improve survival in different gynaecological cancers?","volume":"29","author":"Somashekhar","year":"2015","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2020030903372912000_ref6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ygyno.2016.08.329","article-title":"Conundrums in the management of malignant ovarian germ cell tumors: Toward lessening acute morbidity and late effects of treatment","volume":"143","author":"Gershenson","year":"2016","journal-title":"Gynecol 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