{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:19:23Z","timestamp":1789676363511,"version":"4.0.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean government","award":["RS-2023-00208493"],"award-info":[{"award-number":["RS-2023-00208493"]}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-1-0464"],"award-info":[{"award-number":["W81XWH-16-1-0464"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital Research Fund","doi-asserted-by":"publisher","award":["25-2016-0040"],"award-info":[{"award-number":["25-2016-0040"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During recovery from septic shock, circulating mitochondrial N-formyl peptides predispose to secondary infection by occupying formyl peptide receptor 1 on the neutrophil (polymorphonuclear leukocyte) membrane, suppressing cytosolic calcium ([Ca2+]i)-dependent responses to secondarily encountered bacteria. However, no study has yet investigated therapeutic clearance of circulating mitochondrial N-formyl peptides in clinical settings. Thus, we studied how to remove mitochondrial N-formyl peptides from septic-shock plasma and whether such removal could preserve cell-surface formyl peptide receptor 1 and restore sepsis-induced polymorphonuclear leukocyte dysfunction by normalizing [Ca2+]i flux. In in vitro model systems, mitochondrial N-formyl peptide removal rescued polymorphonuclear leukocyte formyl peptide receptor 1-mediated [Ca2+]i flux and chemotaxis that had been suppressed by prior mitochondrial N-formyl peptide exposure. However, polymorphonuclear leukocyte functional recovery occurred in a stepwise fashion over 30 to 90\u2005min. Intracellular Ca2+-calmodulin appears to contribute to this delay. In ex vivo model, systems using blood samples obtained from patients with septic shock, antimitochondrial N-formyl peptide antibodies alone failed to eliminate mitochondrial N-formyl peptides from septic-shock plasma or inhibit mitochondrial N-formyl peptide activity. We therefore created a beads-based antimitochondrial N-formyl peptide antibody cocktail by combining protein A\/sepharose with antibodies specific for the most potent human mitochondrial N-formyl peptide chemoattractants. The beads-based antimitochondrial N-formyl peptide antibody cocktail treatment successfully removed those active mitochondrial N-formyl peptides from septic-shock plasma. Furthermore, the beads-based antimitochondrial N-formyl peptide antibody cocktail treatment significantly restored chemotactic and bactericidal dysfunction of polymorphonuclear leukocytes obtained from patients with septic shock who developed secondary infections. By clearing circulating mitochondrial N-formyl peptides, the immobilized antimitochondrial N-formyl peptide antibody therapy prevented mitochondrial N-formyl peptide interactions with surface formyl peptide receptor 1, thereby restoring [Ca2+]i-dependent polymorphonuclear leukocyte antimicrobial function in clinical septic-shock environments. This approach may help prevent the development of secondary, nosocomial infections in patients recovering from septic shock.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae169","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:39:48Z","timestamp":1722991188000},"page":"1169-1183","source":"Crossref","is-referenced-by-count":11,"title":["Removal of circulating mitochondrial\n                    <i>N<\/i>\n                    -formyl peptides via immobilized antibody therapy restores sepsis-induced neutrophil dysfunction"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3343-5030","authenticated-orcid":false,"given":"Woon Yong","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University College of Medicine , 103 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]},{"name":"Department of Emergency Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]},{"name":"Research Center for Disaster Medicine, Seoul National University Medical Research Center , 103 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Sun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil Joon","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University College of Medicine , 103 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]},{"name":"Department of Emergency Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]},{"name":"Research Center for Disaster Medicine, Seoul National University Medical Research Center , 103 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areum","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heesu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Shin","sequence":"additional","affiliation":[{"name":"Hospital Medicine Center, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taegyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University Hospital , 101 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]},{"name":"Research Center for Disaster Medicine, Seoul National University Medical Research Center , 103 Daehak-ro, Jongno-gu, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Itagaki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center\/Harvard Medical School , 110 Francis St., Boston, MA 02215 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center\/Harvard Medical School , 110 Francis St., Boston, MA 02215 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"issue":"14","key":"2024110323515531000_qiae169-B1","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1001\/jama.2016.2691","article-title":"incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis","volume":"315","author":"van Vught","year":"2016","journal-title":"JAMA"},{"issue":"1","key":"2024110323515531000_qiae169-B2","doi-asserted-by":"publisher","first-page":"38361","DOI":"10.1038\/srep38361","article-title":"Incidence, risk factors and impact on outcomes of secondary infection in patients with septic shock: an 8-year retrospective study","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci Rep"},{"key":"2024110323515531000_qiae169-B3","doi-asserted-by":"publisher","first-page":"891024","DOI":"10.3389\/fimmu.2022.891024","article-title":"Advances in immune monitoring approaches for sepsis-induced immunosuppression","volume":"13","author":"Yao","year":"2022","journal-title":"Front Immunol"},{"issue":"7","key":"2024110323515531000_qiae169-B4","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1056\/NEJM199802123380706","article-title":"Chemokines\u2013chemotactic cytokines that mediate inflammation","volume":"338","author":"Luster","year":"1998","journal-title":"N Engl J Med"},{"issue":"1","key":"2024110323515531000_qiae169-B5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13054-016-1250-4","article-title":"The role of neutrophils in immune dysfunction during severe inflammation","volume":"20","author":"Leliefeld","year":"2016","journal-title":"Crit Care"},{"issue":"1","key":"2024110323515531000_qiae169-B6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/SHK.0000000000001691","article-title":"Direct airway instillation of neutrophils overcomes chemotactic deficits induced by injury","volume":"56","author":"Zhang","year":"2021","journal-title":"Shock"},{"issue":"4","key":"2024110323515531000_qiae169-B7","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1189\/jlb.2MR1114-573R","article-title":"Store-operated calcium signaling in neutrophils","volume":"98","author":"Clemens","year":"2015","journal-title":"J Leukoc Biol"},{"issue":"1","key":"2024110323515531000_qiae169-B8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/01.TA.0000171456.54921.FE","article-title":"Store-operated calcium channel inhibition attenuates neutrophil function and postshock acute lung injury","volume":"59","author":"Lee","year":"2005","journal-title":"J Trauma"},{"issue":"1","key":"2024110323515531000_qiae169-B9","doi-asserted-by":"publisher","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"2024110323515531000_qiae169-B10","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1097\/CCM.0000000000000742","article-title":"Lactate measurements in sepsis-induced tissue hypoperfusion: results from the surviving sepsis campaign database","volume":"43","author":"Casserly","year":"2015","journal-title":"Crit Care Med"},{"issue":"1","key":"2024110323515531000_qiae169-B11","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/TA.0000000000002973","article-title":"Monocyte exocytosis of mitochondrial danger-associated molecular patterns in sepsis suppresses neutrophil chemotaxis","volume":"90","author":"Konecna","year":"2021","journal-title":"J Trauma Acute Care Surg"},{"issue":"7285","key":"2024110323515531000_qiae169-B12","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"issue":"5","key":"2024110323515531000_qiae169-B13","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/j.ajpath.2015.01.020","article-title":"The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation","volume":"185","author":"Dorward","year":"2015","journal-title":"Am J Pathol"},{"issue":"15","key":"2024110323515531000_qiae169-B14","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1089\/ars.2021.0052","article-title":"Role of mitochondria-derived danger signals released after injury in systemic inflammation and sepsis","volume":"35","author":"Itagaki","year":"2021","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"2024110323515531000_qiae169-B15","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/imr.12752","article-title":"Concepts of GPCR-controlled navigation in the immune system","volume":"289","author":"L\u00e4mmermann","year":"2019","journal-title":"Immunol Rev"},{"issue":"2","key":"2024110323515531000_qiae169-B16","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/TA.0000000000000509","article-title":"Mitochondrial damage-associated molecular patterns from fractures suppress pulmonary immune responses via formyl peptide receptors 1 and 2","volume":"78","author":"Li","year":"2015","journal-title":"J Trauma Acute Care Surg"},{"issue":"17","key":"2024110323515531000_qiae169-B17","doi-asserted-by":"publisher","first-page":"e2018538118","DOI":"10.1073\/pnas.2018538118","article-title":"Circulating mitochondrial N-formyl peptides contribute to secondary nosocomial infection in patients with septic shock","volume":"118","author":"Kwon","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2024110323515531000_qiae169-B18","doi-asserted-by":"publisher","first-page":"e123","DOI":"10.1097\/CCM.0000000000004094","article-title":"Formyl peptide receptor-1 blockade prevents receptor regulation by mitochondrial danger-associated molecular patterns and preserves neutrophil function after trauma","volume":"48","author":"Itagaki","year":"2020","journal-title":"Crit Care Med"},{"issue":"4","key":"2024110323515531000_qiae169-B19","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1097\/SLA.0000000000004379","article-title":"Multiplexed plasma immune mediator signatures can differentiate sepsis from noninfective SIRS: American Surgical Association 2020 annual meeting paper","volume":"272","author":"Cahill","year":"2020","journal-title":"Ann Surg"},{"key":"2024110323515531000_qiae169-B20","doi-asserted-by":"publisher","first-page":"1038086","DOI":"10.3389\/fimmu.2022.1038086","article-title":"Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill","volume":"13","author":"Bonaroti","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"2024110323515531000_qiae169-B21","doi-asserted-by":"publisher","first-page":"5232","DOI":"10.1038\/s41467-022-32822-y","article-title":"Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns","volume":"13","author":"Chen","year":"2022","journal-title":"Nat Commun"},{"issue":"3","key":"2024110323515531000_qiae169-B22","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3109\/08923979909007117","article-title":"Cellular responses to FMLP challenging: a mini-review","volume":"21","author":"Panaro","year":"1999","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"9","key":"2024110323515531000_qiae169-B23","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nchembio.1611","article-title":"Endosomal generation of cAMP in GPCR signaling","volume":"10","author":"Vilardaga","year":"2014","journal-title":"Nat Chem Biol"},{"key":"2024110323515531000_qiae169-B24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cellsig.2017.01.024","article-title":"GPCR desensitization: acute and prolonged phases","volume":"41","author":"Rajagopal","year":"2018","journal-title":"Cell Signal"},{"issue":"8","key":"2024110323515531000_qiae169-B25","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"7","key":"2024110323515531000_qiae169-B26","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction\/failure. On behalf of the working group on sepsis-related problems of the European society of intensive care medicine","volume":"22","author":"Vincent","year":"1996","journal-title":"Intensive Care Med"},{"issue":"3","key":"2024110323515531000_qiae169-B27","doi-asserted-by":"publisher","first-page":"255","DOI":"10.15441\/ceem.23.065","article-title":"Hemodynamic management of septic shock: beyond the surviving sepsis campaign guidelines","volume":"10","author":"Suh","year":"2023","journal-title":"Clin Exp Emerg Med"},{"issue":"5","key":"2024110323515531000_qiae169-B28","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1097\/TA.0000000000001971","article-title":"A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils","volume":"85","author":"Kaczmarek","year":"2018","journal-title":"J Trauma Acute Care Surg"},{"issue":"2-3","key":"2024110323515531000_qiae169-B29","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0143-4160(90)90060-8","article-title":"Assessment of Fura-2 for measurements of cytosolic free calcium","volume":"11","author":"Roe","year":"1990","journal-title":"Cell Calcium"},{"issue":"1","key":"2024110323515531000_qiae169-B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/1056-8719(94)90023-X","article-title":"Fluorescence imaging of intracellular Ca2+","volume":"31","author":"Hayashi","year":"1994","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"10","key":"2024110323515531000_qiae169-B31","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/BF02620982","article-title":"Routine heat inactivation of serum reduces its capacity to promote cell attachment","volume":"23","author":"Giard","year":"1987","journal-title":"In Vitro Cell Dev Biol"},{"issue":"6","key":"2024110323515531000_qiae169-B32","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/0161-5890(80)90144-3","article-title":"Titers of nine complement components, conglutinin and C3b-inactivator in adult and fetal bovine sera","volume":"17","author":"Triglia","year":"1980","journal-title":"Mol Immunol"},{"issue":"10","key":"2024110323515531000_qiae169-B33","doi-asserted-by":"publisher","first-page":"4591","DOI":"10.4049\/jimmunol.150.10.4591","article-title":"Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E","volume":"150","author":"Wenzel-Seifert","year":"1993","journal-title":"J Immunol"},{"issue":"11","key":"2024110323515531000_qiae169-B34","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S1471-4906(02)02316-5","article-title":"Formyl-peptide receptors revisited","volume":"23","author":"Le","year":"2002","journal-title":"Trends Immunol"},{"issue":"44","key":"2024110323515531000_qiae169-B35","doi-asserted-by":"publisher","first-page":"42178","DOI":"10.1074\/jbc.M204531200","article-title":"Calmodulin modulates the delay period between release of calcium from internal stores and activation of calcium influx via endogenous TRP1 channels","volume":"277","author":"Vaca","year":"2002","journal-title":"J Biol Chem"},{"issue":"11","key":"2024110323515531000_qiae169-B36","doi-asserted-by":"publisher","first-page":"8474","DOI":"10.1074\/jbc.M607211200","article-title":"Membrane-permeable calmodulin inhibitors (e.g. W-7\/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation","volume":"282","author":"Sengupta","year":"2007","journal-title":"J Biol Chem"},{"issue":"1","key":"2024110323515531000_qiae169-B37","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1038\/s41467-019-10694-z","article-title":"Mechanisms of Ca2+\/calmodulin-dependent kinase II activation in single dendritic spines","volume":"10","author":"Chang","year":"2019","journal-title":"Nat Commun"},{"issue":"2","key":"2024110323515531000_qiae169-B38","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/JLB.3RU0719-241R","article-title":"Calcium signaling and regulation of neutrophil functions: still a long way to go","volume":"107","author":"Hann","year":"2020","journal-title":"J Leukoc Biol"},{"issue":"1","key":"2024110323515531000_qiae169-B39","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1189\/jlb.69.1.50","article-title":"Neutrophil survival is markedly reduced by incubation with influenza virus and Streptococcus pneumoniae: role of respiratory burst","volume":"69","author":"Engelich","year":"2001","journal-title":"J Leukoc Biol"},{"issue":"2","key":"2024110323515531000_qiae169-B40","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/jlb.55.2.147","article-title":"A single assay for measuring the rates of phagocytosis and bacterial killing by neutrophils","volume":"55","author":"Hampton","year":"1994","journal-title":"J Leukoc Biol"},{"issue":"1","key":"2024110323515531000_qiae169-B41","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/s41467-017-01135-w","article-title":"Calmodulin dissociates the STIM1-orai1 complex and STIM1 oligomers","volume":"8","author":"Li","year":"2017","journal-title":"Nat Commun"},{"issue":"2","key":"2024110323515531000_qiae169-B42","doi-asserted-by":"publisher","first-page":"252","DOI":"10.33594\/000000218","article-title":"Ca2+\/calmodulin binding to STIM1 hydrophobic residues facilitates slow Ca2+-dependent inactivation of the Orai1 channel","volume":"54","author":"Bhardwaj","year":"2020","journal-title":"Cell Physiol Biochem"},{"key":"2024110323515531000_qiae169-B43","volume-title":"Patient safety component manual","author":"National Healthcare Safety Network (NHSN)","year":"2021"},{"issue":"5-6","key":"2024110323515531000_qiae169-B44","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1159\/000487756","article-title":"Neutrophils and bacterial immune evasion","volume":"10","author":"Kobayashi","year":"2018","journal-title":"J Innate Immun"},{"issue":"6","key":"2024110323515531000_qiae169-B45","doi-asserted-by":"publisher","first-page":"e1277","DOI":"10.1097\/SLA.0000000000005898","article-title":"DANGER signals activate G -protein receptor kinases suppressing neutrophil function and predisposing to infection after tissue trauma","volume":"278","author":"Kim","year":"2023","journal-title":"Ann Surg"},{"issue":"4","key":"2024110323515531000_qiae169-B46","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/infdis\/jiz498","article-title":"Formyl-Peptide receptor activation enhances phagocytosis of community-acquired methicillin-resistant Staphylococcus aureus","volume":"221","author":"Wei\u00df","year":"2020","journal-title":"J Infect Dis"},{"issue":"44","key":"2024110323515531000_qiae169-B47","doi-asserted-by":"publisher","first-page":"37021","DOI":"10.1074\/jbc.M506594200","article-title":"Interleukin-8-induced priming of neutrophil oxidative burst requires sequential recruitment of NADPH oxidase components into lipid rafts","volume":"280","author":"Guichard","year":"2005","journal-title":"J Biol Chem"},{"issue":"7","key":"2024110323515531000_qiae169-B48","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.4049\/jimmunol.1401138","article-title":"CXCL1 contributes to host defense in polymicrobial sepsis via modulating T cell and neutrophil functions","volume":"193","author":"Jin","year":"2014","journal-title":"J Immunol"},{"key":"2024110323515531000_qiae169-B49","doi-asserted-by":"publisher","first-page":"102630","DOI":"10.1016\/j.jaut.2021.102630","article-title":"Mitochondrial N-formyl methionine peptides associate with disease activity as well as contribute to neutrophil activation in patients with rheumatoid arthritis","volume":"119","author":"Duvvuri","year":"2021","journal-title":"J Autoimmun"},{"key":"2024110323515531000_qiae169-B50","doi-asserted-by":"publisher","first-page":"785275","DOI":"10.3389\/fimmu.2021.785275","article-title":"N-Formyl methionine peptide-mediated neutrophil activation in systemic sclerosis","volume":"12","author":"Kuley","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"2024110323515531000_qiae169-B51","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s13075-022-02849-z","article-title":"Neutrophil activation in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis and large-vessel vasculitis","volume":"24","author":"Michailidou","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"2024110323515531000_qiae169-B52","doi-asserted-by":"publisher","first-page":"102109","DOI":"10.1016\/j.redox.2021.102109","article-title":"The many roles of myeloperoxidase: from inflammation and immunity to biomarkers, drug metabolism and drug discovery","volume":"46","author":"Siraki","year":"2021","journal-title":"Redox Biol"},{"issue":"1","key":"2024110323515531000_qiae169-B53","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3390\/antiox13010132","article-title":"The roles of neutrophil-derived myeloperoxidase (MPO) in diseases: the new progress","volume":"13","author":"Lin","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"2024110323515531000_qiae169-B54","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.devcel.2012.02.003","article-title":"LTB4 is a signal-relay molecule during neutrophil chemotaxis","volume":"22","author":"Afonso","year":"2012","journal-title":"Dev Cell"},{"issue":"7454","key":"2024110323515531000_qiae169-B55","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature12175","article-title":"Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo","volume":"498","author":"L\u00e4mmermann","year":"2013","journal-title":"Nature"},{"issue":"2","key":"2024110323515531000_qiae169-B56","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0165-6147(00)01620-5","article-title":"Role of endocytosis in mediating downregulation of G-protein-coupled receptors","volume":"22","author":"Tsao","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"2024110323515531000_qiae169-B57","doi-asserted-by":"publisher","first-page":"704173","DOI":"10.3389\/fimmu.2021.704173","article-title":"New pharmacological tools to target leukocyte trafficking in lung disease","volume":"12","author":"Belchamber","year":"2021","journal-title":"Front Immunol"},{"issue":"4","key":"2024110323515531000_qiae169-B58","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1161\/HYPERTENSIONAHA.120.16237","article-title":"FPR-1 (Formyl peptide receptor-1) activation promotes spontaneous, premature hypertension in dahl salt-sensitive rats","volume":"77","author":"Edwards","year":"2021","journal-title":"Hypertension"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiae169\/58817384\/qiae169.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/116\/5\/1169\/60213336\/qiae169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/116\/5\/1169\/60213336\/qiae169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T18:52:10Z","timestamp":1730659930000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/116\/5\/1169\/7728410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":58,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,8,6]]},"published-print":{"date-parts":[[2024,11,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiae169","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,8,6]]}}}