{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:44:23Z","timestamp":1789065863808,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/14815-0"],"award-info":[{"award-number":["2018\/14815-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/13858-0"],"award-info":[{"award-number":["2019\/13858-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gut dysbiosis is linked to type 1 diabetes mellitus (T1D). Inulin (INU), a prebiotic, modulates the gut microbiota, promoting beneficial bacteria that produce essential short-chain fatty acids for immune regulation. However, how INU affects T1D remains uncertain. Using a streptozotocin-induced (STZ) mouse model, we studied INU's protective effects. Remarkably, STZ + INU mice resisted T1D, with none developing the disease. They had lower blood glucose, reduced pancreatic inflammation, and normalized serum insulin compared with STZ + SD mice. STZ + INU mice also had enhanced mucus production, abundant Bifidobacterium, Clostridium cluster IV, Akkermansia muciniphila, and increased fecal butyrate. In cecal lymph nodes, we observed fewer CD4+Foxp3+ regulatory T cells expressing CCR4 and more Foxp3+CCR4+ cells in pancreatic islets, with higher CCL17 expression. This phenotype was absent in CCR4-deficient mice on INU. INU supplementation effectively protects against experimental T1D by recruiting CCR4+ regulatory T cells via CCL17 into the pancreas and altering the butyrate-producing microbiota.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad132","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T08:44:29Z","timestamp":1699605869000},"page":"483-496","source":"Crossref","is-referenced-by-count":21,"title":["Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model"],"prefix":"10.1093","volume":"115","author":[{"given":"Jhefferson Barbosa","family":"Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Laboratory of Imunorregulation of Metabolic Diseases, Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Fernandes","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Imunorregulation of Metabolic Diseases, Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cdtalo Sousa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Imunorregulation of Metabolic Diseases, Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Martins da Costa","family":"Manso","sequence":"additional","affiliation":[{"name":"Laboratory of Imunorregulation of Metabolic Diseases, Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson","family":"Elias-Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Imunorregulation of Metabolic Diseases, Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson Ant\u00f4nio","family":"Leite","sequence":"additional","affiliation":[{"name":"Laboratory of Imunorregulation of Metabolic Diseases, Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Camila Gon\u00e7alves Miranda","family":"Waldetario","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai , New York, NY 10029 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoinflammation, Department of Genetics and Evolution, Microbiology and Immunology, Institute of Biology, State University of Campinas , Campinas, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arilson Bernardo dos Santos Pereira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoinflammation, Department of Genetics and Evolution, Microbiology and Immunology, Institute of Biology, State University of Campinas , Campinas, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Caetano","family":"Faria","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Institute of Biological Sciences, University of Minas Gerais , Belo Horizonte, Minas Gerais,31270-901 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Gusm\u00e3o","family":"Ramos","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Department of Pathology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-2685","authenticated-orcid":false,"given":"V\u00e2nia L D","family":"Bonato","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Pulmonary Inflammation, Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-3927","authenticated-orcid":false,"given":"Jo\u00e3o Santana","family":"Silva","sequence":"additional","affiliation":[{"name":"Fiocruz-Bi-Institutional Translational Medicine Plataform, University of S\u00e3o Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio Ramirez","family":"Vinolo","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoinflammation, Department of Genetics and Evolution, Microbiology and Immunology, Institute of Biology, State University of Campinas , Campinas, S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulliana Marques","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, School of Food Engineering, State University of Campinas , Campinas, S\u00e3o Paulo, 13083-970 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa Pedrosa Silva","family":"Clerici","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, School of Food Engineering, State University of Campinas , Campinas, S\u00e3o Paulo, 13083-970 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-2238","authenticated-orcid":false,"given":"Daniela","family":"Carlos","sequence":"additional","affiliation":[{"name":"Laboratory of Imunorregulation of Metabolic Diseases, Department of Biochemistry and Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ave. Bandeirantes, Ribeir\u00e3o Preto, S\u00e3o Paulo, 14049-900 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"issue":"1","key":"2024022400320538800_qiad132-B1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.00003.2010","article-title":"Type 1 diabetes: etiology, immunology, and therapeutic strategies","volume":"91","author":"Van Belle","year":"2011","journal-title":"Physiol Rev"},{"key":"2024022400320538800_qiad132-B2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0065-2776(08)00804-3","article-title":"Chapter 4 CD8+ T cells in type 1 diabetes","volume":"100","author":"Tsai","year":"2008","journal-title":"Adv Immunol"},{"issue":"7010","key":"2024022400320538800_qiad132-B3","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1136\/bmj.311.7010.913","article-title":"Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins","volume":"311","author":"Kyvik","year":"1995","journal-title":"BMJ"},{"issue":"4","key":"2024022400320538800_qiad132-B4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1464-5491.2005.01499.x","article-title":"Animal models of diabetes mellitus","volume":"22","author":"Rees","year":"2005","journal-title":"Diabet Med"},{"issue":"3","key":"2024022400320538800_qiad132-B5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.imbio.2012.05.010","article-title":"Dynamic changes of the Th17\/Tc17 and regulatory T cell populations interfere in the experimental autoimmune diabetes pathogenesis","volume":"218","author":"Yaochite","year":"2013","journal-title":"Immunobiology"},{"issue":"1","key":"2024022400320538800_qiad132-B6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.00003.2010","article-title":"Type 1 diabetes: etiology, immunology, and therapeutic strategies","volume":"91","author":"Van Belle","year":"2011","journal-title":"Physiol Rev"},{"issue":"4251","key":"2024022400320538800_qiad132-B7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.180605","article-title":"Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus","volume":"193","author":"Like","year":"1976","journal-title":"Science"},{"issue":"2","key":"2024022400320538800_qiad132-B8","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1073\/pnas.79.2.630","article-title":"Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: influence of inbred background, sex, and thymus","volume":"79","author":"Leiter","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"2024022400320538800_qiad132-B9","doi-asserted-by":"crossref","first-page":"992","DOI":"10.2337\/diab.43.8.992","article-title":"Autoimmune diabetes induced by the \u03b2-cell toxin STZ: immunity to the 60-kDa heat shock protein and to insulin","volume":"43","author":"Elias","year":"1994","journal-title":"Diabetes"},{"key":"2024022400320538800_qiad132-B10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3389\/fendo.2017.00343","article-title":"T cell-mediated beta cell destruction: autoimmunity and alloimmunity in the context of type 1 diabetes","volume":"8","author":"Burrack","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2024022400320538800_qiad132-B11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.21.120601.141122","article-title":"Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses","volume":"22","author":"Sakaguchi","year":"2004","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"2024022400320538800_qiad132-B12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/dmrr.945","article-title":"Control of type 1 diabetes by CD4+ Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease","volume":"25","author":"Sgouroudis","year":"2009","journal-title":"Diabetes Metab Res Rev"},{"key":"2024022400320538800_qiad132-B13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.25.022106.141623","article-title":"Regulatory T cells: mechanisms of differentiation and function","volume":"30","author":"Josefowicz","year":"2012","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"2024022400320538800_qiad132-B14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13099-017-0163-3","article-title":"We are not alone: a case for the human microbiome in extra intestinal diseases","volume":"9","author":"Shivaji","year":"2017","journal-title":"Gut Pathog."},{"issue":"5","key":"2024022400320538800_qiad132-B15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1046\/j.1440-1746.2003.03032.x","article-title":"Intestinal barrier: an interface between health and disease","volume":"18","author":"Farhadi","year":"2003","journal-title":"J Gastroenterol Hepatol"},{"issue":"10","key":"2024022400320538800_qiad132-B16","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1136\/gut.2005.085373","article-title":"Alterations in intestinal permeability","volume":"55","author":"Arrieta","year":"2006","journal-title":"Gut"},{"issue":"5","key":"2024022400320538800_qiad132-B17","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3748\/wjg.v20.i5.1165","article-title":"Intestinal barrier in inflammatory bowel disease","volume":"20","author":"Antoni","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"4","key":"2024022400320538800_qiad132-B18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1053\/j.gastro.2016.07.008","article-title":"Inflammation and the intestinal barrier: leukocyte\u2013epithelial cell interactions, cell junction remodeling, and mucosal repair","volume":"151","author":"Luissint","year":"2016","journal-title":"Gastroenterology"},{"issue":"6032","key":"2024022400320538800_qiad132-B19","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.1198719","article-title":"Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans","volume":"332","author":"Muegge","year":"2011","journal-title":"Science"},{"key":"2024022400320538800_qiad132-B20","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1079\/BJN19980108","article-title":"Functional food science and gastrointestinal physiology and function","volume":"80 Suppl 1","author":"Salminen","year":"1998","journal-title":"Br J Nutr"},{"issue":"6","key":"2024022400320538800_qiad132-B21","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"2024022400320538800_qiad132-B22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short Chain Fatty Acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front Immunol"},{"issue":"4","key":"2024022400320538800_qiad132-B23","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.immuni.2015.09.007","article-title":"Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine","volume":"43","author":"Haghikia","year":"2015","journal-title":"Immunity"},{"issue":"6","key":"2024022400320538800_qiad132-B24","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2014.05.014","article-title":"Diet, metabolites, and \u201cwestern-lifestyle\u201d inflammatory diseases","volume":"40","author":"Thorburn","year":"2014","journal-title":"Immunity"},{"issue":"1","key":"2024022400320538800_qiad132-B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02651-5","article-title":"Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases","volume":"9","author":"Fellows","year":"2018","journal-title":"Nature Communications"},{"key":"2024022400320538800_qiad132-B26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/molecules25010076","article-title":"Improvement of oxazolone-induced ulcerative colitis in rats using andrographolide","volume":"25","author":"Zhang","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"2024022400320538800_qiad132-B27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41575-018-0061-2","article-title":"You are what you eat: diet, health and the gut microbiota","volume":"16","author":"Zmora","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"10184","key":"2024022400320538800_qiad132-B28","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0140-6736(19)30500-8","article-title":"Global diet and health: old questions, fresh evidence, and new horizons","volume":"393","author":"Forouhi","year":"2019","journal-title":"Lancet."},{"issue":"4","key":"2024022400320538800_qiad132-B29","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2174\/1381612033391973","article-title":"Role of dietary fiber and short-chain fatty acids in the colon","volume":"9","author":"Andoh","year":"2005","journal-title":"Curr Pharm Des"},{"issue":"3","key":"2024022400320538800_qiad132-B30","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jcmgh.2021.04.014","article-title":"Inulin fermentable fiber ameliorates type I diabetes via IL22 and short-chain fatty acids in experimental models","volume":"12","author":"Zou","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"10","key":"2024022400320538800_qiad132-B31","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1210\/jc.2019-00481","article-title":"Effect of prebiotic on microbiota, intestinal permeability, and glycemic control in children with type 1 diabetes","volume":"104","author":"Ho","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024022400320538800_qiad132-B32","doi-asserted-by":"crossref","first-page":"37627","DOI":"10.1038\/srep37627","article-title":"Oligofructose as an adjunct in treatment of diabetes in NOD mice","volume":"6","author":"Chan","year":"2016","journal-title":"Sci Rep"},{"key":"2024022400320538800_qiad132-B33","doi-asserted-by":"publisher","first-page":"e4446","DOI":"10.7717\/peerj.4446","article-title":"Inulin-type fructan improves diabetic phenotype and gut microbiota profiles in rats","volume":"6","author":"Zhang","year":"2018","journal-title":"PeerJ"},{"issue":"28","key":"2024022400320538800_qiad132-B34","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.3748\/wjg.v24.i28.3120","article-title":"Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells","volume":"24","author":"M\u00fcller-Graff","year":"2018","journal-title":"World J Gastroenterol"},{"issue":"1","key":"2024022400320538800_qiad132-B35","doi-asserted-by":"crossref","first-page":"14766","DOI":"10.1038\/s41598-019-51311-9","article-title":"Dendritic cells and regulatory T cells expressing CCR4 provide resistance to coxsackievirus B5-induced pancreatitis","volume":"9","author":"Fran\u00e7ozo","year":"2019","journal-title":"Sci Rep"},{"issue":"9","key":"2024022400320538800_qiad132-B36","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1007\/s00125-006-0334-0","article-title":"Antibiotic treatment partially protects against type 1 diabetes in the bio-breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?","volume":"49","author":"Brugman","year":"2006","journal-title":"Diabetologia"},{"issue":"4","key":"2024022400320538800_qiad132-B37","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1900\/RDS.2012.9.251","article-title":"Gut microbiota and type 1 diabetes","volume":"9","author":"Vaarala","year":"2012","journal-title":"Rev Diabet Stud"},{"issue":"1","key":"2024022400320538800_qiad132-B38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1471-2172-9-27","article-title":"Effect of the administration of a fermented milk containing Lactobacillus casei DN-114001 on intestinal microbiota and gut associated immune cells of nursing mice and after weaning until immune maturity","volume":"9","author":"de Moreno de LeBlanc","year":"2008","journal-title":"BMC Immunol"},{"issue":"8","key":"2024022400320538800_qiad132-B39","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1172\/JCI26705","article-title":"MUC1 cell surface mucin is a critical element of the mucosal barrier to infection","volume":"117","author":"McAuley","year":"2007","journal-title":"Journal of Clinical Investigation"},{"issue":"22","key":"2024022400320538800_qiad132-B40","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"2024022400320538800_qiad132-B41","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1136\/gutjnl-2017-314508","article-title":"Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice","volume":"67","author":"H\u00e4nninen","year":"2018","journal-title":"Gut"},{"key":"2024022400320538800_qiad132-B42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.micpath.2016.02.005","article-title":"Akkermansia muciniphila and its role in regulating host functions","volume":"106","author":"Derrien","year":"2017","journal-title":"Microb Pathog"},{"issue":"8","key":"2024022400320538800_qiad132-B43","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/ismej.2012.6","article-title":"Microbes insidefrom diversity to function: the case of Akkermansia","volume":"6","author":"Belzer","year":"2012","journal-title":"ISME J"},{"issue":"5","key":"2024022400320538800_qiad132-B44","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/1462-2920.13181","article-title":"Beneficial metabolic effects of selected probiotics on diet-induced obesity and insulin resistance in mice are associated with improvement of dysbiotic gut microbiota","volume":"18","author":"Alard","year":"2016","journal-title":"Environ Microbiol"},{"key":"2024022400320538800_qiad132-B45","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.3389\/fmicb.2017.01955","article-title":"Akkermansia muciniphila may determine chondroitin sulfate ameliorating or aggravating osteoarthritis","volume":"8","author":"Wang","year":"2017","journal-title":"Front Microbiol"},{"issue":"7122","key":"2024022400320538800_qiad132-B46","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"issue":"4","key":"2024022400320538800_qiad132-B47","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.2337\/db12-0526","article-title":"Fecal microbiota composition differs between children with \u03b2-cell autoimmunity and those without","volume":"62","author":"de Goffau","year":"2013","journal-title":"Diabetes"},{"issue":"11","key":"2024022400320538800_qiad132-B48","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1007\/s00125-007-0791-0","article-title":"Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia","volume":"50","author":"Cani","year":"2007","journal-title":"Diabetologia"},{"issue":"8","key":"2024022400320538800_qiad132-B49","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"issue":"7","key":"2024022400320538800_qiad132-B50","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1084\/jem.20150744","article-title":"Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset","volume":"213","author":"Costa","year":"2016","journal-title":"J Exp Med"},{"issue":"1","key":"2024022400320538800_qiad132-B51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/S095442241700018X","article-title":"Probiotics, prebiotics, synbiotics and insulin sensitivity","volume":"31","author":"Kim","year":"2018","journal-title":"Nutr Res Rev"},{"issue":"7480","key":"2024022400320538800_qiad132-B52","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"issue":"4","key":"2024022400320538800_qiad132-B53","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1128\/AEM.66.4.1654-1661.2000","article-title":"Phylogenetic relationships of butyrate-producing bacteria from the human gut","volume":"66","author":"Barcenilla","year":"2000","journal-title":"Appl Environ Microbiol"},{"issue":"3","key":"2024022400320538800_qiad132-B54","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3920\/BM2016.0142","article-title":"Inulin-type fructan degradation capacity of clostridium cluster IV and XlVa butyrate- producing colon bacteria and their associated metabolic outcomes","volume":"8","author":"Moens","year":"2017","journal-title":"Benef Microbes"},{"issue":"3","key":"2024022400320538800_qiad132-B55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1467-3010.2008.00706.x","article-title":"Dietary fibre and the gut microbiota","volume":"33","author":"Scott","year":"2008","journal-title":"Nutr Bull"},{"key":"2024022400320538800_qiad132-B56","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3389\/fmicb.2016.00979","article-title":"Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut","volume":"7","author":"Rivi\u00e8re","year":"2016","journal-title":"Front Microbiol"},{"issue":"1","key":"2024022400320538800_qiad132-B57","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1038\/ncomms7734","article-title":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome","volume":"6","author":"Macia","year":"2015","journal-title":"Nat Commun"},{"issue":"6","key":"2024022400320538800_qiad132-B58","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1038\/nutd.2014.23","article-title":"Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans","volume":"4","author":"Fernandes","year":"2014","journal-title":"Nutr Diabetes"},{"issue":"1","key":"2024022400320538800_qiad132-B59","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chom.2017.11.003","article-title":"Fiber-mediated nourishment of gut microbiota protects against diet-induced obesity by restoring IL-22-mediated colonic health","volume":"23","author":"Zou","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"1-2","key":"2024022400320538800_qiad132-B60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cellimm.2012.06.009","article-title":"A distinct tolerogenic subset of splenic IDO+CD11b+ dendritic cells from orally tolerized mice is responsible for induction of systemic immune tolerance and suppression of collagen-induced arthritis","volume":"278","author":"Park","year":"2012","journal-title":"Cell Immunol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiad132\/53670170\/qiad132.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/115\/3\/483\/56750387\/qiad132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/115\/3\/483\/56750387\/qiad132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:33:09Z","timestamp":1708734789000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/115\/3\/483\/7382080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,8]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,11,8]]},"published-print":{"date-parts":[[2024,2,23]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiad132","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3]]},"published":{"date-parts":[[2023,11,8]]}}}