{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:27:12Z","timestamp":1760909232629,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T00:00:00Z","timestamp":1577491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"IgG4-related Disease Research Program"},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["JP16K08666","JP19K18731"],"award-info":[{"award-number":["JP16K08666","JP19K18731"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Practical Research Project for Rare\/Intractable"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Metastasis-associated in colon cancer 1 (MACC1) has been reported to be an independent indicator of poor prognoses in some kinds of cancer due to disease metastasis or recurrence. We investigated the correlation between MACC1 expression and the prognosis of glottic cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Paraffin-embedded, early-stage (I or II) glottic cancer specimens (n\u00a0=\u00a052) were immunohistochemically analyzed to explore MACC1 expression. The clinical records associated with each case were also examined. Recurrence-free survival (RFS) was estimated using the Kaplan\u2013Meier method, and between-group RFS differences were assessed using the log-rank test. The multivariate analyses were evaluated using the Cox\u2019s proportional-hazard model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients were treated with only radiotherapy (RT) (n\u00a0=\u00a037, including 18 with T1 disease and 19 with T2 disease), or with chemoradiotherapy (CRT) (n\u00a0=\u00a015, including 1 with T1 disease and 14 with T2 disease). Eleven patients demonstrated local recurrence and two patients experienced cervical lymph node recurrence. Tumor specimens were MACC1-positive in 9 of the 13 (69.2%) patients with local or neck recurrence, and 7 of the 11 (63.6%) patients with local recurrence. The RFS rate of patients who were treated with only RT was significantly lower than that of patients who were treated with CRT (P\u00a0=\u00a00.0243). The RFS rate was significantly lower in cases with MACC1 expression than in those without MACC1 expression (P\u00a0=\u00a00.0003). Multivariate analysis revealed that MACC1 expression was an independent risk factor of local recurrence (P\u00a0=\u00a00.0016).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>MACC1 is an independent indicator of recurrence related to RFS in early-stage glottic cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyz206","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T12:11:26Z","timestamp":1575979886000},"page":"392-398","source":"Crossref","is-referenced-by-count":5,"title":["MACC1 expression is an indicator of recurrence in early-stage glottic cancer"],"prefix":"10.1093","volume":"50","author":[{"given":"Takuma","family":"Makino","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorihisa","family":"Orita","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Gion","sequence":"first","affiliation":[{"name":"Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyasu","family":"Tachibana","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Himeji Red-Cross Hospital, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soshi","family":"Takao","sequence":"first","affiliation":[{"name":"Departments of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,28]]},"reference":[{"key":"2020041702553976300_ref1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nm.1889","article-title":"MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis","volume":"15","author":"Stein","year":"2009","journal-title":"Nat Med"},{"key":"2020041702553976300_ref2","first-page":"1141","article-title":"Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis","volume":"31","author":"Chundong","year":"2011","journal-title":"Anticancer Res"},{"key":"2020041702553976300_ref3","first-page":"4150","article-title":"Metastasis-associated colon cancer-1 is a novel prognostic marker for cervical cancer","volume":"7","author":"Guo","year":"2014","journal-title":"Int J Clin Exp 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