{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:39:40Z","timestamp":1791916780119,"version":"4.3.4"},"reference-count":328,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutions of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Progressive memory loss and cognitive dysfunction, encompassing deficits in learning, memory, problem solving, spatial reasoning, and verbal expression, are characteristics of Alzheimer's disease and related dementia. A wealth of studies has described multiple roles of the immune system in the development or exacerbation of dementia. Individuals with autoimmune disorders can also develop cognitive dysfunction, a phenomenon termed \u201cautoimmune dementia.\u201d Together, these findings underscore the pivotal role of the neuroimmune axis in both Alzheimer's disease and related dementia and autoimmune dementia. The dynamic interplay between adaptive and innate immunity, both in and outside the brain, significantly affects the etiology and progression of these conditions. Multidisciplinary research shows that cognitive dysfunction arises from a bidirectional relationship between the nervous and immune systems, though the specific mechanisms that drive cognitive impairments are not fully understood. Intriguingly, this reciprocal regulation occurs at multiple levels, where neuronal signals can modulate immune responses, and immune system\u2013related processes can influence neuronal viability and function. In this review, we consider the implications of autoimmune responses in various autoimmune disorders and Alzheimer's disease and explore their effects on brain function. We also discuss the diverse cellular and molecular crosstalk between the brain and the immune system, as they may shed light on potential triggers of peripheral inflammation, their effect on the integrity of the blood-brain barrier, and brain function. Additionally, we assess challenges and possibilities associated with developing immune-based therapies for the treatment of cognitive decline.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae134","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T11:06:40Z","timestamp":1718276800000},"page":"1269-1290","source":"Crossref","is-referenced-by-count":8,"title":["Brain-immune interactions: implication for cognitive impairments in Alzheimer's disease and autoimmune disorders"],"prefix":"10.1093","volume":"116","author":[{"given":"Rashmi","family":"Kadam","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois College of Medicine, 835 S Wolcott street, MC 790, Chicago , Chicago, IL 60612 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muskan","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Illinois College of Medicine, 808 S Wood street, MC 512, Chicago , Chicago, IL 60612 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Lazarov","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Illinois College of Medicine, 808 S Wood street, MC 512, Chicago , Chicago, IL 60612 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9815-9850","authenticated-orcid":false,"given":"Bellur S","family":"Prabhakar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Illinois College of Medicine, 835 S Wolcott street, MC 790, Chicago , Chicago, IL 60612 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"issue":"10","key":"2024112705063639800_qiae134-B1","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.it.2015.08.007","article-title":"The regulation of immunological processes by peripheral neurons in homeostasis and disease","volume":"36","author":"Ordovas-Montanes","year":"2015","journal-title":"Trends Immunol"},{"issue":"5","key":"2024112705063639800_qiae134-B2","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.immuni.2009.09.009","article-title":"Immune and nervous systems: more than just a superficial similarity?","volume":"31","author":"Kioussis","year":"2009","journal-title":"Immunity"},{"issue":"3","key":"2024112705063639800_qiae134-B3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.immuni.2020.02.017","article-title":"Neuro-immune interactions in the tissues","volume":"52","author":"Chu","year":"2020","journal-title":"Immunity"},{"issue":"4","key":"2024112705063639800_qiae134-B4","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.cell.2016.04.041","article-title":"Neuro-immune interactions at barrier surfaces","volume":"165","author":"Veiga-Fernandes","year":"2016","journal-title":"Cell"},{"key":"2024112705063639800_qiae134-B5","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.3389\/fimmu.2017.01085","article-title":"Expression and function of the cholinergic system in immune cells","volume":"8","author":"Fujii","year":"2017","journal-title":"Front Immunol"},{"key":"2024112705063639800_qiae134-B6","doi-asserted-by":"publisher","first-page":"945","DOI":"10.3389\/fimmu.2017.00945","article-title":"Neuroimmune interactions in inflammation and acute kidney injury","volume":"8","author":"Inoue","year":"2017","journal-title":"Front Immunol"},{"key":"2024112705063639800_qiae134-B7","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.3389\/fimmu.2017.01452","article-title":"The vagus nerve in the neuro-immune axis: implications in the pathology of the gastrointestinal tract","volume":"8","author":"Bonaz","year":"2017","journal-title":"Front Immunol"},{"issue":"S2","key":"2024112705063639800_qiae134-B8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: the devil is in the details","volume":"139 Suppl 2","author":"DiSabato","year":"2016","journal-title":"J Neurochem"},{"key":"2024112705063639800_qiae134-B9","first-page":"1","volume-title":"Neuroscience in the 21st century","author":"Kennedy","year":"2016"},{"key":"2024112705063639800_qiae134-B10","doi-asserted-by":"publisher","first-page":"676621","DOI":"10.3389\/fimmu.2021.676621","article-title":"Immune response in neurological pathology: emerging role of central and peripheral immune crosstalk","volume":"12","author":"Passaro","year":"2021","journal-title":"Front Immunol"},{"issue":"6","key":"2024112705063639800_qiae134-B11","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.immuni.2017.06.008","article-title":"Mechanisms and therapeutic relevance of neuro-immune communication","volume":"46","author":"Chavan","year":"2017","journal-title":"Immunity"},{"issue":"15","key":"2024112705063639800_qiae134-B12","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1007\/s40265-021-01604-z","article-title":"Anifrolumab: first approval","volume":"81","author":"Deeks","year":"2021","journal-title":"Drugs"},{"issue":"11","key":"2024112705063639800_qiae134-B13","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1038\/nm1101-1189","article-title":"A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus","volume":"7","author":"DeGiorgio","year":"2001","journal-title":"Nat Med"},{"issue":"12","key":"2024112705063639800_qiae134-B14","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1002\/art.30616","article-title":"NR2-reactive antibody decreases cell viability through augmentation of Ca(2+) influx in systemic lupus erythematosus","volume":"63","author":"Gono","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"2","key":"2024112705063639800_qiae134-B15","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.immuni.2004.07.011","article-title":"Cognition and immunity; antibody impairs memory","volume":"21","author":"Kowal","year":"2004","journal-title":"Immunity"},{"key":"2024112705063639800_qiae134-B16","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fpsyt.2013.00052","article-title":"NMDA receptor activity in neuropsychiatric disorders","volume":"4","author":"Lakhan","year":"2013","journal-title":"Front Psychiatry"},{"issue":"1","key":"2024112705063639800_qiae134-B17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/(sici)1096-9861(19980105)390:1&lt;75::aid-cne7&gt;3.0.co;2-n","article-title":"Expression of N-methyl-D-aspartate receptor subunit mRNAs in the human brain: hippocampus and cortex","volume":"390","author":"Scherzer","year":"1998","journal-title":"J Comp Neurol"},{"issue":"2","key":"2024112705063639800_qiae134-B18","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s40744-021-00312-0","article-title":"Cognitive dysfunction in systemic lupus erythematosus: immunopathology, clinical manifestations, neuroimaging and management","volume":"8","author":"Seet","year":"2021","journal-title":"Rheumatol Ther"},{"issue":"5","key":"2024112705063639800_qiae134-B19","doi-asserted-by":"publisher","first-page":"10281","DOI":"10.3390\/ijms160510281","article-title":"Anti-NR2A\/B antibodies and other major molecular mechanisms in the pathogenesis of cognitive dysfunction in systemic lupus erythematosus","volume":"16","author":"Tay","year":"2015","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2024112705063639800_qiae134-B20","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/art.37745","article-title":"IgG anti-NR2 glutamate receptor autoantibodies from patients with systemic lupus erythematosus activate endothelial cells","volume":"65","author":"Yoshio","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"1","key":"2024112705063639800_qiae134-B21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s11926-011-0224-4","article-title":"Cognitive dysfunction and antiphospholipid antibodies","volume":"14","author":"Appenzeller","year":"2012","journal-title":"Curr Rheumatol Rep"},{"issue":"5","key":"2024112705063639800_qiae134-B22","doi-asserted-by":"publisher","first-page":"e0196103","DOI":"10.1371\/journal.pone.0196103","article-title":"Cognitive dysfunction improves in systemic lupus erythematosus: results of a 10 years prospective study","volume":"13","author":"Ceccarelli","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"2024112705063639800_qiae134-B23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1191\/096120399678847524","article-title":"Antiphospholipid antibodies permeabilize and depolarize brain synaptoneurosomes","volume":"8","author":"Chapman","year":"1999","journal-title":"Lupus"},{"issue":"9","key":"2024112705063639800_qiae134-B24","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.clineuro.2008.06.011","article-title":"Non-MS autoimmune demyelination","volume":"110","author":"Cikes","year":"2008","journal-title":"Clin Neurol Neurosurg"},{"issue":"4","key":"2024112705063639800_qiae134-B25","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1191\/0961203306lu2272rr","article-title":"Epilepsy as part of systemic lupus erythematosus and systemic Antiphospholipid syndrome (Hughes syndrome)","volume":"15","author":"Cimaz","year":"2006","journal-title":"Lupus"},{"issue":"8","key":"2024112705063639800_qiae134-B26","first-page":"1553","article-title":"Anti-NR2 glutamate receptor antibodies and cognitive function in systemic lupus erythematosus","volume":"33","author":"Hanly","year":"2006","journal-title":"J Rheumatol"},{"issue":"10","key":"2024112705063639800_qiae134-B27","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1136\/ard.2010.148502","article-title":"Autoantibodies as biomarkers for the prediction of neuropsychiatric events in systemic lupus erythematosus","volume":"70","author":"Hanly","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2024112705063639800_qiae134-B28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1742-2094-6-3","article-title":"Antiphospholipid antibodies: paradigm in transition","volume":"6","author":"Horstman","year":"2009","journal-title":"J Neuroinflammation"},{"issue":"9","key":"2024112705063639800_qiae134-B29","doi-asserted-by":"publisher","first-page":"682","DOI":"10.7326\/0003-4819-112-9-682","article-title":"Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in Systemic Lupus Erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance","volume":"112","author":"Love","year":"1990","journal-title":"Ann Intern Med"},{"issue":"5","key":"2024112705063639800_qiae134-B30","first-page":"985","article-title":"Neuropsychiatric manifestations in systemic lupus erythematosus: prevalence and association with antiphospholipid antibodies","volume":"30","author":"Sanna","year":"2003","journal-title":"J Rheumatol"},{"issue":"11","key":"2024112705063639800_qiae134-B31","first-page":"2093","article-title":"The pathogenesis of neuropsychiatric manifestations in systemic lupus erythematosus: a disease in search of autoantibodies, or autoantibodies in search of a disease?","volume":"31","author":"Sen\u00e9cal","year":"2004","journal-title":"J Rheumatol"},{"issue":"4","key":"2024112705063639800_qiae134-B32","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1002\/art.23399","article-title":"Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus","volume":"58","author":"Arinuma","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"5","key":"2024112705063639800_qiae134-B33","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1056\/NEJM198707303170503","article-title":"Association between lupus psychosis and anti-ribosomal P protein antibodies","volume":"317","author":"Bonfa","year":"1987","journal-title":"N Engl J Med"},{"issue":"43","key":"2024112705063639800_qiae134-B34","doi-asserted-by":"publisher","first-page":"18569","DOI":"10.1073\/pnas.1006980107","article-title":"Neurotoxic lupus autoantibodies alter brain function through 2 distinct mechanisms","volume":"107","author":"Faust","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2024112705063639800_qiae134-B35","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1093\/rheumatology\/41.12.1357","article-title":"Clinical and serological associations of ribosomal P autoantibodies in systemic lupus erythematosus: prospective evaluation in a large cohort of Italian patients","volume":"41","author":"Gerli","year":"2002","journal-title":"Rheumatology"},{"issue":"2","key":"2024112705063639800_qiae134-B36","doi-asserted-by":"publisher","first-page":"R77","DOI":"10.1186\/ar4518","article-title":"Blood-brain barrier damages and intrathecal synthesis of anti-N-methyl-D-aspartate receptor NR2 antibodies in diffuse psychiatric\/neuropsychological syndromes in systemic lupus erythematosus","volume":"16","author":"Hirohata","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"2024112705063639800_qiae134-B37","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1002\/art.21539","article-title":"Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus: an international meta-analysis","volume":"54","author":"Karassa","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"6","key":"2024112705063639800_qiae134-B38","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1177\/0961203314555538","article-title":"Anti-N-methyl-D-aspartate receptor and anti-ribosomal-P autoantibodies contribute to cognitive dysfunction in systemic lupus erythematosus","volume":"24","author":"Massardo","year":"2015","journal-title":"Lupus"},{"issue":"13","key":"2024112705063639800_qiae134-B39","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1084\/jem.20071285","article-title":"Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis","volume":"204","author":"Matus","year":"2007","journal-title":"J Exp Med"},{"issue":"11","key":"2024112705063639800_qiae134-B40","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1007\/s10067-019-04707-x","article-title":"Predictors of damage accrual in systemic lupus erythematosus: a longitudinal observational study with focus on neuropsychological factors and anti-neuronal antibodies","volume":"38","author":"Mimica","year":"2019","journal-title":"Clin Rheumatol"},{"issue":"6","key":"2024112705063639800_qiae134-B41","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1002\/art.39081","article-title":"Pathogenicity of lupus anti-ribosomal P antibodies: role of cross-reacting neuronal surface P antigen in glutamatergic transmission and plasticity in a mouse model","volume":"67","author":"Segovia-Miranda","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"2024112705063639800_qiae134-B42","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/art.1780370303","article-title":"Antiribosomal P protein antibodies in systemic lupus erythematosus. A reappraisal","volume":"37","author":"Teh","year":"1994","journal-title":"Arthritis Rheum"},{"issue":"1","key":"2024112705063639800_qiae134-B43","doi-asserted-by":"publisher","first-page":"e000038","DOI":"10.1136\/lupus-2014-000038","article-title":"Blood-based candidate biomarkers of the presence of neuropsychiatric systemic lupus erythematosus in children","volume":"1","author":"Brunner","year":"2014","journal-title":"Lupus Sci Med"},{"key":"2024112705063639800_qiae134-B44","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fimmu.2016.00005","article-title":"Antiglutamate receptor antibodies and cognitive impairment in primary Antiphospholipid syndrome and systemic lupus erythematosus","volume":"7","author":"Gerosa","year":"2016","journal-title":"Front Immunol"},{"issue":"1","key":"2024112705063639800_qiae134-B45","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/art.40591","article-title":"Review: nervous system disease in systemic lupus erythematosus: current status and future directions","volume":"71","author":"Hanly","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"2024112705063639800_qiae134-B46","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1191\/0961203302lu209oa","article-title":"Antiribosomal P protein antibodies in Chilean SLE patients: no association with renal disease","volume":"11","author":"Massardo","year":"2002","journal-title":"Lupus"},{"issue":"11","key":"2024112705063639800_qiae134-B47","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.3390\/jcm10112235","article-title":"Myasthenia gravis: epidemiology, pathophysiology and clinical manifestations","volume":"10","author":"Dresser","year":"2021","journal-title":"J Clin Med"},{"issue":"5","key":"2024112705063639800_qiae134-B48","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s40263-023-01000-z","article-title":"Efgartigimod Alfa in generalised myasthenia gravis: a profile of its use","volume":"37","author":"Heo","year":"2023","journal-title":"CNS Drugs"},{"key":"2024112705063639800_qiae134-B49","doi-asserted-by":"publisher","first-page":"F1000 Faculty Rev-1513","DOI":"10.12688\/f1000research.8206.1","article-title":"Pathogenesis of myasthenia gravis: update on disease types, models, and mechanisms","volume":"5","author":"Phillips","year":"2016","journal-title":"F1000Res"},{"issue":"6","key":"2024112705063639800_qiae134-B50","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1007\/s00415-023-11617-1","article-title":"Ravulizumab pharmacokinetics and pharmacodynamics in patients with generalized myasthenia gravis","volume":"270","author":"Vu","year":"2023","journal-title":"J Neurol"},{"key":"2024112705063639800_qiae134-B51","doi-asserted-by":"publisher","first-page":"680141","DOI":"10.3389\/fneur.2021.680141","article-title":"Association between myasthenia gravis and memory: a systematic review and meta-analysis","volume":"12","author":"Zhou","year":"2021","journal-title":"Front Neurol"},{"key":"2024112705063639800_qiae134-B52","doi-asserted-by":"publisher","first-page":"e04287","DOI":"10.7554\/eLife.04287","article-title":"Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4","volume":"3","author":"Gomez","year":"2014","journal-title":"Elife"},{"issue":"2","key":"2024112705063639800_qiae134-B53","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4103\/0972-2327.156560","article-title":"Association between myasthenia gravis and cognitive function: a systematic review and meta-analysis","volume":"18","author":"Mao","year":"2015","journal-title":"Ann Indian Acad Neurol"},{"issue":"8","key":"2024112705063639800_qiae134-B54","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.4103\/1673-5374.363824","article-title":"FcRn inhibitors: a novel option for the treatment of myasthenia gravis","volume":"18","author":"Zhu","year":"2023","journal-title":"Neural Regen Res"},{"issue":"2","key":"2024112705063639800_qiae134-B55","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3390\/brainsci13020170","article-title":"Frequency and correlates of mild cognitive impairment in myasthenia gravis","volume":"13","author":"Iacono","year":"2023","journal-title":"Brain Sci"},{"issue":"5","key":"2024112705063639800_qiae134-B56","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/ana.21802","article-title":"Intrathecal pathogenic anti\u2013aquaporin-4 antibodies in early neuromyelitis optica","volume":"66","author":"Bennett","year":"2009","journal-title":"Ann Neurol"},{"key":"2024112705063639800_qiae134-B57","doi-asserted-by":"publisher","first-page":"664664","DOI":"10.3389\/fneur.2021.664664","article-title":"Autoimmune disorders of the nervous system: pathophysiology, clinical features, and therapy","volume":"12","author":"Bhagavati","year":"2021","journal-title":"Front Neurol"},{"issue":"4","key":"2024112705063639800_qiae134-B58","doi-asserted-by":"publisher","first-page":"e33878","DOI":"10.1371\/journal.pone.0033878","article-title":"White matter atrophy and cognitive dysfunctions in neuromyelitis optica","volume":"7","author":"Blanc","year":"2012","journal-title":"PLoS One"},{"key":"2024112705063639800_qiae134-B59","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/978-981-19-0209-3_9","volume-title":"Physiotherapy for adult neurological conditions","author":"Joshua","year":"2022"},{"issue":"5","key":"2024112705063639800_qiae134-B60","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s40265-023-01854-z","article-title":"Ublituximab: first approval","volume":"83","author":"Lee","year":"2023","journal-title":"Drugs"},{"issue":"2","key":"2024112705063639800_qiae134-B61","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1212\/WNL.39.2.161","article-title":"Correlation of magnetic resonance imaging with neuropsychological testing in multiple sclerosis","volume":"39","author":"Rao","year":"1989","journal-title":"Neurology"},{"issue":"1-2","key":"2024112705063639800_qiae134-B62","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jneuroim.2012.03.020","article-title":"Axonal and oligodendrocyte-localized IgM and IgG deposits in MS lesions","volume":"247","author":"S\u00e1daba","year":"2012","journal-title":"J Neuroimmunol"},{"issue":"8","key":"2024112705063639800_qiae134-B63","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1038\/s41587-023-01912-7","article-title":"First cell therapy for diabetes approved","volume":"41","year":"2023","journal-title":"Nat Biotechnol"},{"key":"2024112705063639800_qiae134-B64","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3389\/fnins.2017.00529","article-title":"Type 1 diabetes and impaired awareness of hypoglycemia are associated with reduced brain gray matter volumes","volume":"11","author":"Bednarik","year":"2017","journal-title":"Front Neurosci"},{"issue":"4","key":"2024112705063639800_qiae134-B65","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1210\/er.2007-0034","article-title":"Cognitive dysfunction and diabetes mellitus","volume":"29","author":"Kodl","year":"2008","journal-title":"Endocr Rev"},{"issue":"1","key":"2024112705063639800_qiae134-B66","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/nyas.12807","article-title":"Impact of diabetes on cognitive function and brain structure","volume":"1353","author":"Moheet","year":"2015","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"2024112705063639800_qiae134-B67","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2337\/diabetes.55.02.06.db05-0520","article-title":"Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry","volume":"55","author":"Musen","year":"2006","journal-title":"Diabetes"},{"issue":"8","key":"2024112705063639800_qiae134-B68","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1007\/s00125-007-0714-0","article-title":"Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume","volume":"50","author":"Wessels","year":"2007","journal-title":"Diabetologia"},{"issue":"10","key":"2024112705063639800_qiae134-B69","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1007\/s00125-006-0283-7","article-title":"Voxel-based morphometry demonstrates reduced grey matter density on brain MRI in patients with diabetic retinopathy","volume":"49","author":"Wessels","year":"2006","journal-title":"Diabetologia"},{"issue":"4","key":"2024112705063639800_qiae134-B70","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1152\/physrev.00004.2014","article-title":"Regulation and function of adult neurogenesis: from genes to cognition","volume":"94","author":"Aimone","year":"2014","journal-title":"Physiol Rev"},{"issue":"2","key":"2024112705063639800_qiae134-B71","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/ana.10262","article-title":"Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment","volume":"52","author":"Kempermann","year":"2002","journal-title":"Ann Neurol"},{"key":"2024112705063639800_qiae134-B72","doi-asserted-by":"publisher","first-page":"1681590","DOI":"10.1155\/2016\/1681590","article-title":"A common language: how neuroimmunological cross talk regulates adult hippocampal neurogenesis","volume":"2016","author":"Leiter","year":"2016","journal-title":"Stem Cells Int"},{"key":"2024112705063639800_qiae134-B73","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fncel.2014.00097","article-title":"Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment","volume":"8","author":"Singhal","year":"2014","journal-title":"Front Cell Neurosci"},{"issue":"7362","key":"2024112705063639800_qiae134-B74","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nature10357","article-title":"The ageing systemic milieu negatively regulates neurogenesis and cognitive function","volume":"477","author":"Villeda","year":"2011","journal-title":"Nature"},{"key":"2024112705063639800_qiae134-B75","doi-asserted-by":"publisher","first-page":"717958","DOI":"10.1155\/2015\/717958","article-title":"Involvement of adult hippocampal neurogenesis in learning and forgetting","volume":"2015","author":"Yau","year":"2015","journal-title":"Neural Plast"},{"issue":"2","key":"2024112705063639800_qiae134-B76","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.bbi.2010.10.015","article-title":"Immune modulation of learning, memory, neural plasticity and neurogenesis","volume":"25","author":"Yirmiya","year":"2011","journal-title":"Brain Behav Immun"},{"issue":"2","key":"2024112705063639800_qiae134-B77","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/nn1629","article-title":"Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood","volume":"9","author":"Ziv","year":"2006","journal-title":"Nat Neurosci"},{"issue":"2","key":"2024112705063639800_qiae134-B78","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.it.2015.12.008","article-title":"Understanding the role of T cells in CNS homeostasis","volume":"37","author":"Ellwardt","year":"2016","journal-title":"Trends Immunol"},{"issue":"6","key":"2024112705063639800_qiae134-B79","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.bbi.2007.05.005","article-title":"Brain-immune communication pathways","volume":"21","author":"Quan","year":"2007","journal-title":"Brain Behav Immun"},{"issue":"5","key":"2024112705063639800_qiae134-B80","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.exger.2010.01.010","article-title":"Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-\/-) mice","volume":"45","author":"Berry","year":"2010","journal-title":"Exp Gerontol"},{"key":"2024112705063639800_qiae134-B81","doi-asserted-by":"publisher","first-page":"971817","DOI":"10.1155\/2013\/971817","article-title":"Quality and timing of stressors differentially impact on brain plasticity and neuroendocrine-immune function in mice","volume":"2013","author":"Capoccia","year":"2013","journal-title":"Neural Plast"},{"issue":"10","key":"2024112705063639800_qiae134-B82","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.it.2015.08.006","article-title":"Revisiting the mechanisms of CNS immune privilege","volume":"36","author":"Louveau","year":"2015","journal-title":"Trends Immunol"},{"issue":"9","key":"2024112705063639800_qiae134-B83","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.tins.2016.07.001","article-title":"How do meningeal lymphatic vessels drain the CNS?","volume":"39","author":"Raper","year":"2016","journal-title":"Trends Neurosci"},{"issue":"12","key":"2024112705063639800_qiae134-B84","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1046\/j.1532-5415.2002.50619.x","article-title":"Cytokines and cognition--the case for a head-to-toe inflammatory paradigm","volume":"50","author":"Wilson","year":"2002","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"2024112705063639800_qiae134-B85","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.bbi.2007.12.008","article-title":"Adaptive immunity affects learning behavior in mice","volume":"22","author":"Brynskikh","year":"2008","journal-title":"Brain Behav Immun"},{"issue":"21","key":"2024112705063639800_qiae134-B86","doi-asserted-by":"publisher","first-page":"8180","DOI":"10.1073\/pnas.0402268101","article-title":"T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions","volume":"101","author":"Kipnis","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"2024112705063639800_qiae134-B87","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.4049\/jimmunol.0801218","article-title":"CD4-positive t lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis","volume":"182","author":"Wolf","year":"2009","journal-title":"J Immunol"},{"issue":"6","key":"2024112705063639800_qiae134-B88","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An English translation of Alzheimer's 1907 paper, \u201cUber eine eigenartige Erkankung der Hirnrinde\u201d","volume":"8","author":"Alzheimer","year":"1995","journal-title":"Clin Anat"},{"key":"2024112705063639800_qiae134-B89","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/bs.pmbts.2019.10.002","article-title":"Neuroimmune interactions in Alzheimer's disease-New frontier with old challenges?","volume":"168","author":"Prokop","year":"2019","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"7539","key":"2024112705063639800_qiae134-B90","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nature14252","article-title":"Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease","volume":"518","author":"Gjoneska","year":"2015","journal-title":"Nature"},{"key":"2024112705063639800_qiae134-B91","doi-asserted-by":"publisher","first-page":"653334","DOI":"10.3389\/fnagi.2021.653334","article-title":"Role of neuron and glia in Alzheimer's disease and associated vascular dysfunction","volume":"13","author":"Bandyopadhyay","year":"2021","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"2024112705063639800_qiae134-B92","doi-asserted-by":"publisher","first-page":"208","DOI":"10.5498\/wjp.v6.i2.208","article-title":"Linking multiple pathogenic pathways in Alzheimer's disease","volume":"6","author":"Bou Khalil","year":"2016","journal-title":"World J Psychiatry"},{"issue":"5","key":"2024112705063639800_qiae134-B93","doi-asserted-by":"publisher","first-page":"651","DOI":"10.3390\/jcm8050651","article-title":"Vascular dysfunction in Alzheimer's disease: a prelude to the pathological process or a consequence of it?","volume":"8","author":"Govindpani","year":"2019","journal-title":"J Clin Med"},{"issue":"1","key":"2024112705063639800_qiae134-B94","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0197-4580(00)00094-4","article-title":"Microglia, amyloid and dementia in Alzheimer disease. A correlative study","volume":"21","author":"Arends","year":"2000","journal-title":"Neurobiol Aging"},{"issue":"s185","key":"2024112705063639800_qiae134-B95","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1600-0404.2006.00694.x","article-title":"In vivo evidence for microglial activation in neurodegenerative dementia","volume":"185","author":"Cagnin","year":"2006","journal-title":"Acta Neurol Scand Suppl"},{"issue":"5","key":"2024112705063639800_qiae134-B96","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","article-title":"Disease-Associated microglia: a universal immune sensor of neurodegeneration","volume":"173","author":"Deczkowska","year":"2018","journal-title":"Cell"},{"issue":"7","key":"2024112705063639800_qiae134-B97","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer's disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"issue":"1","key":"2024112705063639800_qiae134-B98","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1212\/01.wnl.0000338622.27876.0d","article-title":"Microglial activation and amyloid deposition in mild cognitive impairment: a PET study","volume":"72","author":"Okello","year":"2009","journal-title":"Neurology"},{"issue":"1","key":"2024112705063639800_qiae134-B99","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/0304-3940(90)90748-X","article-title":"Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease","volume":"119","author":"Perlmutter","year":"1990","journal-title":"Neurosci Lett"},{"issue":"5","key":"2024112705063639800_qiae134-B100","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.ajhg.2008.10.008","article-title":"Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE","volume":"83","author":"Bertram","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"4","key":"2024112705063639800_qiae134-B101","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/s41582-019-0158-4","article-title":"Alzheimer disease risk genes: 29 and counting","volume":"15","author":"Bertram","year":"2019","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"2024112705063639800_qiae134-B102","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/WCO.0000000000000911","article-title":"The role of innate immune genes in Alzheimer's disease","volume":"34","author":"Griciuc","year":"2021","journal-title":"Curr Opin Neurol"},{"issue":"5","key":"2024112705063639800_qiae134-B103","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat Genet"},{"issue":"5","key":"2024112705063639800_qiae134-B104","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat Genet"},{"issue":"10","key":"2024112705063639800_qiae134-B105","doi-asserted-by":"publisher","first-page":"169","DOI":"10.21037\/atm.2018.04.21","article-title":"Meta-analysis of the association between CD33 and Alzheimer's disease","volume":"6","author":"Jiang","year":"2018","journal-title":"Ann Transl Med"},{"issue":"11","key":"2024112705063639800_qiae134-B106","doi-asserted-by":"publisher","first-page":"e50976","DOI":"10.1371\/journal.pone.0050976","article-title":"Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains","volume":"7","author":"Karch","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"2024112705063639800_qiae134-B107","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.neuron.2013.04.014","article-title":"Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta","volume":"78","author":"Griciuc","year":"2013","journal-title":"Neuron"},{"key":"2024112705063639800_qiae134-B108","doi-asserted-by":"publisher","first-page":"105303","DOI":"10.1016\/j.nbd.2021.105303","article-title":"INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia","volume":"153","author":"Tsai","year":"2021","journal-title":"Neurobiol Dis"},{"key":"2024112705063639800_qiae134-B109","doi-asserted-by":"publisher","first-page":"105217","DOI":"10.1016\/j.nbd.2020.105217","article-title":"Alzheimer's-associated PU. 1 expression levels regulate microglial inflammatory response","volume":"148","author":"Pimenova","year":"2021","journal-title":"Neurobiol Dis"},{"issue":"1","key":"2024112705063639800_qiae134-B110","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13024-018-0277-1","article-title":"PU.1 regulates Alzheimer's disease-associated genes in primary human microglia","volume":"13","author":"Rustenhoven","year":"2018","journal-title":"Mol Neurodegener"},{"issue":"3","key":"2024112705063639800_qiae134-B111","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/ana.22277","article-title":"CR1 is associated with amyloid plaque burden and age-related cognitive decline","volume":"69","author":"Chibnik","year":"2011","journal-title":"Ann Neurol"},{"issue":"2","key":"2024112705063639800_qiae134-B112","doi-asserted-by":"publisher","first-page":"e0149792","DOI":"10.1371\/journal.pone.0149792","article-title":"Analysis of the putative role of CR1 in Alzheimer's disease: genetic association, expression and function","volume":"11","author":"Fonseca","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"2024112705063639800_qiae134-B113","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s12881-020-01114-x","article-title":"Impacts of CR1 genetic variants on cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease","volume":"21","author":"Zhu","year":"2020","journal-title":"BMC Med Genet"},{"issue":"7889","key":"2024112705063639800_qiae134-B114","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41586-021-04183-x","article-title":"Exercise plasma boosts memory and dampens brain inflammation via clusterin","volume":"600","author":"De Miguel","year":"2021","journal-title":"Nature"},{"issue":"2","key":"2024112705063639800_qiae134-B115","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00401-019-01994-1","article-title":"The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics","volume":"138","author":"De Roeck","year":"2019","journal-title":"Acta Neuropathol"},{"issue":"2","key":"2024112705063639800_qiae134-B116","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/alz.12220","article-title":"ABCA7 and the altered lipidostasis hypothesis of Alzheimer's disease","volume":"17","author":"Lyssenko","year":"2021","journal-title":"Alzheimers Dement"},{"key":"2024112705063639800_qiae134-B117","doi-asserted-by":"publisher","author":"You","DOI":"10.1101\/2023.02.06.23285545"},{"issue":"S12","key":"2024112705063639800_qiae134-B118","doi-asserted-by":"publisher","first-page":"e077275","DOI":"10.1002\/alz.077275","article-title":"Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights for TREM2 biology and identifies novel modulators for Alzheimer's disease","volume":"19","author":"Wang","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"1","key":"2024112705063639800_qiae134-B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-023-00687-4","article-title":"Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease","volume":"19","author":"Wang","year":"2024","journal-title":"Mol Neurodegener"},{"issue":"1","key":"2024112705063639800_qiae134-B120","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13024-022-00588-y","article-title":"TREM2 dependent and independent functions of microglia in Alzheimer's disease","volume":"17","author":"Hou","year":"2022","journal-title":"Mol Neurodegener"},{"issue":"22","key":"2024112705063639800_qiae134-B121","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1016\/j.cell.2022.09.033","article-title":"TREM2 drives microglia response to amyloid-\u03b2 via SYK-dependent and -independent pathways","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"issue":"6","key":"2024112705063639800_qiae134-B122","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"issue":"6553","key":"2024112705063639800_qiae134-B123","doi-asserted-by":"publisher","first-page":"eabf7844","DOI":"10.1126\/science.abf7844","article-title":"Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma","volume":"373","author":"Cugurra","year":"2021","journal-title":"Science"},{"issue":"11","key":"2024112705063639800_qiae134-B124","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1016\/j.cell.2021.04.003","article-title":"A cellular and spatial map of the choroid plexus across brain ventricles and ages","volume":"184","author":"Dani","year":"2021","journal-title":"Cell"},{"issue":"9","key":"2024112705063639800_qiae134-B125","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1038\/s41593-018-0213-2","article-title":"Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration","volume":"21","author":"Herisson","year":"2018","journal-title":"Nat Neurosci"},{"issue":"4","key":"2024112705063639800_qiae134-B126","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.it.2020.02.002","article-title":"Neuroimmune connections in aging and neurodegenerative diseases","volume":"41","author":"Scheiblich","year":"2020","journal-title":"Trends Immunol"},{"issue":"3","key":"2024112705063639800_qiae134-B127","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.immuni.2013.02.012","article-title":"Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus","volume":"38","author":"Shechter","year":"2013","journal-title":"Immunity"},{"issue":"3","key":"2024112705063639800_qiae134-B128","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood\u2013brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"2024112705063639800_qiae134-B129","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/jcbfm.2015.44","article-title":"Accelerated pericyte degeneration and blood\u2013brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease","volume":"36","author":"Halliday","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"2024112705063639800_qiae134-B130","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41591-018-0297-y","article-title":"Blood\u2013brain barrier breakdown is an early biomarker of human cognitive dysfunction","volume":"25","author":"Nation","year":"2019","journal-title":"Nat Med"},{"issue":"8","key":"2024112705063639800_qiae134-B131","doi-asserted-by":"publisher","first-page":"4112","DOI":"10.1002\/mp.12328","article-title":"Subtle blood-brain barrier leakage rate and spatial extent: considerations for dynamic contrast-enhanced MRI","volume":"44","author":"Van De Haar","year":"2017","journal-title":"Med Phys"},{"key":"2024112705063639800_qiae134-B132","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.neurobiolaging.2016.06.006","article-title":"Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging","volume":"45","author":"van de Haar","year":"2016","journal-title":"Neurobiol Aging"},{"issue":"7717","key":"2024112705063639800_qiae134-B133","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","article-title":"Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease","volume":"560","author":"Da Mesquita","year":"2018","journal-title":"Nature"},{"issue":"10","key":"2024112705063639800_qiae134-B134","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1038\/s41593-018-0227-9","article-title":"CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature","volume":"21","author":"Louveau","year":"2018","journal-title":"Nat Neurosci"},{"issue":"10","key":"2024112705063639800_qiae134-B135","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41573-022-00500-9","article-title":"The glymphatic system: implications for drugs for central nervous system diseases","volume":"21","author":"Lohela","year":"2022","journal-title":"Nat Rev Drug Discov"},{"issue":"9","key":"2024112705063639800_qiae134-B136","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1172\/JCI90603","article-title":"Understanding the functions and relationships of the glymphatic system and meningeal lymphatics","volume":"127","author":"Louveau","year":"2017","journal-title":"J Clin Invest"},{"issue":"7858","key":"2024112705063639800_qiae134-B137","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41586-021-03489-0","article-title":"Meningeal lymphatics affect microglia responses and anti-A\u03b2 immunotherapy","volume":"593","author":"Da Mesquita","year":"2021","journal-title":"Nature"},{"issue":"5","key":"2024112705063639800_qiae134-B138","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nri2297","article-title":"CCR7 and its ligands: balancing immunity and tolerance","volume":"8","author":"F\u00f6rster","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"21","key":"2024112705063639800_qiae134-B139","doi-asserted-by":"publisher","first-page":"eabe4601","DOI":"10.1126\/sciadv.abe4601","article-title":"Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and amyloid-\u03b2 pathology","volume":"7","author":"Da Mesquita","year":"2021","journal-title":"Sci Adv"},{"issue":"6205","key":"2024112705063639800_qiae134-B140","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.1252945","article-title":"Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function","volume":"346","author":"Baruch","year":"2014","journal-title":"Science"},{"issue":"1","key":"2024112705063639800_qiae134-B141","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41467-017-00769-0","article-title":"Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner","volume":"8","author":"Deczkowska","year":"2017","journal-title":"Nat Commun"},{"key":"2024112705063639800_qiae134-B142","doi-asserted-by":"publisher","first-page":"105272","DOI":"10.1016\/j.nbd.2021.105272","article-title":"Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer's pathology in 5xFAD mice","volume":"152","author":"Xue","year":"2021","journal-title":"Neurobiol Dis"},{"issue":"4","key":"2024112705063639800_qiae134-B143","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2020.12.040","article-title":"Functional characterization of the dural sinuses as a neuroimmune interface","volume":"184","author":"Rustenhoven","year":"2021","journal-title":"Cell"},{"issue":"8","key":"2024112705063639800_qiae134-B144","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nm.3913","article-title":"Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin","volume":"21","author":"Zenaro","year":"2015","journal-title":"Nat Med"},{"key":"2024112705063639800_qiae134-B145","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3389\/fnagi.2019.00332","article-title":"Predictive value of routine peripheral blood biomarkers in Alzheimer's disease","volume":"11","author":"Dong","year":"2019","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"2024112705063639800_qiae134-B146","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000341583","article-title":"The evaluation of neutrophil-lymphocyte ratio in Alzheimer's disease","volume":"34","author":"Kuyumcu","year":"2012","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"12","key":"2024112705063639800_qiae134-B147","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/s41590-020-00813-0","article-title":"A new neutrophil subset promotes CNS neuron survival and axon regeneration","volume":"21","author":"Sas","year":"2020","journal-title":"Nat Immunol"},{"issue":"3","key":"2024112705063639800_qiae134-B148","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.celrep.2013.10.010","article-title":"Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta","volume":"5","author":"Michaud","year":"2013","journal-title":"Cell Rep"},{"issue":"6","key":"2024112705063639800_qiae134-B149","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nm1781","article-title":"Blocking TGF-beta-Smad2\/3 innate immune signaling mitigates Alzheimer-like pathology","volume":"14","author":"Town","year":"2008","journal-title":"Nat Med"},{"issue":"4","key":"2024112705063639800_qiae134-B150","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/nm1555","article-title":"Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease","volume":"13","author":"El Khoury","year":"2007","journal-title":"Nat Med"},{"issue":"16","key":"2024112705063639800_qiae134-B151","doi-asserted-by":"publisher","first-page":"6208","DOI":"10.1523\/JNEUROSCI.0299-11.2011","article-title":"CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease","volume":"31","author":"Naert","year":"2011","journal-title":"J Neurosci"},{"issue":"3","key":"2024112705063639800_qiae134-B152","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3233\/JAD-2005-7304","article-title":"Ineffective phagocytosis of amyloid-\u03b2 by macrophages of Alzheimer's disease patients","volume":"7","author":"Fiala","year":"2005","journal-title":"J Alzheimers Dis"},{"issue":"7953","key":"2024112705063639800_qiae134-B153","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"2023","journal-title":"Nature"},{"issue":"11","key":"2024112705063639800_qiae134-B154","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41582-021-00549-x","article-title":"Peripheral and central immune system crosstalk in Alzheimer disease\u2014a research prospectus","volume":"17","author":"Bettcher","year":"2021","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"2024112705063639800_qiae134-B155","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41577-021-00508-z","article-title":"Neuromodulation by the immune system: a focus on cytokines","volume":"21","author":"Salvador","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"21","key":"2024112705063639800_qiae134-B156","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1016\/j.neuron.2022.09.007","article-title":"The brain-immune ecosystem: implications for immunotherapy in defeating neurodegenerative diseases","volume":"110","author":"Schwartz","year":"2022","journal-title":"Neuron"},{"issue":"7790","key":"2024112705063639800_qiae134-B157","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41586-019-1895-7","article-title":"Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease","volume":"577","author":"Gate","year":"2020","journal-title":"Nature"},{"issue":"4","key":"2024112705063639800_qiae134-B158","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/alz.12399","article-title":"Plasma IL-12\/IFN-\u03b3 axis predicts cognitive trajectories in cognitively unimpaired older adults","volume":"18","author":"Yang","year":"2022","journal-title":"Alzheimers Dement"},{"issue":"4","key":"2024112705063639800_qiae134-B159","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0197-4580(88)80079-4","article-title":"Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease","volume":"9","author":"Rogers","year":"1988","journal-title":"Neurobiol Aging"},{"issue":"1-2","key":"2024112705063639800_qiae134-B160","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0165-5728(01)00496-9","article-title":"Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases","volume":"124","author":"Togo","year":"2002","journal-title":"J Neuroimmunol"},{"key":"2024112705063639800_qiae134-B161","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.bbi.2020.05.070","article-title":"CD8(+) T-cells infiltrate Alzheimer's disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice","volume":"89","author":"Unger","year":"2020","journal-title":"Brain Behav Immun"},{"issue":"5","key":"2024112705063639800_qiae134-B162","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.4049\/jimmunol.1200947","article-title":"IFN-\u03b3 Production by amyloid \u03b2-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease","volume":"190","author":"Browne","year":"2013","journal-title":"J Immunol"},{"issue":"4","key":"2024112705063639800_qiae134-B163","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s11481-017-9753-6","article-title":"FTY720 attenuates infection-induced enhancement of A\u03b2 accumulation in APP\/PS1 mice by modulating astrocytic activation","volume":"12","author":"McManus","year":"2017","journal-title":"J Neuroimmune Pharmacol"},{"key":"2024112705063639800_qiae134-B164","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.nbd.2017.02.010","article-title":"Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice","volume":"102","author":"MacPherson","year":"2017","journal-title":"Neurobiol Dis"},{"issue":"5","key":"2024112705063639800_qiae134-B165","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1002\/glia.23575","article-title":"CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease","volume":"67","author":"Shukla","year":"2019","journal-title":"Glia"},{"issue":"1","key":"2024112705063639800_qiae134-B166","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s12974-021-02308-7","article-title":"CD4+ effector T cells accelerate Alzheimer's disease in mice","volume":"18","author":"Machhi","year":"2021","journal-title":"J Neuroinflammation"},{"issue":"1","key":"2024112705063639800_qiae134-B167","doi-asserted-by":"publisher","first-page":"12055","DOI":"10.1038\/s41598-019-48538-x","article-title":"Blockade of \u03b14 integrins reduces leukocyte-endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer's disease","volume":"9","author":"Pietronigro","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"2024112705063639800_qiae134-B168","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nm.4022","article-title":"PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease","volume":"22","author":"Baruch","year":"2016","journal-title":"Nat Med"},{"issue":"4","key":"2024112705063639800_qiae134-B169","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1093\/brain\/awv408","article-title":"Regulatory T cells delay disease progression in Alzheimer-like pathology","volume":"139","author":"Dansokho","year":"2016","journal-title":"Brain"},{"key":"2024112705063639800_qiae134-B170","doi-asserted-by":"publisher","first-page":"64.4","DOI":"10.4049\/jimmunol.204.Supp.64.4","article-title":"Cytotoxic T cells infiltrate the brain and interact with microglia to reduce Alzheimer's disease pathogenesis","volume":"204","author":"Sanchez","year":"2020","journal-title":"J Immunol"},{"issue":"1","key":"2024112705063639800_qiae134-B171","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1038\/s41467-021-22479-4","article-title":"Therapeutic B-cell depletion reverses progression of Alzheimer's disease","volume":"12","author":"Kim","year":"2021","journal-title":"Nat Commun"},{"issue":"9","key":"2024112705063639800_qiae134-B172","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/s41593-023-01415-3","article-title":"Infiltrating CD8(+) T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model","volume":"26","author":"Jorfi","year":"2023","journal-title":"Nat Neurosci"},{"issue":"6512","key":"2024112705063639800_qiae134-B173","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1126\/science.abb8587","article-title":"Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases","volume":"370","author":"Bartels","year":"2020","journal-title":"Science"},{"issue":"2","key":"2024112705063639800_qiae134-B174","doi-asserted-by":"publisher","first-page":"e56293","DOI":"10.1371\/journal.pone.0056293","article-title":"Microglia actively regulate the number of functional synapses","volume":"8","author":"Ji","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"2024112705063639800_qiae134-B175","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1146\/annurev-genet-112618-043515","article-title":"Microglia in brain development, homeostasis, and neurodegeneration","volume":"53","author":"Bohlen","year":"2019","journal-title":"Annu Rev Genet"},{"issue":"4","key":"2024112705063639800_qiae134-B176","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol"},{"issue":"4","key":"2024112705063639800_qiae134-B177","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.bcp.2014.01.008","article-title":"Microglial dysfunction in brain aging and Alzheimer's disease","volume":"88","author":"Mosher","year":"2014","journal-title":"Biochem Pharmacol"},{"issue":"21","key":"2024112705063639800_qiae134-B178","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: a field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"issue":"4","key":"2024112705063639800_qiae134-B179","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1152\/jn.00395.2019","article-title":"The interplay between microglial states and major risk factors in Alzheimer's disease through the eyes of single-cell RNA-sequencing: beyond black and white","volume":"122","author":"von Maydell","year":"2019","journal-title":"J Neurophysiol"},{"issue":"1","key":"2024112705063639800_qiae134-B180","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/s41467-018-08279-3","article-title":"Neuropathological correlates and genetic architecture of microglial activation in elderly human brain","volume":"10","author":"Felsky","year":"2019","journal-title":"Nat Commun"},{"issue":"3","key":"2024112705063639800_qiae134-B181","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.celrep.2017.12.066","article-title":"Diverse brain myeloid expression profiles reveal distinct microglial activation states and aspects of Alzheimer's disease not evident in mouse models","volume":"22","author":"Friedman","year":"2018","journal-title":"Cell Rep"},{"issue":"1","key":"2024112705063639800_qiae134-B182","doi-asserted-by":"publisher","first-page":"5370","DOI":"10.1038\/s41467-020-19227-5","article-title":"Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease","volume":"11","author":"McQuade","year":"2020","journal-title":"Nat Commun"},{"issue":"3","key":"2024112705063639800_qiae134-B183","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"issue":"7","key":"2024112705063639800_qiae134-B184","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1038\/s41593-023-01355-y","article-title":"Identification of a protective microglial state mediated by miR-155 and interferon-\u03b3 signaling in a mouse model of Alzheimer's disease","volume":"26","author":"Yin","year":"2023","journal-title":"Nat Neurosci"},{"issue":"11","key":"2024112705063639800_qiae134-B185","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat Neurosci"},{"issue":"7685","key":"2024112705063639800_qiae134-B186","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature25158","article-title":"Microglia-derived ASC specks cross-seed amyloid-\u03b2 in Alzheimer's disease","volume":"552","author":"Venegas","year":"2017","journal-title":"Nature"},{"issue":"1","key":"2024112705063639800_qiae134-B187","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bj.2018.01.003","article-title":"Tau and neuroinflammation: what impact for Alzheimer's disease and tauopathies?","volume":"41","author":"Laurent","year":"2018","journal-title":"Biomed J"},{"issue":"4","key":"2024112705063639800_qiae134-B188","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00401-013-1177-7","article-title":"The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy","volume":"126","author":"McGeer","year":"2013","journal-title":"Acta Neuropathol"},{"issue":"5-6","key":"2024112705063639800_qiae134-B189","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0197-0186(01)00041-9","article-title":"Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation","volume":"39","author":"Sheng","year":"2001","journal-title":"Neurochem Int"},{"issue":"9","key":"2024112705063639800_qiae134-B190","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1016\/j.immuni.2023.08.008","article-title":"Genetic variants of phospholipase C-\u03b32 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease","volume":"56","author":"Tsai","year":"2023","journal-title":"Immunity"},{"issue":"11","key":"2024112705063639800_qiae134-B191","doi-asserted-by":"publisher","first-page":"110961","DOI":"10.1016\/j.celrep.2022.110961","article-title":"Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice","volume":"39","author":"Kiani Shabestari","year":"2022","journal-title":"Cell Rep"},{"issue":"8","key":"2024112705063639800_qiae134-B192","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/s41588-022-01149-1","article-title":"Genetics of the human microglia regulome refines Alzheimer's disease risk loci","volume":"54","author":"Kosoy","year":"2022","journal-title":"Nat Genet"},{"issue":"1","key":"2024112705063639800_qiae134-B193","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41588-021-00976-y","article-title":"Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies","volume":"54","author":"Lopes","year":"2022","journal-title":"Nat Genet"},{"issue":"9","key":"2024112705063639800_qiae134-B194","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1038\/s41588-021-00921-z","article-title":"A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease","volume":"53","author":"Wightman","year":"2021","journal-title":"Nat Genet"},{"issue":"10","key":"2024112705063639800_qiae134-B195","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1038\/s41588-023-01506-8","article-title":"Functional characterization of Alzheimer's disease genetic variants in microglia","volume":"55","author":"Yang","year":"2023","journal-title":"Nat Genet"},{"key":"2024112705063639800_qiae134-B196","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.isci.2019.05.039","article-title":"CD4 T cells induce a subset of MHCII-expressing microglia that attenuates Alzheimer pathology","volume":"16","author":"Mittal","year":"2019","journal-title":"iScience"},{"issue":"7831","key":"2024112705063639800_qiae134-B197","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/s41586-020-2681-2","article-title":"The innate immunity protein IFITM3 modulates \u03b3-secretase in Alzheimer's disease","volume":"586","author":"Hur","year":"2020","journal-title":"Nature"},{"issue":"12","key":"2024112705063639800_qiae134-B198","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1016\/j.neurobiolaging.2006.08.014","article-title":"Inflammatory changes parallel the early stages of Alzheimer disease","volume":"28","author":"Parachikova","year":"2007","journal-title":"Neurobiol Aging"},{"issue":"6286","key":"2024112705063639800_qiae134-B199","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"issue":"1-3","key":"2024112705063639800_qiae134-B200","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0304-3940(89)90843-4","article-title":"Activation of the classical complement pathway in brain tissue of Alzheimer patients","volume":"107","author":"McGeer","year":"1989","journal-title":"Neurosci Lett"},{"issue":"21","key":"2024112705063639800_qiae134-B201","doi-asserted-by":"publisher","first-page":"10016","DOI":"10.1073\/pnas.89.21.10016","article-title":"Complement activation by beta-amyloid in Alzheimer disease","volume":"89","author":"Rogers","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"2024112705063639800_qiae134-B202","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"issue":"5","key":"2024112705063639800_qiae134-B203","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain","volume":"89","author":"Sch\u00f6ll","year":"2016","journal-title":"Neuron"},{"issue":"1","key":"2024112705063639800_qiae134-B204","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neuron.2014.11.018","article-title":"NF\u03baB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease","volume":"85","author":"Lian","year":"2015","journal-title":"Neuron"},{"issue":"392","key":"2024112705063639800_qiae134-B205","doi-asserted-by":"publisher","first-page":"eaaf6295","DOI":"10.1126\/scitranslmed.aaf6295","article-title":"Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP\/PS1 mice","volume":"9","author":"Shi","year":"2017","journal-title":"Sci Transl Med"},{"issue":"1","key":"2024112705063639800_qiae134-B206","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12974-015-0369-6","article-title":"Active immunization against complement factor C5a: a new therapeutic approach for Alzheimer's disease","volume":"12","author":"Landlinger","year":"2015","journal-title":"J Neuroinflammation"},{"issue":"10","key":"2024112705063639800_qiae134-B207","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat Genet"},{"issue":"1","key":"2024112705063639800_qiae134-B208","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/1742-2094-9-220","article-title":"Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice","volume":"9","author":"Britschgi","year":"2012","journal-title":"J Neuroinflammation"},{"issue":"43","key":"2024112705063639800_qiae134-B209","doi-asserted-by":"publisher","first-page":"8576","DOI":"10.1523\/JNEUROSCI.0730-19.2019","article-title":"Depletion of caveolin-1 in type 2 diabetes model induces Alzheimer's disease pathology precursors","volume":"39","author":"Bonds","year":"2019","journal-title":"J Neurosci"},{"issue":"10","key":"2024112705063639800_qiae134-B210","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nrneurol.2017.111","article-title":"A systemic view of Alzheimer disease\u2014insights from amyloid-\u03b2 metabolism beyond the brain","volume":"13","author":"Wang","year":"2017","journal-title":"Nat Rev Neurol"},{"issue":"5-6","key":"2024112705063639800_qiae134-B211","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1159\/000360606","article-title":"Increased serum levels of interleukin-18, \u221223 and \u221217 in Chinese patients with Alzheimer's disease","volume":"38","author":"Chen","year":"2014","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"12","key":"2024112705063639800_qiae134-B212","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1038\/nm.2965","article-title":"Inhibition of IL-12\/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline","volume":"18","author":"Vom Berg","year":"2012","journal-title":"Nat Med"},{"issue":"10","key":"2024112705063639800_qiae134-B213","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1001\/jamaneurol.2017.1658","article-title":"Associations between midlife vascular risk factors and 25-year incident dementia in the Atherosclerosis Risk in Communities (ARIC) cohort","volume":"74","author":"Gottesman","year":"2017","journal-title":"JAMA Neurol"},{"issue":"11","key":"2024112705063639800_qiae134-B214","doi-asserted-by":"publisher","first-page":"e1256","DOI":"10.1212\/WNL.0000000000007094","article-title":"Systemic inflammation during midlife and cognitive change over 20 years: the ARIC study","volume":"92","author":"Walker","year":"2019","journal-title":"Neurology"},{"issue":"3","key":"2024112705063639800_qiae134-B215","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nn.3028","article-title":"The toxic A\u03b2 oligomer and Alzheimer's disease: an emperor in need of clothes","volume":"15","author":"Benilova","year":"2012","journal-title":"Nat Neurosci"},{"issue":"3","key":"2024112705063639800_qiae134-B216","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/0022-510X(83)90157-0","article-title":"Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of Alzheimer type and multi-infarct dementia","volume":"60","author":"Alafuzoff","year":"1983","journal-title":"J Neurol Sci"},{"issue":"3","key":"2024112705063639800_qiae134-B217","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.mehy.2004.08.024","article-title":"Add Alzheimer's disease to the list of autoimmune diseases","volume":"64","author":"D'Andrea","year":"2005","journal-title":"Med Hypotheses"},{"issue":"11","key":"2024112705063639800_qiae134-B218","doi-asserted-by":"publisher","first-page":"849","DOI":"10.2174\/1567205018666211202141650","article-title":"\u03b2-Amyloid is an immunopeptide and Alzheimer's is an autoimmune disease","volume":"18","author":"Weaver","year":"2021","journal-title":"Curr Alzheimer Res"},{"issue":"1","key":"2024112705063639800_qiae134-B219","doi-asserted-by":"publisher","first-page":"e12100","DOI":"10.1002\/trc2.12100","article-title":"Amyloid beta is an early responder cytokine and immunopeptide of the innate immune system","volume":"6","author":"Weaver","year":"2020","journal-title":"Alzheimers Dement (N Y)"},{"issue":"1","key":"2024112705063639800_qiae134-B220","doi-asserted-by":"publisher","first-page":"e12283","DOI":"10.1002\/trc2.12283","article-title":"Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites","volume":"8","author":"Meier-Stephenson","year":"2022","journal-title":"Alzheimers Dement (N Y)"},{"issue":"1","key":"2024112705063639800_qiae134-B221","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1136\/annrheumdis-2013-203863","article-title":"International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies","volume":"73","author":"Agmon-Levin","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"2024112705063639800_qiae134-B222","doi-asserted-by":"publisher","first-page":"e0165373","DOI":"10.1371\/journal.pone.0165373","article-title":"Autoantibodies against modified histone peptides in SLE patients are associated with disease activity and lupus nephritis","volume":"11","author":"Dieker","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"2024112705063639800_qiae134-B223","doi-asserted-by":"publisher","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"2024112705063639800_qiae134-B224","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"2024112705063639800_qiae134-B225","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/art.40396","article-title":"Abnormal B cell development in systemic lupus erythematosus: what the genetics tell us","volume":"70","author":"Karrar","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2024112705063639800_qiae134-B226","doi-asserted-by":"publisher","first-page":"952304","DOI":"10.3389\/fmed.2022.952304","article-title":"B cells in systemic lupus erythematosus: targets of new therapies and surveillance tools","volume":"9","author":"Parodis","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"24","key":"2024112705063639800_qiae134-B227","doi-asserted-by":"publisher","first-page":"6231","DOI":"10.3390\/ijms20246231","article-title":"B cell abnormalities in systemic lupus erythematosus and lupus nephritis-role in pathogenesis and effect of immunosuppressive treatments","volume":"20","author":"Yap","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2024112705063639800_qiae134-B228","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1136\/ard.59.4.243","article-title":"Cytokines and systemic lupus erythematosus","volume":"59","author":"Dean","year":"2000","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"2024112705063639800_qiae134-B229","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/ar3251","article-title":"Abnormalities of T cell signaling in systemic lupus erythematosus","volume":"13","author":"Moulton","year":"2011","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"2024112705063639800_qiae134-B230","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.rdc.2021.04.005","article-title":"T cells in systemic lupus erythematosus","volume":"47","author":"Paredes","year":"2021","journal-title":"Rheum Dis Clin North Am"},{"issue":"1","key":"2024112705063639800_qiae134-B231","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/rheumatology\/kew341","article-title":"Brain histopathology in patients with systemic lupus erythematosus: identification of lesions associated with clinical neuropsychiatric lupus syndromes and the role of complement","volume":"56","author":"Cohen","year":"2017","journal-title":"Rheumatology (Oxford)"},{"issue":"12","key":"2024112705063639800_qiae134-B232","doi-asserted-by":"publisher","first-page":"e499","DOI":"10.1371\/journal.pmed.0030499","article-title":"Selective involvement of the amygdala in systemic lupus erythematosus","volume":"3","author":"Emmer","year":"2006","journal-title":"PLoS Med"},{"issue":"2","key":"2024112705063639800_qiae134-B233","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1191\/096120398678919868","article-title":"Cerebral magnetic resonance imaging in patients with or without antiphospholipid antibodies","volume":"7","author":"Hachulla","year":"1998","journal-title":"Lupus"},{"issue":"1","key":"2024112705063639800_qiae134-B234","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3174\/ajnr.A3645","article-title":"Brain MR findings in patients with systemic lupus erythematosus with and without Antiphospholipid antibody syndrome","volume":"35","author":"Kaichi","year":"2014","journal-title":"Am J Neuroradiol"},{"issue":"4","key":"2024112705063639800_qiae134-B235","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s40265-015-0534-3","article-title":"Management of neuropsychiatric systemic lupus erythematosus: current approaches and future perspectives","volume":"76","author":"Magro-Checa","year":"2016","journal-title":"Drugs"},{"issue":"1","key":"2024112705063639800_qiae134-B236","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1148\/rg.210045","article-title":"Central nervous system systemic lupus erythematosus: pathophysiologic, clinical, and imaging features","volume":"42","author":"Ota","year":"2022","journal-title":"RadioGraphics"},{"issue":"10","key":"2024112705063639800_qiae134-B237","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1002\/1529-0131(199910)42:10&lt;2026::AID-ANR2&gt;3.0.CO;2-J","article-title":"Neuroimaging in neuropsychiatric systemic lupus erythematosus","volume":"42","author":"Sibbitt","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"1","key":"2024112705063639800_qiae134-B238","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.semarthrit.2009.08.005","article-title":"Magnetic resonance imaging and brain histopathology in neuropsychiatric systemic lupus erythematosus","volume":"40","author":"Sibbitt","year":"2010","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"2024112705063639800_qiae134-B239","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00062-015-0397-8","article-title":"Global cognitive impairment in systemic lupus erythematosus patients: a structural MRI study","volume":"27","author":"Zimmermann","year":"2017","journal-title":"Clin Neuroradiol"},{"issue":"2","key":"2024112705063639800_qiae134-B240","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s11065-008-9061-2","article-title":"Neuropsychological impairment in systemic lupus erythematosus: a comparison with multiple sclerosis","volume":"18","author":"Benedict","year":"2008","journal-title":"Neuropsychol Rev"},{"issue":"12","key":"2024112705063639800_qiae134-B241","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1136\/ard.48.12.1014","article-title":"Magnetic resonance and computed tomographic imaging in the evaluation of acute neuropsychiatric disease in systemic lupus erythematosus","volume":"48","author":"Sibbitt","year":"1989","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2024112705063639800_qiae134-B242","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/j.1552-6569.2007.00183.x","article-title":"Cerebral changes in SLE with or without Antiphospholipid syndrome. A case-control MRI study","volume":"18","author":"Vald\u00e9s-Ferrer","year":"2008","journal-title":"J Neuroimaging"},{"key":"2024112705063639800_qiae134-B243","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.3389\/fimmu.2017.01101","article-title":"The role of brain-reactive autoantibodies in brain pathology and cognitive impairment","volume":"8","author":"Mader","year":"2017","journal-title":"Front Immunol"},{"issue":"12","key":"2024112705063639800_qiae134-B244","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/annrheumdis-2020-218004","article-title":"Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment","volume":"79","author":"Kamintsky","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2024112705063639800_qiae134-B245","doi-asserted-by":"publisher","first-page":"432595","DOI":"10.1155\/2011\/432595","article-title":"Inflammatory cytokines in systemic lupus erythematosus","volume":"2011","author":"Ohl","year":"2011","journal-title":"J Biomed Biotechnol"},{"issue":"2-3","key":"2024112705063639800_qiae134-B246","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0304-3940(01)01679-2","article-title":"Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus","volume":"302","author":"Tomita","year":"2001","journal-title":"Neurosci Lett"},{"issue":"2","key":"2024112705063639800_qiae134-B247","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/iub.2568","article-title":"Roles of IL-1 and IL-10 family cytokines in the progression of systemic lupus erythematosus: friends or foes?","volume":"74","author":"Wu","year":"2022","journal-title":"IUBMB Life"},{"issue":"13","key":"2024112705063639800_qiae134-B248","doi-asserted-by":"publisher","first-page":"7305","DOI":"10.1073\/pnas.1917834117","article-title":"Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+ B helper T cells in systemic lupus erythematosus","volume":"117","author":"Facciotti","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"2024112705063639800_qiae134-B249","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1007\/s00415-014-7406-8","article-title":"Autoantibodies involved in neuropsychiatric manifestations associated with systemic lupus erythematosus: a systematic review","volume":"261","author":"Sciascia","year":"2014","journal-title":"J Neurol"},{"issue":"1","key":"2024112705063639800_qiae134-B250","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12974-016-0537-3","article-title":"B cell and\/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus","volume":"13","author":"Wen","year":"2016","journal-title":"J Neuroinflammation"},{"issue":"1","key":"2024112705063639800_qiae134-B251","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12974-023-02901-y","article-title":"Noteworthy perspectives on microglia in neuropsychiatric disorders","volume":"20","author":"Zhu","year":"2023","journal-title":"J Neuroinflammation"},{"issue":"12","key":"2024112705063639800_qiae134-B252","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1191\/0961203303lu501oa","article-title":"The blood-brain barrier in systemic lupus erythematosus","volume":"12","author":"Abbott","year":"2003","journal-title":"Lupus"},{"issue":"11","key":"2024112705063639800_qiae134-B253","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1002\/art.42252","article-title":"Choroid Plexus-infiltrating T cells as drivers of murine neuropsychiatric lupus","volume":"74","author":"Moore","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"2024112705063639800_qiae134-B254","doi-asserted-by":"publisher","first-page":"729635","DOI":"10.3389\/fnagi.2021.729635","article-title":"Longitudinal analysis of brain-predicted age in amnestic and non-amnestic sporadic early-onset Alzheimer's disease","volume":"13","author":"Gautherot","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"2024112705063639800_qiae134-B255","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3389\/fendo.2017.00343","article-title":"T cell-mediated beta cell destruction: autoimmunity and alloimmunity in the context of type 1 diabetes","volume":"8","author":"Burrack","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"2024112705063639800_qiae134-B256","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41574-020-00443-4","article-title":"Type 1 diabetes mellitus as a disease of the \u03b2-cell (do not blame the immune system?)","volume":"17","author":"Roep","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"2024112705063639800_qiae134-B257","doi-asserted-by":"publisher","first-page":"1090842","DOI":"10.3389\/fendo.2022.1090842","article-title":"Mechanisms and therapeutic strategies of immune checkpoint molecules and regulators in type 1 diabetes","volume":"13","author":"Ding","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024112705063639800_qiae134-B258","doi-asserted-by":"publisher","first-page":"102158","DOI":"10.1155\/2014\/102158","article-title":"Diabetes and the brain: oxidative stress, inflammation, and autophagy","volume":"2014","author":"Muriach","year":"2014","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"2024112705063639800_qiae134-B259","doi-asserted-by":"publisher","first-page":"781","DOI":"10.3390\/biomedicines9070781","article-title":"Inflammatory mechanisms contributing to endothelial dysfunction","volume":"9","author":"Theofilis","year":"2021","journal-title":"Biomedicines"},{"issue":"3","key":"2024112705063639800_qiae134-B260","doi-asserted-by":"publisher","first-page":"611","DOI":"10.14336\/AD.2018.0707","article-title":"BDNF alleviates neuroinflammation in the hippocampus of type 1 diabetic mice via blocking the aberrant HMGB1\/RAGE\/NF-\u03baB pathway","volume":"10","author":"Han","year":"2019","journal-title":"Aging Dis"},{"issue":"3","key":"2024112705063639800_qiae134-B261","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1007\/s12035-018-1195-5","article-title":"Hyperglycemia-Driven neuroinflammation compromises BBB leading to memory loss in both Diabetes Mellitus (DM) type 1 and type 2 mouse models","volume":"56","author":"Rom","year":"2019","journal-title":"Mol Neurobiol"},{"issue":"4","key":"2024112705063639800_qiae134-B262","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2337\/dc14-1186","article-title":"Decrease in circulating concentrations of soluble receptors for advanced glycation end products at the time of seroconversion to autoantibody positivity in children with prediabetes","volume":"38","author":"Salonen","year":"2015","journal-title":"Diabetes Care"},{"issue":"7","key":"2024112705063639800_qiae134-B263","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.2337\/dc13-3049","article-title":"Circulating concentrations of soluble receptor for AGE are associated with age and AGER gene polymorphisms in children with newly diagnosed type 1 diabetes","volume":"37","author":"Salonen","year":"2014","journal-title":"Diabetes Care"},{"issue":"4","key":"2024112705063639800_qiae134-B264","doi-asserted-by":"publisher","first-page":"e2872","DOI":"10.1002\/dmrr.2872","article-title":"A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diabetes","volume":"33","author":"Salonen","year":"2017","journal-title":"Diabetes Metab Res Rev"},{"issue":"9","key":"2024112705063639800_qiae134-B265","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.2337\/db22-0177","article-title":"Soluble RAGE prevents type 1 diabetes expanding functional regulatory T cells","volume":"71","author":"Leung","year":"2022","journal-title":"Diabetes"},{"issue":"5","key":"2024112705063639800_qiae134-B266","doi-asserted-by":"publisher","first-page":"e144014","DOI":"10.1172\/jci.insight.144014","article-title":"Brain functions and cognition on transient insulin deprivation in type 1 diabetes","volume":"6","author":"Creo","year":"2021","journal-title":"JCI Insight"},{"issue":"3","key":"2024112705063639800_qiae134-B267","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s11571-020-09571-z","article-title":"Intranasal insulin administration may be highly effective in improving cognitive function in mice with cognitive dysfunction by reversing brain insulin resistance","volume":"14","author":"Lv","year":"2020","journal-title":"Cogn Neurodyn"},{"issue":"1","key":"2024112705063639800_qiae134-B268","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s00125-009-1553-y","article-title":"Diabetes regulates mitochondrial biogenesis and fission in mouse neurons","volume":"53","author":"Edwards","year":"2010","journal-title":"Diabetologia"},{"issue":"3","key":"2024112705063639800_qiae134-B269","doi-asserted-by":"publisher","first-page":"4458","DOI":"10.1096\/fj.201802043R","article-title":"Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes","volume":"33","author":"Ruegsegger","year":"2019","journal-title":"FASEB J"},{"issue":"3 Pt 1","key":"2024112705063639800_qiae134-B270","doi-asserted-by":"publisher","first-page":"E446","DOI":"10.1152\/ajpendo.1993.265.3.E446","article-title":"Amylin-insulin relationships in insulin resistance with and without diabetic hyperglycemia","volume":"265","author":"Pieber","year":"1993","journal-title":"Am J Physiol"},{"issue":"4","key":"2024112705063639800_qiae134-B271","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/ana.23956","article-title":"Amylin deposition in the brain: a second amyloid in Alzheimer disease?","volume":"74","author":"Jackson","year":"2013","journal-title":"Ann Neurol"},{"issue":"3","key":"2024112705063639800_qiae134-B272","doi-asserted-by":"publisher","first-page":"e275","DOI":"10.1212\/WNL.0000000000012243","article-title":"Association of type 1 diabetes and hypoglycemic and hyperglycemic events and risk of dementia","volume":"97","author":"Whitmer","year":"2021","journal-title":"Neurology"},{"key":"2024112705063639800_qiae134-B273","volume-title":"StatPearls [Internet]","author":"Chauhan","year":"2023"},{"issue":"2","key":"2024112705063639800_qiae134-B274","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3390\/ijms23020905","article-title":"Rheumatoid arthritis: pathogenic roles of diverse immune cells","volume":"23","author":"Jang","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"10","key":"2024112705063639800_qiae134-B275","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/cells7100161","article-title":"Pathogenic role of immune cells in rheumatoid arthritis: implications in clinical treatment and biomarker development","volume":"7","author":"Yap","year":"2018","journal-title":"Cells"},{"issue":"17","key":"2024112705063639800_qiae134-B276","doi-asserted-by":"publisher","first-page":"9208","DOI":"10.3390\/ijms22179208","article-title":"Cytokines and chemokines involved in osteoarthritis pathogenesis","volume":"22","author":"Molnar","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2024112705063639800_qiae134-B277","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.3390\/ijms22052719","article-title":"The role of Tumor Necrosis Factor alpha (TNF-\u03b1) in autoimmune disease and current TNF-\u03b1 inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2024112705063639800_qiae134-B278","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1084\/jem.20020439","article-title":"Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis","volume":"196","author":"Ji","year":"2002","journal-title":"J Exp Med"},{"issue":"20","key":"2024112705063639800_qiae134-B279","doi-asserted-by":"publisher","first-page":"10922","DOI":"10.3390\/ijms222010922","article-title":"Cytokine networks in the pathogenesis of rheumatoid arthritis","volume":"22","author":"Kondo","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2024112705063639800_qiae134-B280","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1177\/1759720X10378372","article-title":"The role of interleukin 6 in the pathophysiology of rheumatoid arthritis","volume":"2","author":"Srirangan","year":"2010","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"1","key":"2024112705063639800_qiae134-B281","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/s13075-020-02344-3","article-title":"High levels of interleukin-6 in patients with rheumatoid arthritis are associated with greater improvements in health-related quality of life for sarilumab compared with adalimumab","volume":"22","author":"Strand","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"2024112705063639800_qiae134-B282","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2174\/1874192401004020089","article-title":"Vascular function and inflammation in rheumatoid arthritis: the role of physical activity","volume":"4","author":"Metsios","year":"2010","journal-title":"Open Cardiovasc Med J"},{"key":"2024112705063639800_qiae134-B283","doi-asserted-by":"publisher","first-page":"6813016","DOI":"10.1155\/2016\/6813016","article-title":"Endothelial dysfunction and inflammation: immunity in rheumatoid arthritis","volume":"2016","author":"Yang","year":"2016","journal-title":"Mediators Inflamm"},{"issue":"5","key":"2024112705063639800_qiae134-B284","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1186\/ar114","article-title":"Cell-cell interactions in synovitis. Endothelial cells and immune cell migration","volume":"2","author":"Szekanecz","year":"2000","journal-title":"Arthritis Res"},{"issue":"11","key":"2024112705063639800_qiae134-B285","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1093\/brain\/122.11.2047","article-title":"Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study","volume":"122","author":"Reindl","year":"1999","journal-title":"Brain"},{"key":"2024112705063639800_qiae134-B286","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.3389\/fphys.2017.01125","article-title":"The cerebral brain-derived neurotrophic factor pathway, either neuronal or endothelial, is impaired in rats with adjuvant-induced arthritis. connection with endothelial dysfunction","volume":"8","author":"Pedard","year":"2017","journal-title":"Front Physiol"},{"issue":"1","key":"2024112705063639800_qiae134-B287","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/biom11010081","article-title":"Endothelial dysfunction and extra-articular neurological manifestations in rheumatoid arthritis","volume":"11","author":"Maiuolo","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"2024112705063639800_qiae134-B288","doi-asserted-by":"publisher","first-page":"302","DOI":"10.2174\/1874192401004010302","article-title":"The endothelium and its role in regulating vascular tone","volume":"4","author":"Sandoo","year":"2010","journal-title":"Open Cardiovasc Med J"},{"issue":"8","key":"2024112705063639800_qiae134-B289","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.1016\/j.clinph.2021.02.362","article-title":"P 44. Structural and functional brain alterations in patients with myasthenia gravis","volume":"132","author":"Klaus","year":"2021","journal-title":"Clin Neurophysiol"},{"key":"2024112705063639800_qiae134-B290","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.bbacli.2015.04.003","article-title":"Cognitive impairment as a central cholinergic deficit in patients with myasthenia gravis","volume":"3","author":"Kaltsatou","year":"2015","journal-title":"BBA Clin"},{"issue":"3","key":"2024112705063639800_qiae134-B291","doi-asserted-by":"publisher","first-page":"141","DOI":"10.4103\/2347-8659.143671","article-title":"Assessment of cognitive function in patients with myasthenia gravis","volume":"1","author":"Sherifa","year":"2014","journal-title":"Neuroimmunol Neuroinflamm"},{"issue":"12","key":"2024112705063639800_qiae134-B292","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1001\/archneurol.2011.200","article-title":"Myasthenia gravis\u2013associated neuromyelitis optica\u2013like disease: an immunological link between the central nervous system and muscle?","volume":"68","author":"Vaknin-Dembinsky","year":"2011","journal-title":"Arch Neurol"},{"issue":"1","key":"2024112705063639800_qiae134-B293","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1742-2094-5-22","article-title":"Neuromyelitis optica pathogenesis and aquaporin 4","volume":"5","author":"Graber","year":"2008","journal-title":"J Neuroinflammation"},{"issue":"9","key":"2024112705063639800_qiae134-B294","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1177\/1352458511404917","article-title":"Brain abnormalities as an initial manifestation of neuromyelitis optica spectrum disorder","volume":"17","author":"Kim","year":"2011","journal-title":"Mult Scler"},{"issue":"5","key":"2024112705063639800_qiae134-B295","doi-asserted-by":"publisher","first-page":"e841","DOI":"10.1212\/NXI.0000000000000841","article-title":"Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology","volume":"7","author":"Fujihara","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"1","key":"2024112705063639800_qiae134-B296","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/nyas.12118","article-title":"Immunology of neuromyelitis optica: a T cell-B cell collaboration","volume":"1283","author":"Mitsdoerffer","year":"2013","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"2024112705063639800_qiae134-B297","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S1474-4422(12)70133-3","article-title":"Aquaporin 4 and neuromyelitis optica","volume":"11","author":"Papadopoulos","year":"2012","journal-title":"Lancet Neurol"},{"issue":"9","key":"2024112705063639800_qiae134-B298","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrneurol.2014.129","article-title":"Pain in neuromyelitis optica--prevalence, pathogenesis and therapy","volume":"10","author":"Bradl","year":"2014","journal-title":"Nat Rev Neurol"},{"issue":"11","key":"2024112705063639800_qiae134-B299","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41583-019-0218-1","article-title":"Astrocytes in chronic pain and itch","volume":"20","author":"Ji","year":"2019","journal-title":"Nat Rev Neurosci"},{"key":"2024112705063639800_qiae134-B300","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jocn.2020.09.015","article-title":"AQP4-siRNA alleviates traumatic brain edema by altering post-traumatic AQP4 polarity reversal in TBI rats","volume":"81","author":"Lu","year":"2020","journal-title":"J Clin Neurosci"},{"issue":"8","key":"2024112705063639800_qiae134-B301","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.2337\/diabetes.52.8.2129","article-title":"Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia","volume":"52","author":"Huang","year":"2003","journal-title":"Diabetes"},{"issue":"1","key":"2024112705063639800_qiae134-B302","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12974-022-02408-y","article-title":"Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics","volume":"19","author":"Kamma","year":"2022","journal-title":"J Neuroinflammation"},{"issue":"3","key":"2024112705063639800_qiae134-B303","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.bbadis.2015.10.018","article-title":"Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke","volume":"1862","author":"Lopes Pinheiro","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"2024112705063639800_qiae134-B304","doi-asserted-by":"publisher","first-page":"e73849","DOI":"10.7554\/eLife.73849","article-title":"Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis","volume":"11","author":"Rodr\u00edguez-Lorenzo","year":"2022","journal-title":"Elife"},{"key":"2024112705063639800_qiae134-B305","doi-asserted-by":"publisher","first-page":"1260663","DOI":"10.3389\/fimmu.2023.1260663","article-title":"Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells","volume":"14","author":"Zong","year":"2023","journal-title":"Front Immunol"},{"issue":"3","key":"2024112705063639800_qiae134-B306","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jphs.2020.07.004","article-title":"Microglia as therapeutic target in central nervous system disorders","volume":"144","author":"Fatoba","year":"2020","journal-title":"J Pharmacol Sci"},{"key":"2024112705063639800_qiae134-B307","doi-asserted-by":"publisher","first-page":"742065","DOI":"10.3389\/fnins.2021.742065","article-title":"Microglia in neuroinflammation and neurodegeneration: from understanding to therapy","volume":"15","author":"Muzio","year":"2021","journal-title":"Front Neurosci"},{"issue":"1","key":"2024112705063639800_qiae134-B308","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40478-023-01526-9","article-title":"Roles of neuropathology-associated reactive astrocytes: a systematic review","volume":"11","author":"Lawrence","year":"2023","journal-title":"Acta Neuropathol Commun"},{"issue":"7638","key":"2024112705063639800_qiae134-B309","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"7","key":"2024112705063639800_qiae134-B310","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41583-023-00709-6","article-title":"Roles and regulation of microglia activity in multiple sclerosis: insights from animal models","volume":"24","author":"Dist\u00e9fano-Gagn\u00e9","year":"2023","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"2024112705063639800_qiae134-B311","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2249.2010.04143.x","article-title":"T cells in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"162","author":"Fletcher","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"2024112705063639800_qiae134-B312","doi-asserted-by":"publisher","first-page":"2153534","DOI":"10.1080\/21645515.2022.2153534","article-title":"Regulatory T cell therapy for multiple sclerosis: breaching (blood-brain) barriers","volume":"18","author":"Verreycken","year":"2022","journal-title":"Hum Vaccin Immunother"},{"issue":"11","key":"2024112705063639800_qiae134-B313","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/ni.3269","article-title":"Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants","volume":"16","author":"De Rosa","year":"2015","journal-title":"Nat Immunol"},{"issue":"5","key":"2024112705063639800_qiae134-B314","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.micinf.2009.04.002","article-title":"FOXP3 and the regulation of Treg\/Th17 differentiation","volume":"11","author":"Ziegler","year":"2009","journal-title":"Microbes Infect"},{"issue":"3","key":"2024112705063639800_qiae134-B315","doi-asserted-by":"publisher","first-page":"e17988","DOI":"10.1371\/journal.pone.0017988","article-title":"Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients","volume":"6","author":"Fritzsching","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"2024112705063639800_qiae134-B316","doi-asserted-by":"publisher","first-page":"6411","DOI":"10.4049\/jimmunol.180.9.6411","article-title":"Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression","volume":"180","author":"Venken","year":"2008","journal-title":"J Immunol"},{"issue":"11","key":"2024112705063639800_qiae134-B317","doi-asserted-by":"publisher","first-page":"e15478","DOI":"10.1371\/journal.pone.0015478","article-title":"Temporal pattern of ICAM-I mediated regulatory T cell recruitment to sites of inflammation in adoptive transfer model of multiple sclerosis","volume":"5","author":"Doerck","year":"2010","journal-title":"PLoS One"},{"issue":"8","key":"2024112705063639800_qiae134-B318","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.4049\/jimmunol.0903732","article-title":"Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium","volume":"185","author":"Steiner","year":"2010","journal-title":"J Immunol"},{"key":"2024112705063639800_qiae134-B319","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fneur.2019.00261","article-title":"Cognitive impairment in multiple sclerosis with regards to disease duration and clinical phenotypes","volume":"10","author":"Brochet","year":"2019","journal-title":"Front Neurol"},{"issue":"7","key":"2024112705063639800_qiae134-B320","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1136\/jnnp.74.7.878","article-title":"Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings","volume":"74","author":"Piras","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"2024112705063639800_qiae134-B321","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.msard.2014.03.004","article-title":"Cognitive impairment in multiple sclerosis: an 18 year follow-up study","volume":"3","author":"Strober","year":"2014","journal-title":"Mult Scler Relat Disord"},{"issue":"8","key":"2024112705063639800_qiae134-B322","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1038\/s41380-022-01637-0","article-title":"Neuroimmune contributions to Alzheimer's disease: a focus on human data","volume":"27","author":"Haage","year":"2022","journal-title":"Mol Psychiatry"},{"issue":"5","key":"2024112705063639800_qiae134-B323","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.it.2014.03.004","article-title":"Heterogeneity in immune responses: from populations to single cells","volume":"35","author":"Satija","year":"2014","journal-title":"Trends Immunol"},{"issue":"4","key":"2024112705063639800_qiae134-B324","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.neuron.2018.01.021","article-title":"Multiple sclerosis: mechanisms and immunotherapy","volume":"97","author":"Baecher-Allan","year":"2018","journal-title":"Neuron"},{"issue":"1","key":"2024112705063639800_qiae134-B325","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/ana.25927","article-title":"Role of B cells in multiple sclerosis and related disorders","volume":"89","author":"Comi","year":"2021","journal-title":"Ann Neurol"},{"issue":"3","key":"2024112705063639800_qiae134-B326","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.3390\/ijms24032336","article-title":"Dual role of B cells in multiple sclerosis","volume":"24","author":"Kumar","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024112705063639800_qiae134-B327","doi-asserted-by":"publisher","first-page":"1186016","DOI":"10.3389\/fphar.2023.1186016","article-title":"Impact of anti-CD20 therapies on the immune homeostasis of gastrointestinal mucosa and their relationship with de novo intestinal bowel disease in multiple sclerosis: a review","volume":"14","author":"Quesada-Sim\u00f3","year":"2023","journal-title":"Front Pharmacol"},{"key":"2024112705063639800_qiae134-B328","doi-asserted-by":"publisher","first-page":"835","DOI":"10.3389\/fimmu.2018.00835","article-title":"Targeting B cells and plasma cells in autoimmune diseases","volume":"9","author":"Hofmann","year":"2018","journal-title":"Front Immunol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiae134\/58559532\/qiae134.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/116\/6\/1269\/60829002\/qiae134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/116\/6\/1269\/60829002\/qiae134.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T05:07:16Z","timestamp":1732684036000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/116\/6\/1269\/7692812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,13]]},"references-count":328,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,13]]},"published-print":{"date-parts":[[2024,11,27]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiae134","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,6,13]]}}}