{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:41:41Z","timestamp":1790116901072,"version":"4.0.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Radboudumc personal PhD grant"},{"name":"Spinoza grant"},{"DOI":"10.13039\/501100003246","name":"Dutch Research Council NWO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERC Advanced Grant","award":["#833247"],"award-info":[{"award-number":["#833247"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Trained immunity induces antigen-agnostic enhancement of host defense and protection against secondary infections, but inappropriate activation can contribute to the pathophysiology of inflammatory diseases. Tight regulation of trained immunity is therefore needed to avoid pathology, but little is known about the endogenous processes that modulate it. Here, we investigated the potential of interleukin (IL)-10, a prototypical anti-inflammatory cytokine, to inhibit trained immunity. IL-10 induced tolerance and inhibited trained immunity in primary human monocytes at both functional and transcriptional levels. Inhibition of STAT3, a signaling route that mediates IL-10 signals, induced trained immunity. IL-10 downregulated glycolytic and oxidative metabolism in monocytes but did not impact the metabolic effects of \u03b2-glucan\u2013induced trained immunity. Furthermore, IL-10 prevented increased reactive oxygen species production in Bacillus Calmette\u2013Gu\u00e9rin (BCG)\u2013induced training but did not influence phagocytosis upregulation. In a cohort study of healthy volunteers vaccinated with BCG, genetic variants that influenced IL-10 or its receptor modulated BCG-induced trained immunity. Furthermore, circulating IL-10 concentrations were negatively correlated with induction of trained immunity after BCG vaccination in a sex-specific manner. In conclusion, IL-10 inhibited several, albeit not all, immunological functions amplified after induction of trained immunity. Follow-up studies should explore the precise molecular mechanism that mediates the effects of IL-10 on trained immunity. Addressing these knowledge gaps is an important step toward optimizing IL-10's potential as a therapeutic target in diseases characterized by inappropriate induction of trained immunity.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae240","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T21:46:55Z","timestamp":1731448015000},"source":"Crossref","is-referenced-by-count":17,"title":["Interleukin-10 inhibits important components of trained immunity in human monocytes"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3921-7541","authenticated-orcid":false,"given":"Rutger J","family":"R\u00f6ring","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Geert Grooteplein Zuid 10, 6525 GA Nijmegen ,","place":["the Netherlands"]},{"name":"Inflammatory Origins Group, Murdoch Children\u2019s Research Institute , Royal Children\u2019s Hospital, 50 Flemington Road, 3052 Parkville ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4215-9068","authenticated-orcid":false,"given":"Flavia","family":"Scognamiglio","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Geert Grooteplein Zuid 10, 6525 GA Nijmegen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-3184","authenticated-orcid":false,"given":"Lisanne C","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Geert Grooteplein Zuid 10, 6525 GA Nijmegen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-960X","authenticated-orcid":false,"given":"Laszlo A","family":"Groh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Geert Grooteplein Zuid 10, 6525 GA Nijmegen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5852-6801","authenticated-orcid":false,"given":"Vasiliki","family":"Matzaraki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Geert Grooteplein Zuid 10, 6525 GA Nijmegen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5783-9013","authenticated-orcid":false,"given":"Valerie A C M","family":"Koeken","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Geert Grooteplein Zuid 10, 6525 GA Nijmegen ,","place":["the Netherlands"]},{"name":"Research Centre Innovations in Care, Rotterdam University of Applied Sciences , Rochussenstraat 198, 3015 EK Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6166-9830","authenticated-orcid":false,"given":"Leo A B","family":"Joosten","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Geert Grooteplein Zuid 10, 6525 GA Nijmegen ,","place":["the Netherlands"]},{"name":"Department of Medical Genetics, Iuliu Ha\u021bieganu University of Medicine and Pharmacy , Strada Louis Pasteur 6, Cluj-Napoca 400535 ,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3731-4463","authenticated-orcid":false,"given":"Athanasios","family":"Ziogas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Geert Grooteplein Zuid 10, 6525 GA Nijmegen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G","family":"Netea","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Geert Grooteplein Zuid 10, 6525 GA Nijmegen ,","place":["the Netherlands"]},{"name":"Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn , Carl-Troll-Stra\u00dfe 31, 53115 Bonn 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