{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:24:23Z","timestamp":1778657063099,"version":"3.51.4"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Mexican National Council for Science and Technology","award":["302978"],"award-info":[{"award-number":["302978"]}]},{"name":"Consejo Nacional de Humanidades, Ciencias, y Tecnolog\u00edas","award":["21887"],"award-info":[{"award-number":["21887"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that is still fatal in many cases. T cell blasts are characterized by hyperactivation and strong proliferative and migratory capacities. The chemokine receptor CXCR4 is involved in mediating malignant T cell properties, and cortactin has been shown to control CXCR4 surface localization in T-ALL cells. We have previously shown that cortactin overexpression is correlated with organ infiltration and relapse in B-ALL. However, the role of cortactin in T cell biology and T-ALL remains elusive. Here, we analyzed the functional relevance of cortactin for T cell activation and migration and the implications for T-ALL development. We found that cortactin is upregulated in response to T cell receptor engagement and recruited to the immune synapse in normal T cells. Loss of cortactin caused reduced IL-2 production and proliferation. Cortactin-depleted T cells showed defects in immune synapse formation and migrated less due to impaired actin polymerization in response to T cell receptor and CXCR4 stimulation. Leukemic T cells expressed much higher levels of cortactin compared to normal T cells that correlated with greater migratory capacity. Xenotransplantation assays in NSG mice revealed that cortactin-depleted human leukemic T cells colonized the bone marrow significantly less and failed to infiltrate the central nervous system, suggesting that cortactin overexpression drives organ infiltration, which is a major complication of T-ALL relapse. Thus, cortactin could serve as a potential therapeutic target for T-ALL and other pathologies involving aberrant T cell responses.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad001","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T11:54:40Z","timestamp":1674129280000},"page":"315-325","source":"Crossref","is-referenced-by-count":6,"title":["T cell functions and organ infiltration by leukemic T cells require cortactin"],"prefix":"10.1093","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8301-1626","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Castellanos-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedicine, CINVESTAV-IPN , Av. IPN 2508, San Pedro Zacatenco, 07360 Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iliana I","family":"Le\u00f3n-Vega","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, CINVESTAV-IPN , Av. IPN 2508, San Pedro Zacatenco, 07360 Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idaira M","family":"Guerrero-Fonseca","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, CINVESTAV-IPN , Av. IPN 2508, San Pedro Zacatenco, 07360 Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda","family":"Vargas-Robles","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, CINVESTAV-IPN , Av. IPN 2508, San Pedro Zacatenco, 07360 Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina E","family":"Jim\u00e9nez-Camacho","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, CINVESTAV-IPN , Av. IPN 2508, San Pedro Zacatenco, 07360 Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Hern\u00e1ndez-Galicia","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, CINVESTAV-IPN , Av. IPN 2508, San Pedro Zacatenco, 07360 Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vianney F","family":"Ortiz-Navarrete","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, CINVESTAV-IPN , Av. IPN 2508, San Pedro Zacatenco, 07360 Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klemens","family":"Rottner","sequence":"additional","affiliation":[{"name":"Division of Molecular Cell Biology, Zoological Institute, TU Braunschweig , Spielmannstr. 7, 38106 Braunschweig , Germany"},{"name":"Department of Cell Biology, Helmholtz Centre for Infection Research , Inhoffenstr. 7, 38124 Braunschweig , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Medina-Contreras","sequence":"additional","affiliation":[{"name":"Department of Hemato-oncology, Hospital Infantil \u201cFederico G\u00f3mez,\u201d , Av. Dr. M\u00e1rquez 162, 06720 Mexico City , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-5884","authenticated-orcid":false,"given":"Michael","family":"Schnoor","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine, CINVESTAV-IPN , Av. 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