{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T22:01:00Z","timestamp":1794261660228,"version":"4.9.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although thymic carcinoma is a rare epithelial neoplasm that tends to be aggressive and metastasize widely, its incidence in Japan remains unclear. This study was to examine the incidence and initial treatment of thymic carcinoma in the Japanese population using data from a hospital-based cancer registry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using data from the national database of hospital-based cancer registries, we examined the incidence and initial treatment of thymic carcinoma diagnosed and treated in designated and non-designated cancer care hospitals between 2009 and 2015. Based on Japanese population estimates, we calculated the incidence rate of thymic cancer in Japan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2587 thymic carcinoma cases were diagnosed between 1 January 2009 and 31 December 2015. These patients consisted of 1705 (66%) men and 882 (34%) women, with a median age of 65.5\u00a0years (range, 16\u201396\u00a0years). The number and proportion of thymic carcinoma to all registered cancer cases per year increased each year. The incidence rate was estimated to be 0.29\/100000 during the observation period, with an annual onset incidence of 0.38\/100000 in 2015. Almost half of all cases of thymic carcinoma were treated surgically, while the others were treated with non-surgical therapy consisting of chemotherapy with or without radiotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We estimated the incidence rate of thymic carcinoma in Japan based on the designated cancer care hospital-based cancer registry. The half of all patients with thymic carcinoma was unfit for multimodality therapy, including thoracic surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyz203","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T12:10:47Z","timestamp":1579867847000},"page":"434-439","source":"Crossref","is-referenced-by-count":28,"title":["National incidence and initial therapy for thymic carcinoma in Japan: based on analysis of hospital-based cancer registry data, 2009\u20132015"],"prefix":"10.1093","volume":"50","author":[{"given":"Tomonobu","family":"Koizumi","sequence":"first","affiliation":[{"name":"Department of Comprehensive Cancer Therapy, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Otsuki","sequence":"first","affiliation":[{"name":"Department of Comprehensive Cancer Therapy, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Comprehensive Cancer Therapy, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Noguchi","sequence":"first","affiliation":[{"name":"Department of Comprehensive Cancer Therapy, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshirou","family":"Fukushuima","sequence":"first","affiliation":[{"name":"Department of Comprehensive Cancer Therapy, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Comprehensive Cancer Therapy, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takesumi","family":"Ozawa","sequence":"first","affiliation":[{"name":"Department of Comprehensive Cancer Therapy, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nodoka","family":"Sekiguchi","sequence":"first","affiliation":[{"name":"Department of Comprehensive Cancer Therapy, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Hamanaka","sequence":"first","affiliation":[{"name":"Department of Breast, Endocrine and Thoracic Surgery, Shinshu University School of Medicine, Matsumoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"2020041702554502900_ref1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/1097-0142(19910215)67:4<1025::AID-CNCR2820670427>3.0.CO;2-F","article-title":"Thymic carcinoma. A clinicopathologic study of 60 cases","volume":"67","author":"Suster","year":"1991","journal-title":"Cancer"},{"key":"2020041702554502900_ref2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0022-5223(94)70112-1","article-title":"Thymic carcinoma. 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The IASLC\/ITMIG thymic epithelial tumors staging project: proposal for an evidence-based stage classification system for the forthcoming(8th)edition of the TNM classification of malignant tumors","volume":"9","author":"Detterbeck","year":"2014","journal-title":"J Thorac Oncol"},{"key":"2020041702554502900_ref8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jtcvs.2014.09.124","article-title":"Thymic carcinoma outcomes and prognosis: results of an international analysis","volume":"149","author":"Ahmad","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020041702554502900_ref9","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/ejcts\/ezw107","article-title":"Comparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the international thymic malignancy interest group","volume":"50","author":"Filosso","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020041702554502900_ref10","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/ejcts\/ezv239","article-title":"Japanese Association for Research on the thymus (JART). Long-term outcome and prognostic factors of surgically treated thymic carcinoma: results of 306 cases from a Japanese Nationwide database study","volume":"49","author":"Hishida","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020041702554502900_ref11","doi-asserted-by":"crossref","DOI":"10.1634\/theoncologist.2017-0586","article-title":"North East Japan study group. Prognostic factors and efficacy of first-line chemotherapy in patients with advanced thymic carcinoma: a retrospective analysis of 286 patients from NEJ023 study","author":"Ko","year":"2018","journal-title":"Oncologist"},{"key":"2020041702554502900_ref12","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ijc.11099","article-title":"Malignant thymoma in the United States: Demographic patterns in inci- dence and associations with subsequent malignan- cies","volume":"105","author":"Engels","year":"2003","journal-title":"Int J Cancer"},{"key":"2020041702554502900_ref13","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.canep.2014.07.014","article-title":"The burden of rare cancer in Japan: application of the RARECARE definition","volume":"38","author":"Tamaki","year":"2014","journal-title":"Cancer Epidemiol"},{"key":"2020041702554502900_ref14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/jjco\/hyt013","article-title":"The national database of hospital-based cancer registries: a nationwide infrastructure to support evidence-based cancer care and cancer control policy in Japan","volume":"44","author":"Higashi","year":"2014","journal-title":"Jpn J Clin Oncol"},{"key":"2020041702554502900_ref15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.canep.2017.10.010","article-title":"Cancer in adolescents and young adults: National incidence and characteristics in Japan","volume":"51","author":"Inoue","year":"2017","journal-title":"Cancer Epidemiol"},{"key":"2020041702554502900_ref16","author":"Center for Cancer Control and Information Services"},{"key":"2020041702554502900_ref17","volume-title":"World Health Organization Classification of Tumours of the Lung, Pleura, Thymus and Heart","author":"Travis","year":"2015"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/50\/4\/434\/33096173\/hyz203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/50\/4\/434\/33096173\/hyz203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T06:56:04Z","timestamp":1587106564000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/50\/4\/434\/5781839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,3,5]]},"published-print":{"date-parts":[[2020,4,7]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyz203","relation":{},"ISSN":["1465-3621"],"issn-type":[{"value":"1465-3621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2020,3,5]]}}}