{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:48:01Z","timestamp":1789087681353,"version":"build-2803163510"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jan Kornelis de Cock"},{"name":"Skim Latihan Akademik Bumiputra"},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sepsis is a dysregulated systemic inflammatory response to an infection, which can lead to multiple organ dysfunction syndrome that includes the kidney. Leukocyte recruitment is an important process of the host immune defense in response to sepsis. Endothelial cells (EC) actively regulate leukocyte recruitment by expressing adhesion molecules following the activation of dedicated intracellular signal transduction pathways. Previous studies reported that the expression of adhesion molecules was associated with the activation of endothelial nuclear factor kappa-light-chain-enhancer of activated B cells (NF-\u03baB) p65 and mitogen-activated protein kinase (MAPK) c-Jun pathways in vitro in response to conditions that mimic processes that occur in inflammation. This study aimed to investigate the spatiotemporal patterns of leukocyte recruitment, expression of adhesion molecules, and endothelial nuclear p65 and c-Jun localization in renal microvascular beds of septic mice. Here, we used a cecal ligation and puncture (CLP) sepsis mouse model and RT-qPCR and immunohistochemical staining. We showed that neutrophils, macrophages, and T lymphocytes were all present in the kidney, yet only neutrophils accumulated in a spatiotemporally discernible pattern, mainly in glomeruli at 4 h after CLP sepsis initiation. E-selectin, not vascular cell adhesion molecule-1 (VCAM-1), was expressed in glomeruli at the same time point. In a subset of mice at 72 h after CLP sepsis started, VCAM-1 expression was prominent in glomerular EC, which was not related to changes in mmu-microRNA(miR)-126a-3p levels, a short noncoding microRNA previously shown to inhibit the translation of VCAM-1 mRNA into protein. Nuclear localization of p65 and c-Jun occurred in EC of all microvascular segments at 4 and 7 h after CLP sepsis initiation. In summary, sepsis-induced recruitment of neutrophils, E-selectin expression, and NF-\u03baB p65 and MAPK c-Jun pathway activation coincided in glomeruli at the early stage of the disease. In the other microvascular beds, sepsis led to NF-\u03baB p65 and MAPK c-Jun pathway activation with limited expression of E-selectin and no association with VCAM-1 expression or leukocyte recruitment.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae146","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T13:24:11Z","timestamp":1719926651000},"page":"1479-1497","source":"Crossref","is-referenced-by-count":7,"title":["Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase pathways"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5026-4944","authenticated-orcid":false,"given":"Zhendong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9543-1556","authenticated-orcid":false,"given":"Erna-Zulaikha","family":"Dayang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6493-1897","authenticated-orcid":false,"given":"Peter J","family":"Zwiers","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha L","family":"Hernandez Garcia","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0685-3894","authenticated-orcid":false,"given":"Matthijs","family":"Luxen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]},{"name":"Department of Critical Care, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-2772","authenticated-orcid":false,"given":"Matijs","family":"van Meurs","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]},{"name":"Department of Critical Care, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2066-0140","authenticated-orcid":false,"given":"Jan A A M","family":"Kamps","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9614-2577","authenticated-orcid":false,"given":"Jill","family":"Moser","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]},{"name":"Department of Critical Care, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4147-6676","authenticated-orcid":false,"given":"Grietje","family":"Molema","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen , Hanzeplein 1, 9713 GZ Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"issue":"3","key":"2024112705074780000_qiae146-B1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1189\/jlb.0912437","article-title":"Current trends in inflammatory and immunomodulatory mediators in sepsis","volume":"93","author":"Aziz","year":"2013","journal-title":"J Leukoc Biol"},{"issue":"1","key":"2024112705074780000_qiae146-B2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12882-017-0487-8","article-title":"Incidence, timing and outcome of AKI in critically ill patients varies with the definition used and the addition of urine output criteria","volume":"18","author":"Koeze","year":"2017","journal-title":"BMC Nephrol"},{"issue":"11","key":"2024112705074780000_qiae146-B3","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"issue":"4","key":"2024112705074780000_qiae146-B4","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1093\/jleuko\/qiad015","article-title":"Early treatment with C-reactive protein-derived peptide reduces septic acute kidney injury in mice via controlled activation of kidney macrophages","volume":"113","author":"Ito","year":"2023","journal-title":"J Leukoc Biol"},{"issue":"6","key":"2024112705074780000_qiae146-B5","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1002\/JLB.5A0817-328RRR","article-title":"Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression","volume":"104","author":"D'Antoni","year":"2018","journal-title":"J Leukoc Biol"},{"key":"2024112705074780000_qiae146-B6","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.3389\/fimmu.2019.01169","article-title":"Identification of LPS-activated endothelial subpopulations with distinct inflammatory phenotypes and regulatory signaling mechanisms","volume":"10","author":"Dayang","year":"2019","journal-title":"Front Immunol"},{"issue":"2","key":"2024112705074780000_qiae146-B7","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1189\/jlb.68.2.233","article-title":"Resting and activated T cells induce expression of E-selectin and VCAM-1 by vascular endothelial cells through a contact-dependent but CD40 ligand-independent mechanism","volume":"68","author":"Yarwood","year":"2000","journal-title":"J Leukoc Biol"},{"issue":"10","key":"2024112705074780000_qiae146-B8","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"2024112705074780000_qiae146-B9","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.3389\/fimmu.2018.02739","article-title":"Organ-specific mechanisms of transendothelial neutrophil migration in the lung, liver, kidney, and aorta","volume":"9","author":"Maas","year":"2018","journal-title":"Front Immunol"},{"issue":"6","key":"2024112705074780000_qiae146-B10","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.3892\/ijmm.2016.2579","article-title":"Artemisinin inhibits monocyte adhesion to HUVECs through the NF-kappaB and MAPK pathways in vitro","volume":"37","author":"Wang","year":"2016","journal-title":"Int J Mol Med"},{"issue":"9","key":"2024112705074780000_qiae146-B11","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1161\/01.atv.19.9.2078","article-title":"Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human endothelial cells","volume":"19","author":"Wang","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"2024112705074780000_qiae146-B12","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41581-021-00489-1","article-title":"Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury","volume":"18","author":"Molema","year":"2022","journal-title":"Nat Rev Nephrol"},{"issue":"12","key":"2024112705074780000_qiae146-B13","doi-asserted-by":"publisher","first-page":"e567","DOI":"10.1097\/CCM.0000000000001203","article-title":"Histone deacetylase inhibition and IkappaB kinase\/nuclear factor-kappaB blockade ameliorate microvascular proinflammatory responses associated with hemorrhagic shock\/resuscitation in mice","volume":"43","author":"Li","year":"2015","journal-title":"Crit Care Med"},{"issue":"2","key":"2024112705074780000_qiae146-B14","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1097\/SHK.0000000000001126","article-title":"Early heterogenic response of renal microvasculature to hemorrhagic shock\/resuscitation and the influence of NF-kappaB pathway blockade","volume":"51","author":"Yan","year":"2019","journal-title":"Shock"},{"issue":"4","key":"2024112705074780000_qiae146-B15","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41419-022-04794-w","article-title":"Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis"},{"issue":"7","key":"2024112705074780000_qiae146-B16","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.4049\/jimmunol.159.7.3508","article-title":"TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC\/CDC42-JNK-c-Jun\/ATF2 pathways","volume":"159","author":"Min","year":"1997","journal-title":"J Immunol"},{"issue":"11","key":"2024112705074780000_qiae146-B17","doi-asserted-by":"publisher","first-page":"e7655","DOI":"10.1590\/1414-431X20187655","article-title":"Propofol attenuates sepsis-induced acute kidney injury by regulating miR-290-5p\/CCL-2 signaling pathway","volume":"51","author":"Zheng","year":"2018","journal-title":"Braz J Med Biol Res"},{"key":"2024112705074780000_qiae146-B18","doi-asserted-by":"publisher","first-page":"Unit 19 13","DOI":"10.1002\/0471142735.im1913s91","article-title":"Cecal ligation and puncture","volume":"Chapter 19","author":"Cuenca","year":"2010","journal-title":"Curr Protoc Immunol"},{"issue":"8","key":"2024112705074780000_qiae146-B19","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1177\/42.8.8027531","article-title":"A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues","volume":"42","author":"Beckstead","year":"1994","journal-title":"J Histochem Cytochem"},{"issue":"3","key":"2024112705074780000_qiae146-B20","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1177\/43.3.7868864","article-title":"A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues: addendum","volume":"43","author":"Beckstead","year":"1995","journal-title":"J Histochem Cytochem"},{"issue":"4","key":"2024112705074780000_qiae146-B21","doi-asserted-by":"publisher","first-page":"355","DOI":"10.4132\/KoreanJPathol.2013.47.4.355","article-title":"ERG immunohistochemistry as an endothelial marker for assessing lymphovascular invasion","volume":"47","author":"Kim","year":"2013","journal-title":"Korean J Pathol"},{"issue":"1","key":"2024112705074780000_qiae146-B22","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1186\/1471-2164-11-342","article-title":"Bioinformatic identification and characterization of human endothelial cell-restricted genes","volume":"11","author":"Bhasin","year":"2010","journal-title":"BMC Genomics"},{"issue":"4","key":"2024112705074780000_qiae146-B23","doi-asserted-by":"publisher","first-page":"968","DOI":"10.3390\/molecules23040968","article-title":"Co-localization of crotamine with internal membranes and accentuated accumulation in tumor cells","volume":"23","author":"Mambelli-Lisboa","year":"2018","journal-title":"Molecules"},{"key":"2024112705074780000_qiae146-B24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.mimet.2016.09.018","article-title":"Resolving colocalization of bacteria and metal(loid)s on plant root surfaces by combining fluorescence in situ hybridization (FISH) with multiple-energy micro-focused X-ray fluorescence (ME muXRF)","volume":"131","author":"Honeker","year":"2016","journal-title":"J Microbiol Methods"},{"issue":"1","key":"2024112705074780000_qiae146-B25","doi-asserted-by":"publisher","first-page":"1600332","DOI":"10.1002\/biot.201600332","article-title":"Fluorescence colocalization microscopy analysis can be improved by combining object-recognition with pixel-intensity-correlation","volume":"12","author":"Moser","year":"2017","journal-title":"Biotechnol J"},{"issue":"3","key":"2024112705074780000_qiae146-B26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00134-009-1723-x","article-title":"Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration","volume":"36","author":"Lerolle","year":"2010","journal-title":"Intensive Care Med"},{"issue":"10","key":"2024112705074780000_qiae146-B27","doi-asserted-by":"publisher","first-page":"e13333","DOI":"10.1111\/eci.13333","article-title":"The role of resistin and myeloperoxidase in severe sepsis and septic shock: results from the ALBIOS trial","volume":"50","author":"Bonaventura","year":"2020","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"2024112705074780000_qiae146-B28","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1189\/jlb.0407237","article-title":"Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis","volume":"82","author":"Zhang","year":"2007","journal-title":"J Leukoc Biol"},{"issue":"5","key":"2024112705074780000_qiae146-B29","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1159\/000358238","article-title":"Adhesion molecules involved in neutrophil recruitment during sepsis-induced acute kidney injury","volume":"6","author":"Herter","year":"2014","journal-title":"J Innate Immun"},{"issue":"5","key":"2024112705074780000_qiae146-B30","doi-asserted-by":"publisher","first-page":"e0196976","DOI":"10.1371\/journal.pone.0196976","article-title":"Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia","volume":"13","author":"Li","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"2024112705074780000_qiae146-B31","doi-asserted-by":"publisher","first-page":"F1262","DOI":"10.1152\/ajprenal.00445.2006","article-title":"The role of ICAM-1 in endotoxin-induced acute renal failure","volume":"293","author":"Wu","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6","key":"2024112705074780000_qiae146-B32","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1093\/ndt\/gfh705","article-title":"Agonist of peroxisome proliferator-activated receptor-gamma, rosiglitazone, reduces renal injury and dysfunction in a murine sepsis model","volume":"20","author":"Lee","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"2024112705074780000_qiae146-B33","doi-asserted-by":"publisher","first-page":"992262","DOI":"10.3389\/fphar.2022.992262","article-title":"Pharmacological inhibition of protein tyrosine kinases axl and fyn reduces TNF-alpha-induced endothelial inflammatory activation in vitro","volume":"13","author":"Ellermann","year":"2022","journal-title":"Front Pharmacol"},{"issue":"12","key":"2024112705074780000_qiae146-B34","doi-asserted-by":"publisher","first-page":"e1196","DOI":"10.1097\/CCM.0000000000003427","article-title":"Renal klotho is reduced in septic patients and pretreatment with recombinant klotho attenuates organ injury in lipopolysaccharide-challenged mice","volume":"46","author":"Jou-Valencia","year":"2018","journal-title":"Crit Care Med"},{"issue":"3","key":"2024112705074780000_qiae146-B35","doi-asserted-by":"publisher","first-page":"e18432","DOI":"10.1371\/journal.pone.0018432","article-title":"Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation","volume":"6","author":"Wielinga","year":"2011","journal-title":"PLoS One"},{"issue":"12","key":"2024112705074780000_qiae146-B36","doi-asserted-by":"publisher","first-page":"F1630","DOI":"10.1152\/ajprenal.00400.2011","article-title":"MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation","volume":"302","author":"Asgeirsdottir","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"issue":"8","key":"2024112705074780000_qiae146-B37","doi-asserted-by":"publisher","first-page":"e0160860","DOI":"10.1371\/journal.pone.0160860","article-title":"Overexpression of hypo-phosphorylated IkappaBbeta at Ser313 protects the heart against sepsis","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"issue":"9","key":"2024112705074780000_qiae146-B38","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1111\/jcmm.13112","article-title":"Neutrophil dysregulation during sepsis: an overview and update","volume":"21","author":"Shen","year":"2017","journal-title":"J Cell Mol Med"},{"issue":"14","key":"2024112705074780000_qiae146-B39","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.4103\/0366-6999.209889","article-title":"Effect of platelet-derived P-selectin on neutrophil recruitment in a mouse model of sepsis-induced acute kidney injury","volume":"130","author":"Li","year":"2017","journal-title":"Chin Med J (Engl)"},{"issue":"6","key":"2024112705074780000_qiae146-B40","doi-asserted-by":"publisher","first-page":"e39484","DOI":"10.1371\/journal.pone.0039484","article-title":"An intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes","volume":"7","author":"Maugeri","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"2024112705074780000_qiae146-B41","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/JLB.3A0817-327RR","article-title":"CIRP increases ICAM-1(+) phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis","volume":"103","author":"Ode","year":"2018","journal-title":"J Leukoc Biol"},{"key":"2024112705074780000_qiae146-B42","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.freeradbiomed.2019.11.004","article-title":"Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients","volume":"152","author":"Carr","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"2024112705074780000_qiae146-B43","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.thromres.2024.03.014","article-title":"Sepsis induces heterogeneous transcription of coagulation- and inflammation-associated genes in renal microvasculature","volume":"237","author":"Luxen","year":"2024","journal-title":"Thromb Res"},{"issue":"1","key":"2024112705074780000_qiae146-B44","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40635-020-0297-3","article-title":"Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury","volume":"8","author":"Wen","year":"2020","journal-title":"Intensive Care Med Exp"},{"key":"2024112705074780000_qiae146-B45","doi-asserted-by":"publisher","first-page":"843782","DOI":"10.3389\/fimmu.2022.843782","article-title":"The pathogenesis of ischemia-reperfusion induced acute kidney injury depends on renal neutrophil recruitment whereas sepsis-induced AKI does not","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"issue":"5","key":"2024112705074780000_qiae146-B46","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1161\/01.res.0000013835.53611.97","article-title":"Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium","volume":"90","author":"Bowden","year":"2002","journal-title":"Circ Res"},{"issue":"2","key":"2024112705074780000_qiae146-B47","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1182\/blood-2004-12-4942","article-title":"ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow","volume":"106","author":"Yang","year":"2005","journal-title":"Blood"},{"issue":"5","key":"2024112705074780000_qiae146-B48","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1128\/cdli.2.5.549-553.1995","article-title":"Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin","volume":"2","author":"Villa","year":"1995","journal-title":"Clin Diagn Lab Immunol"},{"issue":"1","key":"2024112705074780000_qiae146-B49","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12929-017-0370-8","article-title":"Comprehensive comparison of three different animal models for systemic inflammation","volume":"24","author":"Seemann","year":"2017","journal-title":"J Biomed Sci"},{"key":"2024112705074780000_qiae146-B50","doi-asserted-by":"publisher","first-page":"674079","DOI":"10.3389\/fimmu.2021.674079","article-title":"Kinetics of neutrophil subsets in acute, subacute, and chronic inflammation","volume":"12","author":"Bongers","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"2024112705074780000_qiae146-B51","doi-asserted-by":"publisher","first-page":"H634","DOI":"10.1152\/ajpheart.2001.280.2.H634","article-title":"Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1","volume":"280","author":"Forlow","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"9","key":"2024112705074780000_qiae146-B52","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"2024112705074780000_qiae146-B53","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1124\/mol.107.034140","article-title":"Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium","volume":"72","author":"Asgeirsdottir","year":"2007","journal-title":"Mol Pharmacol"},{"key":"2024112705074780000_qiae146-B54","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.vascn.2017.10.004","article-title":"Characterization of immune cell, endothelial, and renal responses upon experimental human endotoxemia","volume":"89","author":"van Poelgeest","year":"2018","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"4","key":"2024112705074780000_qiae146-B55","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1007\/s11033-021-07106-1","article-title":"The role of microRNA-155 in glomerular endothelial cell injury induced by high glucose","volume":"49","author":"He","year":"2022","journal-title":"Mol Biol Rep"},{"issue":"7","key":"2024112705074780000_qiae146-B56","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/emmm.201202318","article-title":"MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways","volume":"5","author":"Cheng","year":"2013","journal-title":"EMBO Mol Med"},{"issue":"1","key":"2024112705074780000_qiae146-B57","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1182\/blood-2004-09-3417","article-title":"VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin","volume":"106","author":"Ulyanova","year":"2005","journal-title":"Blood"},{"issue":"9","key":"2024112705074780000_qiae146-B58","doi-asserted-by":"publisher","first-page":"e0138870","DOI":"10.1371\/journal.pone.0138870","article-title":"Targeting rapamycin to podocytes using a vascular cell adhesion molecule-1 (VCAM-1)-harnessed SAINT-based lipid carrier system","volume":"10","author":"Visweswaran","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"2024112705074780000_qiae146-B59","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/path.2666","article-title":"Selective blockade of endothelial NF-kappaB pathway differentially affects systemic inflammation and multiple organ dysfunction and injury in septic mice","volume":"220","author":"Xu","year":"2010","journal-title":"J Pathol"},{"key":"2024112705074780000_qiae146-B60","doi-asserted-by":"publisher","first-page":"807452","DOI":"10.3389\/fphar.2022.807452","article-title":"Maslinic acid attenuates ischemia\/reperfusion-induced acute kidney injury by suppressing inflammation and apoptosis through inhibiting NF-kappaB and MAPK signaling pathway","volume":"13","author":"Sun","year":"2022","journal-title":"Front Pharmacol"},{"issue":"1","key":"2024112705074780000_qiae146-B61","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1038\/s41598-018-20837-9","article-title":"P38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells","volume":"8","author":"Zhong","year":"2018","journal-title":"Sci Rep"},{"issue":"3","key":"2024112705074780000_qiae146-B62","doi-asserted-by":"publisher","first-page":"F299","DOI":"10.1152\/ajprenal.00005.2023","article-title":"Unique miRNome and transcriptome profiles underlie microvascular heterogeneity in mouse kidney","volume":"325","author":"Luxen","year":"2023","journal-title":"Am J Physiol Renal Physiol"},{"key":"2024112705074780000_qiae146-B63","doi-asserted-by":"publisher","first-page":"111073","DOI":"10.1016\/j.biopha.2020.111073","article-title":"Pharmacological inhibition of focal adhesion kinase 1 (FAK1) and anaplastic lymphoma kinase (ALK) identified via kinome profile analysis attenuates lipopolysaccharide-induced endothelial inflammatory activation","volume":"133","author":"Dayang","year":"2021","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiae146\/58721455\/qiae146.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/116\/6\/1479\/60829139\/qiae146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/116\/6\/1479\/60829139\/qiae146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T05:09:16Z","timestamp":1732684156000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/116\/6\/1479\/7702523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":63,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,7,2]]},"published-print":{"date-parts":[[2024,11,27]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiae146","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,7,2]]}}}