{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:18:41Z","timestamp":1769602721698,"version":"3.49.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Qingpu Commission of Science & Technology Development Foundation","award":["QKY2018\u201305"],"award-info":[{"award-number":["QKY2018\u201305"]}]},{"name":"Health System Key Specialist Fund of Qingpu District","award":["WZ2015\u201303"],"award-info":[{"award-number":["WZ2015\u201303"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to explore the prognostic role of c-MYC amplification in colorectal cancer, particularly in schistosomiasis-associated colorectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and fifty four cases of colorectal cancer, which were from Qingpu Branch of Zhongshan Hospital affiliated to Fudan University, were retrospectively analyzed in a tissue microarray (TMA) format, with fluorescence in situ hybridization (FISH) assay and immunohistochemistry (IHC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>c-MYC gene amplification was found in 14.1% (50 out of 354) of patients with colorectal cancer and was correlated with old age (P\u00a0=\u00a00.028), positive lymph node metastasis (P\u00a0=\u00a00.004) and advanced stage tumors (P\u00a0=\u00a00.002). The overexpression of c-MYC was closely associated with the amplification status (P\u00a0=\u00a00.023). Kaplan\u2013Meier survival curves for overall survival (OS) showed a statistically significant difference for patients with c-MYC amplification in full cohort of colorectal cancer, stage III-IV set and patients with lymph node metastasis (P\u00a0=\u00a00.002, 0.034, 0.012, respectively). Further analysis found c-MYC amplification associated with poorer survival in the subgroup of colorectal cancer with schistosomiasis (CRC-S, P &amp;lt; 0.001), but not in colorectal cancer without schistosomiasis (CRC-NS, P\u00a0=\u00a00.155). By multivariate analysis, c-MYC amplification was an independent poor-prognostic factor in CRC-S set (P\u00a0=\u00a00.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study firstly found c-MYC amplification could predict poor prognosis in schistosomiasis-associated colorectal cancer, but not in colorectal cancer without schistosomiasis.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jjco\/hyz210","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T12:10:52Z","timestamp":1576843852000},"page":"446-455","source":"Crossref","is-referenced-by-count":18,"title":["The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer"],"prefix":"10.1093","volume":"50","author":[{"given":"Weiyu","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinian","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 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