{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:57:09Z","timestamp":1790121429417,"version":"4.0.1"},"reference-count":140,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sj\u00f6gren's syndrome is a systemic autoimmune disease characterized by dysfunction of the affected exocrine glands. Lymphocytic infiltration within the inflamed glands and aberrant B-cell hyperactivation are the two salient pathologic features in Sj\u00f6gren's syndrome. Increasing evidence indicates that salivary gland epithelial cells act as a key regulator in the pathogenesis of Sj\u00f6gren's syndrome, as revealed by the dysregulated innate immune signaling pathways in salivary gland epithelium and increased expression of various proinflammatory molecules as well as their interaction with immune cells. In addition, salivary gland epithelial cells can regulate adaptive immune responses as nonprofessional antigen-presenting cells and promote the activation and differentiation of infiltrated immune cells. Moreover, the local inflammatory milieu can modulate the survival of salivary gland epithelial cells, leading to enhanced apoptosis and pyroptosis with the release of intracellular autoantigens, which further contributes to SG autoimmune inflammation and tissue destruction in Sj\u00f6gren's syndrome. Herein, we reviewed recent advances in elucidating the role of salivary gland epithelial cells in the pathogenesis of Sj\u00f6gren's syndrome, which may provide rationales for potential therapeutic targeting of salivary gland epithelial cells to alleviate salivary gland dysfunction alongside treatments with immunosuppressive reagents in Sj\u00f6gren's syndrome.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad049","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T13:20:12Z","timestamp":1683120012000},"page":"57-67","source":"Crossref","is-referenced-by-count":23,"title":["The role of epithelial cells in the immunopathogenesis of Sj\u00f6gren's syndrome"],"prefix":"10.1093","volume":"115","author":[{"given":"Yuan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong , Pok Fu Lam, Hong Kong Island, Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong , Pok Fu Lam, Hong Kong Island, Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Second People's Hospital of Three Gorges University , College street, Xiling District, Yichang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Nanjing Medical University , Guangzhou Road, Gulou District, Nanjing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Medical Immunology, Affiliated Hospital of Jiangsu University , Jiefang Road, Jingkou District, Zhenjiang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5663-6866","authenticated-orcid":false,"given":"Kwan","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Clinical Medicine, Faculty of Medicine, The University of Hong Kong , Pok Fu Lam, Hong Kong Island, Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Rui","sequence":"additional","affiliation":[{"name":"Institute of Medical Immunology, Affiliated Hospital of Jiangsu University , Jiefang Road, Jingkou District, Zhenjiang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Second People's Hospital of Three Gorges University , College street, Xiling District, Yichang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong , Pok Fu Lam, Hong Kong Island, Hong Kong , China"},{"name":"Centre for Oncology and Immunology, Hong Kong Science Park , Sha Tin, New Territories, Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"issue":"3","key":"2024010518183074800_qiad049-B1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrrheum.2018.1","article-title":"B cells in the pathogenesis of primary Sj\u00f6gren syndrome","volume":"14","author":"Nocturne","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"2024010518183074800_qiad049-B2","first-page":"2211","article-title":"Sj\u00f6gren's syndrome: one year in review 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