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Increasing evidence has linked MIF to the pathogenesis of both solid tumors and hematologic malignancies, including chronic lymphocytic leukemia (CLL). We previously showed that the global deletion of Mif in the TCL1 transgenic mouse model for CLL significantly delayed disease development leading to longer overall survival of the knockout mice. In this study, we demonstrated that adaptive transfer of murine CLL cells failed to establish disease in Mif-deficient recipients due to impaired homing of leukemic cells into the spleens, indicating that host-derived Mif is essential for leukemic infiltration and expansion. To identify the most relevant source of Mif in CLL, we generated two CLL mouse strains with B-lymphoid- or myeloid-lineage-specific Mif deletion. In contrast to the global Mif knockout, neither conditional Mif knockout significantly altered CLL progression, illustrating that the cellular source of Mif is less critical than its systemic presence in the tissue environment.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf170","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T13:07:24Z","timestamp":1764335244000},"source":"Crossref","is-referenced-by-count":1,"title":["Systemic MIF facilitates chronic lymphocytic leukemia development independent of its cellular source"],"prefix":"10.1093","volume":"117","author":[{"given":"Viktoria","family":"Kohlhas","sequence":"first","affiliation":[{"name":"Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne , Kerpener Str. 62, Cologne 50937 ,","place":["Germany"]},{"name":"Center for Molecular Medicine Cologne; CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne , Joseph-Stelzmann Str. 26, Cologne 50931 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Reinart","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne , Kerpener Str. 62, Cologne 50937 ,","place":["Germany"]},{"name":"Center for Molecular Medicine Cologne; CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne , Joseph-Stelzmann Str. 26, Cologne 50931 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascha","family":"Rosen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen 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D","family":"Schreurs","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne , Kerpener Str. 62, Cologne 50937 ,","place":["Germany"]},{"name":"Center for Molecular Medicine Cologne; CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne , Joseph-Stelzmann Str. 26, Cologne 50931 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-7264","authenticated-orcid":false,"given":"Phuong-Hien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne , Kerpener Str. 62, Cologne 50937 ,","place":["Germany"]},{"name":"Center for 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