{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:25:22Z","timestamp":1787009122016,"version":"build-2736575974"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010380","name":"Stiftung Universit\u00e4tsmedizin Essen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The transforming growth factor \u03b2 (TGF-\u03b2)\/ALK1\/ENG signaling pathway maintains quiescent state of endothelial cells, but at the same time, it regulates neutrophil functions. Importantly, mutations of this pathway lead to a rare autosomal disorder called hereditary hemorrhagic telangiectasia (HHT), characterized with abnormal blood vessel formation (angiogenesis). As neutrophils are potent regulators of angiogenesis, we investigated how disturbed TGF-\u03b2\/ALK1\/ENG signaling influences angiogenic properties of these cells in HHT. We could show for the first time that not only endothelial cells, but also neutrophils isolated from such patients are ENG\/ALK1 deficient. This deficiency obviously stimulates proangiogenic switch of such neutrophils. Elevated proangiogenic activity of HHT neutrophils is mediated by the increased spontaneous degranulation of gelatinase granules, resulting in high release of matrix-degrading matrix metalloproteinase 9 (MMP9). In agreement, therapeutic disturbance of this process using Src tyrosine kinase inhibitors impaired proangiogenic capacity of such neutrophils. Similarly, inhibition of MMP9 activity resulted in significant impairment of neutrophil-mediated angiogenesis. All in all, deficiency in TGF-\u03b2\/ALK1\/ENG signaling in HHT neutrophils results in their proangiogenic activation and disease progression. Therapeutic strategies targeting neutrophil degranulation and MMP9 release and activity may serve as a potential therapeutic option for HHT.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad090","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T05:49:32Z","timestamp":1691560172000},"page":"639-650","source":"Crossref","is-referenced-by-count":3,"title":["Nonfunctional TGF-\u03b2\/ALK1\/ENG signaling pathway supports neutrophil proangiogenic activity in hereditary hemorrhagic telangiectasia"],"prefix":"10.1093","volume":"114","author":[{"given":"Inga","family":"Duerig","sequence":"first","affiliation":[{"name":"Translational Oncology, Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen , Hufelandstrasse 55, 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Pylaeva","sequence":"additional","affiliation":[{"name":"Translational Oncology, Department of 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"Geisthoff","sequence":"additional","affiliation":[{"name":"VASCERN HHT Reference Centre and Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Marburg, University of Gie\u00dfen and Marburg , Baldingerstra\u00dfe, 35043 Marburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Lang","sequence":"additional","affiliation":[{"name":"VASCERN HHT Reference Centre and Department of Otorhinolaryngology, Head and Neck Surgery, Essen University Hospital, University Duisburg-Essen , Hufelandstrasse 55, 45147 Essen , Germany"},{"name":"German Cancer Consortium, Partner Site D\u00fcsseldorf\/Essen , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya","family":"Droege","sequence":"additional","affiliation":[{"name":"VASCERN HHT Reference Centre and Department of Otorhinolaryngology, Head and Neck 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