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We, and others, have shown that atypical chemokine receptor 2 (ACKR2)-deficient mice (ACKR2\u2212\/\u2212) are protected from metastasis development in cell line and spontaneous mouse models. We have shown that this relates to enhanced CCR2 expression on ACKR2\u2212\/\u2212 natural killer cells, allowing them to home more effectively to CCR2 ligand-expressing metastatic deposits. Here we demonstrate that the metastatic-suppression phenotype in ACKR2\u2212\/\u2212 mice is not a direct effect of the absence of ACKR2. Instead, enhanced natural killer cell CCR2 expression is caused by passenger mutations that originate from the creation of the ACKR2\u2212\/\u2212 mouse strain in 129 embryonic stem cells. We further demonstrate that simple selection of CCR2+ natural killer cells enriches for a population of cells with enhanced antimetastatic capabilities. Given the widespread expression of CCR2 ligands by tumors, our study highlights CCR2 as a potentially important contributor to natural killer cell tumoricidal cell therapy.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae162","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T19:13:16Z","timestamp":1721934796000},"page":"1544-1553","source":"Crossref","is-referenced-by-count":4,"title":["Enhanced CCR2 expression by ACKR2-deficient NK cells increases tumoricidal cell therapy efficacy"],"prefix":"10.1093","volume":"116","author":[{"given":"Alan J","family":"Hayes","sequence":"first","affiliation":[{"name":"Chemokine Research Group, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow , Sir Graeme Davis Building, 120 University Place, Glasgow G12 8TA ,","place":["United 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