{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T02:48:00Z","timestamp":1774406880060,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lymphocytic leukemia (CLL) is characterized by an expansion of mature B cells in the bone marrow, peripheral lymphoid organs, and blood. CD4 T helper (Th) lymphocytes significantly contribute to the physiopathology of CLL, but the subset(s) of Th cell involved in CLL pathogenesis is (are) still under debate. In this study, we performed flow cytometry analysis of the circulatory T cells of untreated CLL patients and observed an increase in follicular helper T cells (Tfh), which is a subset of T cells specialized in B cell help. Elevated numbers of Tfh cells correlated with disease severity as measured by the Binet staging system. Tfh from CLL patients were activated and skewed toward a Th1 profile as evidenced by their PD-1+IL-21+IFN\u03b3+ phenotype and their CXCR3+CCR6\u2212 chemokine receptor profile. Tfh efficiently enhanced B-CLL survival and proliferation through IL-21 but independently of IFN\u03b3. Finally, we observed an inverse correlation between the Tfh1 and IgA and IgG serum levels in patients, suggesting a role for this Tfh subset in the immune dysfunction associated with CLL. Altogether, our data highlight an impairment in circulatory Tfh subsets in CLL patients and their critical role in CLL physiopathology.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad006","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T01:48:38Z","timestamp":1674784118000},"page":"305-314","source":"Crossref","is-referenced-by-count":9,"title":["Elevated levels of circulatory follicular T helper cells in chronic lymphocytic leukemia contribute to B cell expansion"],"prefix":"10.1093","volume":"113","author":[{"given":"Corentin","family":"Le Saos-Patrinos","sequence":"first","affiliation":[{"name":"Immunoconcept, CNRS UMR 5164, Universit\u00e9 de Bordeaux , 146 rue Leo Saignat, 33076 Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9verine","family":"Loizon","sequence":"additional","affiliation":[{"name":"Immunoconcept, CNRS UMR 5164, Universit\u00e9 de Bordeaux , 146 rue Leo Saignat, 33076 Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atika","family":"Zouine","sequence":"additional","affiliation":[{"name":"TBM Core, UB Facsility, CNRS UMS 3427, Inserm US 005 , 146 rue Leo Saignat, 33076 Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Turpin","sequence":"additional","affiliation":[{"name":"Immunoconcept, CNRS UMR 5164, Universit\u00e9 de Bordeaux , 146 rue Leo Saignat, 33076 Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Sarah","family":"Dilhuydy","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire, Centre Hospitalier Universitaire de Bordeaux, H\u00f4pital Haut L\u00e9v\u00eaque, Av de Magellan , 33600 Pessac, Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Blanco","sequence":"additional","affiliation":[{"name":"Immunoconcept, CNRS UMR 5164, Universit\u00e9 de Bordeaux , 146 rue Leo Saignat, 33076 Bordeaux , France"},{"name":"Service d'immunologie et immunog\u00e9n\u00e9tique, Centre Hospitalier Universitaire de Bordeaux, Place Am\u00e9lie Raba-L\u00e9on , 33000 Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanja","family":"Sisirak","sequence":"additional","affiliation":[{"name":"Immunoconcept, CNRS UMR 5164, Universit\u00e9 de Bordeaux , 146 rue Leo Saignat, 33076 Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Forcade","sequence":"additional","affiliation":[{"name":"Immunoconcept, CNRS UMR 5164, Universit\u00e9 de Bordeaux , 146 rue Leo Saignat, 33076 Bordeaux , France"},{"name":"Service d'H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire, Centre Hospitalier Universitaire de Bordeaux, H\u00f4pital Haut L\u00e9v\u00eaque, Av de Magellan , 33600 Pessac, Bordeaux , 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