{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:18:23Z","timestamp":1793114303950,"version":"4.5.0"},"reference-count":112,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONAHCyT","doi-asserted-by":"crossref","award":["214"],"award-info":[{"award-number":["214"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ralph H. 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Selective elimination of CD38's ectoenzyme function licenses them to decrease the oxygen consumption rate\/extracellular acidification rate ratio upon TCR signaling and to increase cycling, proliferation, survival, and CD40L induction. Pharmacological inhibition of ecto-CD38 catalytic activity in TM cells from chronic HIV-infected patients rescued TCR-triggered responses, including differentiation and effector functions, while reverting abnormally increased basal glycolysis, cycling, and spontaneous proinflammatory cytokine production. Additionally, ecto-CD38 blockage normalized basal and TCR-induced mitochondrial morphofunctionality, while increasing respiratory capacity in cells from HIV+ patients and healthy individuals. Ectoenzyme CD38's immunometabolic restriction of TCR-involving stimulation is relevant to CD4T cell biology and to the deleterious effects of CD38 overexpression in HIV disease.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae060","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T18:32:13Z","timestamp":1710181933000},"page":"440-455","source":"Crossref","is-referenced-by-count":6,"title":["The ecto-enzyme CD38 modulates CD4T cell immunometabolic responses and participates in HIV pathogenesis"],"prefix":"10.1093","volume":"116","author":[{"given":"Fernando","family":"D\u00edaz-Basilio","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Immunology, National Institute of Respiratory Diseases Ismael Cos\u00edo Villegas , Calzada de Tlalpan 4502, Tlalpan, 14080 Mexico City , Mexico"},{"name":"PECEM Graduate Program, Faculty of Medicine, National Autonomous University of Mexico , Circuito Escolar, Ciudad Universitaria, Coyoac\u00e1n, 04510 Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s","family":"Vergara-Mendoza","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, National Institute of Medical Sciences and Nutrition Salvador Zubir\u00e1n , Vasco de Quiroga 15, Tlalpan, 14080 Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Romero-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Flow Cytometry Core Facility, National Institute of Respiratory Diseases Ismael Cos\u00edo Villegas , Calzada de Tlalpan 4502, Tlalpan, 14080 Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharik","family":"Hern\u00e1ndez-Rizo","sequence":"additional","affiliation":[{"name":"Laboratory for Cellular Physiology and Translational Medicine, Department of Health Sciences, Autonomous Metropolitan University, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Juan 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