{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:43:54Z","timestamp":1788576234511,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Youth Science Foundation of China","doi-asserted-by":"crossref","award":["82200194"],"award-info":[{"award-number":["82200194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Youth Foundation of Jiangxi Province","award":["20232BAB216035"],"award-info":[{"award-number":["20232BAB216035"]}]},{"name":"Science and Technology Program of Traditional Chinese Medicine Administration of Jiangxi Province","award":["2023Z030"],"award-info":[{"award-number":["2023Z030"]}]},{"name":"Jiangxi Health Committee's Science and Technology Plan","award":["SKJP-220212554"],"award-info":[{"award-number":["SKJP-220212554"]}]},{"name":"Youth Scientific Research Foundation of the First Affiliated Hospital of Nanchang University","award":["YFYPY202115"],"award-info":[{"award-number":["YFYPY202115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), an emerging immune checkpoint molecule, exhibits therapeutic potential in acute myeloid leukemia (AML). While single nucleotide polymorphisms (SNPs) of immune checkpoint genes have been extensively investigated in AML, the association between LILRB4 genetic polymorphisms and clinical outcomes remains unexplored. We investigated SNPs within the LILRB4 immunoglobulin domain and immunoreceptor tyrosine-based inhibitory motif regions in 151 AML patients and 203 controls. The rs1048801 G allele was significantly associated with increased LILRB4 mRNA expression, higher disease susceptibility, and reduced overall survival. Functional studies revealed that the G allele enhanced AML cell proliferation and colony formation. Furthermore, protein-protein interaction network analysis identified CD4 as a pivotal downstream mediator of LILRB4. Flow cytometry revealed elevated LILRB4 expression in CD45+ leukocytes and CD45+ CD33+ CD14+ monocytic AML cells from G allele carriers, concomitant with reduced CD3+ CD4+ T cell populations and impaired proliferation. Collectively, these findings establish rs1048801 as a critical modulator of AML progression through LILRB4-mediated CD4+ T cell suppression, providing new insights for personalized therapeutic strategies.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf052","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:03:38Z","timestamp":1745564618000},"source":"Crossref","is-referenced-by-count":7,"title":["Presence of <i>LILRB4<\/i> SNP rs1048801 modulates acute myeloid leukemia progression and inhibits CD4+ T cells proliferation"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4830-2219","authenticated-orcid":false,"given":"Zhiyong","family":"Zhou","sequence":"first","affiliation":[{"name":"Center for Molecular Diagnosis and Precision Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University , 1519 Dongyue Dadao, Nanchang 330209 ,","place":["China"]},{"name":"Jiangxi Provincial Center for Advanced 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Precision Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University , 1519 Dongyue Dadao, Nanchang 330209 ,","place":["China"]},{"name":"Jiangxi Provincial Center for Advanced Diagnostic Technology and Precision Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University , 1519 Dongyue Dadao, Nanchang 330209 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Molecular Diagnosis and Precision Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University , 1519 Dongyue Dadao, Nanchang 330209 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Molecular Diagnosis and Precision Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University , 1519 Dongyue Dadao, Nanchang 330209 ,","place":["China"]},{"name":"Jiangxi Provincial Center for Advanced Diagnostic Technology and Precision Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University , 1519 Dongyue Dadao, Nanchang 330209 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for Molecular Diagnosis and Precision Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University , 1519 Dongyue Dadao, Nanchang 330209 ,","place":["China"]},{"name":"Jiangxi Provincial Center for Advanced Diagnostic Technology and Precision Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University , 1519 Dongyue Dadao, Nanchang 330209 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Molecular Diagnosis and Precision 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