{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:51:54Z","timestamp":1789480314975,"version":"build-2803163510"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["T32 GM145438"],"award-info":[{"award-number":["T32 GM145438"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["T32 GM007491"],"award-info":[{"award-number":["T32 GM007491"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["R35 GM147416"],"award-info":[{"award-number":["R35 GM147416"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology Minority Graduate Student Award","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liang Zhu Fellowship","award":["2020\/14368-3"],"award-info":[{"award-number":["2020\/14368-3"]}]},{"name":"Liang Zhu Fellowship","award":["2022\/14025-4"],"award-info":[{"award-number":["2022\/14025-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Overnutrition and the consumption of Western-type diets lead to chronic low-grade systemic inflammation (ie metainflammation) and a dysfunctional immune response. Although neutrophils are affected by metainflammation, mechanistic evidence regarding the direct effects of dietary fat exposure on neutrophil function and migration in vivo, particularly in response to injury, remains limited. Here, we investigated how metainflammation induced by a high-cholesterol diet (HCD) influences neutrophil function and migration following tissue injury. We employed a tailfin transection model in juvenile zebrafish larvae with fluorescently tagged neutrophils fed an HCD and assessed neutrophil function and migration dynamics in vivo at the injury site and whole animal. We combined long-term, noninvasive intravital confocal microscopy with computational analysis to examine neutrophil behavior, and photoconversion techniques to track neutrophil mobilization across the larvae. Exposure to HCD resulted in a dysfunctional neutrophil response characterized by exacerbated recruitment, increased reactive oxygen species production and NETosis, impaired apoptosis, and delayed inflammation resolution. Neutrophil forward and reverse migration were also significantly impacted at the injury site. Moreover, we identified diet-inflamed regions such as the liver and intestine as sources of activated neutrophils that reverse migrate and respond to injuries at distant sites, contributing to interorgan transmission of inflammation. Finally, ameliorating steatosis and systemic chronic inflammation rescued the exaggerated neutrophil recruitment to injury. Overall, our study highlights the crucial role of neutrophil dysregulation and reverse migration from diet-induced inflamed tissues in driving exacerbated and dysfunctional inflammatory responses to injury, providing insight into potential therapeutic strategies to alleviate these effects in metabolic disease context.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf094","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T07:39:04Z","timestamp":1750750744000},"source":"Crossref","is-referenced-by-count":4,"title":["Metainflammation alters neutrophil function and migration in vivo in response to tissue injury"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1021-8754","authenticated-orcid":false,"given":"Cassia","family":"Michael","sequence":"first","affiliation":[{"name":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-3623","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Cant\u00f3n-Sandoval","sequence":"additional","affiliation":[{"name":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-6647","authenticated-orcid":false,"given":"Mar\u00eda","family":"Feliz-Norberto","sequence":"additional","affiliation":[{"name":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4614-669X","authenticated-orcid":false,"given":"Pablo","family":"Scharf","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of S\u00e3o Paulo , S\u00e3o Paulo 05508-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-111X","authenticated-orcid":false,"given":"Sofia","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]},{"name":"Department of Medicine (Hepatology), Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]},{"name":"Harold and Muriel Block Institute for Clinical and Translational Research, Albert Einstein College of Medicine and Montefiore Medical Center , 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]},{"name":"Marion Bessin Liver Research Center, Albert Einstein College of Medicine and Montefiore Medical Center , 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]},{"name":"Montefiore-Einstein Comprehensive Cancer Research Center, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]},{"name":"Cancer Dormancy Institute, Albert Einstein College of Medicine , 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]},{"name":"Marilyn and Stanley M. Katz Institute for Immunotherapy for Cancer and Inflammatory Disorders, 1300 Morris Park Avenue, Bronx, NY 10461 ,","place":["United States"]},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin Madison , 1550 Linden Dr, Madison, WI 53706 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"2025112611522179600_qiaf094-B1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.3389\/fimmu.2016.00490","article-title":"Immune imbalances in non-alcoholic fatty liver disease: from general biomarkers and neutrophils to interleukin-17 axis activation and new therapeutic targets","volume":"7","author":"Paquissi","year":"2016","journal-title":"Front Immunol"},{"key":"2025112611522179600_qiaf094-B2","doi-asserted-by":"publisher","first-page":"5556354","DOI":"10.1155\/2021\/5556354","article-title":"NAFLD and infection, a nuanced 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