{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:53:38Z","timestamp":1793055218499,"version":"4.5.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neutrophils infiltrate several types of cancer; however, whether their presence is associated with disease progression remains controversial. Here, we show that colon tumors overexpress neutrophil chemoattractants compared to healthy tissues, leading to their recruitment to the invasive margin and the central part of colon tumors. Of note, tumor-associated neutrophils expressing tumor necrosis factor \u03b1, which usually represents an antitumoral phenotype, were predominantly located in the invasive margin. Tumor-associated neutrophils from the invasive margin displayed an antitumoral phenotype with higher ICAM-1 and CD95 expression than neutrophils from healthy adjacent tissues. A higher neutrophil\/lymphocyte ratio was found at later stages compared to the early phases of colon cancer. A neutrophil\/lymphocyte ratio \u22643.5 predicted tumor samples had significantly more neutrophils at the invasive margin and the central part. Moreover, tumor-associated neutrophils at the invasive margin of early-stage tumors showed higher ICAM-1 and CD95 expression. Coculture of colon cancer cell lines with primary neutrophils induced ICAM-1 and CD95 expression, confirming our in situ findings. Thus, our data demonstrate that tumor-associated neutrophils with an antitumoral phenotype characterized by high ICAM-1 and CD95 expression infiltrate the invasive margin of early-stage colon tumors, suggesting that these cells can combat the disease at its early courses. The presence of tumor-associated neutrophils with antitumoral phenotype could help predict outcomes of patients with colon cancer.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad123","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:28:56Z","timestamp":1697066936000},"page":"672-683","source":"Crossref","is-referenced-by-count":13,"title":["The invasive margin of early-stage human colon tumors is infiltrated with neutrophils of an antitumoral phenotype"],"prefix":"10.1093","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-8031","authenticated-orcid":false,"given":"Eduardo","family":"Vadillo","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, UMAE Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (CMN S.XXI IMSS) , Avenida Cuauht\u00e9moc No. 330, Colonia Doctores, Mexico City 06720 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Mantilla","sequence":"additional","affiliation":[{"name":"Servicio de Patolog\u00eda, Hospital de Oncolog\u00eda CMN S.XXI IMSS , Avenida Cuauht\u00e9moc No. 330, Colonia Doctores, Mexico City 06720 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Aguilar-Flores","sequence":"additional","affiliation":[{"name":"UMAE Hospital de Pediatr\u00eda, CMN S.XXI IMSS , Avenida Cuauht\u00e9moc No. 330, Colonia Doctores, Mexico City 06720 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara\u00ed Gisel","family":"De Le\u00f3n-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica, UMAE Hospital de Especialidades, CMN S.XXI IMSS , Avenida Cuauht\u00e9moc No. 330, Colonia Doctores, Mexico City 06720 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Vela-Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, UMAE Hospital de Especialidades, CMN S.XXI IMSS , Avenida Cuauht\u00e9moc No. 330, Colonia Doctores, Mexico City 06720 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Badillo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, UMAE Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (CMN S.XXI IMSS) , Avenida Cuauht\u00e9moc No. 330, Colonia Doctores, Mexico City 06720 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Taniguchi-Ponciano","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, UMAE Hospital de Especialidades, CMN S.XXI IMSS , Avenida Cuauht\u00e9moc No. 330, Colonia Doctores, Mexico City 06720 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Marrero-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Endocrinas, UMAE Hospital de Especialidades, CMN S.XXI IMSS , Avenida Cuauht\u00e9moc No. 330, Colonia Doctores, Mexico City 06720 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Servicio de Colon y Recto, Hospital de Oncolog\u00eda CMN S.XXI IMSS , Avenida Cuauht\u00e9moc No. 330, Colonia Doctores, Mexico City 06720 , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iliana Itzel","family":"Le\u00f3n-Vega","sequence":"additional","affiliation":[{"name":"Departmento de Biomedicina Molecular, CINVESTAV-IPN , Av. 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