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Maternal immune tolerance toward the foreign fetus is critical for a successful pregnancy. Decidual macrophages are the primary antigen-presenting and phagocytic cells responsible for antigen presentation and apoptotic cell removal. Their phenotype changes dynamically during pregnancy. Placenta-derived exosomes are small vesicles carrying active biological molecules such as microRNAs, proteins, and lipids. The placenta-derived exosomes have been implicated in endothelial cell activation, smooth muscle cell migration, and T-cell apoptosis, but it is unknown whether placenta-derived exosomes would affect the development and functions of decidual macrophages. In this study, we reported that placenta-derived exosomes stimulated macrophage polarization into alternatively activated (M2) macrophages. Mechanistically, miRNA-30d-5p from the placenta-derived exosomes induced macrophage polarization to the M2 phenotype by targeting histone deacetylase 9. Furthermore, the conditioned medium of placenta-derived exosome\u2013treated macrophages promoted trophoblast migration and invasion. By contrast, the conditioned medium impaired the ability of endothelial cell tube formation and migration. Placenta-derived exosome\u2013treated macrophages had no impact on T-cell proliferation. Together, we demonstrated that placenta-derived exosomes polarize macrophages to acquire a decidua-like macrophage phenotype to modulate trophoblast and endothelial cell functions.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad022","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T15:08:00Z","timestamp":1677164880000},"page":"434-444","source":"Crossref","is-referenced-by-count":19,"title":["Placenta exosomal miRNA-30d-5p facilitates decidual macrophage polarization by targeting HDAC9"],"prefix":"10.1093","volume":"113","author":[{"given":"Kunfeng","family":"Bai","sequence":"first","affiliation":[{"name":"Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guandong Provincial Clinical Research Center for Child Health , 9 Jinsui Rd, Guangzhou 510623 , China"},{"name":"Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong , 21 Sassoon Road, Pokfulam, Hong Kong S.A.R. , China"},{"name":"Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong , 21 Sassoon Road, Pokfulam, Hong Kong S.A.R. , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leqian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong , 21 Sassoon Road, Pokfulam, Hong Kong S.A.R. , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong , 21 Sassoon Road, Pokfulam, Hong Kong S.A.R. , China"},{"name":"Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong , 21 Sassoon Road, Pokfulam, Hong Kong S.A.R. , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"},{"name":"Center of Reproduction and Prenatal Diagnosis, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Cao","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"},{"name":"Center of Reproduction and Prenatal Diagnosis, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Gang","family":"Duan","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"},{"name":"Center of Reproduction and Prenatal Diagnosis, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Yao","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"},{"name":"Center of Reproduction and Prenatal Diagnosis, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond H W","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong , 21 Sassoon Road, Pokfulam, Hong Kong S.A.R. , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-Wang","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong , 21 Sassoon Road, Pokfulam, Hong Kong S.A.R. , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-0879","authenticated-orcid":false,"given":"William S B","family":"Yeung","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"},{"name":"Center of Reproduction and Prenatal Diagnosis, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C N","family":"Chiu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital , 1 Haiyuan 1st Road, Futian District, Shenzhen 518009 , 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