{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:14:52Z","timestamp":1792167292228,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds de recherche du Qu\u00e9bec\u2014Sant\u00e9"},{"name":"Frederick Banting and Charles Best Canada Graduate Scholarship from the Canadian Institutes of Health Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Prostaglandin E2 (PGE2) is a recognized inhibitor of granulocyte functions. However, most of the data supporting this was obtained when available pharmacological tools mainly targeted the EP2 receptor. Herein, we revisited the inhibitory effect of PGE2 on reactive oxygen species production, leukotriene biosynthesis, and migration in human neutrophils. Our data confirm the inhibitory effect of PGE2 on these functions and unravel that the effect of PGE2 on human neutrophils is obtained by the combined action of EP2 and EP4 agonism. Accordingly, we also demonstrate that the inhibitory effect of PGE2 is fully prevented only by the combination of EP2 and EP4 receptor antagonists, underscoring the importance of targeting both receptors in the effect of PGE2. Conversely, we also show that the inhibition of ROS production by human eosinophils only involves the EP4 receptor, despite the fact that they also express the EP2 receptor.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae029","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T14:30:37Z","timestamp":1707748237000},"page":"1183-1189","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacological evidence that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils"],"prefix":"10.1093","volume":"115","author":[{"given":"Jean-Philippe C","family":"Lavoie","sequence":"first","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, D\u00e9partement de m\u00e9decine, Facult\u00e9 de m\u00e9decine, Universit\u00e9 Laval , 2725 Chemin Sainte-Foy, Qu\u00e9bec City, QC G1V 4G5 , Canada"},{"name":"Canada Excellence Research Chair on the 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Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Universit\u00e9 Laval , 2325 Rue de l'Universit\u00e9, Qu\u00e9bec City, QC G1V 0A6 , Canada"},{"name":"Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale Delle Ricerche , 80078 Pozzuoli , Italy"},{"name":"Institut sur la nutrition et les aliments fonctionnels, Centre NUTRISS, \u00c9cole de Nutrition, Facult\u00e9 des Sciences de l\u2019agriculture et de l\u2019alimentation, Universit\u00e9 Laval , 2440 Bd Hochelaga Suite 1710, Qu\u00e9bec City, QC G1V 0A6 , Canada"},{"name":"Joint International Unit between the Consiglio Nazionale delle Ricerche (Italy) and Universit\u00e9 Laval (Canada) on Chemical and Biomolecular Research on the Microbiome and Its Impact on Metabolic Health and Nutrition (UMI-MicroMeNu) , 80078 Pozzuoli, Italy and Qu\u00e9bec City, QC , 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