{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:17:56Z","timestamp":1787267876034,"version":"build-2736575974"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Ca2+-permeable TRPV4 cation channel is expressed in neutrophils and contributes to myocardial ischemia\/reperfusion injury. Here we tested the hypotheses that TRPV4 promotes neutrophil activation and subsequently aggregates myocardial ischemia\/reperfusion injury. TRPV4 protein was confirmed in neutrophils, and its function was assessed by the current and intracellular Ca2+ concentration elevations evoked by TRPV4 agonists. Furthermore, TRPV4 agonists dose-dependently promoted migration toward fMLP, reactive oxygen species production, and myeloperoxidase release, which were prevented by pretreatment with a selective TRPV4 antagonist, in neutrophils from TRPV4 knockout mice, Ca2+-free medium, or BAPTA-AM + Ca2+-free medium. Blockade of TRPV4 also inhibited the effects of commonly used neutrophil activators fMLP and PMA. Mechanically, TRPV4 regulated neutrophil activation, particularly reactive oxygen species production, by affecting PKC\u03b1, P38, and AKT via Ca2+ signaling. In addition, isolated hearts infused with neutrophils from wild-type mice showed additional myocardial ischemia\/reperfusion injuries but not those infused with TRPV4 knockout. Our study reveals that TRPV4-mediated neutrophil activation enhances myocardial ischemia\/reperfusion injury, and it might be a novel therapeutic target for myocardial ischemia\/reperfusion injury and other neutrophil-mediated inflammatory diseases.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad063","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T13:34:34Z","timestamp":1685108074000},"page":"266-279","source":"Crossref","is-referenced-by-count":22,"title":["Transient receptor potential vanilloid 4 (TRPV4) in neutrophils enhances myocardial ischemia\/reperfusion injury"],"prefix":"10.1093","volume":"114","author":[{"given":"Yuwei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University , 183 Yiling Avenue, Yichang 443003 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoshao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaitao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nanjing Medical University , 101 Longmian Avenue, Jiangning District, Nanjing 211166 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Research Center of Ion Channelopathy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , 1277 Jiefang Avenue, Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"issue":"10065","key":"2023090116544318700_qiad063-B1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"issue":"10159","key":"2023090116544318700_qiad063-B2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the Global Burden of Disease study 2017","volume":"392","author":"GBD 2017 Causes of Death Collaborators","year":"2018","journal-title":"Lancet"},{"issue":"4","key":"2023090116544318700_qiad063-B3","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current mechanistic concepts in ischemia and reperfusion injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"11","key":"2023090116544318700_qiad063-B4","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N Engl J Med"},{"issue":"9","key":"2023090116544318700_qiad063-B5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1160\/TH13-03-0211","article-title":"Pathophysiological role of neutrophils in acute myocardial infarction","volume":"110","author":"Carbone","year":"2013","journal-title":"Thromb Haemost"},{"issue":"3","key":"2023090116544318700_qiad063-B6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cardiores.2003.10.011","article-title":"Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury","volume":"61","author":"Vinten-Johansen","year":"2004","journal-title":"Cardiovasc Res"},{"issue":"4","key":"2023090116544318700_qiad063-B7","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0008-6363(99)00187-X","article-title":"The role of neutrophils in myocardial ischemia-reperfusion injury","volume":"43","author":"Jordan","year":"1999","journal-title":"Cardiovasc Res"},{"issue":"2","key":"2023090116544318700_qiad063-B8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/JLB.3RU0719-241R","article-title":"Calcium signaling and regulation of neutrophil functions: still a long way to go","volume":"107","author":"Hann","year":"2020","journal-title":"J Leukoc Biol"},{"issue":"3","key":"2023090116544318700_qiad063-B9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/physrev.00016.2015","article-title":"TRPV4: molecular conductor of a diverse orchestra","volume":"96","author":"White","year":"2016","journal-title":"Physiol Rev"},{"issue":"1","key":"2023090116544318700_qiad063-B10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1073\/pnas.0303329101","article-title":"Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4","volume":"101","author":"Vriens","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2023090116544318700_qiad063-B11","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1165\/rcmb.2014-0225OC","article-title":"Role of transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury","volume":"54","author":"Yin","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2023090116544318700_qiad063-B12","doi-asserted-by":"crossref","first-page":"7283683","DOI":"10.1155\/2019\/7283683","article-title":"Blockade of transient receptor potential vanilloid 4 enhances antioxidation after myocardial ischemia\/reperfusion","volume":"2019","author":"Wu","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"2023090116544318700_qiad063-B13","doi-asserted-by":"crossref","first-page":"e2828","DOI":"10.1038\/cddis.2017.227","article-title":"Activation of transient receptor potential vanilloid 4 involves in hypoxia\/reoxygenation injury in cardiomyocytes","volume":"8","author":"Wu","year":"2017","journal-title":"Cell Death Dis"},{"issue":"1","key":"2023090116544318700_qiad063-B14","doi-asserted-by":"crossref","first-page":"42678","DOI":"10.1038\/srep42678","article-title":"Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia\/reperfusion injury in mice","volume":"7","author":"Dong","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"2023090116544318700_qiad063-B15","doi-asserted-by":"crossref","first-page":"C96","DOI":"10.1152\/ajpcell.00559.2002","article-title":"Impaired osmotic sensation in mice lacking TRPV4","volume":"285","author":"Mizuno","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"2023090116544318700_qiad063-B16","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1365-2133.2005.06559.x","article-title":"Dapsone suppresses human neutrophil superoxide production and elastase release in a calcium-dependent manner","volume":"152","author":"Suda","year":"2005","journal-title":"Br J Dermatol"},{"key":"2023090116544318700_qiad063-B17","first-page":"57","article-title":"Relationship between the chemiluminescent response of bovine neutrophils and changes in intracellular free calcium concentration","volume":"61(1)","author":"Higuchi","year":"1997","journal-title":"Can J Vet Res"},{"issue":"3","key":"2023090116544318700_qiad063-B18","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1254\/jphs.FP0072083","article-title":"Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca2+ rise and migration of human neutrophils","volume":"106","author":"Morita","year":"2008","journal-title":"J Pharmacol Sci"},{"issue":"6","key":"2023090116544318700_qiad063-B19","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.4049\/jimmunol.137.6.1954","article-title":"Calcium modulation and chemotactic response: divergent stimulation of neutrophil chemotaxis and cytosolic calcium response by the chemotactic peptide receptor","volume":"137","author":"Meshulam","year":"1986","journal-title":"J Immunol"},{"key":"2023090116544318700_qiad063-B20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","article-title":"Myeloperoxidase: its role for host defense, inflammation, and neutrophil function","volume":"640","author":"Aratani","year":"2018","journal-title":"Arch Biochem Biophys"},{"issue":"6","key":"2023090116544318700_qiad063-B21","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1089\/ars.2008.2333","article-title":"Compartmentalization of redox signaling through NADPH oxidase-derived ROS","volume":"11","author":"Ushio-Fukai","year":"2009","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"2023090116544318700_qiad063-B22","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood.V93.5.1464","article-title":"NADPH oxidase: an update","volume":"93","author":"Babior","year":"1999","journal-title":"Blood"},{"issue":"1","key":"2023090116544318700_qiad063-B23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.atherosclerosis.2004.12.044","article-title":"Enhanced oxidative stress in neutrophils from hyperlipidemic guinea pig","volume":"181","author":"Maeda","year":"2005","journal-title":"Atherosclerosis"},{"issue":"3","key":"2023090116544318700_qiad063-B24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.bbamcr.2006.10.007","article-title":"Selective roles for \u03b1-PKC in positive signaling for O2\u2212 generation and calcium mobilization but not elastase release in differentiated HL60 cells","volume":"1773","author":"Korchak","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"24","key":"2023090116544318700_qiad063-B25","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1021\/bi011953s","article-title":"Phosphorylation of p47phox sites by PKC \u03b1, \u03b2\u0399\u0399, \u03b4, and \u03b6: effect on binding to p22phox and on NADPH oxidase activation","volume":"41","author":"Fontayne","year":"2002","journal-title":"Biochemistry"},{"issue":"5","key":"2023090116544318700_qiad063-B26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1172\/JCI119263","article-title":"Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP","volume":"99","author":"Nick","year":"1997","journal-title":"J Clin Invest"},{"issue":"2","key":"2023090116544318700_qiad063-B27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1006\/bbrc.1999.0759","article-title":"Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2\/p38","volume":"259","author":"Lal","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"2023090116544318700_qiad063-B28","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1172\/JCI27544","article-title":"A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites","volume":"116","author":"Dang","year":"2006","journal-title":"J Clin Invest"},{"issue":"21","key":"2023090116544318700_qiad063-B29","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1182\/blood-2009-11-255323","article-title":"Akt isoforms differentially regulate neutrophil functions","volume":"115","author":"Chen","year":"2010","journal-title":"Blood"},{"issue":"3","key":"2023090116544318700_qiad063-B30","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1182\/blood.V101.3.1172","article-title":"Decreased phosphorylation of protein kinase B and extracellular signal-regulated kinase in neutrophils from patients with myelodysplasia","volume":"101","author":"Fuhler","year":"2003","journal-title":"Blood"},{"issue":"2","key":"2023090116544318700_qiad063-B31","doi-asserted-by":"crossref","first-page":"L158","DOI":"10.1152\/ajplung.00065.2014","article-title":"TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury","volume":"307","author":"Balakrishna","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2023090116544318700_qiad063-B32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1744-8069-4-51","article-title":"Quantitative real-time PCR detection of TRPV1\u20134 gene expression in human leukocytes from healthy and hyposensitive subjects","volume":"4","author":"Spinsanti","year":"2008","journal-title":"Mol Pain"},{"issue":"1","key":"2023090116544318700_qiad063-B33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1748-1716.2008.01918.x","article-title":"The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils","volume":"195","author":"Damann","year":"2009","journal-title":"Acta Physiol (Oxf)"},{"issue":"1","key":"2023090116544318700_qiad063-B34","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4049\/jimmunol.1501688","article-title":"TRPV4 mechanosensitive ion channel regulates lipopolysaccharide-stimulated macrophage phagocytosis","volume":"196","author":"Scheraga","year":"2016","journal-title":"J Immunol"},{"issue":"5","key":"2023090116544318700_qiad063-B35","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/glia.22306","article-title":"Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide","volume":"60","author":"Konno","year":"2012","journal-title":"Glia"},{"issue":"14","key":"2023090116544318700_qiad063-B36","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.3390\/ijms20143378","article-title":"Expression and functional role of TRPV4 in bone marrow-derived CD11c+ cells","volume":"20","author":"Naert","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"14","key":"2023090116544318700_qiad063-B37","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1111\/febs.13306","article-title":"Functional expression of TRPV channels in T cells and their implications in immune regulation","volume":"282","author":"Majhi","year":"2015","journal-title":"FEBS J"},{"issue":"12","key":"2023090116544318700_qiad063-B38","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1136\/annrheumdis-2021-220295","article-title":"Mechanosensitive TRPV4 is required for crystal-induced inflammation","volume":"80","author":"Lan","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"2023090116544318700_qiad063-B39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbrc.2022.04.032","article-title":"Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion channels regulate microglial activity","volume":"611","author":"Chakraborty","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"2023090116544318700_qiad063-B40","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/glia.24243","article-title":"Acute inhibition of transient receptor potential vanilloid-type 4 cation channel halts cytoskeletal dynamism in microglia","volume":"70","author":"Beeken","year":"2022","journal-title":"Glia"},{"issue":"3","key":"2023090116544318700_qiad063-B41","doi-asserted-by":"crossref","first-page":"L353","DOI":"10.1152\/ajplung.00315.2009","article-title":"TRPV4 channels augment macrophage activation and ventilator-induced lung injury","volume":"299","author":"Hamanaka","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"2023090116544318700_qiad063-B42","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bbrc.2019.04.020","article-title":"Transient receptor potential vanilloid 4 is a critical mediator in LPS mediated inflammation by mediating calcineurin\/NFATc3 signaling","volume":"513","author":"Li","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"2023090116544318700_qiad063-B43","doi-asserted-by":"crossref","first-page":"H634","DOI":"10.1152\/ajpheart.00717.2011","article-title":"Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling","volume":"302","author":"Bubolz","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"2023090116544318700_qiad063-B44","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12906-016-1411-7","article-title":"Anvillea garcinii extract inhibits the oxidative burst of primary human neutrophils","volume":"16","author":"Boukemara","year":"2016","journal-title":"BMC Complement Altern Med"},{"issue":"3","key":"2023090116544318700_qiad063-B45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00281-008-0118-3","article-title":"Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane","volume":"30","author":"El-Benna","year":"2008","journal-title":"Semin Immunopathol"},{"key":"2023090116544318700_qiad063-B46","article-title":"TRPV4 activates cytosolic phospholipase A2 via Ca2+-dependent PKC\/ERK1\/2 signalling in controlling hypertensive contraction","author":"Li","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2023090116544318700_qiad063-B47","doi-asserted-by":"crossref","first-page":"113375","DOI":"10.1016\/j.envpol.2019.113375","article-title":"Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb\/c mice","volume":"256","author":"Duan","year":"2020","journal-title":"Environ Pollut"},{"issue":"12","key":"2023090116544318700_qiad063-B48","doi-asserted-by":"crossref","first-page":"e10867","DOI":"10.1590\/1414-431x2021e10867","article-title":"TRPV4 induces apoptosis via p38 MAPK in human lung cancer cells","volume":"54","author":"Zhao","year":"2021","journal-title":"Braz J Med Biol Res"},{"issue":"25","key":"2023090116544318700_qiad063-B49","doi-asserted-by":"crossref","first-page":"37622","DOI":"10.18632\/oncotarget.9376","article-title":"A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis","volume":"7","author":"Xu","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"2023090116544318700_qiad063-B50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/cvr\/cvy156","article-title":"TRPV4 increases cardiomyocyte calcium cycling and contractility yet contributes to damage in the aged heart following hypoosmotic stress","volume":"115","author":"Jones","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2023090116544318700_qiad063-B51","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3389\/fphar.2019.01150","article-title":"Propofol induces cardioprotection against ischemia-reperfusion injury via suppression of transient receptor potential vanilloid 4 channel","volume":"10","author":"Wang","year":"2019","journal-title":"Front Pharmacol"},{"key":"2023090116544318700_qiad063-B52","doi-asserted-by":"crossref","first-page":"102483","DOI":"10.1016\/j.ceca.2021.102483","article-title":"Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts","volume":"100","author":"Zhang","year":"2021","journal-title":"Cell Calcium"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiad063\/50571173\/qiad063.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/114\/3\/266\/51330110\/qiad063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/114\/3\/266\/51330110\/qiad063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T16:55:08Z","timestamp":1693587308000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/114\/3\/266\/7180258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,26]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,5,26]]},"published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiad063","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,5,26]]}}}