{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:47:42Z","timestamp":1773769662661,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K22AI143922"],"award-info":[{"award-number":["K22AI143922"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boettcher Foundation Webb-Waring Biomedical Research Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The early immune response to bacterial pneumonia requires a careful balance between pathogen clearance and tissue damage. The anti-inflammatory cytokine interleukin (IL)-10 is critical for restraining otherwise lethal pulmonary inflammation. However, pathogen-induced IL-10 is associated with bacterial persistence in the lungs. In this study, we used mice with myeloid cell specific deletion of IL-10R to investigate the cellular targets of IL-10 immune suppression during infection with Streptococcus pneumoniae, the most common bacterial cause of pneumonia. Our findings suggest that IL-10 restricts the neutrophil response to S. pneumoniae, as neutrophil recruitment to the lungs was elevated in myeloid IL-10 receptor (IL-10R)\u2013deficient mice and neutrophils in the lungs of these mice were more effective at killing S. pneumoniae. Improved killing of S. pneumoniae was associated with increased production of reactive oxygen species and serine protease activity in IL-10R\u2013deficient neutrophils. Similarly, IL-10 suppressed the ability of human neutrophils to kill S. pneumoniae. Burdens of S. pneumoniae were lower in myeloid IL-10R\u2013deficient mice compared with wild-type mice, and adoptive transfer of IL-10R\u2013deficient neutrophils into wild-type mice significantly improved pathogen clearance. Despite the potential for neutrophils to contribute to tissue damage, lung pathology scores were similar between genotypes. This contrasts with total IL-10 deficiency, which is associated with increased immunopathology during S. pneumoniae infection. Together, these findings identify neutrophils as a critical target of S. pneumoniae-induced immune suppression and highlight myeloid IL-10R abrogation as a mechanism to selectively reduce pathogen burdens without exacerbating pulmonary damage.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad070","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T09:14:45Z","timestamp":1688030085000},"page":"4-15","source":"Crossref","is-referenced-by-count":16,"title":["Neutrophil responsiveness to IL-10 impairs clearance of <i>Streptococcus pneumoniae<\/i> from the lungs"],"prefix":"10.1093","volume":"115","author":[{"given":"Kadi J","family":"Horn","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, University of Colorado School of Medicine , 12700 East 19th Avenue, Aurora, CO 80045 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Fulte","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Colorado School of Medicine , 12700 East 19th Avenue, Aurora, CO 80045 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Colorado School of Medicine, 12631 East 17th Avenue, Aurora, CO 80045 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian P","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Colorado School of Medicine , 12700 East 19th Avenue, Aurora, CO 80045 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5975-5032","authenticated-orcid":false,"given":"Sarah E","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Colorado School of Medicine , 12700 East 19th Avenue, Aurora, CO 80045 , United 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