{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:56:21Z","timestamp":1793476581914,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A2C2006898"],"award-info":[{"award-number":["2022R1A2C2006898"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms. Fatty acids, especially polyunsaturated fatty acids, are susceptible to peroxidation, leading to the formation of lipid peroxides. Iron metabolism plays a critical role, as excessive free iron catalyzes the production of reactive oxygen species via the Fenton reaction, further promoting lipid peroxidation. Antioxidative mechanisms, including glutathione peroxidase 4 and other components of the glutathione system, are crucial for neutralizing lipid peroxides and preventing ferroptosis. Recent studies have highlighted the role of ferroptosis in neutrophils, particularly under pathological conditions. Neutrophils, due to their high iron content and abundance of polyunsaturated fatty acids, are inherently predisposed to ferroptosis. Recent studies indicate that polymorphonuclear myeloid-derived suppressor cells and tumor-infiltrating neutrophils exhibit high susceptibility to ferroptosis due to a dysregulated antioxidant defense mechanism through hypoxia-mediated downregulation of glutathione peroxidase 4. Conversely, tumor-infiltrating neutrophils resist ferroptosis through nuclear factor erythroid 2\u2013related factor 2\u2013dependent antioxidant pathway. Moreover, neutrophils induce ferroptosis in various cell types, such as endothelial cells, smooth muscle cells, and cardiomyocytes, through the release of neutrophil extracellular traps. This neutrophil extracellular trap\u2013mediated ferroptosis contributes to the pathogenesis of conditions such as intestinal ischemia\u2013reperfusion injury, aortic aneurysm, acute lung injury, and doxorubicin-induced cardiotoxicity. This review consolidates current knowledge on the mechanisms of ferroptosis in neutrophils and its implications in disease progression and immune regulation. Understanding these processes may provide new therapeutic targets for modulating immune responses and improving outcomes in ferroptosis-related diseases.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf039","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T09:58:55Z","timestamp":1743587935000},"source":"Crossref","is-referenced-by-count":25,"title":["Ferroptosis in neutrophils"],"prefix":"10.1093","volume":"117","author":[{"given":"Yu-Bin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Kyungpook National University , Daegu 41944 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong-Wook","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Kyungpook National University , Daegu 41944 ,","place":["Republic of 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