{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:26:48Z","timestamp":1793226408938,"version":"4.5.0"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000182","name":"U.S. Army Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["W81XWH-16-1-0464"],"award-info":[{"award-number":["W81XWH-16-1-0464"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cytomegalovirus (CMV) is a ubiquitous herpes virus that infects most humans, thereafter persisting lifelong in tissues of the host. It is a known pathogen in immunosuppressed patients, but its impact on immunocompetent hosts remains less understood. Recent data have shown that CMV leaves a significant and long-lasting imprint in host immunity that may confer some protection against subsequent bacterial infection. Such innate immune activation may come at a cost, however, with potential to cause immunopathology. Neutrophils are central to many models of immunopathology, and while acute CMV infection is known to influence neutrophil biology, the impact of chronic CMV infection on neutrophil function remains unreported. Using our murine model of CMV infection and latency, we show that chronic CMV causes persistent enhancement of neutrophil oxidative burst well after resolution of acute infection. Moreover, this in vivo priming of marrow neutrophils is associated with enhanced formyl peptide receptor expression, and ultimately constitutive c-Jun N-terminal kinase phosphorylation and enhanced CD14 expression in\/on circulating neutrophils. Finally, we show that neutrophil priming is dependent on viral load, suggesting that naturally infected human hosts will show variability in CMV-related neutrophil priming. Altogether, these findings represent a previously unrecognized and potentially important impact of chronic CMV infection on neutrophil responsiveness in immunocompetent hosts.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad091","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T20:41:38Z","timestamp":1691613698000},"page":"459-474","source":"Crossref","is-referenced-by-count":4,"title":["Cytomegalovirus durably primes neutrophil oxidative burst"],"prefix":"10.1093","volume":"114","author":[{"given":"Thomas F","family":"Marandu","sequence":"first","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School , 110 Francis St., Boston, MA 02215 , United States"},{"name":"Department of Microbiology & Immunology, Mbeya College of Health and Allied Sciences, Hospital Hill Rd, University of Dar es Salaam , Mbeya 53107 , 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Comenius University , 4 Sasinkova St, Bratislava 811 08 , Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Panagioti","sequence":"additional","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School , 110 Francis St., Boston, MA 02215 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital and Harvard Medical School , 75 Francis St., Boston, MA 02215 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lederer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital and Harvard Medical School , 75 Francis St., Boston, MA 02215 , United 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