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Although the recent availability of biologic therapies that directly and indirectly target eosinophils has the potential to dramatically improve treatment options for all EADs, clinical trials addressing their safety and efficacy in rare EADs have been relatively few. Consequently, patient access to therapy is limited for many biologics, and the establishment of evidence-based treatment guidelines has been extremely difficult. In this regard, multicenter retrospective collaborative studies focusing on disease manifestations and treatment responses in rare EADs have provided invaluable data for physicians managing patients with these conditions and helped identify important questions for future translational research. During the Clinical Pre-Meeting Workshop held in association with the July 2023 biennial meeting of the International Eosinophil Society in Hamilton, Ontario, Canada, the successes and limitations of pivotal multicenter retrospective studies in EADs were summarized and unmet needs regarding the establishment of guidelines for use of biologics in rare EADs were discussed. Key topics of interest included (1) clinical outcome measures, (2) minimally invasive biomarkers of disease activity, (3) predictors of response to biologic agents, and (4) long-term safety of eosinophil depletion. Herein, we report a summary of these discussions, presenting a state-of-the-art overview of data currently available for each of these topics, the limitations of the data, and avenues for future data generation through implementation of multidisciplinary and multicenter studies.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae051","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T16:16:41Z","timestamp":1709914601000},"page":"307-320","source":"Crossref","is-referenced-by-count":5,"title":["Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities"],"prefix":"10.1093","volume":"116","author":[{"given":"Paneez","family":"Khoury","sequence":"first","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , 4 Memorial Drive, Bethesda, MD 20892 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Roufosse","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles , 808 Route de Lennik, Brussels 1070 , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei Li","family":"Kuang","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine , 240 East Huron Street, Chicago, IL 60611 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8183-4693","authenticated-orcid":false,"given":"Steven J","family":"Ackerman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, 900 S. 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