{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:18:32Z","timestamp":1792700312085,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Efficient cutaneous wound healing requires a coordinated transition between inflammatory phases mediated by dynamic changes in leukocyte subset populations. Here, we identify STING as a key innate immune mediator governing timely resolution of inflammation by regulating macrophage dynamics during skin repair. Using a mouse model, we show STING deficiency caused delayed wound closure associated with abnormal persistence of TNF-\u03b1+ leukocytes. This resulted from the impaired macrophage recruitment. STING controlled the trafficking of bone marrow myeloid cells into blood and wounds, intrinsically enhancing macrophage migratory capacity through STAT3 activation. Specifically, STING modulated the production of monocyte chemokines and their receptors CCR2\/CCR5 to enable efficient egress and wound infiltration. Consequently, disrupted systemic and local STING\u2013STAT3\u2013chemokine signaling combine to delay macrophage influx. This study elucidates STING as a critical rheostat tuning macrophage responses through STAT3 to orchestrate inflammatory resolution necessary for efficient wound healing. Our findings have broad implications for targeting STING therapeutically in both regenerative medicine and inflammatory disease contexts.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae175","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:52:45Z","timestamp":1723117965000},"source":"Crossref","is-referenced-by-count":10,"title":["STING coordinates resolution of inflammation during wound repair by modulating macrophage trafficking through STAT3"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-1074","authenticated-orcid":false,"given":"Cheng","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]},{"name":"Chongqing Key Laboratory for Disease Proteomics , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]},{"name":"Chongqing Key Laboratory for Disease Proteomics , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 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30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]},{"name":"Chongqing Key Laboratory for Disease Proteomics , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4540-7771","authenticated-orcid":false,"given":"Junyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]},{"name":"Chongqing Key Laboratory for Disease Proteomics , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]},{"name":"Chongqing Key Laboratory for Disease Proteomics , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]},{"name":"Chongqing Key Laboratory for Disease Proteomics , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]},{"name":"Academy of Biological Engineering, Chongqing University , 174 Shazheng Street, Chongqing 400044 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Shang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University) , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 ,","place":["China"]},{"name":"Chongqing Key Laboratory for Disease Proteomics , 30 Gaotanyan Main Street, Shapingba District, Chongqing 400038 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