{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:51:08Z","timestamp":1772459468753,"version":"3.50.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2020-01842"],"award-info":[{"award-number":["2020-01842"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["21 1392 Pj 01 H"],"award-info":[{"award-number":["21 1392 Pj 01 H"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Malm\u00f6 Allm\u00e4nna Sjukhuset"},{"name":"Gyllenstiernska Krapperups Foundation"},{"DOI":"10.13039\/501100005753","name":"Royal Physiographic Society in Lund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005753","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maja and Hjalmar Leanders Foundation"},{"DOI":"10.13039\/501100003461","name":"Gunnar Nilsson Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003461","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u00c5ke Wibergs Foundation"},{"name":"Percy Falks Foundation"},{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The autoimmune regulator (AIRE) is a transcriptional regulator expressed in the thymus and is necessary for maintaining immunological self-tolerance. Extrathymic AIRE expression is rare, and a role for AIRE in tumor-associated innate immune cells has not yet been established. In this study, we show that AIRE is expressed in human pro-tumor neutrophils. In breast cancer, AIRE was primarily located to tumor-associated neutrophils (TANs), and to a lesser extent to tumor-associated macrophages (TAMs) and tumor cells. Expression of AIRE in TAN\/TAMs, but not in cancer cells, was associated with an adverse prognosis. We show that the functional role for AIRE in neutrophils and macrophages is to regulate expression of immune mediators and the extrinsic apoptotic pathway involving the Fas\/TNFR death receptors and cathepsin G. Here, we propose that the role for AIRE in TAN\/TAMs in breast tumors is to regulate cell death and inflammation, thus promoting tumor progression.<\/jats:p>","DOI":"10.1093\/jleuko\/qiad152","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T22:42:49Z","timestamp":1701988969000},"page":"664-678","source":"Crossref","is-referenced-by-count":5,"title":["AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation"],"prefix":"10.1093","volume":"115","author":[{"given":"Eva","family":"K\u00e4llberg","sequence":"first","affiliation":[{"name":"Cancer Immunology, Department of Translational Medicine, Lund University , Jan Waldenstr\u00f6msg 35, 214 28 Malm\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meliha","family":"Mehmeti-Ajradini","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Department of Translational Medicine, Lund University , Jan Waldenstr\u00f6msg 35, 214 28 Malm\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frida","family":"Bj\u00f6rk Gunnarsdottir","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Department of Translational Medicine, Lund University , Jan Waldenstr\u00f6msg 35, 214 28 Malm\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"G\u00f6ransson","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Department of Translational Medicine, Lund University , Jan Waldenstr\u00f6msg 35, 214 28 Malm\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Bergenfelz","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Department of Translational Medicine, Lund University , Jan Waldenstr\u00f6msg 35, 214 28 Malm\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roni","family":"Allaoui Fredriksson","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Department of Translational Medicine, Lund University , Jan Waldenstr\u00f6msg 35, 214 28 Malm\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"Hagerling","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Department of Translational Medicine, Lund University , Jan Waldenstr\u00f6msg 35, 214 28 Malm\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin E","family":"Johansson","sequence":"additional","affiliation":[{"name":"Sahlgrenska Center for Cancer Research, Department of Biomedicine, Vasaparken Universitetsplatsen 1, University of Gothenburg , 405 30 Gothenburg , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Welinder","sequence":"additional","affiliation":[{"name":"Mass Spectrometry, Department for Clinical Sciences, Lund University , S\u00f6lvegatan 19, 221 84 Lund , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Jirstr\u00f6m","sequence":"additional","affiliation":[{"name":"Oncology and Therapeutic Pathology, Department of Clinical Sciences Lund, Lund University , S\u00f6lvegatan 19, 221 84 Lund , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-3137","authenticated-orcid":false,"given":"Karin","family":"Leandersson","sequence":"additional","affiliation":[{"name":"Cancer Immunology, Department of Translational Medicine, Lund University , Jan Waldenstr\u00f6msg 35, 214 28 Malm\u00f6 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"issue":"6","key":"2024032919241133500_qiad152-B1","doi-asserted-by":"crossref","first-page":"a006957","DOI":"10.1101\/cshperspect.a006957","article-title":"T-cell tolerance: central and peripheral","volume":"4","author":"Xing","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2024032919241133500_qiad152-B2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fimmu.2018.00098","article-title":"Twenty years of AIRE","volume":"9","author":"Perniola","year":"2018","journal-title":"Front Immunol"},{"issue":"12","key":"2024032919241133500_qiad152-B3","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nri2450","article-title":"Transcriptional regulation by AIRE: molecular mechanisms of central tolerance","volume":"8","author":"Peterson","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"2024032919241133500_qiad152-B4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng1297-399","article-title":"An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains","volume":"17","author":"Finnish-German","year":"1997","journal-title":"Nat Genet"},{"issue":"4","key":"2024032919241133500_qiad152-B5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng1297-393","article-title":"Positional cloning of the APECED gene","volume":"17","author":"Nagamine","year":"1997","journal-title":"Nat Genet"},{"issue":"4","key":"2024032919241133500_qiad152-B6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri.2016.9","article-title":"AIRE expands: new roles in immune tolerance and beyond","volume":"16","author":"Anderson","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"2024032919241133500_qiad152-B7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.coi.2009.08.007","article-title":"AIRE in the thymus and beyond","volume":"21","author":"Gardner","year":"2009","journal-title":"Curr Opin Immunol"},{"issue":"10","key":"2024032919241133500_qiad152-B8","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00109-008-0374-7","article-title":"Critical immunological pathways are downregulated in APECED patient dendritic cells","volume":"86","author":"Pontynen","year":"2008","journal-title":"J Mol Med (Berl)"},{"issue":"3","key":"2024032919241133500_qiad152-B9","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1006\/bbrc.1999.0308","article-title":"Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla","volume":"257","author":"Heino","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"2024032919241133500_qiad152-B10","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.3389\/fimmu.2018.02902","article-title":"Maturing human CD127+ CCR7+ PDL1+ dendritic cells express AIRE in the absence of tissue restricted antigens","volume":"9","author":"Fergusson","year":"2018","journal-title":"Front Immunol"},{"issue":"5","key":"2024032919241133500_qiad152-B11","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.20181430","article-title":"Aire-expressing ILC3-like cells in the lymph node display potent APC features","volume":"216","author":"Yamano","year":"2019","journal-title":"J Exp Med"},{"issue":"3","key":"2024032919241133500_qiad152-B12","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1074\/jbc.M707211200","article-title":"AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity","volume":"283","author":"Ferguson","year":"2008","journal-title":"J Biol Chem"},{"issue":"22","key":"2024032919241133500_qiad152-B13","doi-asserted-by":"crossref","first-page":"16802","DOI":"10.1074\/jbc.M908944199","article-title":"The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein","volume":"275","author":"Pitkanen","year":"2000","journal-title":"J Biol Chem"},{"issue":"3","key":"2024032919241133500_qiad152-B14","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.bbrc.2005.05.187","article-title":"Cooperative activation of transcription by autoimmune regulator AIRE and CBP","volume":"333","author":"Pitkanen","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"2024032919241133500_qiad152-B15","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/s41590-022-01247-6","article-title":"Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans","volume":"23","author":"Dobes","year":"2022","journal-title":"Nat Immunol"},{"issue":"1","key":"2024032919241133500_qiad152-B16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/08916934.2017.1422124","article-title":"Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice","volume":"51","author":"Huo","year":"2018","journal-title":"Autoimmunity"},{"key":"2024032919241133500_qiad152-B17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.intimp.2017.05.023","article-title":"Transplantation of Aire-overexpressing bone marrow-derived dendritic cells delays the onset of type 1 diabetes","volume":"49","author":"Li","year":"2017","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2024032919241133500_qiad152-B18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbrc.2012.05.057","article-title":"AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH","volume":"423","author":"Liiv","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"issue":"23","key":"2024032919241133500_qiad152-B19","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1080\/15384101.2016.1241918","article-title":"Expression and prognostic significance of the autoimmune regulator gene in breast cancer cells","volume":"15","author":"Bianchi","year":"2016","journal-title":"Cell Cycle"},{"issue":"7","key":"2024032919241133500_qiad152-B20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.it.2008.03.004","article-title":"Death in the AIRE","volume":"29","author":"Ferguson","year":"2008","journal-title":"Trends Immunol"},{"issue":"2","key":"2024032919241133500_qiad152-B21","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1086\/302765","article-title":"Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein","volume":"66","author":"Bjorses","year":"2000","journal-title":"Am J Hum Genet"},{"issue":"2","key":"2024032919241133500_qiad152-B22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/hmg\/8.2.259","article-title":"Localization of the APECED protein in distinct nuclear structures","volume":"8","author":"Bjorses","year":"1999","journal-title":"Hum Mol Genet"},{"issue":"2","key":"2024032919241133500_qiad152-B23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/hmg\/8.2.277","article-title":"AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers","volume":"8","author":"Rinderle","year":"1999","journal-title":"Hum Mol Genet"},{"issue":"1","key":"2024032919241133500_qiad152-B24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/imr.13026","article-title":"AIRE in context: leveraging chromatin plasticity to trigger ectopic gene expression","volume":"305","author":"Kaiser","year":"2022","journal-title":"Immunol Rev"},{"issue":"3","key":"2024032919241133500_qiad152-B25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/ni.3675","article-title":"The transcriptional regulator Aire binds to and activates super-enhancers","volume":"18","author":"Bansal","year":"2017","journal-title":"Nat Immunol"},{"key":"2024032919241133500_qiad152-B26","doi-asserted-by":"crossref","first-page":"6058147","DOI":"10.1155\/2016\/6058147","article-title":"Tumor-associated macrophages and neutrophils in tumor microenvironment","volume":"2016","author":"Kim","year":"2016","journal-title":"Mediators Inflamm"},{"issue":"10","key":"2024032919241133500_qiad152-B27","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41571-019-0222-4","article-title":"Tumour-associated neutrophils in patients with cancer","volume":"16","author":"Shaul","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"2024032919241133500_qiad152-B28","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.3389\/fimmu.2019.02099","article-title":"Metabolic insight of neutrophils in health and disease","volume":"10","author":"Kumar","year":"2019","journal-title":"Front Immunol"},{"issue":"12","key":"2024032919241133500_qiad152-B29","doi-asserted-by":"crossref","first-page":"108164","DOI":"10.1016\/j.celrep.2020.108164","article-title":"Tumor-promoting Ly-6G(+) SiglecF(high) cells are mature and long-lived neutrophils","volume":"32","author":"Pfirschke","year":"2020","journal-title":"Cell Rep"},{"issue":"1","key":"2024032919241133500_qiad152-B30","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/imr.13176","article-title":"N1 versus N2 and PMN-MDSC: a critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncology","volume":"314","author":"Antuamwine","year":"2023","journal-title":"Immunol Rev"},{"key":"2024032919241133500_qiad152-B31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fonc.2020.00109","article-title":"The generation and identity of human myeloid-derived suppressor cells","volume":"10","author":"Bergenfelz","year":"2020","journal-title":"Front Oncol"},{"key":"2024032919241133500_qiad152-B32","doi-asserted-by":"crossref","first-page":"631821","DOI":"10.3389\/fimmu.2021.631821","article-title":"Neutrophils: many ways to die","volume":"12","author":"Perez-Figueroa","year":"2021","journal-title":"Front Immunol"},{"issue":"12","key":"2024032919241133500_qiad152-B33","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1016\/j.celrep.2019.05.065","article-title":"Cathepsin G inhibition by Serpinb1 and Serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation","volume":"27","author":"Burgener","year":"2019","journal-title":"Cell Rep"},{"issue":"1","key":"2024032919241133500_qiad152-B34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s42003-020-1083-1","article-title":"Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses","volume":"3","author":"Benitez","year":"2020","journal-title":"Commun Biol"},{"issue":"18","key":"2024032919241133500_qiad152-B35","doi-asserted-by":"crossref","first-page":"e93265","DOI":"10.1172\/jci.insight.93265","article-title":"Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity","volume":"2","author":"Bakhru","year":"2017","journal-title":"JCI Insight"},{"issue":"4","key":"2024032919241133500_qiad152-B36","doi-asserted-by":"crossref","first-page":"e35005","DOI":"10.1371\/journal.pone.0035005","article-title":"The immune response to melanoma is limited by thymic selection of self-antigens","volume":"7","author":"Trager","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"2024032919241133500_qiad152-B37","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1158\/0008-5472.CAN-12-3781","article-title":"Aire deficiency promotes TRP-1-specific immune rejection of melanoma","volume":"73","author":"Zhu","year":"2013","journal-title":"Cancer Res"},{"issue":"5","key":"2024032919241133500_qiad152-B38","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1084\/jem.20131889","article-title":"Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance","volume":"211","author":"Khan","year":"2014","journal-title":"J Exp Med"},{"issue":"1","key":"2024032919241133500_qiad152-B39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.clim.2010.03.002","article-title":"The role of AIRE polymorphisms in melanoma","volume":"136","author":"Conteduca","year":"2010","journal-title":"Clin Immunol"},{"issue":"2","key":"2024032919241133500_qiad152-B40","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1172\/JCI43757","article-title":"Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice","volume":"121","author":"Elkabets","year":"2011","journal-title":"J Clin Invest"},{"issue":"3","key":"2024032919241133500_qiad152-B41","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3109\/0284186X.2011.631576","article-title":"Expression of ghrelin is correlated to a favorable outcome in invasive breast cancer","volume":"51","author":"Gronberg","year":"2012","journal-title":"Acta Oncol"},{"issue":"1","key":"2024032919241133500_qiad152-B42","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1186\/1471-2407-10-639","article-title":"Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer","volume":"10","author":"Rexhepaj","year":"2010","journal-title":"BMC Cancer"},{"issue":"4","key":"2024032919241133500_qiad152-B43","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3233\/CBM-170026","article-title":"Infiltration of gammadelta T cells, IL-17+ T cells and FoxP3+ T cells in human breast cancer","volume":"20","author":"Allaoui","year":"2017","journal-title":"Cancer Biomark."},{"issue":"8","key":"2024032919241133500_qiad152-B44","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/bjc.2015.346","article-title":"S100a9 expressed in ER(-)PgR(-) breast cancers induces inflammatory cytokines and is associated with an impaired overall survival","volume":"113","author":"Bergenfelz","year":"2015","journal-title":"Br J Cancer"},{"issue":"1","key":"2024032919241133500_qiad152-B45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/1471-2407-12-306","article-title":"The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients","volume":"12","author":"Medrek","year":"2012","journal-title":"BMC Cancer"},{"issue":"2","key":"2024032919241133500_qiad152-B46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cncy.20147","article-title":"Biospecimen reporting for improved study quality (BRISQ)","volume":"119","author":"Moore","year":"2011","journal-title":"Cancer Cytopathol"},{"issue":"1","key":"2024032919241133500_qiad152-B47","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"Qupath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"issue":"D1","key":"2024032919241133500_qiad152-B48","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2024032919241133500_qiad152-B49","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13058-015-0640-x","article-title":"Expression of functional toll like receptor 4 in estrogen receptor\/progesterone receptor-negative breast cancer","volume":"17","author":"Mehmeti","year":"2015","journal-title":"Breast Cancer Res"},{"issue":"11","key":"2024032919241133500_qiad152-B50","doi-asserted-by":"crossref","first-page":"e202000893","DOI":"10.26508\/lsa.202000893","article-title":"Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer","volume":"3","author":"Mehmeti-Ajradini","year":"2020","journal-title":"Life Sci Alliance"},{"issue":"5","key":"2024032919241133500_qiad152-B51","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/JLB.5HR0120-459R","article-title":"On the origin of low-density neutrophils","volume":"107","author":"Hassani","year":"2020","journal-title":"J Leukoc Biol"},{"issue":"11","key":"2024032919241133500_qiad152-B52","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.neo.2018.09.001","article-title":"Mipanda: a resource for analyzing and visualizing next-generation sequencing transcriptomics data","volume":"20","author":"Niknafs","year":"2018","journal-title":"Neoplasia"},{"issue":"1","key":"2024032919241133500_qiad152-B53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2009.12.030","article-title":"Aire's partners in the molecular control of immunological tolerance","volume":"140","author":"Abramson","year":"2010","journal-title":"Cell"},{"issue":"2","key":"2024032919241133500_qiad152-B54","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbadis.2013.11.020","article-title":"The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein","volume":"1842","author":"Perniola","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"2024032919241133500_qiad152-B55","doi-asserted-by":"crossref","first-page":"e003495","DOI":"10.1136\/jitc-2021-003495","article-title":"Uncoupled biological and chronological aging of neutrophils in cancer promotes tumor progression","volume":"9","author":"Mittmann","year":"2021","journal-title":"J Immunother Cancer"},{"issue":"11","key":"2024032919241133500_qiad152-B56","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1182\/blood.V80.11.2920.2920","article-title":"Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death","volume":"80","author":"Brach","year":"1992","journal-title":"Blood"},{"issue":"12","key":"2024032919241133500_qiad152-B57","first-page":"485","article-title":"The Senescence-Associated Secretory Phenotype (SASP) in the challenging future of cancer therapy and age-related diseases","volume":"9","author":"Cuollo","year":"2020","journal-title":"Biology (Basel)"},{"issue":"4","key":"2024032919241133500_qiad152-B58","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1084\/jem.20031771","article-title":"p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils","volume":"199","author":"Alvarado-Kristensson","year":"2004","journal-title":"J Exp Med"},{"issue":"1","key":"2024032919241133500_qiad152-B59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1021\/bi701559f","article-title":"4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to fas","volume":"47","author":"Sharma","year":"2008","journal-title":"Biochemistry"},{"issue":"11","key":"2024032919241133500_qiad152-B60","doi-asserted-by":"crossref","first-page":"7761","DOI":"10.4049\/jimmunol.177.11.7761","article-title":"IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3","volume":"177","author":"Qin","year":"2006","journal-title":"J Immunol"},{"issue":"6204","key":"2024032919241133500_qiad152-B61","doi-asserted-by":"crossref","first-page":"1251086","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science"},{"key":"2024032919241133500_qiad152-B62","doi-asserted-by":"crossref","first-page":"155773","DOI":"10.1016\/j.cyto.2021.155773","article-title":"IL-1 family cytokines as drivers and inhibitors of trained immunity","volume":"150","author":"Teufel","year":"2022","journal-title":"Cytokine"},{"issue":"6","key":"2024032919241133500_qiad152-B63","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.celrep.2020.01.030","article-title":"Targeting macrophage histone H3 modification as a Leishmania strategy to dampen the NF-kappaB\/NLRP3-mediated inflammatory response","volume":"30","author":"Lecoeur","year":"2020","journal-title":"Cell Rep"},{"issue":"11","key":"2024032919241133500_qiad152-B64","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.biochi.2012.04.018","article-title":"Histone H3 phosphorylation\u2014a versatile chromatin modification for different occasions","volume":"94","author":"Sawicka","year":"2012","journal-title":"Biochimie"},{"issue":"2","key":"2024032919241133500_qiad152-B65","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3892\/ijo.2014.2454","article-title":"Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract","volume":"45","author":"Kikuchi","year":"2014","journal-title":"Int J Oncol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiad152\/54945644\/qiad152.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/115\/4\/664\/57121099\/qiad152.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/115\/4\/664\/57121099\/qiad152.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T19:24:53Z","timestamp":1711740293000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/115\/4\/664\/7462185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,7]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,12,7]]},"published-print":{"date-parts":[[2024,3,29]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiad152","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2023,12,7]]}}}