{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:36:27Z","timestamp":1791412587585,"version":"4.3.3"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Social Development Foundation of Zhenjiang City"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bronchopulmonary dysplasia, a common complication of premature infants, is mainly characterized by blocked alveolarization. Proverbially, the injury of alveolar type II epithelial cells is regarded as the pathologic basis of occurrence and development of bronchopulmonary dysplasia. In the case of alveolar epithelial damage, alveolar type II epithelial cells can also differentiate to alveolar type I epithelial cells as progenitor cells. During bronchopulmonary dysplasia, the differentiation of alveolar type II epithelial cells becomes abnormal. Group 2 innate lymphoid cells can produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines IL-25, IL-33, and thymic stromal lymphopoietin. Previous studies have shown that group 2 innate lymphoid cells can inhibit the alveolarization process of bronchopulmonary dysplasia by secreting IL-13. However, whether group 2 innate lymphoid cells can affect the differentiation of alveolar type II epithelial cells in the pathologic process of bronchopulmonary dysplasia remains unclear. In this study, we have shown that IL-13 secreted by group 2 innate lymphoid cells increased during bronchopulmonary dysplasia, which was related to the release of large amounts of IL-33 by impaired alveolar type II epithelial cells. This led to abnormal differentiation of alveolar type II epithelial cells, reduced differentiation to alveolar type I epithelial cells, and increased transdifferentiation to mesenchymal cells through the epithelial\u2013mesenchymal transition. Taken together, our study provides a complementary understanding of the development of bronchopulmonary dysplasia and highlights a novel immune mechanism in the pathogenesis of bronchopulmonary dysplasia.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad092","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T05:45:45Z","timestamp":1691646345000},"page":"604-614","source":"Crossref","is-referenced-by-count":4,"title":["ILC2 influence the differentiation of alveolar type II epithelial cells in bronchopulmonary dysplasia mice"],"prefix":"10.1093","volume":"114","author":[{"given":"Hong-yan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Jiangsu University , 438 Jiefang Road, Zhenjiang 212001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Jiangsu University , 438 Jiefang Road, Zhenjiang 212001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-xuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Jiangsu University , 438 Jiefang Road, Zhenjiang 212001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-min","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Jiangsu University , 438 Jiefang Road, Zhenjiang 212001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-qing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Jiangsu University , 438 Jiefang Road, Zhenjiang 212001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Jiangsu University , 438 Jiefang Road, Zhenjiang 212001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-jie","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital of Jiangsu University , 438 Jiefang Road, Zhenjiang 212001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5998-5575","authenticated-orcid":false,"given":"Zhao-liang","family":"Su","sequence":"additional","affiliation":[{"name":"International Genome Center, Jiangsu University , 301 Xuefu Road, Zhenjiang 212013 , China"},{"name":"Institute for medical Immunology, The Affiliated Hospital of Jiangsu University , 438 Jiefang Road, Zhenjiang 212001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"issue":"7","key":"2023112504071858900_qiad092-B1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM196702162760701","article-title":"Pulmonary disease following respirator therapy of hyaline-membrane disease. 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