{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:29:07Z","timestamp":1740137347810,"version":"3.37.3"},"reference-count":109,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000221"],"award-info":[{"award-number":["82000221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Follicular helper T cells are a subset of CD4+ T cells that are fundamental to forming germinal centers, which are the primary sites of antibody affinity maturation and the proliferation of activated B cells. Follicular helper T cells have been extensively studied over the past 10 years, especially regarding their roles in cancer genesis. This review describes the characteristics of normal follicular helper T cells and focuses on the emerging link between follicular helper T cells and lymphomagenesis. Advances in lymphoma genetics have substantially expanded our understanding of the role of follicular helper T cells in lymphomagenesis. Moreover, we detail a range of agents and new therapies, with a major focus on chimeric antigen receptor T-cell therapy; these novel approaches may offer new treatment opportunities for patients with lymphomas.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad140","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:08:00Z","timestamp":1699488480000},"page":"54-63","source":"Crossref","is-referenced-by-count":2,"title":["Follicular helper T cells: emerging roles in lymphomagenesis"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4036-7547","authenticated-orcid":false,"given":"Ji-nuo","family":"Wang","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine , No.79 Qingchun Road, Hangzhou, 311106 , China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center , 1369 West Wenyi Road, Hangzhou, 311121 , China"},{"name":"Institute of Hematology, Zhejiang University , No.17 Old Zhejiang University Road, Hangzhou, 311112 , China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy , No.17 Old Zhejiang University Road, Hangzhou, 311112 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaofeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine , No.79 Qingchun Road, Hangzhou, 311106 , China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center , 1369 West Wenyi Road, Hangzhou, 311121 , China"},{"name":"Institute of Hematology, Zhejiang University , No.17 Old Zhejiang University Road, Hangzhou, 311112 , China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy , No.17 Old Zhejiang University Road, Hangzhou, 311112 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine , No.79 Qingchun Road, Hangzhou, 311106 , China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center , 1369 West Wenyi Road, Hangzhou, 311121 , China"},{"name":"Institute of Hematology, Zhejiang University , No.17 Old Zhejiang University Road, Hangzhou, 311112 , China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy , No.17 Old Zhejiang University Road, Hangzhou, 311112 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2723-1621","authenticated-orcid":false,"given":"He","family":"Huang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine , No.79 Qingchun Road, Hangzhou, 311106 , China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center , 1369 West Wenyi Road, Hangzhou, 311121 , China"},{"name":"Institute of Hematology, Zhejiang University , No.17 Old Zhejiang University Road, Hangzhou, 311112 , China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy , No.17 Old Zhejiang University Road, Hangzhou, 311112 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"issue":"3","key":"2024062817352631300_qiad140-B1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/bjh.12941","article-title":"Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment","volume":"166","author":"Ahearne","year":"2014","journal-title":"Br J 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