{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:21:12Z","timestamp":1785860472254,"version":"3.56.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM118097"],"award-info":[{"award-number":["R35 GM118097"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25 GM083270"],"award-info":[{"award-number":["R25 GM083270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL134625"],"award-info":[{"award-number":["T32 HL134625"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM065085"],"award-info":[{"award-number":["T32 GM065085"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sepsis is a dysregulated systemic immune response to infection i.e. responsible for \u223c35% of in-hospital deaths at a significant fiscal healthcare cost. Our laboratory, among others, has demonstrated the efficacy of targeting negative checkpoint regulators (NCRs) to improve survival in a murine model of sepsis, cecal ligation and puncture (CLP). B7-CD28 superfamily member, V-domain immunoglobulin suppressor of T cell activation (VISTA), is an ideal candidate for strategic targeting in sepsis. VISTA is a 35 to 45\u2005kDa type 1 transmembrane protein with unique biology that sets it apart from all other NCRs. We recently reported that VISTA\u2212\/\u2212 mice had a significant survival deficit post-CLP, which was rescued upon adoptive transfer of a VISTA-expressing pMSCV-mouse Foxp3-EF1\u03b1-GFP-T2A-puro stable Jurkat cell line (Jurkatfoxp3 T cells). Based on our prior study, we investigated the effector cell target of Jurkatfoxp3 T cells in VISTA\u2212\/\u2212 mice. \u03b3\u03b4 T cells are a powerful lymphoid subpopulation that require regulatory fine-tuning by regulatory T cells to prevent overt inflammation\/pathology. In this study, we hypothesized that Jurkatfoxp3 T cells nonredundantly modulate the \u03b3\u03b4 T cell population post-CLP. We found that VISTA\u2212\/\u2212 mice have an increased accumulation of intestinal CD69low \u03b3\u03b4 T cells, which are not protective in murine sepsis. Adoptive transfer of Jurkatfoxp3 T cells decreased the intestinal \u03b3\u03b4 T cell population, suppressed proliferation, skewed remaining \u03b3\u03b4 T cells toward a CD69high phenotype, and increased soluble CD40L in VISTA\u2212\/\u2212 mice post-CLP. These results support a potential regulatory mechanism by which VISTA skews intestinal \u03b3\u03b4 T cell lineage representation in murine sepsis.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad149","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T02:07:05Z","timestamp":1701396425000},"page":"1005-1019","source":"Crossref","is-referenced-by-count":7,"title":["VISTA nonredundantly regulates proliferation and CD69low \u03b3\u03b4 T cell accumulation in the intestine in murine sepsis"],"prefix":"10.1093","volume":"115","author":[{"given":"Chyna C","family":"Gray","sequence":"first","affiliation":[{"name":"Division of Surgical Research, Department of Surgery, Brown University , Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon E","family":"Armstead","sequence":"additional","affiliation":[{"name":"Division of Surgical Research, Department of Surgery, Brown University , Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 , United States"},{"name":"Pathobiology Graduate Program, Brown University , Box G-B495, Providence, RI 02912 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Shiang","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Surgical Research, Department of Surgery, Brown University , Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Surgical Research, Department of Surgery, Brown University , Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5034-2995","authenticated-orcid":false,"given":"Alfred","family":"Ayala","sequence":"additional","affiliation":[{"name":"Division of Surgical Research, Department of Surgery, Brown University , Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 , United States"},{"name":"Pathobiology Graduate Program, Brown University , Box G-B495, Providence, RI 02912 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"issue":"2","key":"2024052916301954500_qiad149-B1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1089\/sur.2017.278","article-title":"Sepsis 2018: definitions and guideline changes","volume":"19","author":"Napolitano","year":"2018","journal-title":"Surg Infect 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