{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:57:25Z","timestamp":1792515445883,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI124681"],"award-info":[{"award-number":["R21AI124681"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI160613"],"award-info":[{"award-number":["R21AI160613"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute for Human Infections and Immunity"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CXCL17, a novel member of the CXC chemokine class, has been implicated in several human pathologies, but its role in mediating immune response is not well understood. Characteristic features of immune response include resident macrophages orchestrating successive and structured recruitment of neutrophils and monocytes to the insult site. Here, we show that Cxcl17 knockout (KO) mice, compared with the littermate wild-type control mice, were significantly impaired in peritoneal neutrophil recruitment post\u2013lipopolysaccharide (LPS) challenge. Further, the KO mice show dysregulated Cxcl1, Cxcr2, and interleukin-6 levels, all of which directly impact neutrophil recruitment. Importantly, the KO mice showed no difference in monocyte recruitment post\u2013LPS challenge or in peritoneal macrophage levels in both unchallenged and LPS-challenged mice. We conclude that Cxcl17 is a proinflammatory chemokine and that it plays an important role in the early proinflammatory response by promoting neutrophil recruitment to the insult site.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae028","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:30:23Z","timestamp":1706776223000},"page":"1177-1182","source":"Crossref","is-referenced-by-count":28,"title":["CXCL17 is a proinflammatory chemokine and promotes neutrophil trafficking"],"prefix":"10.1093","volume":"115","author":[{"given":"Emily","family":"Lowry","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rani C","family":"Chellappa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigith","family":"Penaranda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti V","family":"Sawant","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Wakamiya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9513-9416","authenticated-orcid":false,"given":"Roberto P","family":"Garofalo","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"},{"name":"Department of Pediatrics, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"},{"name":"Institute for Human Infections and Immunity, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0077-700X","authenticated-orcid":false,"given":"Krishna","family":"Rajarathnam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"},{"name":"Department of Microbiology and Immunology, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"},{"name":"Institute for Human Infections and Immunity, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX 77555 , United States"},{"name":"Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch , 301 University Boulevard, Galveston, TX , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"2024052916290182800_qiae028-B1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cytogfr.2020.04.004","article-title":"The protective and pathogenic roles of CXCL17 in human health and disease: potential in respiratory medicine","volume":"53","author":"Chore\u00f1o-Parra","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"2024052916290182800_qiae028-B2","doi-asserted-by":"crossref","first-page":"e12965","DOI":"10.1111\/sji.12965","article-title":"Mucosal chemokine CXCL17: what is known and not known","volume":"93","author":"Xiao","year":"2021","journal-title":"Scand J Immunol"},{"key":"2024052916290182800_qiae028-B3","doi-asserted-by":"crossref","first-page":"156224","DOI":"10.1016\/j.cyto.2023.156224","article-title":"What defines a chemokine?\u2014the curious case of CXCL17","volume":"168","author":"Giblin","year":"2023","journal-title":"Cytokine"},{"issue":"3","key":"2024052916290182800_qiae028-B4","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302471","article-title":"The origin, evolution, and molecular diversity of the chemokine system","volume":"7","author":"Aleotti","year":"2024","journal-title":"Life Sci Alliance"},{"issue":"4","key":"2024052916290182800_qiae028-B5","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.4049\/jimmunol.176.4.2069","article-title":"Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods","volume":"176","author":"Pisabarro","year":"2006","journal-title":"J Immunol"},{"issue":"3","key":"2024052916290182800_qiae028-B6","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.4049\/jimmunol.1400551","article-title":"CXCL17 is a major chemotactic factor for lung macrophages","volume":"193","author":"Burkhardt","year":"2014","journal-title":"J Immunol"},{"issue":"1","key":"2024052916290182800_qiae028-B7","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1152\/ajpendo.00083.2012","article-title":"CXCL17, an orphan chemokine, acts as a novel angiogenic and anti-inflammatory factor","volume":"304","author":"Lee","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"8","key":"2024052916290182800_qiae028-B8","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.4049\/jimmunol.1701474","article-title":"CXCL17 chemokine-dependent mobilization of CXCR8+CD8+ effector memory and tissue-resident memory T cells in the vaginal mucosa is associated with protection against genital herpes","volume":"200","author":"Srivastava","year":"2018","journal-title":"J Immunol"},{"issue":"12","key":"2024052916290182800_qiae028-B9","doi-asserted-by":"crossref","first-page":"6399","DOI":"10.4049\/jimmunol.1102903","article-title":"CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity","volume":"188","author":"Burkhardt","year":"2012","journal-title":"J Immunol"},{"issue":"5","key":"2024052916290182800_qiae028-B10","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/JLB.3A0918-345RR","article-title":"Cxcl17\u2212\/\u2212 mice develop exacerbated disease in a T cell-dependent autoimmune model","volume":"105","author":"Hern\u00e1ndez-Ruiz","year":"2019","journal-title":"J Leukoc Biol"},{"key":"2024052916290182800_qiae028-B11","doi-asserted-by":"crossref","first-page":"633297","DOI":"10.3389\/fimmu.2021.633297","article-title":"CXCL17 is a specific diagnostic biomarker for severe pandemic influenza A(H1N1) that predicts poor clinical outcome","volume":"12","author":"Chore\u00f1o-Parra","year":"2021","journal-title":"Front Immunol"},{"issue":"7762","key":"2024052916290182800_qiae028-B12","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41586-019-1276-2","article-title":"Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis","volume":"570","author":"Ardain","year":"2019","journal-title":"Nature"},{"issue":"8","key":"2024052916290182800_qiae028-B13","doi-asserted-by":"crossref","first-page":"e44080","DOI":"10.1371\/journal.pone.0044080","article-title":"CXCL17 expression by tumor cells recruits CD11b+Gr1 high F4\/80- cells and promotes tumor progression","volume":"7","author":"Matsui","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"2024052916290182800_qiae028-B14","doi-asserted-by":"crossref","first-page":"e110064","DOI":"10.1371\/journal.pone.0110064","article-title":"CXCL17 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"2024052916290182800_qiae028-B15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00441-017-2753-2","article-title":"Partners in crime: neutrophils and monocytes\/macrophages in inflammation and disease","volume":"371","author":"Prame Kumar","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"5","key":"2024052916290182800_qiae028-B16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/emmm.201202382","article-title":"Resolution of inflammation: an integrated view","volume":"5","author":"Ortega-G\u00f3mez","year":"2013","journal-title":"EMBO Mol Med"},{"issue":"6","key":"2024052916290182800_qiae028-B17","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.4049\/jimmunol.180.6.4308","article-title":"Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways","volume":"180","author":"De Filippo","year":"2008","journal-title":"J Immunol"},{"issue":"5","key":"2024052916290182800_qiae028-B18","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1182\/blood-2008-10-183699","article-title":"\u03b2-Arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation","volume":"114","author":"Molteni","year":"2009","journal-title":"Blood"},{"issue":"4","key":"2024052916290182800_qiae028-B19","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.4049\/jimmunol.155.4.2158","article-title":"Chemokine binding and activities mediated by the mouse IL-8 receptor","volume":"155","author":"Lee","year":"1995","journal-title":"J Immunol"},{"issue":"4","key":"2024052916290182800_qiae028-B20","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/JLB.3A0820-207R","article-title":"Neutrophil recruitment by chemokines Cxcl1\/KC and Cxcl2\/MIP2: role of Cxcr2 activation and glycosaminoglycan interactions","volume":"109","author":"Sawant","year":"2021","journal-title":"J Leukoc Biol"},{"issue":"3","key":"2024052916290182800_qiae028-B21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1189\/jlb.3HI0714-340R","article-title":"Regulation of CXCR2 expression and function by a disintegrin and metalloprotease-17 (ADAM17)","volume":"97","author":"Mishra","year":"2015","journal-title":"J Leukoc Biol"},{"issue":"6","key":"2024052916290182800_qiae028-B22","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1159\/000430914","article-title":"Chemokine CXCL1-mediated neutrophil trafficking in the lung: role of CXCR2 activation","volume":"7","author":"Sawant","year":"2015","journal-title":"J Innate Immun"},{"issue":"3","key":"2024052916290182800_qiae028-B23","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.4049\/jimmunol.181.3.2189","article-title":"IL-6 regulates neutrophil trafficking during acute inflammation via STAT3","volume":"181","author":"Fielding","year":"2008","journal-title":"J Immunol"},{"key":"2024052916290182800_qiae028-B24","doi-asserted-by":"crossref","first-page":"1254697","DOI":"10.3389\/fimmu.2023.1254697","article-title":"CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signaling","volume":"14","author":"Giblin","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"2024052916290182800_qiae028-B25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4049\/jimmunol.1401704","article-title":"Cutting edge: GPR35\/CXCR8 is the receptor of the mucosal chemokine CXCL17","volume":"194","author":"Maravillas-Montero","year":"2015","journal-title":"J Immunol"},{"issue":"2","key":"2024052916290182800_qiae028-B26","doi-asserted-by":"crossref","first-page":"714","DOI":"10.4049\/jimmunol.1700884","article-title":"Evidence for the existence of a CXCL17 receptor distinct from GPR35","volume":"201","author":"Binti Mohd Amir","year":"2018","journal-title":"J Immunol"},{"issue":"5","key":"2024052916290182800_qiae028-B27","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cell.2022.01.010","article-title":"GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA","volume":"185","author":"De Giovanni","year":"2022","journal-title":"Cell"},{"key":"2024052916290182800_qiae028-B28","first-page":"225","article-title":"Revisiting mouse peritoneal macrophages: heterogeneity, development, and function","volume":"6","author":"Cassado Ados","year":"2015","journal-title":"Front Immunol"},{"issue":"6","key":"2024052916290182800_qiae028-B29","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1073\/pnas.0915000107","article-title":"Two physically, functionally, and developmentally distinct peritoneal macrophage subsets","volume":"107","author":"Ghosn","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2024052916290182800_qiae028-B30","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/1753425916651330","article-title":"Single-cell analysis reveals new subset markers of murine peritoneal macrophages and highlights macrophage dynamics upon Staphylococcus aureus peritonitis","volume":"22","author":"Accarias","year":"2016","journal-title":"Innate Immun"},{"issue":"3","key":"2024052916290182800_qiae028-B31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jlb.57.3.361","article-title":"Review of the macrophage disappearance reaction","volume":"57","author":"Barth","year":"1995","journal-title":"J Leukoc Biol"},{"issue":"10","key":"2024052916290182800_qiae028-B32","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.4049\/jimmunol.1601607","article-title":"CXCL17 attenuates imiquimod-induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells","volume":"198","author":"Oka","year":"2017","journal-title":"J Immunol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiae028\/56732924\/qiae028.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/115\/6\/1177\/57985556\/qiae028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/115\/6\/1177\/57985556\/qiae028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T16:29:28Z","timestamp":1717000168000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/115\/6\/1177\/7595552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,1,31]]},"published-print":{"date-parts":[[2024,5,29]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiae028","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6]]},"published":{"date-parts":[[2024,1,31]]}}}