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However, the impact of maternal allergy and obesity on offspring lung insulin signaling and allergen responsiveness is not known. To evaluate this, allergic and nonallergic female mice were fed a high-fat diet or low-fat diet from 7 wk before pregnancy until weaning. Neonatal pups were allergen-sensitized and allergen-challenged and then were assessed for obesity, insulin signaling, and allergic inflammation. Compared with pups of nonobese nonallergic mothers, allergen-challenged pups of obese nonallergic mothers, nonobese allergic mothers, and obese allergic mothers had bronchoalveolar lavage (BAL) eosinophilia, with the pups of obese allergic mothers having the highest BAL eosinophilia. These pups also had lower insulin-induced lung AKT phosphorylation, indicating a decrease in lung parenchymal insulin sensitivity. In cross-fostering experiments, allergen-challenged pups exposed to both pre- and postnatal obese allergic mothers had the highest level of BAL eosinophilia. Maternal obesity or allergy increased offspring serum allergen-specific IgE and interleukin-5 that was highest when the mother was both obese and allergic. Also, allergen-challenged pups exposed to both pre- and postnatal obese allergic mothers had the highest level of interleukin-5. In summary, offspring born to obese allergic mothers have decreased lung insulin sensitivity and increased lung allergic inflammation. Interestingly, our data also demonstrate that there is both a pregnancy and postpregnancy aspect of maternal allergy and obesity that enhances allergen responsiveness in offspring.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae135","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T09:42:40Z","timestamp":1718617360000},"page":"985-994","source":"Crossref","is-referenced-by-count":1,"title":["Increased allergic inflammation and decreased lung insulin sensitivity in offspring of obese allergic mothers"],"prefix":"10.1093","volume":"116","author":[{"given":"Christopher Luke","family":"Damron","sequence":"first","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine , 1044 W. 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