{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T16:30:18Z","timestamp":1762965018635,"version":"3.45.0"},"reference-count":100,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100016004","name":"Institute of Biomedical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"Taiwan National Science and Technology","doi-asserted-by":"publisher","award":["NSTC 114-2320-B-001-028-MY3"],"award-info":[{"award-number":["NSTC 114-2320-B-001-028-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neutrophils, the most abundant leukocytes in humans, exhibit significant differences from their murine counterparts, shaping immune responses and disease outcomes. Recent studies indicate that fungal exposure in rewilded mice modifies neutrophil development, aligning it more closely with human neutrophil characteristics and emphasizing the role of environmental cues in neutrophil ontogeny. Beyond their immune defense functions, intestinal fungi contribute to granulopoiesis, sustaining immune activation through mechanisms distinct from those observed in invasive fungal infections. This review explores the complex interplay between fungi and neutrophils, focusing on how neutrophils respond to fungal colonization and infection. We examine the influence of fungal components, such as cell wall structures and toxins, on neutrophil activation and differentiation, which ultimately dictate their immune function. Additionally, we discuss the impact of gut mycobiota on disease progression and highlight emerging therapeutic strategies that target these interactions to manage immune-related disorders effectively. Understanding these mechanisms provides new insights into immune regulation and potential treatments for conditions driven by neutrophil dysfunction.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf148","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:31:14Z","timestamp":1760959874000},"source":"Crossref","is-referenced-by-count":0,"title":["Intricate interplay between fungi and neutrophils"],"prefix":"10.1093","volume":"117","author":[{"given":"Yi-Fen","family":"Cheng","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica , Taipei 115201 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Yu","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica , Taipei 115201 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Yu","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica , Taipei 115201 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-8610","authenticated-orcid":false,"given":"Ying-Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica , Taipei 115201 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"2025111211273623000_qiaf148-B1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.it.2010.05.006","article-title":"Neutrophil kinetics in health and disease","volume":"31","author":"Summers","year":"2010","journal-title":"Trends Immunol"},{"key":"2025111211273623000_qiaf148-B2","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.3324\/haematol.2018.196329","article-title":"Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium","volume":"105","author":"Rademakers","year":"2020","journal-title":"Haematologica"},{"key":"2025111211273623000_qiaf148-B3","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/jlb.67.5.651","article-title":"Neutrophil chemotaxis in moving gradients of fmlp","volume":"67","author":"Ebrahimzadeh","year":"2000","journal-title":"J Leukoc Biol"},{"key":"2025111211273623000_qiaf148-B4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00430-020-00691-1","article-title":"Bacterial aggregate size determines phagocytosis efficiency of polymorphonuclear leukocytes","volume":"209","author":"Alhede","year":"2020","journal-title":"Med Microbiol Immunol"},{"key":"2025111211273623000_qiaf148-B5","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/ni.2987","article-title":"Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens","volume":"15","author":"Branzk","year":"2014","journal-title":"Nat Immunol"},{"key":"2025111211273623000_qiaf148-B6","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1182\/blood-2008-02-140533","article-title":"Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles","volume":"112","author":"Dalli","year":"2008","journal-title":"Blood"},{"key":"2025111211273623000_qiaf148-B7","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.3389\/fimmu.2019.03030","article-title":"Phagocytosis of necrotic debris at sites of injury and inflammation","volume":"10","author":"Westman","year":"2019","journal-title":"Front Immunol"},{"key":"2025111211273623000_qiaf148-B8","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.it.2019.05.001","article-title":"The healing power of neutrophils","volume":"40","author":"Phillipson","year":"2019","journal-title":"Trends Immunol"},{"key":"2025111211273623000_qiaf148-B9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1189\/jlb.3HI1014-493R","article-title":"Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis","volume":"98","author":"Gregory","year":"2015","journal-title":"J Leukoc Biol"},{"key":"2025111211273623000_qiaf148-B10","doi-asserted-by":"publisher","first-page":"L1062","DOI":"10.1152\/ajplung.00327.2016","article-title":"Neutrophils promote alveolar epithelial regeneration by enhancing type ii pneumocyte proliferation in a model of acid-induced acute lung injury","volume":"311","author":"Paris","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2025111211273623000_qiaf148-B11","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/s41467-019-09046-8","article-title":"Neutrophils promote the development of reparative macrophages mediated by ros to orchestrate liver repair","volume":"10","author":"Yang","year":"2019","journal-title":"Nat Commun"},{"key":"2025111211273623000_qiaf148-B12","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.3390\/cells10071676","article-title":"Role of neutrophils in cardiac injury and repair following myocardial infarction","volume":"10","author":"Ma","year":"2021","journal-title":"Cells"},{"key":"2025111211273623000_qiaf148-B13","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.cell.2020.10.003","article-title":"Co-option of neutrophil fates by tissue environments","volume":"183","author":"Ballesteros","year":"2020","journal-title":"Cell"},{"key":"2025111211273623000_qiaf148-B14","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.immuni.2018.02.002","article-title":"Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions","volume":"48","author":"Evrard","year":"2018","journal-title":"Immunity"},{"key":"2025111211273623000_qiaf148-B15","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.immuni.2019.01.002","article-title":"A neutrophil timer coordinates immune defense and vascular protection","volume":"50","author":"Adrover","year":"2019","journal-title":"Immunity"},{"key":"2025111211273623000_qiaf148-B16","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41577-019-0141-8","article-title":"Heterogeneity of neutrophils","volume":"19","author":"Ng","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"2025111211273623000_qiaf148-B17","doi-asserted-by":"publisher","first-page":"102711","DOI":"10.1016\/j.isci.2021.102711","article-title":"Cd177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death","volume":"24","author":"Levy","year":"2021","journal-title":"iScience"},{"key":"2025111211273623000_qiaf148-B18","doi-asserted-by":"publisher","first-page":"670574","DOI":"10.3389\/fimmu.2021.670574","article-title":"Single-cell transcriptional heterogeneity of neutrophils during acute pulmonary Cryptococcus neoformans infection","volume":"12","author":"Deerhake","year":"2021","journal-title":"Front Immunol"},{"key":"2025111211273623000_qiaf148-B19","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12950-023-00341-2","article-title":"Pkm2\/stat1-mediated pd-l1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role","volume":"20","author":"Li","year":"2023","journal-title":"J Inflamm (Lond)"},{"key":"2025111211273623000_qiaf148-B20","doi-asserted-by":"publisher","first-page":"1279837","DOI":"10.3389\/fimmu.2023.1279837","article-title":"Interactions between neutrophils and t-helper 17 cells","volume":"14","author":"Fan","year":"2023","journal-title":"Front Immunol"},{"key":"2025111211273623000_qiaf148-B21","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1093\/rheumatology\/kead007","article-title":"Neutrophil function following treatment of psoriatic arthritis patients with secukinumab: altered cytokine signalling but no impairment of host defence","volume":"62","author":"Cross","year":"2023","journal-title":"Rheumatology (Oxford)"},{"key":"2025111211273623000_qiaf148-B22","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1056\/NEJMoa1314258","article-title":"Secukinumab in plaque psoriasis\u2013results of two phase 3 trials","volume":"371","author":"Langley","year":"2014","journal-title":"N Engl J Med"},{"key":"2025111211273623000_qiaf148-B23","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1038\/s44321-024-00100-7","article-title":"Immune-enhancing neutrophils reprogrammed by subclinical low-dose endotoxin in cancer treatment","volume":"16","author":"Zhang","year":"2024","journal-title":"EMBO Mol Med"},{"key":"2025111211273623000_qiaf148-B24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41419-022-04809-6","article-title":"Generation of resolving memory neutrophils through pharmacological training with 4-pba or genetic deletion of tram","volume":"13","author":"Lin","year":"2022","journal-title":"Cell Death Dis"},{"key":"2025111211273623000_qiaf148-B25","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J Immunol"},{"key":"2025111211273623000_qiaf148-B26","doi-asserted-by":"publisher","first-page":"383","DOI":"10.4049\/jimmunol.1700453","article-title":"Of mice, dirty mice, and men: using mice to understand human immunology","volume":"199","author":"Masopust","year":"2017","journal-title":"J Immunol"},{"key":"2025111211273623000_qiaf148-B27","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/nature17655","article-title":"Normalizing the environment recapitulates adult human immune traits in laboratory mice","volume":"532","author":"Beura","year":"2016","journal-title":"Nature"},{"key":"2025111211273623000_qiaf148-B28","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cyto.2011.08.031","article-title":"C-type lectin receptors and cytokines in fungal immunity","volume":"58","author":"Vautier","year":"2012","journal-title":"Cytokine"},{"key":"2025111211273623000_qiaf148-B29","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.it.2016.12.007","article-title":"Making mouse models that reflect human immune responses","volume":"38","author":"Tao","year":"2017","journal-title":"Trends Immunol"},{"key":"2025111211273623000_qiaf148-B30","doi-asserted-by":"publisher","first-page":"14811","DOI":"10.1038\/ncomms14811","article-title":"The comparative immunology of wild and laboratory mice, mus musculus domesticus","volume":"8","author":"Abolins","year":"2017","journal-title":"Nat Commun"},{"key":"2025111211273623000_qiaf148-B31","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41590-018-0303-z","article-title":"Serpinb1-mediated checkpoint of inflammatory caspase activation","volume":"20","author":"Choi","year":"2019","journal-title":"Nat Immunol"},{"key":"2025111211273623000_qiaf148-B32","doi-asserted-by":"publisher","first-page":"6452","DOI":"10.1126\/science.aaw4361","article-title":"Laboratory mice born to wild mice have natural microbiota and model human immune responses","volume":"365","author":"Rosshart","year":"2019","journal-title":"Science"},{"key":"2025111211273623000_qiaf148-B33","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.chom.2016.04.003","article-title":"Sequential infection with common pathogens promotes human-like immune gene expression and altered vaccine response","volume":"19","author":"Reese","year":"2016","journal-title":"Cell Host Microbe"},{"key":"2025111211273623000_qiaf148-B34","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.cell.2017.09.016","article-title":"Wild mouse gut microbiota promotes host fitness and improves disease resistance","volume":"171","author":"Rosshart","year":"2017","journal-title":"Cell"},{"key":"2025111211273623000_qiaf148-B35","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/j.chom.2021.10.001","article-title":"Mice with diverse microbial exposure histories as a model for preclinical vaccine testing","volume":"29","author":"Fiege","year":"2021","journal-title":"Cell Host Microbe"},{"key":"2025111211273623000_qiaf148-B36","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.chom.2020.02.015","article-title":"Altered immunity of laboratory mice in the natural environment is associated with fungal colonization","volume":"27","author":"Yeung","year":"2020","journal-title":"Cell Host Microbe"},{"key":"2025111211273623000_qiaf148-B37","doi-asserted-by":"publisher","first-page":"eads2364","DOI":"10.1126\/sciadv.ads2364","article-title":"Rewilding catalyzes maturation of the humoral immune system","volume":"11","author":"Chen","year":"2025","journal-title":"Sci Adv"},{"key":"2025111211273623000_qiaf148-B38","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/s41590-024-01842-9","article-title":"Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease","volume":"25","author":"Liu","year":"2024","journal-title":"Nat Immunol"},{"key":"2025111211273623000_qiaf148-B39","doi-asserted-by":"publisher","first-page":"eadd6910","DOI":"10.1126\/sciimmunol.add6910","article-title":"Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization","volume":"8","author":"Chen","year":"2023","journal-title":"Sci Immunol"},{"key":"2025111211273623000_qiaf148-B40","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.mib.2013.05.004","article-title":"Striking a balance: fungal commensalism versus pathogenesis","volume":"16","author":"Iliev","year":"2013","journal-title":"Curr Opin Microbiol"},{"key":"2025111211273623000_qiaf148-B41","doi-asserted-by":"publisher","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2025111211273623000_qiaf148-B42","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41577-022-00826-w","article-title":"Immune responses to human fungal pathogens and therapeutic prospects","volume":"23","author":"Lionakis","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"2025111211273623000_qiaf148-B43","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000321157","article-title":"Organ-specific innate immune responses in a mouse model of invasive candidiasis","volume":"3","author":"Lionakis","year":"2011","journal-title":"J Innate Immun"},{"key":"2025111211273623000_qiaf148-B44","doi-asserted-by":"publisher","first-page":"102508","DOI":"10.1016\/j.mib.2024.102508","article-title":"Epithelial responses to fungal pathogens","volume":"80","author":"Mills","year":"2024","journal-title":"Curr Opin Microbiol"},{"key":"2025111211273623000_qiaf148-B45","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/ni1460","article-title":"Syk- and card9-dependent coupling of innate immunity to the induction of t helper cells that produce interleukin 17","volume":"8","author":"LeibundGut-Landmann","year":"2007","journal-title":"Nat Immunol"},{"key":"2025111211273623000_qiaf148-B46","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1093\/infdis\/jir458","article-title":"Genetic variation in the dectin-1\/card9 recognition pathway and susceptibility to candidemia","volume":"204","author":"Rosentul","year":"2011","journal-title":"J Infect Dis"},{"key":"2025111211273623000_qiaf148-B47","doi-asserted-by":"publisher","first-page":"38854","DOI":"10.1074\/jbc.M606542200","article-title":"Dectin-2 is a pattern recognition receptor for fungi that couples with the fc receptor gamma chain to induce innate immune responses","volume":"281","author":"Sato","year":"2006","journal-title":"J Biol Chem"},{"key":"2025111211273623000_qiaf148-B48","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1093\/glycob\/cwn046","article-title":"Human and mouse macrophage-inducible c-type lectin (mincle) bind candida albicans","volume":"18","author":"Bugarcic","year":"2008","journal-title":"Glycobiology"},{"key":"2025111211273623000_qiaf148-B49","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1056\/NEJMoa0810719","article-title":"A homozygous card9 mutation in a family with susceptibility to fungal infections","volume":"361","author":"Glocker","year":"2009","journal-title":"N Engl J Med"},{"key":"2025111211273623000_qiaf148-B50","doi-asserted-by":"publisher","first-page":"e1005293","DOI":"10.1371\/journal.ppat.1005293","article-title":"Card9-dependent neutrophil recruitment protects against fungal invasion of the central nervous system","volume":"11","author":"Drummond","year":"2015","journal-title":"PLoS Pathog"},{"key":"2025111211273623000_qiaf148-B51","doi-asserted-by":"publisher","first-page":"e89890","DOI":"10.1172\/jci.insight.89890","article-title":"Extrapulmonary aspergillus infection in patients with card9 deficiency","volume":"1","author":"Rieber","year":"2016","journal-title":"JCI Insight"},{"key":"2025111211273623000_qiaf148-B52","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.chom.2024.09.011","article-title":"Immunity to fungi and vaccine considerations","volume":"32","author":"Whitehead","year":"2024","journal-title":"Cell Host Microbe"},{"key":"2025111211273623000_qiaf148-B53","doi-asserted-by":"publisher","first-page":"qiaf002","DOI":"10.1093\/jleuko\/qiaf002","article-title":"Neutrophil extracellular traps capture the human pathogen, candida albicans, in blood and delay hyphal transformation","volume":"117","author":"Sakuma","year":"2025","journal-title":"J Leukoc Biol"},{"key":"2025111211273623000_qiaf148-B54","doi-asserted-by":"publisher","first-page":"16238","DOI":"10.1038\/nmicrobiol.2016.238","article-title":"Lactate signalling regulates fungal beta-glucan masking and immune evasion","volume":"2","author":"Ballou","year":"2016","journal-title":"Nat Microbiol"},{"key":"2025111211273623000_qiaf148-B55","doi-asserted-by":"publisher","first-page":"e57571","DOI":"10.15252\/embr.202357571","article-title":"Candida albicans induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin","volume":"24","author":"Unger","year":"2023","journal-title":"EMBO Rep"},{"key":"2025111211273623000_qiaf148-B56","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.3389\/fimmu.2018.01573","article-title":"Candida albicans-induced netosis is independent of peptidylarginine deiminase 4","volume":"9","author":"Guiducci","year":"2018","journal-title":"Front Immunol"},{"key":"2025111211273623000_qiaf148-B57","doi-asserted-by":"publisher","first-page":"e1012319","DOI":"10.1371\/journal.ppat.1012319","article-title":"Regulation of candidalysin underlies candida albicans persistence in intravascular catheters by modulating netosis","volume":"20","author":"Tseng","year":"2024","journal-title":"PLoS Pathog"},{"key":"2025111211273623000_qiaf148-B58","doi-asserted-by":"publisher","first-page":"105779","DOI":"10.1016\/j.phrs.2021.105779","article-title":"Neutrophil extracellular traps in inflammatory bowel diseases: implications in pathogenesis and therapeutic targets","volume":"171","author":"Dos Santos Ramos","year":"2021","journal-title":"Pharmacol Res"},{"key":"2025111211273623000_qiaf148-B59","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.3390\/biomedicines9121867","article-title":"Pad inhibitors as a potential treatment for sars-cov-2 immunothrombosis","volume":"9","author":"Elliott","year":"2021","journal-title":"Biomedicines"},{"key":"2025111211273623000_qiaf148-B60","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.3390\/ijms21134662","article-title":"Putative roles for peptidylarginine deiminases in covid-19","volume":"21","author":"Arisan","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025111211273623000_qiaf148-B61","doi-asserted-by":"publisher","first-page":"103382","DOI":"10.1016\/j.ebiom.2021.103382","article-title":"Defective net clearance contributes to sustained fxii activation in covid-19-associated pulmonary thrombo-inflammation","volume":"67","author":"Englert","year":"2021","journal-title":"EBioMedicine"},{"key":"2025111211273623000_qiaf148-B62","doi-asserted-by":"publisher","first-page":"2001940","DOI":"10.1002\/advs.202001940","article-title":"Bioinspired dnase-i-coated melanin-like nanospheres for modulation of infection-associated netosis dysregulation","volume":"7","author":"Park","year":"2020","journal-title":"Adv Sci (Weinh)"},{"key":"2025111211273623000_qiaf148-B63","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/biomedicines8080275","article-title":"Neutrophil extracellular traps impair intestinal barrier function during experimental colitis","volume":"8","author":"Lin","year":"2020","journal-title":"Biomedicines"},{"key":"2025111211273623000_qiaf148-B64","doi-asserted-by":"publisher","first-page":"838011","DOI":"10.3389\/fimmu.2022.838011","article-title":"Netosis and neutrophil extracellular traps in covid-19: immunothrombosis and beyond","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Immunol"},{"key":"2025111211273623000_qiaf148-B65","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41586-022-04502-w","article-title":"Immune regulation by fungal strain diversity in inflammatory bowel disease","volume":"603","author":"Li","year":"2022","journal-title":"Nature"},{"key":"2025111211273623000_qiaf148-B66","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s40168-017-0373-4","article-title":"The gut mycobiome of the human microbiome project healthy cohort","volume":"5","author":"Nash","year":"2017","journal-title":"Microbiome"},{"key":"2025111211273623000_qiaf148-B67","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.chom.2019.02.004","article-title":"Commensal candida albicans positively calibrates systemic th17 immunological responses","volume":"25","author":"Shao","year":"2019","journal-title":"Cell Host Microbe"},{"key":"2025111211273623000_qiaf148-B68","doi-asserted-by":"publisher","first-page":"16465","DOI":"10.1073\/pnas.2003022117","article-title":"Immunity to commensal skin fungi promotes psoriasiform skin inflammation","volume":"117","author":"Hurabielle","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025111211273623000_qiaf148-B69","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/ni1354","article-title":"C\/ebpbeta is required for \u2018emergency\u2019 granulopoiesis","volume":"7","author":"Hirai","year":"2006","journal-title":"Nat Immunol"},{"key":"2025111211273623000_qiaf148-B70","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1172\/JCI60588","article-title":"Cxcr2 and cxcl5 regulate the il-17\/g-csf axis and neutrophil homeostasis in mice","volume":"122","author":"Mei","year":"2012","journal-title":"J Clin Invest"},{"key":"2025111211273623000_qiaf148-B71","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.1182\/blood.V95.12.3725.3725","article-title":"Emergency\u201d granulopoiesis in g-csf-deficient mice in response to candida albicans infection","volume":"95","author":"Basu","year":"2000","journal-title":"Blood"},{"key":"2025111211273623000_qiaf148-B72","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1084\/jem.188.6.1173","article-title":"Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor ccaat enhancer binding protein alpha (c\/ebp alpha) is critical for granulopoiesis","volume":"188","author":"Zhang","year":"1998","journal-title":"J Exp Med"},{"key":"2025111211273623000_qiaf148-B73","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.immuni.2006.04.008","article-title":"Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment","volume":"24","author":"Nagai","year":"2006","journal-title":"Immunity"},{"key":"2025111211273623000_qiaf148-B74","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1182\/blood.V91.3.863","article-title":"Essential roles for granulocyte-macrophage colony-stimulating factor (gm-csf) and g-csf in the sustained hematopoietic response of listeria monocytogenes-infected mice","volume":"91","author":"Zhan","year":"1998","journal-title":"Blood"},{"key":"2025111211273623000_qiaf148-B75","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1182\/blood-2018-10-878082","article-title":"Cxcl1 regulates neutrophil homeostasis in pneumonia-derived sepsis caused by streptococcus pneumoniae serotype 3","volume":"133","author":"Paudel","year":"2019","journal-title":"Blood"},{"key":"2025111211273623000_qiaf148-B76","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.4049\/jimmunol.1602006","article-title":"Reactive oxygen species-producing myeloid cells act as a bone marrow niche for sterile inflammation-induced reactive granulopoiesis","volume":"198","author":"Zhu","year":"2017","journal-title":"J Immunol"},{"key":"2025111211273623000_qiaf148-B77","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.immuni.2014.12.017","article-title":"Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis","volume":"42","author":"Kwak","year":"2015","journal-title":"Immunity"},{"key":"2025111211273623000_qiaf148-B78","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.chom.2014.05.004","article-title":"Infection mobilizes hematopoietic stem cells through cooperative nod-like receptor and toll-like receptor signaling","volume":"15","author":"Burberry","year":"2014","journal-title":"Cell Host Microbe"},{"key":"2025111211273623000_qiaf148-B79","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1038\/s41590-023-01637-4","article-title":"Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe covid-19","volume":"24","author":"Kusakabe","year":"2023","journal-title":"Nat Immunol"},{"key":"2025111211273623000_qiaf148-B80","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"key":"2025111211273623000_qiaf148-B81","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/s41586-024-07142-4","article-title":"The hyphal-specific toxin candidalysin promotes fungal gut commensalism","volume":"627","author":"Liang","year":"2024","journal-title":"Nature"},{"key":"2025111211273623000_qiaf148-B82","doi-asserted-by":"publisher","first-page":"e0340923","DOI":"10.1128\/mbio.03409-23","article-title":"Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis","volume":"15","author":"Valentine","year":"2024","journal-title":"mBio"},{"key":"2025111211273623000_qiaf148-B83","doi-asserted-by":"publisher","first-page":"e0060324","DOI":"10.1128\/mbio.00603-24","article-title":"Candidalysin biology and activation of host cells","volume":"16","author":"Lortal","year":"2025","journal-title":"mBio"},{"key":"2025111211273623000_qiaf148-B84","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"2025111211273623000_qiaf148-B85","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.cell.2020.09.058","article-title":"Innate immune training of granulopoiesis promotes anti-tumor activity","volume":"183","author":"Kalafati","year":"2020","journal-title":"Cell"},{"key":"2025111211273623000_qiaf148-B86","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41590-024-02041-2","article-title":"Beta-glucan reprograms neutrophils to promote disease tolerance against influenza a virus","volume":"26","author":"Khan","year":"2025","journal-title":"Nat Immunol"},{"key":"2025111211273623000_qiaf148-B87","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.chom.2022.02.017","article-title":"Fungal sensing enhances neutrophil metabolic fitness by regulating antifungal glut1 activity","volume":"30","author":"Li","year":"2022","journal-title":"Cell Host Microbe"},{"key":"2025111211273623000_qiaf148-B88","doi-asserted-by":"publisher","first-page":"RP102068","DOI":"10.7554\/eLife.102068","article-title":"Beta-glucan reprograms alveolar macrophages via neutrophil\/ifngamma axis in a murine model of lung injury","volume":"13","author":"Prevel","year":"2025","journal-title":"Elife"},{"key":"2025111211273623000_qiaf148-B89","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1080\/19390211.2025.2539876","article-title":"Yeast beta-glucan enhances antibody response following influenza vaccination\u2014a double-blind, randomized, placebo-controlled pilot trial","volume":"22","author":"Moreno","year":"2025","journal-title":"J Diet Suppl"},{"key":"2025111211273623000_qiaf148-B90","doi-asserted-by":"publisher","first-page":"2489900","DOI":"10.1080\/21645515.2025.2489900","article-title":"Immunogenicity, safety, and tolerability of a beta-glucan-cpg-adjuvanted respiratory syncytial virus vaccine in Japanese healthy participants aged 60 to 80 yr: a phase 2, randomized, double-blind, dose-finding study","volume":"21","author":"Nakayama","year":"2025","journal-title":"Hum Vaccin Immunother"},{"key":"2025111211273623000_qiaf148-B91","doi-asserted-by":"publisher","first-page":"887457","DOI":"10.3389\/fphar.2022.887457","article-title":"Beta-glucan combined with pd-1\/pd-l1 checkpoint blockade for immunotherapy in patients with advanced cancer","volume":"13","author":"Wang","year":"2022","journal-title":"Front Pharmacol"},{"key":"2025111211273623000_qiaf148-B92","doi-asserted-by":"publisher","first-page":"100751","DOI":"10.1016\/j.bj.2024.100751","article-title":"Unveiling the mycobiota: the fungal frontier of human health","volume":"47","author":"Iyer","year":"2024","journal-title":"Biomed J"},{"key":"2025111211273623000_qiaf148-B93","doi-asserted-by":"publisher","first-page":"100133","DOI":"10.1016\/j.fochms.2022.100133","article-title":"New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood","volume":"5","author":"Ortega-Gomez","year":"2022","journal-title":"Food Chem (Oxf)"},{"key":"2025111211273623000_qiaf148-B94","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1136\/gutjnl-2015-310746","article-title":"Fungal microbiota dysbiosis in ibd","volume":"66","author":"Sokol","year":"2017","journal-title":"Gut"},{"key":"2025111211273623000_qiaf148-B95","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1093\/ecco-jcc\/jjv209","article-title":"Fungal dysbiosis in mucosa-associated microbiota of crohn's disease patients","volume":"10","author":"Liguori","year":"2016","journal-title":"J Crohns Colitis"},{"key":"2025111211273623000_qiaf148-B96","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/1751-2980.12825","article-title":"Colonic mucosa-associated candida assessed by biopsy culture is associated with disease severity in ulcerative colitis: a prospective study","volume":"20","author":"Shah","year":"2019","journal-title":"J Dig Dis"},{"key":"2025111211273623000_qiaf148-B97","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1111\/j.1365-2036.2010.04444.x","article-title":"The effects of itraconazole on inflammatory bowel disease activity in patients treated for histoplasmosis","volume":"32","author":"Samuel","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"2025111211273623000_qiaf148-B98","doi-asserted-by":"publisher","first-page":"3841","DOI":"10.3390\/ijms25073841","article-title":"Multi-omics profiling reveals phenotypic and functional heterogeneity of neutrophils in covid-19","volume":"25","author":"Zhang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2025111211273623000_qiaf148-B99","doi-asserted-by":"publisher","first-page":"1558496","DOI":"10.3389\/fimmu.2025.1558496","article-title":"Integrated multiomics analysis and machine learning refine neutrophil extracellular trap-related molecular subtypes and prognostic models for acute myeloid leukemia","volume":"16","author":"Zhong","year":"2025","journal-title":"Front Immunol"},{"key":"2025111211273623000_qiaf148-B100","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/j.csbj.2024.03.006","article-title":"Deep learning-based characterization of neutrophil activation phenotypes in ex vivo human candida blood infections","volume":"23","author":"Sarkar","year":"2024","journal-title":"Comput Struct Biotechnol J"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiaf148\/64858545\/qiaf148.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/117\/11\/qiaf148\/64858545\/qiaf148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/117\/11\/qiaf148\/64858545\/qiaf148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T16:27:43Z","timestamp":1762964863000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/doi\/10.1093\/jleuko\/qiaf148\/8297239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":100,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiaf148","relation":{},"ISSN":["1938-3673"],"issn-type":[{"type":"electronic","value":"1938-3673"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,10,23]]},"article-number":"qiaf148"}}