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The current antibacterial arsenal is becoming obsolete, and the pace of drug development is decreasing, highlighting the importance of investment in alternative approaches to treat or prevent infections caused by antimicrobial-resistant bacteria. A significant mechanism of antimicrobial resistance employed by Gram-negative bacteria is the overexpression of efflux pumps that can extrude several compounds from the bacteria, including antimicrobials. The overexpression of efflux pump proteins has been detected in several multidrug-resistant Gram-negative bacteria, drawing attention to these proteins as potential targets against these pathogens. This review will focus on the role of outer membrane proteins from efflux pumps as potential vaccine candidates against clinically relevant multidrug-resistant Gram-negative bacteria, discussing advantages and pitfalls. Additionally, we will explore the relevance of efflux pump outer membrane protein diversity and the possible impact of vaccination on microbiota.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae154","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T11:36:08Z","timestamp":1721129768000},"page":"1237-1253","source":"Crossref","is-referenced-by-count":5,"title":["Bacterial efflux pump OMPs as vaccine candidates against multidrug-resistant Gram-negative bacteria"],"prefix":"10.1093","volume":"116","author":[{"given":"Thaynara O","family":"Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Estudos em Imunologia, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, Bloco A 2\u00ba Andar sala 05, Cidade Universit\u00e1ria, Ilha do Fund\u00e3o , Rio de Janeiro, RJ, 21941-902 ,","place":["Brazil"]},{"name":"Laborat\u00f3rio de Bacteriologia e Imunologia Cl\u00ednica, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, Bloco A 2\u00ba Andar sala 07, Cidade Universit\u00e1ria, Ilha do Fund\u00e3o , Rio de Janeiro, RJ, 21941-902 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina S","family":"Bulla","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Avenida Brasil 4365, Manguinhos , Rio de Janeiro, RJ, 21040-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara A","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Estudos em Imunologia, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal do Rio de Janeiro, Av. 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Carlos Chagas Filho 373, Bloco A 2\u00ba Andar sala 05, Cidade Universit\u00e1ria, Ilha do Fund\u00e3o , Rio de Janeiro, RJ, 21941-902 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza S","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Estudos em Imunologia, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, Bloco A 2\u00ba Andar sala 05, Cidade Universit\u00e1ria, Ilha do Fund\u00e3o , Rio de Janeiro, RJ, 21941-902 ,","place":["Brazil"]},{"name":"Laborat\u00f3rio de Bacteriologia e Imunologia Cl\u00ednica, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho 373, Bloco A 2\u00ba Andar sala 07, Cidade Universit\u00e1ria, Ilha do Fund\u00e3o , Rio de Janeiro, RJ, 21941-902 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela Leal","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Funda\u00e7\u00e3o Oswaldo Cruz, Avenida Brasil 4365, Manguinhos , Rio de Janeiro, RJ, 21040-900 ,","place":["Brazil"]},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o Multic\u00eantrico em Ci\u00eancias Fisiol\u00f3gicas, Instituto de Biodiversidade e Sustentabilidade NUPEM, Universidade Federal do Rio de Janeiro, Avenida S\u00e3o Jos\u00e9 do Barreto, 764. 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