{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:41:18Z","timestamp":1790959278534,"version":"4.1.0"},"reference-count":144,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neutrophils are the most abundant leukocytes in humans and play a role in the innate immune response by being the first cells attracted to the site of infection. While early studies presented neutrophils as almost exclusively glycolytic cells, recent advances show that these cells use several metabolic pathways other than glycolysis, such as the pentose phosphate pathway, oxidative phosphorylation, fatty acid oxidation, and glutaminolysis, which they modulate to perform their functions. Metabolism shifts from fatty acid oxidation\u2013mediated mitochondrial respiration in immature neutrophils to glycolysis in mature neutrophils. Tissue environments largely influence neutrophil metabolism according to nutrient sources, inflammatory mediators, and oxygen availability. Inhibition of metabolic pathways in neutrophils results in impairment of certain effector functions, such as NETosis, chemotaxis, degranulation, and reactive oxygen species generation. Alteration of these neutrophil functions is implicated in certain human diseases, such as antiphospholipid syndrome, coronavirus disease 2019, and bronchiectasis. Metabolic regulators such as AMPK, HIF-1\u03b1, mTOR, and Arf6 are linked to neutrophil metabolism and function and could potentially be targeted for the treatment of diseases associated with neutrophil dysfunction. This review details the effects of alterations in neutrophil metabolism on the effector functions of these cells.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae025","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T15:17:26Z","timestamp":1709824646000},"page":"456-468","source":"Crossref","is-referenced-by-count":44,"title":["Metabolic regulation of neutrophil functions in homeostasis and diseases"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1991-3663","authenticated-orcid":false,"given":"Pier-Olivier","family":"Leblanc","sequence":"first","affiliation":[{"name":"Infectious and Immune Diseases Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center , 2705 Boul. Laurier, Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]},{"name":"ARThrite Research Center, Laval University , 2705 Boul. Laurier, Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-0368","authenticated-orcid":false,"given":"Sylvain G","family":"Bourgoin","sequence":"additional","affiliation":[{"name":"Infectious and Immune Diseases Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center , 2705 Boul. Laurier, Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]},{"name":"ARThrite Research Center, Laval University , 2705 Boul. Laurier, Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]},{"name":"Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University , 1050 Av. de la M\u00e9decine, Qu\u00e9bec City, Qu\u00e9bec G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-4812","authenticated-orcid":false,"given":"Patrice E","family":"Poubelle","sequence":"additional","affiliation":[{"name":"Infectious and Immune Diseases Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center , 2705 Boul. Laurier, Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]},{"name":"Department of Medicine, Faculty of Medicine, Laval University , 1050 Av. de la M\u00e9decine, Qu\u00e9bec City, Qu\u00e9bec G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-7763","authenticated-orcid":false,"given":"Philippe A","family":"Tessier","sequence":"additional","affiliation":[{"name":"Infectious and Immune Diseases Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center , 2705 Boul. Laurier, Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]},{"name":"ARThrite Research Center, Laval University , 2705 Boul. Laurier, Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]},{"name":"Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University , 1050 Av. de la M\u00e9decine, Qu\u00e9bec City, Qu\u00e9bec G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-4947","authenticated-orcid":false,"given":"Martin","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Infectious and Immune Diseases Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center , 2705 Boul. Laurier, Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]},{"name":"ARThrite Research Center, Laval University , 2705 Boul. Laurier, Qu\u00e9bec City, Qu\u00e9bec G1V 4G2 ,","place":["Canada"]},{"name":"Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University , 1050 Av. de la M\u00e9decine, Qu\u00e9bec City, Qu\u00e9bec G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"issue":"3","key":"2025071610562638000_qiae025-B1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11302-012-9305-8","article-title":"ATP synthesis and storage","volume":"8","author":"Bonora","year":"2012","journal-title":"Purinergic Signal."},{"issue":"5","key":"2025071610562638000_qiae025-B2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrc3038","article-title":"Otto Warburg's contributions to current concepts of cancer metabolism","volume":"11","author":"Koppenol","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"2025071610562638000_qiae025-B3","doi-asserted-by":"crossref","first-page":"939","DOI":"10.4161\/cbt.12.11.18140","article-title":"Tumor cell metabolism: an integral view","volume":"12","author":"Romero-Garcia","year":"2011","journal-title":"Cancer Biol Ther"},{"issue":"23","key":"2025071610562638000_qiae025-B4","first-page":"6449","article-title":"Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review","volume":"49","author":"Vaupel","year":"1989","journal-title":"Cancer Res"},{"issue":"7","key":"2025071610562638000_qiae025-B5","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/ard.2009.119776","article-title":"Synovial tissue hypoxia and inflammation in vivo","volume":"69","author":"Ng","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"2025071610562638000_qiae025-B6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/ard.22.2.106","article-title":"Joint fluid pressure in chronic knee effusions","volume":"22","author":"Caughey","year":"1963","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2025071610562638000_qiae025-B7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12935-020-01719-5","article-title":"The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment","volume":"21","author":"Emami Nejad","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"10","key":"2025071610562638000_qiae025-B8","doi-asserted-by":"crossref","first-page":"170360","DOI":"10.1098\/rsos.170360","article-title":"Modelling pyruvate dehydrogenase under hypoxia and its role in cancer metabolism","volume":"4","author":"Eyassu","year":"2017","journal-title":"R Soc Open Sci"},{"issue":"8","key":"2025071610562638000_qiae025-B9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.gassur.2003.09.005","article-title":"Metabolic acidosis stimulates intestinal glutamine absorption","volume":"7","author":"Epler","year":"2003","journal-title":"J Gastrointest Surg"},{"issue":"1","key":"2025071610562638000_qiae025-B10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1172\/JCI107738","article-title":"Glutamine transport in rat kidney mitochondria in metabolic acidosis","volume":"54","author":"Adam","year":"1974","journal-title":"J Clin Invest"},{"issue":"3","key":"2025071610562638000_qiae025-B11","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.4049\/jimmunol.0902584","article-title":"Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes","volume":"184","author":"Dietl","year":"2009","journal-title":"J Immunol"},{"issue":"5","key":"2025071610562638000_qiae025-B12","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3390\/cancers15051417","article-title":"How warburg-associated lactic acidosis rewires cancer cell energy metabolism to resist glucose deprivation","volume":"15","author":"Daverio","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"7","key":"2025071610562638000_qiae025-B13","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1172\/JCI124616","article-title":"More friend than foe: the emerging role of neutrophils in tissue repair","volume":"129","author":"Peiseler","year":"2019","journal-title":"J Clin Invest"},{"issue":"3","key":"2025071610562638000_qiae025-B14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1515\/cclm-2016-0438","article-title":"Lactic acidosis: an update","volume":"55","author":"Seheult","year":"2017","journal-title":"Clin Chem Lab Med (CCLM)"},{"issue":"7","key":"2025071610562638000_qiae025-B15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: the ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nat Metab"},{"issue":"4","key":"2025071610562638000_qiae025-B16","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1365-2362.2007.01786.x","article-title":"Glucose transporter expression on the plasma membrane of resting and activated white blood cells","volume":"37","author":"Maratou","year":"2007","journal-title":"Eur J Clin Invest"},{"issue":"2","key":"2025071610562638000_qiae025-B17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/imm.12437","article-title":"Metabolic requirements for neutrophil extracellular traps formation","volume":"145","author":"Rodr\u00edguez-Espinosa","year":"2015","journal-title":"Immunology"},{"key":"2025071610562638000_qiae025-B18","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.3389\/fimmu.2019.02099","article-title":"Metabolic insight of neutrophils in health and disease","volume":"10","author":"Kumar","year":"2019","journal-title":"Front Immunol"},{"issue":"3","key":"2025071610562638000_qiae025-B19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00916406","article-title":"Granulocytes utilize different energy sources for movement and phagocytosis","volume":"6","author":"Weisdorf","year":"1982","journal-title":"Inflammation"},{"issue":"3","key":"2025071610562638000_qiae025-B20","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1189\/jlb.3MA0117-020R","article-title":"S100a9 potentiates the activation of neutrophils by the etiological agent of gout, monosodium urate crystals","volume":"102","author":"Rousseau","year":"2017","journal-title":"J Leukoc Biol."},{"issue":"2","key":"2025071610562638000_qiae025-B21","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1096\/fasebj.8.2.8119488","article-title":"Glucose-6-phosphate dehydrogenase: a \u201chousekeeping\u201d enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress","volume":"8","author":"Kletzien","year":"1994","journal-title":"Faseb J"},{"issue":"36","key":"2025071610562638000_qiae025-B22","doi-asserted-by":"crossref","first-page":"22174","DOI":"10.1074\/jbc.M115.640094","article-title":"A metabolic shift toward pentose phosphate pathway is necessary for amyloid fibril- and phorbol 12-myristate 13-acetate-induced neutrophil extracellular trap (NET) formation","volume":"290","author":"Azevedo","year":"2015","journal-title":"J Biol Chem"},{"issue":"1","key":"2025071610562638000_qiae025-B23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1089\/ars.2018.7518","article-title":"Autophagy: a lysosome-dependent process with implications in cellular redox homeostasis and human disease","volume":"30","author":"Ryter","year":"2019","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"2025071610562638000_qiae025-B24","doi-asserted-by":"crossref","first-page":"e20201006","DOI":"10.1084\/jem.20201006","article-title":"LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages","volume":"218","author":"Omarjee","year":"2021","journal-title":"J Exp Med"},{"issue":"3","key":"2025071610562638000_qiae025-B25","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.immuni.2017.08.005","article-title":"Autophagy-Dependent generation of free fatty acids is critical for normal neutrophil differentiation","volume":"47","author":"Riffelmacher","year":"2017","journal-title":"Immunity"},{"issue":"4","key":"2025071610562638000_qiae025-B26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1084\/jem.134.4.907","article-title":"The development of neutrophilic polymorphonuclear leukocytes in human bone marrow","volume":"134","author":"Bainton","year":"1971","journal-title":"J Exp Med"},{"issue":"2","key":"2025071610562638000_qiae025-B27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/sj.cdd.4401320","article-title":"Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis","volume":"11","author":"Maianski","year":"2004","journal-title":"Cell Death Differ"},{"issue":"6","key":"2025071610562638000_qiae025-B28","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/labinvest.2013.53","article-title":"Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood","volume":"93","author":"Chacko","year":"2013","journal-title":"Lab Invest"},{"issue":"4","key":"2025071610562638000_qiae025-B29","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.4049\/jimmunol.170.4.1964","article-title":"The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis","volume":"170","author":"Fossati","year":"2003","journal-title":"J Immunol"},{"issue":"4","key":"2025071610562638000_qiae025-B30","doi-asserted-by":"crossref","first-page":"e2013","DOI":"10.1371\/journal.pone.0002013","article-title":"Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation","volume":"3","author":"van Raam","year":"2008","journal-title":"PLoS One"},{"key":"2025071610562638000_qiae025-B31","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.freeradbiomed.2016.01.004","article-title":"Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation","volume":"93","author":"Awasthi","year":"2016","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"2025071610562638000_qiae025-B32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1677\/joe.1.06438","article-title":"Diabetes causes marked changes in function and metabolism of rat neutrophils","volume":"188","author":"Alba-Loureiro","year":"2006","journal-title":"J Endocrinol"},{"issue":"1","key":"2025071610562638000_qiae025-B33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2014.12.002","article-title":"Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability","volume":"21","author":"Lodhi","year":"2015","journal-title":"Cell Metab"},{"issue":"6","key":"2025071610562638000_qiae025-B34","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.nut.2009.07.006","article-title":"Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41\/GPR-43 pathways","volume":"26","author":"Aoyama","year":"2010","journal-title":"Nutrition"},{"issue":"1","key":"2025071610562638000_qiae025-B35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/cbf.1533","article-title":"Effects of short chain fatty acids on effector mechanisms of neutrophils","volume":"27","author":"Vinolo","year":"2009","journal-title":"Cell Biochem Funct"},{"issue":"6","key":"2025071610562638000_qiae025-B36","doi-asserted-by":"crossref","first-page":"e21205","DOI":"10.1371\/journal.pone.0021205","article-title":"SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor","volume":"6","author":"Vinolo","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"2025071610562638000_qiae025-B37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5045\/br.2018.53.2.177","article-title":"Acetate moderately attenuates the generation of neutrophil extracellular traps","volume":"53","author":"Ohbuchi","year":"2018","journal-title":"Blood Res"},{"issue":"11","key":"2025071610562638000_qiae025-B38","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3390\/nu10111564","article-title":"Glutamine: metabolism and immune function, supplementation and clinical translation","volume":"10","author":"Cruzat","year":"2018","journal-title":"Nutrients"},{"issue":"9 Suppl","key":"2025071610562638000_qiae025-B39","doi-asserted-by":"crossref","first-page":"2515S","DOI":"10.1093\/jn\/131.9.2515S","article-title":"Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection?","volume":"131","author":"Newsholme","year":"2001","journal-title":"J Nutr"},{"key":"2025071610562638000_qiae025-B40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphys.2018.00113","article-title":"Neutrophil: a cell with many roles in inflammation or several cell types?","volume":"9","author":"Rosales","year":"2018","journal-title":"Front Physiol"},{"issue":"3","key":"2025071610562638000_qiae025-B41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.stem.2010.07.011","article-title":"The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche","volume":"7","author":"Simsek","year":"2010","journal-title":"Cell Stem Cell"},{"issue":"3","key":"2025071610562638000_qiae025-B42","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1172\/JCI110647","article-title":"Energy metabolism of human neutrophils during phagocytosis","volume":"70","author":"Borregaard","year":"1982","journal-title":"J Clin Invest"},{"issue":"3","key":"2025071610562638000_qiae025-B43","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1159\/000443882","article-title":"Francisella tularensis modulates a distinct subset of regulatory factors and sustains mitochondrial integrity to impair human neutrophil apoptosis","volume":"8","author":"McCracken","year":"2016","journal-title":"J Innate Immun"},{"issue":"7","key":"2025071610562638000_qiae025-B44","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.4049\/jimmunol.1102863","article-title":"Francisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespan","volume":"188","author":"Schwartz","year":"2012","journal-title":"J Immunol"},{"issue":"2","key":"2025071610562638000_qiae025-B45","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000342430","article-title":"Francisella tularensis alters human neutrophil gene expression: insights into the molecular basis of delayed neutrophil apoptosis","volume":"5","author":"Schwartz","year":"2013","journal-title":"J Innate Immun"},{"key":"2025071610562638000_qiae025-B46","doi-asserted-by":"crossref","first-page":"836754","DOI":"10.3389\/fimmu.2022.836754","article-title":"Metabolic reprogramming mediates delayed apoptosis of human neutrophils infected with Francisella tularensis","volume":"13","author":"Krysa","year":"2022","journal-title":"Front Immunol"},{"key":"2025071610562638000_qiae025-B47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jleuko\/qiad122","article-title":"G-CSF reshapes the cytosolic PCNA scaffold and modulates glycolysis in neutrophils","volume":"115","author":"Aymonnier","year":"2023","journal-title":"J Leukoc Biol."},{"issue":"5663","key":"2025071610562638000_qiae025-B48","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"2025071610562638000_qiae025-B49","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/978-1-4939-9424-3_31","article-title":"Neutrophil extracellular traps","volume":"1982","author":"Rada","year":"2019","journal-title":"Methods Mol Biol."},{"issue":"2","key":"2025071610562638000_qiae025-B50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J Cell Biol"},{"key":"2025071610562638000_qiae025-B51","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fcimb.2017.00104","article-title":"Understanding the entanglement: Neutrophil Extracellular Traps (NETs) in cystic fibrosis","volume":"7","author":"Mart\u00ednez-Alem\u00e1n","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"2025071610562638000_qiae025-B52","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/biomedicines9010053","article-title":"Orchestration of neutrophil extracellular traps (nets), a unique innate immune function during Chronic Obstructive Pulmonary Disease (COPD) development","volume":"9","author":"Trivedi","year":"2021","journal-title":"Biomedicines"},{"key":"2025071610562638000_qiae025-B53","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fimmu.2017.00184","article-title":"Extracellular acidification inhibits the ROS-dependent formation of neutrophil extracellular traps","volume":"8","author":"Behnen","year":"2017","journal-title":"Front Immunol"},{"issue":"1","key":"2025071610562638000_qiae025-B54","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","article-title":"OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion","volume":"126","author":"Frezza","year":"2006","journal-title":"Cell"},{"issue":"28","key":"2025071610562638000_qiae025-B55","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1074\/jbc.M503062200","article-title":"Disruption of fusion results in mitochondrial heterogeneity and dysfunction*","volume":"280","author":"Chen","year":"2005","journal-title":"J Biol Chem"},{"issue":"1","key":"2025071610562638000_qiae025-B56","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1038\/s41467-018-05387-y","article-title":"Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production","volume":"9","author":"Amini","year":"2018","journal-title":"Nat Commun"},{"issue":"24","key":"2025071610562638000_qiae025-B57","doi-asserted-by":"crossref","first-page":"26148","DOI":"10.18632\/aging.203802","article-title":"Free fatty acids-induced neutrophil extracellular traps lead to dendritic cells activation and T cell differentiation in acute lung injury","volume":"13","author":"Chen","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"2025071610562638000_qiae025-B58","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00441-017-2776-8","article-title":"Neutrophil chemotaxis","volume":"371","author":"Petri","year":"2018","journal-title":"Cell Tissue Res."},{"issue":"5","key":"2025071610562638000_qiae025-B59","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1164\/rccm.200507-1152OC","article-title":"Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease","volume":"175","author":"Yoshikawa","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"39","key":"2025071610562638000_qiae025-B60","doi-asserted-by":"crossref","first-page":"26794","DOI":"10.1074\/jbc.M114.572495","article-title":"Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling","volume":"289","author":"Bao","year":"2014","journal-title":"J Biol Chem"},{"issue":"5","key":"2025071610562638000_qiae025-B61","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1182\/blood.V64.5.986.986","article-title":"A reassessment of the energy requirements for neutrophil migration: adenosine triphosphate depletion enhances chemotaxis","volume":"64","author":"Lane","year":"1984","journal-title":"Blood"},{"issue":"18","key":"2025071610562638000_qiae025-B62","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1182\/blood-2013-05-502435","article-title":"Molecular mechanisms of neutrophil dysfunction in glycogen storage disease type ib","volume":"123","author":"Jun","year":"2014","journal-title":"Blood"},{"issue":"7454","key":"2025071610562638000_qiae025-B63","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature12175","article-title":"Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo","volume":"498","author":"L\u00e4mmermann","year":"2013","journal-title":"Nature"},{"issue":"1","key":"2025071610562638000_qiae025-B64","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/imr.13157","article-title":"The emerging role for metabolism in fueling neutrophilic inflammation","volume":"314","author":"Morrison","year":"2023","journal-title":"Immunol Rev"},{"issue":"4597","key":"2025071610562638000_qiae025-B65","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.6301011","article-title":"Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation","volume":"220","author":"Samuelsson","year":"1983","journal-title":"Science"},{"issue":"6","key":"2025071610562638000_qiae025-B66","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.4049\/jimmunol.174.6.3617","article-title":"Involvement of BLT1 endocytosis and yes kinase activation in leukotriene B4-induced neutrophil degranulation","volume":"174","author":"Gaudreault","year":"2005","journal-title":"J Immunol"},{"issue":"4","key":"2025071610562638000_qiae025-B67","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1182\/blood.V93.4.1399","article-title":"Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes","volume":"93","author":"L\u00e4rfars","year":"1999","journal-title":"Blood"},{"issue":"14","key":"2025071610562638000_qiae025-B68","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.micinf.2003.09.008","article-title":"Neutrophil granules and secretory vesicles in inflammation","volume":"5","author":"Faurschou","year":"2003","journal-title":"Microbes Infect"},{"issue":"5","key":"2025071610562638000_qiae025-B69","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1189\/jlb.1009676","article-title":"Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism","volume":"87","author":"Simard","year":"2010","journal-title":"J Leukoc Biol."},{"issue":"1","key":"2025071610562638000_qiae025-B70","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/jcp.54.1.7","article-title":"Neutrophil disorders and their management","volume":"54","author":"Lakshman","year":"2001","journal-title":"J Clin Pathol."},{"issue":"4","key":"2025071610562638000_qiae025-B71","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF00918213","article-title":"Activation of the human neutrophil secretory process with 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid","volume":"8","author":"Smith","year":"1984","journal-title":"Inflammation."},{"issue":"2","key":"2025071610562638000_qiae025-B72","first-page":"367","article-title":"Biochemical, metabolic and morphological characteristics of human neutrophil activation with pepstatin A","volume":"49","author":"Smith","year":"1983","journal-title":"Immunology"},{"key":"2025071610562638000_qiae025-B73","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1146\/annurev-biochem-060815-014442","article-title":"Reactive Oxygen species and neutrophil function","volume":"85","author":"Winterbourn","year":"2016","journal-title":"Annu Rev Biochem."},{"issue":"3","key":"2025071610562638000_qiae025-B74","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen Species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol Rev."},{"issue":"6","key":"2025071610562638000_qiae025-B75","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/CIRCRESAHA.108.184325","article-title":"Reactive oxygen species: finding the right balance","volume":"103","author":"Morrell","year":"2008","journal-title":"Circ Res"},{"issue":"6","key":"2025071610562638000_qiae025-B76","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00296-018-3997-1","article-title":"Activation status of peripheral blood neutrophils and the complement system in adult rheumatoid arthritis patients undergoing combined therapy with infliximab and methotrexate","volume":"38","author":"Marchi","year":"2018","journal-title":"Rheumatol Int."},{"issue":"4","key":"2025071610562638000_qiae025-B77","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/eji.200636651","article-title":"Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B","volume":"37","author":"Bylund","year":"2007","journal-title":"Eur J Immunol"},{"issue":"5","key":"2025071610562638000_qiae025-B78","doi-asserted-by":"crossref","first-page":"165664","DOI":"10.1016\/j.bbadis.2020.165664","article-title":"Mitochondrial permeability transition pore is involved in oxidative burst and NETosis of human neutrophils","volume":"1866","author":"Vorobjeva","year":"2020","journal-title":"Biochim Biophys Acta (BBA)\u2014Mol Basis Dis"},{"issue":"6","key":"2025071610562638000_qiae025-B79","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/14767050500361679","article-title":"Oxidant release is dramatically increased by elevated glucose concentrations in neutrophils from pregnant women","volume":"18","author":"Petty","year":"2005","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"5","key":"2025071610562638000_qiae025-B80","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0899-9007(00)00228-8","article-title":"Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro","volume":"16","author":"Furukawa","year":"2000","journal-title":"Nutrition"},{"key":"2025071610562638000_qiae025-B81","doi-asserted-by":"crossref","first-page":"584116","DOI":"10.3389\/fimmu.2020.584116","article-title":"Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen Species, and neutrophil extracellular traps","volume":"11","author":"Wright","year":"2020","journal-title":"Front Immunol"},{"issue":"11","key":"2025071610562638000_qiae025-B82","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.3390\/ijms21113750","article-title":"In vivo transmigrated human neutrophils are highly primed for intracellular radical production induced by monosodium urate crystals","volume":"21","author":"Davidsson","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"43","key":"2025071610562638000_qiae025-B83","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"7","key":"2025071610562638000_qiae025-B84","doi-asserted-by":"crossref","first-page":"108387","DOI":"10.1016\/j.celrep.2020.108387","article-title":"BCG vaccination induces long-term functional reprogramming of human neutrophils","volume":"33","author":"Moorlag","year":"2020","journal-title":"Cell Rep"},{"issue":"21","key":"2025071610562638000_qiae025-B85","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1073\/pnas.1620910114","article-title":"Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway","volume":"114","author":"Cri\u015fan","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"8","key":"2025071610562638000_qiae025-B86","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/ATVBAHA.114.303887","article-title":"Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes","volume":"34","author":"Bekkering","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"2025071610562638000_qiae025-B87","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/imr.13142","article-title":"The role of neutrophils in trained immunity","volume":"314","author":"Kalafati","year":"2023","journal-title":"Immunol Rev."},{"issue":"6","key":"2025071610562638000_qiae025-B88","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat Rev Immunol."},{"issue":"2","key":"2025071610562638000_qiae025-B89","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.chom.2020.05.014","article-title":"BCG vaccination in humans elicits trained immunity via the hematopoietic progenitor compartment","volume":"28","author":"Cirovic","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"1\u20132","key":"2025071610562638000_qiae025-B90","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"issue":"3","key":"2025071610562638000_qiae025-B91","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2020.09.058","article-title":"Innate immune training of granulopoiesis promotes anti-tumor activity","volume":"183","author":"Kalafati","year":"2020","journal-title":"Cell"},{"issue":"4","key":"2025071610562638000_qiae025-B92","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41577-019-0141-8","article-title":"Heterogeneity of neutrophils","volume":"19","author":"Ng","year":"2019","journal-title":"Nat Rev Immunol."},{"issue":"11","key":"2025071610562638000_qiae025-B93","doi-asserted-by":"crossref","first-page":"120134","DOI":"10.1098\/rsob.120134","article-title":"Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity","volume":"2","author":"Beyrau","year":"2012","journal-title":"Open Biol"},{"key":"2025071610562638000_qiae025-B94","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.12688\/f1000research.9691.1","article-title":"Recent advances in understanding neutrophils","volume":"5","author":"Deniset","year":"2016","journal-title":"F1000Res"},{"key":"2025071610562638000_qiae025-B95","doi-asserted-by":"crossref","first-page":"8016254","DOI":"10.1155\/2019\/8016254","article-title":"Different faces for different places: heterogeneity of neutrophil phenotype and function","volume":"2019","author":"Yang","year":"2019","journal-title":"J Immunol Res"},{"issue":"2","key":"2025071610562638000_qiae025-B96","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.immuni.2004.07.006","article-title":"Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus","volume":"21","author":"Tsuda","year":"2004","journal-title":"Immunity"},{"issue":"6","key":"2025071610562638000_qiae025-B97","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.4049\/jimmunol.169.6.3180","article-title":"CD80 + Gr-1 + myeloid cells inhibit development of antifungal th1 immunity in mice with candidiasis","volume":"169","author":"Mencacci","year":"2002","journal-title":"J Immunol"},{"issue":"3","key":"2025071610562638000_qiae025-B98","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"issue":"1","key":"2025071610562638000_qiae025-B99","doi-asserted-by":"crossref","first-page":"2052418","DOI":"10.1080\/2162402X.2022.2052418","article-title":"Neutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cells","volume":"11","author":"Jiang","year":"2022","journal-title":"Oncoimmunology"},{"issue":"11","key":"2025071610562638000_qiae025-B100","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/s41590-018-0229-5","article-title":"Unique pattern of neutrophil migration and function during tumor progression","volume":"19","author":"Patel","year":"2018","journal-title":"Nat Immunol"},{"issue":"1","key":"2025071610562638000_qiae025-B101","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40364-023-00493-6","article-title":"The role and metabolic adaptations of neutrophils in premetastatic niches","volume":"11","author":"Chen","year":"2023","journal-title":"Biomark Res."},{"issue":"4","key":"2025071610562638000_qiae025-B102","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.celrep.2014.12.039","article-title":"Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer","volume":"10","author":"Sagiv","year":"2015","journal-title":"Cell Rep"},{"key":"2025071610562638000_qiae025-B103","doi-asserted-by":"crossref","first-page":"11037","DOI":"10.1038\/ncomms11037","article-title":"Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis","volume":"7","author":"Guglietta","year":"2016","journal-title":"Nat Commun"},{"issue":"2","key":"2025071610562638000_qiae025-B104","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/BJ20082055","article-title":"AMPK and the biochemistry of exercise: implications for human health and disease","volume":"418","author":"Richter","year":"2009","journal-title":"Biochem J"},{"issue":"7","key":"2025071610562638000_qiae025-B105","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI29044","article-title":"AMP-activated protein kinase signaling in metabolic regulation","volume":"116","author":"Long","year":"2006","journal-title":"J Clin Invest"},{"issue":"7","key":"2025071610562638000_qiae025-B106","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1038\/emm.2016.81","article-title":"Regulation and function of AMPK in physiology and diseases","volume":"48","author":"Jeon","year":"2016","journal-title":"Exp Mol Med"},{"issue":"12","key":"2025071610562638000_qiae025-B107","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1096\/fj.11-190587","article-title":"AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils","volume":"25","author":"Bae","year":"2011","journal-title":"Faseb j"},{"issue":"1","key":"2025071610562638000_qiae025-B108","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2119\/molmed.2013.00065","article-title":"Activation of AMPK enhances neutrophil chemotaxis and bacterial killing","volume":"19","author":"Park","year":"2013","journal-title":"Mol Med"},{"issue":"9","key":"2025071610562638000_qiae025-B109","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1101\/gad.1529107","article-title":"The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis","volume":"21","author":"Lum","year":"2007","journal-title":"Genes Dev"},{"issue":"10","key":"2025071610562638000_qiae025-B110","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.placenta.2004.02.011","article-title":"Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae","volume":"25","author":"Rajakumar","year":"2004","journal-title":"Placenta"},{"issue":"1","key":"2025071610562638000_qiae025-B111","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20040624","article-title":"Hypoxia-induced neutrophil survival is mediated by HIF-1\u03b1\u2013dependent NF-\u03baB activity","volume":"201","author":"Walmsley","year":"2005","journal-title":"J Exp Med."},{"issue":"8","key":"2025071610562638000_qiae025-B112","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1182\/blood-2002-02-0454","article-title":"Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis","volume":"100","author":"Mecklenburgh","year":"2002","journal-title":"Blood"},{"issue":"15","key":"2025071610562638000_qiae025-B113","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1182\/blood-2012-01-405993","article-title":"Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 \u03b1","volume":"120","author":"McInturff","year":"2012","journal-title":"Blood"},{"key":"2025071610562638000_qiae025-B114","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3389\/fimmu.2016.00518","article-title":"Formation of neutrophil extracellular traps under low oxygen level","volume":"7","author":"Branitzki-Heinemann","year":"2016","journal-title":"Front Immunol."},{"issue":"6","key":"2025071610562638000_qiae025-B115","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"issue":"1","key":"2025071610562638000_qiae025-B116","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J Clin Invest"},{"issue":"3","key":"2025071610562638000_qiae025-B117","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1152\/physrev.00026.2020","article-title":"Regulation and metabolic functions of mTORC1 and mTORC2","volume":"101","author":"Szwed","year":"2021","journal-title":"Physiol Rev."},{"issue":"9","key":"2025071610562638000_qiae025-B118","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.3390\/ijms20092351","article-title":"mTOR in human diseases","volume":"20","author":"Dormond","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"7","key":"2025071610562638000_qiae025-B119","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1083\/jcb.201503066","article-title":"mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis","volume":"210","author":"Bao","year":"2015","journal-title":"J Cell Biol"},{"key":"2025071610562638000_qiae025-B120","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.freeradbiomed.2021.07.001","article-title":"Arf6 regulates energy metabolism in neutrophils","volume":"172","author":"Gamara","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"2025071610562638000_qiae025-B121","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.lfs.2017.06.008","article-title":"Roles of Arf6 in cancer cell invasion, metastasis and proliferation","volume":"182","author":"Li","year":"2017","journal-title":"Life Sci"},{"issue":"9","key":"2025071610562638000_qiae025-B122","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/ni.3532","article-title":"C13orf31 (FAMIN) is a central regulator of immunometabolic function","volume":"17","author":"Cader","year":"2016","journal-title":"Nat Immunol."},{"issue":"5","key":"2025071610562638000_qiae025-B123","doi-asserted-by":"crossref","first-page":"861","DOI":"10.4161\/auto.20060","article-title":"The plasma membrane as a control center for autophagy","volume":"8","author":"Moreau","year":"2012","journal-title":"Autophagy"},{"issue":"6","key":"2025071610562638000_qiae025-B124","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00210-013-0851-6","article-title":"Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils","volume":"386","author":"Tsai","year":"2013","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"issue":"8","key":"2025071610562638000_qiae025-B125","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1590\/S0100-879X2006005000143","article-title":"Neutrophil function and metabolism in individuals with diabetes mellitus","volume":"40","author":"Alba-Loureiro","year":"2007","journal-title":"Braz J Med Biol Res"},{"issue":"11","key":"2025071610562638000_qiae025-B126","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1073\/pnas.0712386105","article-title":"Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways","volume":"105","author":"Tirouvanziam","year":"2008","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"10","key":"2025071610562638000_qiae025-B127","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1182\/blood-2007-12-128967","article-title":"Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}","volume":"112","author":"Reddy","year":"2008","journal-title":"Blood"},{"issue":"3","key":"2025071610562638000_qiae025-B128","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1089\/sur.2015.262","article-title":"Biology and metabolism of sepsis: innate immunity, bioenergetics, and autophagy","volume":"17","author":"Lewis","year":"2016","journal-title":"Surg Infect (Larchmt)"},{"issue":"12","key":"2025071610562638000_qiae025-B129","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.4049\/jimmunol.1201755","article-title":"Metabolic adaptation of neutrophils in cystic fibrosis airways involves distinct shifts in nutrient transporter expression","volume":"190","author":"Laval","year":"2013","journal-title":"J Immunol"},{"issue":"3","key":"2025071610562638000_qiae025-B130","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/eji.202149481","article-title":"Metabolic reprograming shapes neutrophil functions in severe COVID-19","volume":"52","author":"Borella","year":"2022","journal-title":"Eur J Immunol."},{"issue":"1","key":"2025071610562638000_qiae025-B131","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1038\/s41467-023-37567-w","article-title":"Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation","volume":"14","author":"Li","year":"2023","journal-title":"Nat Commun"},{"issue":"2","key":"2025071610562638000_qiae025-B132","doi-asserted-by":"crossref","first-page":"2003157","DOI":"10.1183\/13993003.03157-2020","article-title":"Neutrophil dysfunction in bronchiectasis: an emerging role for immunometabolism","volume":"58","author":"Giam","year":"2021","journal-title":"Eur Respir J"},{"issue":"7","key":"2025071610562638000_qiae025-B133","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1164\/rccm.201712-2423OC","article-title":"Blood neutrophils are reprogrammed in bronchiectasis","volume":"198","author":"Bedi","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"2025071610562638000_qiae025-B134","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1002\/art.39247","article-title":"Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome","volume":"67","author":"Yalavarthi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2025071610562638000_qiae025-B135","doi-asserted-by":"crossref","first-page":"e069717","DOI":"10.1136\/bmj-2021-069717","article-title":"Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management","volume":"380","author":"Knight","year":"2023","journal-title":"BMJ"},{"key":"2025071610562638000_qiae025-B136","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.thromres.2022.05.001","article-title":"Association between neutrophil extracellular traps (NETs) and thrombosis in antiphospholipid syndrome","volume":"214","author":"Mazetto","year":"2022","journal-title":"Thromb Res"},{"issue":"suppl 9","key":"2025071610562638000_qiae025-B137","first-page":"1973","article-title":"Immunometabolism of neutrophils in antiphospholipid syndrome (APS)","volume":"73","author":"Tambralli","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"2025071610562638000_qiae025-B138","volume-title":"Statpearls [internet]","author":"Cascella","year":"2023"},{"issue":"11","key":"2025071610562638000_qiae025-B139","first-page":"e138999","article-title":"Neutrophil extracellular traps in COVID-19","volume":"5","author":"Zuo","year":"2020","journal-title":"JCI Insight"},{"issue":"12","key":"2025071610562638000_qiae025-B140","doi-asserted-by":"crossref","first-page":"e20201979","DOI":"10.1084\/jem.20201129","article-title":"SARS-CoV-2\u2013triggered neutrophil extracellular traps mediate COVID-19 pathology","volume":"217","author":"Veras","year":"2020","journal-title":"J Exp Med"},{"issue":"11","key":"2025071610562638000_qiae025-B141","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1038\/s41418-021-00805-z","article-title":"Patients with COVID-19: in the dark-NETs of neutrophils","volume":"28","author":"Ackermann","year":"2021","journal-title":"Cell Death Differ"},{"issue":"6","key":"2025071610562638000_qiae025-B142","doi-asserted-by":"crossref","first-page":"e20200652","DOI":"10.1084\/jem.20200652","article-title":"Targeting potential drivers of COVID-19: neutrophil extracellular traps","volume":"217","author":"Barnes","year":"2020","journal-title":"J Exp Med"},{"issue":"6","key":"2025071610562638000_qiae025-B143","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMra2202819","article-title":"Bronchiectasis\u2014a clinical review","volume":"387","author":"O'Donnell","year":"2022","journal-title":"N Engl J Med"},{"issue":"8","key":"2025071610562638000_qiae025-B144","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S2213-2600(20)30504-X","article-title":"Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study","volume":"9","author":"Keir","year":"2021","journal-title":"Lancet Respir Med"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiae025\/56902197\/qiae025.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/116\/3\/456\/58994963\/qiae025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/116\/3\/456\/58994963\/qiae025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T14:56:44Z","timestamp":1752677804000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/116\/3\/456\/7624094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":144,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiae025","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,3,7]]}}}