{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:27:40Z","timestamp":1792988860081,"version":"4.5.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005897","name":"French Society of Dermatology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Atopic dermatitis and other type 2 immune response diseases are often linked to elevated eosinophil levels in the blood. Although the role of eosinophils in atopic dermatitis pathophysiology is suspected, it remains unclear. The development of new treatments targeting the type 2 response, particularly cytokines involved in eosinophil activation and chemotaxis, makes it necessary to identify potential eosinophil profiles in atopic dermatitis that may respond to these treatments. A prospective study was conducted comparing blood eosinophil phenotypes in patients with moderate to severe atopic dermatitis (n = 19) without recent systemic treatment to healthy individuals (n = 19). The primary outcome was the membranous phenotypic signature of eosinophils, assessed by flow cytometry. Most patients with atopic dermatitis (84%) had early onset in childhood, a severe disease (mean SCORing Atopic Dermatitis of 57.5), and elevated blood eosinophil counts (310 per \u00b5L in atopic dermatitis vs 120 in healthy individuals, P &amp;lt; 0.0001). Patients with atopic dermatitis exhibited lower CRTH2 on eosinophils but higher levels of human leukocyte antigen\u2013DR isotype and Siglec-8 compared to healthy individuals. Other surface proteins showed no significant differences. Clustering analysis confirmed increased Siglec-8 in patients with atopic dermatitis. Additionally, patients with atopic dermatitis had higher serum levels of type 2 immune response markers such as eotaxin-2, IL-5, IL-3, and TARC. Circulating eosinophils in patients with atopic dermatitis show a distinct phenotypic profile, suggesting a role in atopic dermatitis pathophysiology and potential involvement in differential treatment responses.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf023","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T16:25:43Z","timestamp":1740500743000},"source":"Crossref","is-referenced-by-count":6,"title":["Enhanced Siglec-8 and HLA-DR and reduced CRTH2 surface expression highlight a distinct phenotypic signature of circulating eosinophils in atopic dermatitis"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-1042","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Dezoteux","sequence":"first","affiliation":[{"name":"CHU Lille, Univ. Lille, Service de Dermatologie , Rue Michel Polonowski, F-59000 Lille ,","place":["France"]},{"name":"U1286-Infinite-Institute for Translational Research in Inflammation, Univ. Lille, Inserm, CHU Lille , 1, Place Verdun, F-59000 Lille ,","place":["France"]},{"name":"Centre de R\u00e9f\u00e9rence National des Syndromes Hyper\u00e9osinophiliques (CEREO) , Rue Michel Polonowki, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-1181","authenticated-orcid":false,"given":"Pierre","family":"Marcant","sequence":"additional","affiliation":[{"name":"CHU Lille, Univ. Lille, Service de Dermatologie , Rue Michel Polonowski, F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-2223","authenticated-orcid":false,"given":"Arnaud","family":"Dendooven","sequence":"additional","affiliation":[{"name":"U1286-Infinite-Institute for Translational Research in Inflammation, Univ. Lille, Inserm, CHU Lille , 1, Place Verdun, F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9meline","family":"Delaunay","sequence":"additional","affiliation":[{"name":"U1286-Infinite-Institute for Translational Research in Inflammation, Univ. Lille, Inserm, CHU Lille , 1, Place Verdun, F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-8671","authenticated-orcid":false,"given":"St\u00e9phane","family":"Esnault","sequence":"additional","affiliation":[{"name":"U1286-Infinite-Institute for Translational Research in Inflammation, Univ. Lille, Inserm, CHU Lille , 1, Place Verdun, F-59000 Lille ,","place":["France"]},{"name":"Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin , 5158 Medical Foundation Centennial Building, 1685 Highland Ave, Madison, WI 53705 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Trauet","sequence":"additional","affiliation":[{"name":"Institut d\u2019Immunologie, CHU Lille , Boulevard du Pr Jules Leclercq, F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-7267","authenticated-orcid":false,"given":"Guillaume","family":"Lef\u00e8vre","sequence":"additional","affiliation":[{"name":"U1286-Infinite-Institute for Translational Research in Inflammation, Univ. Lille, Inserm, CHU Lille , 1, Place Verdun, F-59000 Lille ,","place":["France"]},{"name":"Centre de R\u00e9f\u00e9rence National des Syndromes Hyper\u00e9osinophiliques (CEREO) , Rue Michel Polonowki, F-59000 Lille, France"},{"name":"Institut d\u2019Immunologie, CHU Lille , Boulevard du Pr Jules Leclercq, F-59000 Lille ,","place":["France"]},{"name":"D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO), CHU Lille , Rue Michel Polonowski, F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-4212","authenticated-orcid":false,"given":"Delphine","family":"Staumont-Sall\u00e9","sequence":"additional","affiliation":[{"name":"CHU Lille, Univ. 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Lille, Inserm, CHU Lille , 1, Place Verdun, F-59000 Lille ,","place":["France"]},{"name":"Centre de R\u00e9f\u00e9rence National des Syndromes Hyper\u00e9osinophiliques (CEREO) , Rue Michel Polonowki, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"2025042506263407200_qiaf023-B1","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1111\/all.13401","article-title":"Epidemiology of atopic dermatitis in adults: results from an international survey","volume":"73","author":"Barbarot","year":"2018","journal-title":"Allergy"},{"key":"2025042506263407200_qiaf023-B2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s13671-011-0003-5","article-title":"Comorbidity in atopic dermatitis","volume":"1","author":"Simpson","year":"2012","journal-title":"Curr Dermatol Rep"},{"key":"2025042506263407200_qiaf023-B3","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1034\/j.1398-9995.2000.00391.x","article-title":"Development of allergies and asthma in infants and young children with atopic dermatitis\u2013a prospective follow-up to 7 yr of age","volume":"55","author":"Gustafsson","year":"2000","journal-title":"Allergy"},{"key":"2025042506263407200_qiaf023-B4","doi-asserted-by":"publisher","first-page":"A106","DOI":"10.1016\/j.annder.2019.09.114","article-title":"Pr\u00e9valence de l\u2019\u00e9osinophilie sanguine dans la dermatite atopique mod\u00e9r\u00e9e \u00e0 s\u00e9v\u00e8re de l\u2019adulte: \u00c9tude r\u00e9trospective au chu de lille","volume":"146","author":"Marcant","year":"2019","journal-title":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie"},{"key":"2025042506263407200_qiaf023-B5","doi-asserted-by":"publisher","first-page":"e23214","DOI":"10.1002\/jcla.23214","article-title":"Clinical relevance of eosinophils, basophils, serum total IgE level, allergen-specific IgE, and clinical features in atopic dermatitis","volume":"34","author":"Hu","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"2025042506263407200_qiaf023-B6","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1111\/all.14318","article-title":"Type 2 immunity in the skin and lungs","volume":"75","author":"Akdis","year":"2020","journal-title":"Allergy"},{"key":"2025042506263407200_qiaf023-B7","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/j.1398-9995.2004.00476.x","article-title":"Eosinophils and atopic dermatitis","volume":"59","author":"Simon","year":"2004","journal-title":"Allergy"},{"key":"2025042506263407200_qiaf023-B8","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/j.1365-2230.1990.tb02086.x","article-title":"Blood eosinophilia in atopic dermatitis","volume":"15","author":"Uehara","year":"1990","journal-title":"Clin Exp Dermatol"},{"key":"2025042506263407200_qiaf023-B9","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1111\/all.14050","article-title":"Efficacy and safety of mepolizumab administered subcutaneously for moderate to severe atopic dermatitis","volume":"75","author":"Kang","year":"2020","journal-title":"Allergy"},{"key":"2025042506263407200_qiaf023-B10","doi-asserted-by":"publisher","first-page":"e1211","DOI":"10.1111\/jdv.19195","article-title":"Lack of effect of benralizumab on signs and symptoms of moderate-to-severe atopic dermatitis: results from the phase 2 randomized, double-blind, placebo-controlled hillier trial","volume":"37","author":"Guttman-Yassky","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025042506263407200_qiaf023-B11","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1442-200x.2004.02004.x","article-title":"Expansion of activated eosinophils in infants with severe atopic dermatitis","volume":"47","author":"Toma","year":"2005","journal-title":"Pediatr Int"},{"key":"2025042506263407200_qiaf023-B12","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1365-2133.1994.tb08532.x","article-title":"The U.K. working party's diagnostic criteria for atopic dermatitis. 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