{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T01:13:25Z","timestamp":1769908405016,"version":"3.49.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Myeloid-derived suppressor cells are heterogenous immature myeloid lineage cells that can differentiate into neutrophils, monocytes, and dendritic cells as well. These cells have been characterized to have potent immunosuppressive capacity in neoplasia and a neoplastic chronic inflammatory microenvironment. Increased accumulation of myeloid-derived suppressor cells was reported with poor clinical outcomes in patients. They support neoplastic progression by abrogating antitumor immunity through inhibition of lymphocyte functions and directly by facilitating tumor development. Yet the shifting genetic signatures of this myeloid lineage cell toward immunosuppressive functionality in progressive tumor development remain elusive. We have attempted to identify the gene expression profile using lineage-specific markers of these unique myeloid lineage cells in a tumor microenvironment and bone marrow using a liquid transplantable mice tumor model to trace the changing influence of the tumor microenvironment on myeloid-derived suppressor cells. We analyzed the phenotype, functional shift, suppressive activity, differentiation status, and microarray-based gene expression profile of CD11b+Gr1+ lineage-specific cells isolated from the tumor microenvironment and bone marrow of 4 stages of tumor-bearing mice and compared them with control counterparts. Our analysis of differentially expressed genes of myeloid-derived suppressor cells isolated from bone marrow and the tumor microenvironment reveals unique gene expression patterns in the bone marrow and tumor microenvironment\u2013derived myeloid-derived suppressor cells. It also suggests T-cell suppressive activity of myeloid-derived suppressor cells progressively increases toward the mid-to-late phase of the tumor and a significant differentiation bias of tumor site myeloid-derived suppressor cells toward macrophages, even in the presence of differentiating agents, indicating potential molecular characteristics of myeloid-derived suppressor cells in different stages of the tumor that can emerge as an intervention target.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae013","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T15:41:45Z","timestamp":1705592505000},"page":"958-984","source":"Crossref","is-referenced-by-count":9,"title":["Alteration of functionality and differentiation directed by changing gene expression patterns in myeloid-derived suppressor cells (MDSCs) in tumor microenvironment and bone marrow through early to terminal phase of tumor progression"],"prefix":"10.1093","volume":"115","author":[{"given":"Krishna","family":"Mahanti","sequence":"first","affiliation":[{"name":"Immunobiology and Translational Medicine Laboratory, Department of Zoology, Sidho Kanho Birsha University , Ranchi Road, Saink School, Purulia, West Bengal 723104 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayasree","family":"Saha","sequence":"additional","affiliation":[{"name":"Immunobiology and Translational Medicine Laboratory, Department of Zoology, Sidho Kanho Birsha University , Ranchi Road, Saink School, Purulia, West Bengal 723104 , India"},{"name":"Currently, DST-SERB NPDF, School of Bioscience, IIT Kharagpur , Paschim Medinipur, West Bengal 721302 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debanjan","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Immunobiology and Translational Medicine Laboratory, Department of Zoology, Sidho Kanho Birsha University , Ranchi Road, Saink School, Purulia, West Bengal 723104 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anik","family":"Pramanik","sequence":"additional","affiliation":[{"name":"Immunobiology and Translational Medicine Laboratory, Department of Zoology, Sidho Kanho Birsha University , Ranchi Road, Saink School, Purulia, West Bengal 723104 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabanita","family":"Roy Chattopadhyay","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Siksha Bhaban, Visva Bharati , Shantiniketan, Birbhum, West Bengal 731235 , India"},{"name":"Currently, Department of Biotechnology, Haldia Institute of Technology, ICARE Complex , Haldia, West Bengal 721657 , 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