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To address this, mice with conditional deletions of Irgm1 were created and challenged with model pathogens. Irgm1fl\/flLyz2-Cre+ mice (a myeloid deletion) displayed marked susceptibility to infections with Salmonella typhimurium, Listeria monocytogenes, and Toxoplasma gondii, paralleling those of global Irgm1\u2212\/\u2212 mice. However, infections of Irgm1fl\/flLyz2-Cre+ mice with Citrobacter rodentium showed no increase in susceptibility, contrasting with marked increases in Irgm1fl\/flVav-Cre+ mice (a hematopoietic deletion). Macrophages from Irgm1fl\/flLyz2-Cre+ mice displayed pathologies present in macrophages from global Irgm1\u2212\/\u2212 mice, validating the conditional deletion in myeloid cells. These results suggest that Irgm1 functioning in myeloid cells is critical for immune resistance to intracellular pathogens, while Irgm1 functioning in additional hematopoietic population(s) is required for resistance to extracellular pathogens in the intestinal lumen.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf167","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:13:47Z","timestamp":1763558027000},"source":"Crossref","is-referenced-by-count":1,"title":["Differential roles for Irgm1 in myeloid cells for immune resistance to pathogenic bacteria"],"prefix":"10.1093","volume":"117","author":[{"given":"Brian E","family":"Fee","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center , PO Box 3003, Durham, NC 27710 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanette 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