{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:38:38Z","timestamp":1787503118332,"version":"build-2736575974"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81922078"],"award-info":[{"award-number":["81922078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071145"],"award-info":[{"award-number":["32071145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hong Kong Research Grant Council Early Career Scheme","award":["24122318"],"award-info":[{"award-number":["24122318"]}]},{"name":"General Research Fund","award":["14109519"],"award-info":[{"award-number":["14109519"]}]},{"name":"General Research Fund","award":["14105321"],"award-info":[{"award-number":["14105321"]}]},{"name":"General Research Fund","award":["14107822"],"award-info":[{"award-number":["14107822"]}]},{"name":"Hong Kong Food and Health Bureau Health and Medical Research Fund","award":["08191156"],"award-info":[{"award-number":["08191156"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asthma is the chronic pulmonary inflammatory response that could lead to respiratory failure when allergic reactions exacerbate. It is featured by type 2 immunity with eosinophilic inflammation, mucus, and IgE production, and Th2 cytokine secretion upon repeated challenge of allergens. The symptom severity of asthma displays an apparent circadian rhythm with aggravated airway resistance in the early morning in patients. Bmal1 is the core regulator of the circadian clock, while the regulatory role of Bmal1 in asthma remains unclear. Here, we investigate whether the myeloid Bmal1 is involved in the pathogenesis of house dust mite (HDM)\u2013induced lung allergy. We found that knockdown of Bmal1 in macrophages suppressed the time-of-day variance of the eosinophil infiltration in the alveolar spaces in chronic asthmatic mice. This was accompanied by decreased bronchial mucus production, collagen deposition, and HDM-specific IgE production. However, the suppression effects of myeloid Bmal1 deletion did not alter the allergic responses in short-term exposure to HDM. The transcriptome profile of alveolar macrophages (AMs) showed that Bmal1-deficient AMs have enhanced phagocytosis and reduced production of allergy-mediating prostanoids thromboxane A2 and prostaglandin F2\u03b1 synthesis. The attenuated thromboxane A2 and prostaglandin F2\u03b1 may lead to less induction of the eosinophil chemokine Ccl11 expression in bronchial epithelial cells. In summary, our study demonstrates that Bmal1 ablation in macrophages attenuates eosinophilic inflammation in HDM-induced chronic lung allergy, which involves enhanced phagocytosis and reduced prostanoid secretion.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad047","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T06:06:40Z","timestamp":1683871600000},"page":"164-176","source":"Crossref","is-referenced-by-count":7,"title":["Myeloid Bmal1 deletion suppresses the house dust mite\u2013induced chronic lung allergy"],"prefix":"10.1093","volume":"115","author":[{"given":"Huiling","family":"Hong","sequence":"first","affiliation":[{"name":"Chinese University of Hong Kong, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Shatin, N.T. Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Science Center, Chinese University of Hong Kong, Shatin , N.T. Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Cao","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Shatin, N.T. Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Wu","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Shatin, N.T. Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting Fung","family":"Chan","sequence":"additional","affiliation":[{"name":"Science Center, Chinese University of Hong Kong, Shatin , N.T. Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3472-9898","authenticated-orcid":false,"given":"Xiao Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Chinese University of Hong Kong, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Shatin, N.T. 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