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Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of osteoclasts and deficiency in bone resorption. Here, we demonstrate that homozygous Csf1r mutation in rat leads to delayed postnatal skeletal ossification associated with substantial loss of osteal macrophages in addition to osteoclasts. Osteosclerosis and site-specific skeletal abnormalities were reversed by intraperitoneal transfer of wild-type bone marrow cells (bone marrow cell transfer, BMT) at weaning. Following BMT, IBA1+ macrophages were detected before TRAP+ osteoclasts at sites of ossification restoration. These observations extend evidence that osteal macrophages independently contribute to bone anabolism and are required for normal postnatal bone growth and morphogenesis.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae077","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T13:45:50Z","timestamp":1711374350000},"page":"753-765","source":"Crossref","is-referenced-by-count":8,"title":["Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer"],"prefix":"10.1093","volume":"116","author":[{"given":"Lena","family":"Batoon","sequence":"first","affiliation":[{"name":"Mater Research Institute, The University of Queensland , Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102 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M","family":"Millard","sequence":"additional","affiliation":[{"name":"Mater Research Institute, The University of Queensland , Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-1478","authenticated-orcid":false,"given":"David A","family":"Hume","sequence":"additional","affiliation":[{"name":"Mater Research Institute, The University of Queensland , Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4707-7892","authenticated-orcid":false,"given":"Allison R","family":"Pettit","sequence":"additional","affiliation":[{"name":"Mater Research Institute, The University of Queensland , Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102 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