{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:45:30Z","timestamp":1775245530352,"version":"3.50.1"},"reference-count":171,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["2022YFS0235"],"award-info":[{"award-number":["2022YFS0235"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pediatric sepsis has constantly increased over the world, and is now a leading cause of children's morbidity and mortality. Due to this alarming trend, intense research has been sparked into the unique characteristics of pediatric sepsis, the mechanisms behind the immune dysfunction, and opportunities for improving treatment. Recent findings have underscored the critical role of \u03b3\u03b4 T cells in the immune response, and their dysfunction has been linked to various diseases, including pediatric sepsis. This review explores \u03b3\u03b4 T-cell dysfunction in pediatric sepsis, focusing on their impaired activation, proliferation, altered cytokine production, exhaustion, and apoptosis, all of which collectively weaken the immune response in children. The review underscores the significance of \u03b3\u03b4 T-cell immunology in pediatric sepsis and highlights the notable functional disparities between children and adults. Ongoing research is essential to fully understand the role of \u03b3\u03b4 T cells in the pathogenesis of sepsis and to develop more effective treatments that will enhance outcomes for affected children.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf118","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T19:32:02Z","timestamp":1755027122000},"source":"Crossref","is-referenced-by-count":1,"title":["\u03b3\u03b4 T cells in pediatric sepsis"],"prefix":"10.1093","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4434-2523","authenticated-orcid":false,"given":"Wenjie","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, West China Second University Hospital, Sichuan University , No. 20, Section 3, Ren Min Nan Lu, Chengdu 610041, Sichuan ,","place":["China"]},{"name":"Center of Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University , No. 20, Section 3, Ren Min Nan Lu, Chengdu 610041, Sichuan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Feng","sequence":"additional","affiliation":[{"name":"Center of Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University , No. 20, Section 3, Ren Min Nan Lu, Chengdu 610041, Sichuan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liman","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital of Sichuan University , Chengdu, Sichuan Province, No. 17, Guo Xue Xiang, Chengdu 610041, Sichuan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3903-4368","authenticated-orcid":false,"given":"Zhuoxu","family":"He","sequence":"additional","affiliation":[{"name":"Center of Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University , No. 20, Section 3, Ren Min Nan Lu, Chengdu 610041, Sichuan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueli","family":"Mu","sequence":"additional","affiliation":[{"name":"Center of Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University , No. 20, Section 3, Ren Min Nan Lu, Chengdu 610041, Sichuan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-6038","authenticated-orcid":false,"given":"Dong","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University , No. 20, Section 3, Ren Min Nan Lu, Chengdu 610041, Sichuan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7948-0171","authenticated-orcid":false,"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University , No. 20, Section 3, Ren Min Nan Lu, Chengdu 610041, Sichuan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"2025082903465297300_qiaf118-B1","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/S2352-4642(24)00140-8","article-title":"The burden and contemporary epidemiology of sepsis in children","volume":"8","author":"Watson","year":"2024","journal-title":"Lancet Child Adolesc Health"},{"key":"2025082903465297300_qiaf118-B2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"2025082903465297300_qiaf118-B3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12887-018-1364-8","article-title":"Evaluation of systemic inflammatory response syndrome-negative sepsis from a Chinese regional pediatric network","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Pediatr"},{"key":"2025082903465297300_qiaf118-B4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1556\/1886.2019.00011","article-title":"Immune response in bacterial and Candida sepsis","volume":"9","author":"Patricio","year":"2019","journal-title":"Eur J Microbiol Immunol (Bp)."},{"key":"2025082903465297300_qiaf118-B5","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.3390\/biom13091332","article-title":"Infection, inflammation, and immunity in sepsis","volume":"13","author":"Das","year":"2023","journal-title":"Biomolecules"},{"key":"2025082903465297300_qiaf118-B6","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1097\/JS9.0000000000000789","article-title":"Neutrophil membrane engineered Panax ginseng root derived exosomes loaded miRNA 182-5p targets NOX4\/Drp-1\/NLRP3 signal pathway to alleviate acute lung injury in sepsis: experimental studies","volume":"110","author":"Ma","year":"2023","journal-title":"Int J Surg"},{"key":"2025082903465297300_qiaf118-B7","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1007\/s10753-023-01897-0","article-title":"PD-L1 Blockade improves survival in sepsis by reversing monocyte dysfunction and immune disorder","volume":"47","author":"Yang","year":"2024:","journal-title":"Inflammation"},{"key":"2025082903465297300_qiaf118-B8","doi-asserted-by":"publisher","first-page":"1101918","DOI":"10.3389\/fimmu.2023.1101918","article-title":"Natural killer cells in sepsis: friends or foes?","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B9","doi-asserted-by":"publisher","first-page":"1257572","DOI":"10.3389\/fimmu.2023.1257572","article-title":"Comprehensive single-cell analysis reveals novel anergic antigen-presenting cell subtypes in human sepsis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B10","doi-asserted-by":"publisher","first-page":"3756","DOI":"10.1016\/j.apsb.2023.06.012","article-title":"Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages","volume":"13","author":"Fang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"2025082903465297300_qiaf118-B11","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/cmi.2012.43","article-title":"\u03b3\u03b4-T cells: an unpolished sword in human anti-infection immunity","volume":"10","author":"Zheng","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"2025082903465297300_qiaf118-B12","first-page":"13","article-title":"Achievements in the field of pediatrics over the last 50 years and the prospects of its development in the Ukraine","volume":"51","author":"Luk'ianova","year":"1972","journal-title":"Pediatriia"},{"key":"2025082903465297300_qiaf118-B13","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","article-title":"International Pediatric Sepsis Consensus Conference: definitions for sepsis and organ dysfunction in pediatrics","volume":"6","author":"Goldstein","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"2025082903465297300_qiaf118-B14","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1002\/emp2.12173","article-title":"Updates on pediatric sepsis","volume":"1","author":"Cruz","year":"2020","journal-title":"J Am Coll Emerg Physicians Open"},{"key":"2025082903465297300_qiaf118-B15","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1001\/jama.2016.0289","article-title":"Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Shankar-Hari","year":"2016","journal-title":"JAMA"},{"issue":"8","key":"2025082903465297300_qiaf118-B16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1001\/jama.2024.0179","article-title":"International consensus criteria for pediatric sepsis and septic shock","volume":"331","author":"Schlapbach","year":"2024","journal-title":"JAMA"},{"key":"2025082903465297300_qiaf118-B17","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/SHK.0000000000000857","article-title":"Phenotypic changes and impaired function of peripheral gammadelta T cells in patients with sepsis","volume":"48","author":"Liao","year":"2017","journal-title":"Shock"},{"key":"2025082903465297300_qiaf118-B18","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ccm.2016.01.018","article-title":"Early identification and treatment of pathogens in sepsis: molecular diagnostics and antibiotic choice","volume":"37","author":"Riedel","year":"2016","journal-title":"Clin Chest Med"},{"key":"2025082903465297300_qiaf118-B19","doi-asserted-by":"publisher","first-page":"14919","DOI":"10.1038\/ncomms14919","article-title":"IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population","volume":"8","author":"Nascimento","year":"2017","journal-title":"Nat Commun"},{"key":"2025082903465297300_qiaf118-B20","doi-asserted-by":"publisher","first-page":"R1338","DOI":"10.1152\/ajpregu.00283.2006","article-title":"Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis","volume":"291","author":"Chung","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2025082903465297300_qiaf118-B21","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2025082903465297300_qiaf118-B22","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1038\/s41390-021-01749-3","article-title":"Neonatal sepsis definitions from randomised clinical trials","volume":"93","author":"Hayes","year":"2023","journal-title":"Pediatr Res"},{"key":"2025082903465297300_qiaf118-B23","doi-asserted-by":"publisher","first-page":"269681","DOI":"10.1155\/2014\/269681","article-title":"Neonatal sepsis and inflammatory mediators","volume":"2014","author":"Machado","year":"2014","journal-title":"Mediators Inflamm"},{"key":"2025082903465297300_qiaf118-B24","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/SHK.0000000000001943","article-title":"Impaired lymphocyte responses in pediatric sepsis vary by pathogen type and are associated with features of immunometabolic dysregulation","volume":"57","author":"Lindell","year":"2022","journal-title":"Shock"},{"key":"2025082903465297300_qiaf118-B25","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fimmu.2015.00020","article-title":"Gammadelta T lymphocytes in the diagnosis of human T cell receptor immunodeficiencies","volume":"6","author":"Garcillan","year":"2015","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cellimm.2015.04.008","article-title":"Human gamma delta T cells: evolution and ligand recognition","volume":"296","author":"Adams","year":"2015","journal-title":"Cell Immunol"},{"key":"2025082903465297300_qiaf118-B27","doi-asserted-by":"publisher","first-page":"8903","DOI":"10.3390\/ijms21238903","article-title":"A cell for the ages: human gammadelta T cells across the lifespan","volume":"21","author":"Clark","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025082903465297300_qiaf118-B28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-immunol-032713-120216","article-title":"Gammadelta T cells: first line of defense and beyond","volume":"32","author":"Chien","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"2025082903465297300_qiaf118-B29","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.3389\/fimmu.2018.02389","article-title":"Gammadelta T lymphocytes: an effector cell in autoimmunity and infection","volume":"9","author":"Shiromizu","year":"2018","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B30","doi-asserted-by":"publisher","first-page":"928441","DOI":"10.3389\/fimmu.2022.928441","article-title":"Role of Vgamma9vdelta2 T lymphocytes in infectious diseases","volume":"13","author":"Gay","year":"2022","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B31","doi-asserted-by":"publisher","first-page":"18638","DOI":"10.1073\/pnas.1922595117","article-title":"Fetal public Vgamma9Vdelta2 T cells expand and gain potent cytotoxic functions early after birth","volume":"117","author":"Papadopoulou","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025082903465297300_qiaf118-B32","doi-asserted-by":"publisher","first-page":"E556","DOI":"10.1073\/pnas.1412058112","article-title":"Effector Vgamma9Vdelta2 T cells dominate the human fetal gammadelta T-cell repertoire","volume":"112","author":"Dimova","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025082903465297300_qiaf118-B33","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3390\/cells9040800","article-title":"Human gammadelta TCR repertoires in health and disease","volume":"9","author":"Fichtner","year":"2020","journal-title":"Cells"},{"key":"2025082903465297300_qiaf118-B34","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1084\/jem.20090348","article-title":"Human cytomegalovirus elicits fetal gammadelta T cell responses in utero","volume":"207","author":"Vermijlen","year":"2010","journal-title":"J Exp Med"},{"key":"2025082903465297300_qiaf118-B35","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.jaci.2018.04.022","article-title":"Reference values for peripheral blood lymphocyte subsets of healthy children in China","volume":"142","author":"Ding","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"2025082903465297300_qiaf118-B36","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1651-2227.1992.tb12187.x","article-title":"Blood T and B lymphocyte subpopulations in healthy infants and children","volume":"81","author":"Heldrup","year":"1992","journal-title":"Acta Paediatr"},{"key":"2025082903465297300_qiaf118-B37","doi-asserted-by":"publisher","first-page":"5603566","DOI":"10.1155\/2022\/5603566","article-title":"Establishing reference values for peripheral blood lymphocyte subsets of healthy children in China using a single platform","volume":"2022","author":"Zhang","year":"2022","journal-title":"J Immunol Res"},{"key":"2025082903465297300_qiaf118-B38","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/imcb.12594","article-title":"A high-dimensional cytometry atlas of peripheral blood over the human life span","volume":"100","author":"Jalali","year":"2022","journal-title":"Immunol Cell Biol"},{"key":"2025082903465297300_qiaf118-B39","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.4049\/jimmunol.172.3.1637","article-title":"Ontogeny of gamma delta T cells in humans","volume":"172","author":"Rosa","year":"2004","journal-title":"J Immunol"},{"key":"2025082903465297300_qiaf118-B40","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.4049\/jimmunol.1900592","article-title":"TCR Sequencing reveals the distinct development of fetal and adult human Vgamma9Vdelta2 T cells","volume":"203","author":"Papadopoulou","year":"2019","journal-title":"J Immunol"},{"key":"2025082903465297300_qiaf118-B41","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.3892\/etm.2020.8615","article-title":"Characterization of human peripheral blood gammadelta T cells in patients with sepsis","volume":"19","author":"Wang","year":"2020","journal-title":"Exp Ther Med"},{"key":"2025082903465297300_qiaf118-B42","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/BF01552310","article-title":"Elevated numbers of gamma-delta (gamma delta+) T lymphocytes in children with immune thrombocytopenic purpura","volume":"14","author":"Ware","year":"1994","journal-title":"J Clin Immunol"},{"key":"2025082903465297300_qiaf118-B43","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1084\/jem.20171285","article-title":"Peripherally derived T regulatory and gammadelta T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy","volume":"215","author":"Xu","year":"2018","journal-title":"J Exp Med"},{"key":"2025082903465297300_qiaf118-B44","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.bbmt.2014.09.027","article-title":"Gamma delta T cell reconstitution is associated with fewer infections and improved event-free survival after hematopoietic stem cell transplantation for pediatric leukemia","volume":"21","author":"Perko","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"2025082903465297300_qiaf118-B45","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.immuni.2018.07.011","article-title":"Lung gammadelta T cells mediate protective responses during neonatal influenza infection that are associated with type 2 immunity","volume":"49","author":"Guo","year":"2018","journal-title":"Immunity"},{"key":"2025082903465297300_qiaf118-B46","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1038\/s41423-021-00720-w","article-title":"Self-activation of Vgamma9Vdelta2 T cells by exogenous phosphoantigens involves TCR and butyrophilins","volume":"18","author":"Laplagne","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"2025082903465297300_qiaf118-B47","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3390\/cells9040829","article-title":"Vgamma9Vdelta2 T cells: can we re-purpose a potent anti-infection mechanism for cancer therapy?","volume":"9","author":"Kunkele","year":"2020","journal-title":"Cells"},{"key":"2025082903465297300_qiaf118-B48","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1172\/JCI115053","article-title":"Selective expansion of human gamma delta T cells by monocytes infected with live Mycobacterium tuberculosis","volume":"87","author":"Havlir","year":"1991","journal-title":"J Clin Invest"},{"key":"2025082903465297300_qiaf118-B49","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1007\/s00018-011-0699-1","article-title":"Modulation of gammadelta T cell responses by TLR ligands","volume":"68","author":"Wesch","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"2025082903465297300_qiaf118-B50","doi-asserted-by":"publisher","first-page":"105210","DOI":"10.1016\/j.meegid.2022.105210","article-title":"Emerging role of gammadelta T cells in protozoan infection and their potential clinical application","volume":"98","author":"Kumar","year":"2022","journal-title":"Infect Genet Evol"},{"key":"2025082903465297300_qiaf118-B51","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.4049\/jimmunol.178.7.4304","article-title":"Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy","volume":"178","author":"Vermijlen","year":"2007","journal-title":"J Immunol"},{"key":"2025082903465297300_qiaf118-B52","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/cmi.2012.42","article-title":"Mechanisms underlying lineage commitment and plasticity of human gammadelta T cells","volume":"10","author":"Caccamo","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"2025082903465297300_qiaf118-B53","doi-asserted-by":"publisher","first-page":"18649","DOI":"10.1073\/pnas.1922588117","article-title":"Microbial exposure drives polyclonal expansion of innate gammadelta T cells immediately after birth","volume":"117","author":"Ravens","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025082903465297300_qiaf118-B54","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/s0014-5793(03)00483-6","article-title":"Microbial isoprenoid biosynthesis and human gammadelta T cell activation","volume":"544","author":"Eberl","year":"2003","journal-title":"FEBS Lett"},{"key":"2025082903465297300_qiaf118-B55","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41590-020-00847-4","article-title":"Gammadelta T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis","volume":"22","author":"Junqueira","year":"2021","journal-title":"Nat Immunol"},{"key":"2025082903465297300_qiaf118-B56","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/imcb.12303","article-title":"Characterization of the gammadelta T-cell compartment during infancy reveals clear differences between the early neonatal period and 2 yr of age","volume":"98","author":"van der Heiden","year":"2020","journal-title":"Immunol Cell Biol"},{"key":"2025082903465297300_qiaf118-B57","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3389\/fimmu.2018.00662","article-title":"Regulation of human gammadelta T cells by BTN3A1 protein stability and ATP-binding cassette transporters","volume":"9","author":"Rhodes","year":"2018","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B58","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.1038\/s41467-023-41938-8","article-title":"A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human gammadelta T cell phosphoantigen sensing","volume":"14","author":"Karunakaran","year":"2023","journal-title":"Nat Commun"},{"key":"2025082903465297300_qiaf118-B59","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1182\/blood-2012-05-430470","article-title":"Key implication of CD277\/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset","volume":"120","author":"Harly","year":"2012","journal-title":"Blood"},{"key":"2025082903465297300_qiaf118-B60","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.immuni.2014.03.003","article-title":"The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vgamma9Vdelta2 T cells","volume":"40","author":"Sandstrom","year":"2014","journal-title":"Immunity"},{"key":"2025082903465297300_qiaf118-B61","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41392-023-01653-8","article-title":"Gammadelta T cells: origin and fate, subsets, diseases and immunotherapy","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2025082903465297300_qiaf118-B62","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.smim.2010.04.004","article-title":"Human Vgamma9Vdelta2 T cells: from signals to functions","volume":"22","author":"Nedellec","year":"2010","journal-title":"Semin Immunol"},{"key":"2025082903465297300_qiaf118-B63","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"2025082903465297300_qiaf118-B64","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"2025082903465297300_qiaf118-B65","doi-asserted-by":"publisher","first-page":"4505","DOI":"10.1128\/IAI.00088-06","article-title":"Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-like receptor 2 agonist Pam3Cys","volume":"74","author":"Deetz","year":"2006","journal-title":"Infect Immun"},{"key":"2025082903465297300_qiaf118-B66","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.intimp.2018.03.002","article-title":"Toll-like receptors in immunity and inflammatory diseases: past, present, and future","volume":"59","author":"Vijay","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"2025082903465297300_qiaf118-B67","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3390\/microorganisms10030622","article-title":"Recent research in cell stress and microbial infection","volume":"10","author":"Trinh","year":"2022","journal-title":"Microorganisms"},{"key":"2025082903465297300_qiaf118-B68","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/s1074-7613(01)00168-6","article-title":"MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function","volume":"15","author":"Das","year":"2001","journal-title":"Immunity"},{"key":"2025082903465297300_qiaf118-B69","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3390\/microorganisms7090350","article-title":"Vdelta2 T-cells kill ZIKV-infected cells by NKG2D-mediated cytotoxicity","volume":"7","author":"Cimini","year":"2019","journal-title":"Microorganisms"},{"key":"2025082903465297300_qiaf118-B70","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.3892\/mmr.2019.9831","article-title":"Optimized protocols for gammadelta T cell expansion and lentiviral transduction","volume":"19","author":"Wang","year":"2019","journal-title":"Mol Med Rep"},{"key":"2025082903465297300_qiaf118-B71","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.4049\/jimmunol.1701618","article-title":"Sepsis-induced T cell immunoparalysis: the ins and outs of impaired T cell immunity","volume":"200","author":"Jensen","year":"2018","journal-title":"J Immunol"},{"key":"2025082903465297300_qiaf118-B72","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1002\/eji.201646837","article-title":"CD69: from activation marker to metabolic gatekeeper","volume":"47","author":"Cibrian","year":"2017","journal-title":"Eur J Immunol."},{"key":"2025082903465297300_qiaf118-B73","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.4049\/jimmunol.172.7.3983","article-title":"IL-2, regulatory T cells, and tolerance","volume":"172","author":"Nelson","year":"2004","journal-title":"J Immunol"},{"key":"2025082903465297300_qiaf118-B74","doi-asserted-by":"publisher","first-page":"621931","DOI":"10.3389\/fimmu.2020.621931","article-title":"Interleukin-1 as innate mediator of T cell immunity","volume":"11","author":"Van Den Eeckhout","year":"2021","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B75","first-page":"264","article-title":"Two types of septic shock classified by the plasma levels of cytokines and endotoxin","volume":"38","author":"Endo","year":"1992","journal-title":"Circ Shock"},{"key":"2025082903465297300_qiaf118-B76","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/cc1843","article-title":"Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit","volume":"7","author":"Balc","year":"2002","journal-title":"Crit Care"},{"key":"2025082903465297300_qiaf118-B77","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1182\/blood-2011-06-363655","article-title":"Antibody-dependent anti-cytomegalovirus activity of human gammadelta T cells expressing CD16 (FcgammaRIIIa)","volume":"119","author":"Couzi","year":"2012","journal-title":"Blood"},{"key":"2025082903465297300_qiaf118-B78","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/icb.2014.79","article-title":"Impaired gamma delta T cell-derived IL-17A and inflammasome activation during early respiratory syncytial virus infection in infants","volume":"93","author":"Huang","year":"2015","journal-title":"Immunol Cell Biol"},{"key":"2025082903465297300_qiaf118-B79","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1177\/0885066620912989","article-title":"Cytokine levels in critically ill children with severe sepsis and their relation with the severity of illness and mortality","volume":"36","author":"Angurana","year":"2021","journal-title":"J Intensive Care Med"},{"key":"2025082903465297300_qiaf118-B80","doi-asserted-by":"publisher","first-page":"156006","DOI":"10.1016\/j.cyto.2022.156006","article-title":"Proinflammatory cytokines levels in sepsis and healthy volunteers, and tumor necrosis factor-alpha associated sepsis mortality: a systematic review and meta-analysis","volume":"158","author":"Gharamti","year":"2022","journal-title":"Cytokine"},{"key":"2025082903465297300_qiaf118-B81","doi-asserted-by":"publisher","first-page":"901433","DOI":"10.3389\/fcimb.2022.901433","article-title":"Cytokines as potential biomarkers for differential diagnosis of sepsis and other non-septic disease conditions","volume":"12","author":"Frimpong","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2025082903465297300_qiaf118-B82","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1089\/jir.2012.0073","article-title":"Complex role of gammadelta T-cell-derived cytokines and growth factors in cancer","volume":"32","author":"Ramstead","year":"2012","journal-title":"J Interferon Cytokine Res"},{"key":"2025082903465297300_qiaf118-B83","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1465-9921-4-9","article-title":"Gammadelta T lymphocytes from cystic fibrosis patients and healthy donors are high TNF-alpha and IFN-gamma-producers in response to Pseudomonas aeruginosa","volume":"4","author":"Raga","year":"2003","journal-title":"Respir Res"},{"key":"2025082903465297300_qiaf118-B84","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/ni.1717","article-title":"CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets","volume":"10","author":"Ribot","year":"2009","journal-title":"Nat Immunol"},{"key":"2025082903465297300_qiaf118-B85","doi-asserted-by":"publisher","first-page":"5081634","DOI":"10.1155\/2018\/5081634","article-title":"Protective role of gammadelta T cells in different pathogen infections and its potential clinical application","volume":"2018","author":"Zhao","year":"2018","journal-title":"J Immunol Res"},{"key":"2025082903465297300_qiaf118-B86","doi-asserted-by":"publisher","first-page":"E48","DOI":"10.1542\/peds.107.4.e48","article-title":"High levels of interferon gamma in the plasma of children with complete interferon gamma receptor deficiency","volume":"107","author":"Fieschi","year":"2001","journal-title":"Pediatrics"},{"key":"2025082903465297300_qiaf118-B87","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/cmi.2010.50","article-title":"Current progress in gammadelta T-cell biology","volume":"7","author":"Hao","year":"2010","journal-title":"Cell Mol Immunol"},{"key":"2025082903465297300_qiaf118-B88","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFNgamma: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"2025082903465297300_qiaf118-B89","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12879-020-4910-6","article-title":"Evaluation of TNF-alpha genetic polymorphisms as predictors for sepsis susceptibility and progression","volume":"20","author":"Georgescu","year":"2020","journal-title":"BMC Infect Dis"},{"key":"2025082903465297300_qiaf118-B90","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1684\/ecn.2018.0414","article-title":"Cytokine and molecular networks in sepsis cases: a network biology approach","volume":"29","author":"Jekarl","year":"2018","journal-title":"Eur Cytokine Netw"},{"key":"2025082903465297300_qiaf118-B91","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1189\/jlb.0509307","article-title":"The role of interferon-gamma in the pathogenesis of acute intra-abdominal sepsis","volume":"88","author":"Romero","year":"2010","journal-title":"J Leukoc Biol"},{"key":"2025082903465297300_qiaf118-B92","doi-asserted-by":"publisher","first-page":"940930","DOI":"10.3389\/fimmu.2022.940930","article-title":"The neonatal innate immune response to sepsis: checkpoint proteins as novel mediators of this response and as possible therapeutic\/diagnostic levers","volume":"13","author":"Hensler","year":"2022","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B93","doi-asserted-by":"publisher","first-page":"5174","DOI":"10.1182\/bloodadvances.2020002592","article-title":"Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children","volume":"4","author":"Diorio","year":"2020","journal-title":"Blood Adv"},{"key":"2025082903465297300_qiaf118-B94","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41390-021-01879-8","article-title":"Mechanisms and modulation of sepsis-induced immune dysfunction in children","volume":"91","author":"Mithal","year":"2022","journal-title":"Pediatr Res"},{"key":"2025082903465297300_qiaf118-B95","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1164\/rccm.201710-2006OC","article-title":"Early immune function and duration of organ dysfunction in critically III children with sepsis","volume":"198","author":"Muszynski","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"2025082903465297300_qiaf118-B96","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s10020-023-00690-x","article-title":"Interferon-gamma regulates immunosuppression in septic mice by promoting the Warburg effect through the PI3K\/AKT\/mTOR pathway","volume":"29","author":"Fu","year":"2023","journal-title":"Mol Med"},{"key":"2025082903465297300_qiaf118-B97","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.cyto.2012.11.016","article-title":"Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock","volume":"61","author":"Kothari","year":"2013","journal-title":"Cytokine"},{"key":"2025082903465297300_qiaf118-B98","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1203\/00006450-199708000-00018","article-title":"Cytokine production differs in children and adults","volume":"42","author":"Lilic","year":"1997","journal-title":"Pediatr Res"},{"key":"2025082903465297300_qiaf118-B99","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3389\/fped.2017.00255","article-title":"Influence of age and other factors on cytokine expression profiles in healthy children-A systematic review","volume":"5","author":"Decker","year":"2017","journal-title":"Front Pediatr"},{"key":"2025082903465297300_qiaf118-B100","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"2025082903465297300_qiaf118-B101","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1182\/blood.V83.1.113.113","article-title":"Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55","volume":"83","author":"Tilg","year":"1994","journal-title":"Blood"},{"key":"2025082903465297300_qiaf118-B102","doi-asserted-by":"publisher","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2025082903465297300_qiaf118-B103","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3892\/mmr.2014.2796","article-title":"Novel IL-6-secreting gammadeltaT cells increased in patients with atherosclerotic cerebral infarction","volume":"11","author":"He","year":"2015","journal-title":"Mol Med Rep"},{"key":"2025082903465297300_qiaf118-B104","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000505099","article-title":"Interleukin-6: a masterplayer in the cytokine network","volume":"98","author":"Uciechowski","year":"2020","journal-title":"Oncology"},{"key":"2025082903465297300_qiaf118-B105","first-page":"15238","article-title":"Accuracy of serum interleukin (IL)-6 in sepsis diagnosis: a systematic review and meta-analysis","volume":"8","author":"Hou","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"2025082903465297300_qiaf118-B106","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1038\/s41390-022-02329-9","article-title":"Cut-off values of serum interleukin-6 for culture-confirmed sepsis in neonates","volume":"93","author":"Kung","year":"2023","journal-title":"Pediatr Res"},{"key":"2025082903465297300_qiaf118-B107","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cyto.2016.08.033","article-title":"Role of interleukin-6 to differentiate sepsis from non-infectious systemic inflammatory response syndrome","volume":"88","author":"Ma","year":"2016","journal-title":"Cytokine"},{"key":"2025082903465297300_qiaf118-B108","doi-asserted-by":"publisher","first-page":"8201585","DOI":"10.1155\/2020\/8201585","article-title":"Diagnostic and prognostic value of IL-6 and sTREM-1 in SIRS and sepsis in children","volume":"2020","author":"Smok","year":"2020","journal-title":"Mediators Inflamm"},{"key":"2025082903465297300_qiaf118-B109","doi-asserted-by":"publisher","first-page":"840778","DOI":"10.3389\/fped.2022.840778","article-title":"Reliability of interleukin-6 alone and in combination for diagnosis of early onset neonatal sepsis: systematic review","volume":"10","author":"Eichberger","year":"2022","journal-title":"Front Pediatr"},{"key":"2025082903465297300_qiaf118-B110","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1556\/1646.2020.00006","article-title":"Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock","volume":"11","author":"Vivas","year":"2021","journal-title":"Interv Med Appl Sci"},{"key":"2025082903465297300_qiaf118-B111","doi-asserted-by":"publisher","first-page":"165974","DOI":"10.1155\/2013\/165974","article-title":"Cytokines in sepsis: potent immunoregulators and potential therapeutic targets\u2013an updated view","volume":"2013","author":"Schulte","year":"2013","journal-title":"Mediators Inflamm"},{"key":"2025082903465297300_qiaf118-B112","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41577-022-00746-9","article-title":"IL-17 and IL-17-producing cells in protection versus pathology","volume":"23","author":"Mills","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"2025082903465297300_qiaf118-B113","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1002\/eji.201242569","article-title":"IL-17-producing gammadelta T cells and innate lymphoid cells","volume":"42","author":"Sutton","year":"2012","journal-title":"Eur J Immunol"},{"key":"2025082903465297300_qiaf118-B114","doi-asserted-by":"publisher","first-page":"3664","DOI":"10.1002\/jcb.27644","article-title":"Interleukin 17 is an important pathogenicity gene in pediatric sepsis","volume":"120","author":"Han","year":"2019","journal-title":"J Cell Biochem"},{"key":"2025082903465297300_qiaf118-B115","doi-asserted-by":"publisher","first-page":"7268","DOI":"10.4049\/jimmunol.1000600","article-title":"Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells","volume":"184","author":"Ness-Schwickerath","year":"2010","journal-title":"J Immunol"},{"key":"2025082903465297300_qiaf118-B116","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1182\/blood-2011-01-331298","article-title":"Differentiation, phenotype, and function of interleukin-17-producing human Vgamma9Vdelta2 T cells","volume":"118","author":"Caccamo","year":"2011","journal-title":"Blood"},{"key":"2025082903465297300_qiaf118-B117","doi-asserted-by":"publisher","first-page":"17549","DOI":"10.1073\/pnas.1204327109","article-title":"Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells","volume":"109","author":"Michel","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025082903465297300_qiaf118-B118","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1189\/jlb.0910501","article-title":"IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17","volume":"89","author":"Moens","year":"2011","journal-title":"J Leukoc Biol"},{"key":"2025082903465297300_qiaf118-B119","doi-asserted-by":"publisher","first-page":"5290","DOI":"10.4049\/jimmunol.177.8.5290","article-title":"CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production","volume":"177","author":"Caccamo","year":"2006","journal-title":"J Immunol"},{"key":"2025082903465297300_qiaf118-B120","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12865-017-0216-x","article-title":"GammadeltaTFH cells promote B cell maturation and antibody production in neuroblastoma","volume":"18","author":"Mou","year":"2017","journal-title":"BMC Immunol"},{"key":"2025082903465297300_qiaf118-B121","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1615\/critrevimmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"Iyer","year":"2012","journal-title":"Crit Rev Immunol"},{"key":"2025082903465297300_qiaf118-B122","doi-asserted-by":"publisher","first-page":"27158","DOI":"10.1074\/jbc.M115.682708","article-title":"Interleukin 10 (IL-10)-mediated Immunosuppression: MARCH-I INDUCTION REGULATES ANTIGEN PRESENTATION BY MACROPHAGES BUT NOT DENDRITIC CELLS","volume":"290","author":"Mittal","year":"2015","journal-title":"J Biol Chem"},{"key":"2025082903465297300_qiaf118-B123","doi-asserted-by":"publisher","first-page":"1043968","DOI":"10.3389\/fimmu.2022.1043968","article-title":"Evaluating IL-6 and IL-10 as rapid diagnostic tools for Gram-negative bacteria and as disease severity predictors in pediatric sepsis patients in the intensive care unit","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B124","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1086\/315214","article-title":"Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options","volume":"181","author":"Gogos","year":"2000","journal-title":"J Infect Dis"},{"key":"2025082903465297300_qiaf118-B125","doi-asserted-by":"publisher","first-page":"e0179050","DOI":"10.1371\/journal.pone.0179050","article-title":"Interleukin-10\/lymphocyte ratio predicts mortality in severe septic patients","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"2025082903465297300_qiaf118-B126","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/s0006-291x(03)01482-7","article-title":"Susceptibility to programmed cell death in T-lymphocytes from septic patients: a mechanism for lymphopenia and Th2 predominance","volume":"308","author":"Roth","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"2025082903465297300_qiaf118-B127","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jcrc.2007.11.008","article-title":"The interleukin-4 expression in patients with severe sepsis","volume":"23","author":"Wu","year":"2008","journal-title":"J Crit Care"},{"key":"2025082903465297300_qiaf118-B128","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/j.1365-2567.2009.03162.x","article-title":"Human peripheral gammadelta T cells possess regulatory potential","volume":"128","author":"Kuhl","year":"2009","journal-title":"Immunology"},{"key":"2025082903465297300_qiaf118-B129","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/s41551-023-01050-0","article-title":"Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells","volume":"7","author":"Schrijver","year":"2023","journal-title":"Nat Biomed Eng"},{"key":"2025082903465297300_qiaf118-B130","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1093\/infdis\/jiu668","article-title":"Interleukin 4 deficiency reverses development of secondary Pseudomonas aeruginosa pneumonia during sepsis-associated immunosuppression","volume":"211","author":"Song","year":"2015","journal-title":"J Infect Dis"},{"key":"2025082903465297300_qiaf118-B131","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor beta in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N Engl J Med"},{"key":"2025082903465297300_qiaf118-B132","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3109\/14653249.2011.553595","article-title":"Human Vdelta1 gammadelta T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells","volume":"13","author":"Siegers","year":"2011","journal-title":"Cytotherapy"},{"key":"2025082903465297300_qiaf118-B133","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1001\/archsurg.1993.01420130101015","article-title":"Role of interleukin 6 and transforming growth factor-beta in the induction of depressed splenocyte responses following sepsis","volume":"128","author":"Ayala","year":"1993","journal-title":"Arch Surg"},{"key":"2025082903465297300_qiaf118-B134","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1164\/rccm.201311-2033OC","article-title":"Transforming growth factor beta-induced protein promotes severe vascular inflammatory responses","volume":"189","author":"Bae","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"2025082903465297300_qiaf118-B135","doi-asserted-by":"publisher","first-page":"520","DOI":"10.7326\/0003-4819-125-6-199609150-00034","article-title":"Elevated levels of circulating transforming growth factor-beta 1 in patients with the sepsis syndrome","volume":"125","author":"Marie","year":"1996","journal-title":"Ann Intern Med"},{"key":"2025082903465297300_qiaf118-B136","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.imlet.2004.07.009","article-title":"The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration","volume":"95","author":"Monneret","year":"2004","journal-title":"Immunol Lett"},{"key":"2025082903465297300_qiaf118-B137","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1182\/blood-2012-07-446146","article-title":"Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack","volume":"121","author":"Lopez","year":"2013","journal-title":"Blood"},{"key":"2025082903465297300_qiaf118-B138","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.3389\/fimmu.2020.01839","article-title":"Perforins expression by cutaneous gamma delta T cells","volume":"11","author":"O'Neill","year":"2020","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B139","doi-asserted-by":"publisher","first-page":"11906","DOI":"10.1073\/pnas.1818488116","article-title":"Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVdelta1 and TCRVdelta2 gammadelta T lymphocytes","volume":"116","author":"Pizzolato","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025082903465297300_qiaf118-B140","doi-asserted-by":"publisher","first-page":"3439025","DOI":"10.1155\/2018\/3439025","article-title":"Differentiation and function of T cell subsets in infectious diseases","volume":"2018","author":"Liang","year":"2018","journal-title":"J Immunol Res"},{"key":"2025082903465297300_qiaf118-B141","doi-asserted-by":"publisher","first-page":"e138066","DOI":"10.1172\/jci.insight.138066","article-title":"Effector Vgamma9Vdelta2 T cell response to congenital Toxoplasma gondii infection","volume":"6","author":"Ma","year":"2021","journal-title":"JCI Insight"},{"key":"2025082903465297300_qiaf118-B142","doi-asserted-by":"publisher","first-page":"e13102","DOI":"10.1111\/sji.13102","article-title":"Perforin, COVID-19 and a possible pathogenic auto-inflammatory feedback loop","volume":"94","author":"Cunningham","year":"2021","journal-title":"Scand J Immunol"},{"key":"2025082903465297300_qiaf118-B143","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.virol.2006.08.044","article-title":"Protection against polyoma virus-induced tumors is perforin-independent","volume":"358","author":"Byers","year":"2007","journal-title":"Virology"},{"key":"2025082903465297300_qiaf118-B144","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.4049\/jimmunol.169.9.5202","article-title":"Perforin-mediated CTL cytolysis counteracts direct cell-cell spread of Listeria monocytogenes","volume":"169","author":"San Mateo","year":"2002","journal-title":"J Immunol"},{"key":"2025082903465297300_qiaf118-B145","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s12985-020-01449-0","article-title":"Role of gammadelta T cells in controlling viral infections with a focus on influenza virus: implications for designing novel therapeutic approaches","volume":"17","author":"Sabbaghi","year":"2020","journal-title":"Virol J"},{"key":"2025082903465297300_qiaf118-B146","doi-asserted-by":"publisher","first-page":"6035","DOI":"10.1038\/s41467-023-41634-7","article-title":"Modulation of lytic molecules restrain serial killing in gammadelta T lymphocytes","volume":"14","author":"Sandoz","year":"2023","journal-title":"Nat Commun"},{"key":"2025082903465297300_qiaf118-B147","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3389\/fimmu.2013.00441","article-title":"Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function","volume":"4","author":"Voskoboinik","year":"2013","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B148","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/bs.mie.2019.07.034","article-title":"Distinguishing perforin-mediated lysis and granzyme-dependent apoptosis","volume":"629","author":"Rudd-Schmidt","year":"2019","journal-title":"Methods Enzymol"},{"key":"2025082903465297300_qiaf118-B149","doi-asserted-by":"publisher","first-page":"e24838","DOI":"10.1002\/jcla.24838","article-title":"Baseline red blood cell distribution width and perforin, dynamic levels of interleukin 6 and lactate are predictors of mortality in patients with sepsis","volume":"37","author":"Li","year":"2023","journal-title":"J Clin Lab Anal"},{"key":"2025082903465297300_qiaf118-B150","doi-asserted-by":"publisher","first-page":"16084","DOI":"10.1038\/cddiscovery.2016.84","article-title":"Granzymes A and K differentially potentiate LPS-induced cytokine response","volume":"2","author":"Wensink","year":"2016","journal-title":"Cell Death Discov"},{"key":"2025082903465297300_qiaf118-B151","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.clim.2005.03.006","article-title":"Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction","volume":"116","author":"Zeerleder","year":"2005","journal-title":"Clin Immunol"},{"key":"2025082903465297300_qiaf118-B152","doi-asserted-by":"publisher","first-page":"e24216","DOI":"10.1371\/journal.pone.0024216","article-title":"Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity","volume":"6","author":"Hollestelle","year":"2011","journal-title":"PLoS One"},{"key":"2025082903465297300_qiaf118-B153","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.3389\/fimmu.2020.01054","article-title":"The multifaceted function of granzymes in sepsis: some facts and a lot to discover","volume":"11","author":"Garzon-Tituana","year":"2020","journal-title":"Front Immunol"},{"key":"2025082903465297300_qiaf118-B154","doi-asserted-by":"publisher","first-page":"115694","DOI":"10.1016\/j.diagmicrobio.2022.115694","article-title":"High mortality rate of septic patients with high blood granzyme B concentrations","volume":"103","author":"Lorente","year":"2022","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2025082903465297300_qiaf118-B155","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/cei.13601","article-title":"Intracellular expression of granzymes A, B, K and M in blood lymphocyte subsets of critically ill patients with or without sepsis","volume":"205","author":"Garcia-Laorden","year":"2021","journal-title":"Clin Exp Immunol"},{"key":"2025082903465297300_qiaf118-B156","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1084\/jem.191.6.937","article-title":"Self-recognition of CD1 by gamma\/delta T cells: implications for innate immunity","volume":"191","author":"Spada","year":"2000","journal-title":"J Exp Med"},{"key":"2025082903465297300_qiaf118-B157","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12865-023-00588-7","article-title":"Screening of four lysosome-related genes in sepsis based on RNA sequencing technology","volume":"24","author":"Chen","year":"2023","journal-title":"BMC Immunol"},{"key":"2025082903465297300_qiaf118-B158","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1002\/eji.200323977","article-title":"Granulysin in human serum as a marker of cell-mediated immunity","volume":"33","author":"Ogawa","year":"2003","journal-title":"Eur J Immunol"},{"key":"2025082903465297300_qiaf118-B159","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.coi.2019.04.013","article-title":"Granulysin: killer lymphocyte safeguard against microbes","volume":"60","author":"Dotiwala","year":"2019","journal-title":"Curr Opin Immunol"},{"key":"2025082903465297300_qiaf118-B160","doi-asserted-by":"publisher","first-page":"92","DOI":"10.2174\/1874285800903010092","article-title":"Comparative antimicrobial activity of granulysin against bacterial biothreat agents","volume":"3","author":"Endsley","year":"2009","journal-title":"Open Microbiol J"},{"key":"2025082903465297300_qiaf118-B161","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.cell.2017.10.004","article-title":"Granzyme B disrupts central metabolism and protein synthesis in bacteria to promote an immune cell death program","volume":"171","author":"Dotiwala","year":"2017","journal-title":"Cell"},{"key":"2025082903465297300_qiaf118-B162","doi-asserted-by":"publisher","first-page":"5243","DOI":"10.4049\/jimmunol.174.9.5243","article-title":"Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator","volume":"174","author":"Deng","year":"2005","journal-title":"J Immunol"},{"key":"2025082903465297300_qiaf118-B163","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/imm.13248","article-title":"The cytotoxic molecule granulysin is capable of inducing either chemotaxis or fugetaxis in dendritic cells depending on maturation: a role for vdelta2(+) gammadelta T cells in the modulation of immune response to tumour?","volume":"161","author":"Sparrow","year":"2020","journal-title":"Immunology"},{"key":"2025082903465297300_qiaf118-B164","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1126\/science.1110267","article-title":"Professional antigen-presentation function by human gammadelta T cells","volume":"309","author":"Brandes","year":"2005","journal-title":"Science"},{"key":"2025082903465297300_qiaf118-B165","doi-asserted-by":"publisher","first-page":"e0247669","DOI":"10.1371\/journal.pone.0247669","article-title":"Immune gene expression networks in sepsis: a network biology approach","volume":"16","author":"Kim","year":"2021","journal-title":"PLoS One"},{"key":"2025082903465297300_qiaf118-B166","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1093\/cei\/uxab029","article-title":"Impairment of antigen-presenting function of peripheral gammadelta T cells in patients with sepsis","volume":"207","author":"Yang","year":"2022","journal-title":"Clin Exp Immunol"},{"key":"2025082903465297300_qiaf118-B167","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.micinf.2019.04.002","article-title":"An imbalance of T cell subgroups exists in children with sepsis","volume":"21","author":"Ye","year":"2019","journal-title":"Microbes Infect"},{"key":"2025082903465297300_qiaf118-B168","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.it.2014.09.003","article-title":"Gammadelta T cell surveillance via CD1 molecules","volume":"35","author":"Luoma","year":"2014","journal-title":"Trends Immunol"},{"key":"2025082903465297300_qiaf118-B169","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.it.2006.01.002","article-title":"Gammadelta T cells: an alternative type of professional APC","volume":"27","author":"Moser","year":"2006","journal-title":"Trends Immunol"},{"key":"2025082903465297300_qiaf118-B170","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/s41419-019-2015-1","article-title":"Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis","volume":"10","author":"Cao","year":"2019","journal-title":"Cell Death Dis"},{"key":"2025082903465297300_qiaf118-B171","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nri797","article-title":"Gammadelta T cells: functional plasticity and heterogeneity","volume":"2","author":"Carding","year":"2002","journal-title":"Nat Rev Immunol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiaf118\/63974805\/qiaf118.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/117\/8\/qiaf118\/63974805\/qiaf118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/117\/8\/qiaf118\/63974805\/qiaf118.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T07:46:57Z","timestamp":1756453617000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/doi\/10.1093\/jleuko\/qiaf118\/8224582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":171,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiaf118","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,8]]},"article-number":"qiaf118"}}