{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:10:40Z","timestamp":1773879040567,"version":"3.50.1"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eosinophils (EOS), named after the Greek dawn goddess Eos, are multifunctional granulocytes with roles surpassing their well-established involvement in allergic diseases and parasitic infections. Herein, we highlighted the recent advancements in understanding the cellular structure, lineage development, surface receptors, and diverse phenotypes of EOS. In particular, we focused on their emerging roles in the tumor microenvironment and type 1 inflammatory responses. Additionally, we explored the cytokine signaling and transcription factor networks governing the differentiation of EOS, emphasizing the interplay among IL-5, IL-33, and GM-CSF. Notably, EOS exhibit phenotypic plasticity, with the ability to polarize into type 1 (E1) and type 2 (E2) subsets under different inflammatory conditions. This suggests their dual roles in antitumor and protumor activities. Our review underscores the potential of targeting EOS-specific receptors, including IL-5R\u03b1 and Siglec-8, for therapeutic interventions in EOS-related diseases. By combining recent findings on the metabolic milieu and interactions of EOS within complex tissue environments, we provide a comprehensive perspective on their physiological and pathological functions, paving the way for novel therapeutic strategies.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf171","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T13:17:26Z","timestamp":1764854246000},"source":"Crossref","is-referenced-by-count":0,"title":["Eosinophils (EOS): the Greek dawn goddess of the same name"],"prefix":"10.1093","volume":"118","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Social Services, Shengjing Hospital of China Medical University , No. 36 Sanhao Street, Heping District, Shenyang, Liaoning Province 110004 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8680-5288","authenticated-orcid":false,"given":"Bo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University , No. 36 Sanhao Street, Heping District, Shenyang, Liaoning Province 110004 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"2026031813364480600_qiaf171-B1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nri3341","article-title":"Eosinophils: changing perspectives in health and disease","volume":"13","author":"Rosenberg","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2026031813364480600_qiaf171-B2","doi-asserted-by":"publisher","first-page":"MCHD-0032-2016","DOI":"10.1128\/microbiolspec.MCHD-0032-2016","article-title":"Paul Ehrlich and the early history of granulocytes","volume":"4","author":"Kay","year":"2016","journal-title":"Microbiol Spectr"},{"key":"2026031813364480600_qiaf171-B3","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1016\/j.mayocp.2021.04.025","article-title":"Eosinophils in health and disease: a state-of-the-art review","volume":"96","author":"Wechsler","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"2026031813364480600_qiaf171-B4","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1038\/s41590-022-01291-2","article-title":"Eosinophil-lymphocyte interactions in the tumor microenvironment and cancer immunotherapy","volume":"23","author":"Grisaru-Tal","year":"2022","journal-title":"Nat Immunol"},{"key":"2026031813364480600_qiaf171-B5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fmed.2017.00093","article-title":"The biology of eosinophils and their role in asthma","volume":"4","author":"McBrien","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"2026031813364480600_qiaf171-B6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/JLB.3MR1217-476R","article-title":"Contemporary understanding of the secretory granules in human eosinophils","volume":"104","author":"Melo","year":"2018","journal-title":"J Leukoc Biol"},{"key":"2026031813364480600_qiaf171-B7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jaci.2020.01.013","article-title":"Charcot-Leyden crystal protein\/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis","volume":"146","author":"Grozdanovic","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"2026031813364480600_qiaf171-B8","doi-asserted-by":"publisher","first-page":"7091","DOI":"10.3390\/ijms22137091","article-title":"The enigma of eosinophil degranulation","volume":"22","author":"Fettrelet","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026031813364480600_qiaf171-B9","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/j.jaci.2010.12.1103","article-title":"Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways","volume":"127","author":"Dworski","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"2026031813364480600_qiaf171-B10","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.14670\/HH-25.1341","article-title":"Piecemeal degranulation in human eosinophils: a distinct secretion mechanism underlying inflammatory responses","volume":"25","author":"Melo","year":"2010","journal-title":"Histol Histopathol"},{"key":"2026031813364480600_qiaf171-B11","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1189\/jlb.0707503","article-title":"Mechanisms of eosinophil secretion: large vesiculotubular carriers mediate transport and release of granule-derived cytokines and other proteins","volume":"83","author":"Melo","year":"2008","journal-title":"J Leukoc Biol"},{"key":"2026031813364480600_qiaf171-B12","doi-asserted-by":"publisher","DOI":"10.1111\/all.70021","article-title":"Physiological level of eosinophils is essential for the regeneration and homeostasis of murine hematopoietic stem cells","author":"Zhang","year":"2025","journal-title":"Allergy"},{"key":"2026031813364480600_qiaf171-B13","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/nri.2017.95","article-title":"Functions of tissue-resident eosinophils","volume":"17","author":"Weller","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"2026031813364480600_qiaf171-B14","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1172\/JCI85664","article-title":"Lung-resident eosinophils represent a distinct regulatory eosinophil subset","volume":"126","author":"Mesnil","year":"2016","journal-title":"J Clin Invest"},{"key":"2026031813364480600_qiaf171-B15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature"},{"key":"2026031813364480600_qiaf171-B16","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/s41568-020-0283-9","article-title":"A new Dawn for eosinophils in the tumour microenvironment","volume":"20","author":"Grisaru-Tal","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"2026031813364480600_qiaf171-B17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/MOH.0000000000000552","article-title":"Transcription factor and cytokine regulation of eosinophil lineage commitment","volume":"27","author":"Mack","year":"2020","journal-title":"Curr Opin Hematol"},{"key":"2026031813364480600_qiaf171-B18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1186\/s12967-023-04418-7","article-title":"Eosinophils in the tumor microenvironment: implications for cancer immunotherapy","volume":"21","author":"Ghaffari","year":"2023","journal-title":"J Transl Med"},{"key":"2026031813364480600_qiaf171-B19","doi-asserted-by":"publisher","first-page":"e1393134","DOI":"10.1080\/2162402X.2017.1393134","article-title":"Eosinophils: the unsung heroes in cancer","volume":"7","author":"Varricchi","year":"2018","journal-title":"Oncoimmunology"},{"key":"2026031813364480600_qiaf171-B20","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fmed.2017.00101","article-title":"Homeostatic eosinophils: characteristics and functions","volume":"4","author":"Marichal","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"2026031813364480600_qiaf171-B21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000350662","article-title":"Eosinophils: multifunctional and distinctive properties","volume":"161","author":"Kita","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"2026031813364480600_qiaf171-B22","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jaci.2017.09.022","article-title":"Eosinophils and eosinophil-associated diseases: an update","volume":"141","author":"O'Sullivan","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"2026031813364480600_qiaf171-B23","doi-asserted-by":"publisher","first-page":"155961","DOI":"10.1016\/j.cyto.2022.155961","article-title":"IL-33 biology in cancer: an update and future perspectives","volume":"157","author":"Yeoh","year":"2022","journal-title":"Cytokine"},{"key":"2026031813364480600_qiaf171-B24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/MOH.0000000000000293","article-title":"Regulation of eosinophil development and survival","volume":"24","author":"Willebrand","year":"2017","journal-title":"Curr Opin Hematol"},{"key":"2026031813364480600_qiaf171-B25","doi-asserted-by":"publisher","first-page":"e0163751","DOI":"10.1371\/journal.pone.0163751","article-title":"IL-33-induced cytokine secretion and survival of mouse eosinophils is promoted by autocrine GM-CSF","volume":"11","author":"Willebrand","year":"2016","journal-title":"PLoS One"},{"key":"2026031813364480600_qiaf171-B26","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.bbrc.2017.02.068","article-title":"Forced FOG1 expression in erythroleukemia cells: induction of erythroid genes and repression of myelo-lymphoid transcription factor PU.1","volume":"485","author":"Fujiwara","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"2026031813364480600_qiaf171-B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ai.2018.03.001","article-title":"Eosinophil development, disease involvement, and therapeutic suppression","volume":"138","author":"Fulkerson","year":"2018","journal-title":"Adv Immunol"},{"key":"2026031813364480600_qiaf171-B28","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1182\/blood.2018872218","article-title":"Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program","volume":"133","author":"Mack","year":"2019","journal-title":"Blood"},{"key":"2026031813364480600_qiaf171-B29","doi-asserted-by":"publisher","first-page":"5066","DOI":"10.3390\/ijms23095066","article-title":"Eosinophils and lung cancer: from bench to bedside","volume":"23","author":"Sibille","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026031813364480600_qiaf171-B30","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrc.2017.51","article-title":"Microenvironmental regulation of tumour angiogenesis","volume":"17","author":"De Palma","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"2026031813364480600_qiaf171-B31","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.pharmthera.2012.06.005","article-title":"Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions","volume":"135","author":"Kiwamoto","year":"2012","journal-title":"Pharmacol Ther"},{"key":"2026031813364480600_qiaf171-B32","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"2026031813364480600_qiaf171-B33","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1189\/jlb.0808494","article-title":"Role of atopic status in toll-like receptor (TLR)7- and TLR9-mediated activation of human eosinophils","volume":"85","author":"M\u00e5nsson","year":"2009","journal-title":"J Leukoc Biol"},{"key":"2026031813364480600_qiaf171-B34","doi-asserted-by":"publisher","first-page":"510","DOI":"10.3389\/fimmu.2017.00510","article-title":"The innate immune cross talk between NK cells and eosinophils is regulated by the interaction of natural cytotoxicity receptors with eosinophil surface ligands","volume":"8","author":"Pesce","year":"2017","journal-title":"Front Immunol"},{"key":"2026031813364480600_qiaf171-B35","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/j.1365-2222.2010.03484.x","article-title":"Eosinophils in health and disease: the LIAR hypothesis","volume":"40","author":"Lee","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"2026031813364480600_qiaf171-B36","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.1182\/blood-2012-06-330845","article-title":"The expanding role(s) of eosinophils in health and disease","volume":"120","author":"Jacobsen","year":"2012","journal-title":"Blood"},{"key":"2026031813364480600_qiaf171-B37","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/JLB.1MR1117-442RR","article-title":"Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease","volume":"104","author":"Abdala-Valencia","year":"2018","journal-title":"J Leukoc Biol"},{"key":"2026031813364480600_qiaf171-B38","doi-asserted-by":"publisher","first-page":"802839","DOI":"10.3389\/fimmu.2021.802839","article-title":"Transcriptional profiling of mouse eosinophils identifies distinct gene signatures following cellular activation","volume":"12","author":"Dolitzky","year":"2021","journal-title":"Front Immunol"},{"key":"2026031813364480600_qiaf171-B39","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1158\/2326-6066.CIR-18-0494","article-title":"Activated eosinophils exert antitumorigenic activities in colorectal cancer","volume":"7","author":"Reichman","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"2026031813364480600_qiaf171-B40","doi-asserted-by":"publisher","first-page":"5555","DOI":"10.1158\/0008-5472.CAN-21-0839","article-title":"Metastasis-entrained eosinophils enhance lymphocyte-mediated antitumor immunity","volume":"81","author":"Grisaru-Tal","year":"2021","journal-title":"Cancer Res"},{"key":"2026031813364480600_qiaf171-B41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1146\/annurev-pathmechdis-012419-032756","article-title":"Contributions of eosinophils to human health and disease","volume":"15","author":"Klion","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"2026031813364480600_qiaf171-B42","doi-asserted-by":"publisher","first-page":"44571","DOI":"10.1038\/srep44571","article-title":"Eosinophils are key regulators of perivascular adipose tissue and vascular functionality","volume":"7","author":"Withers","year":"2017","journal-title":"Sci Rep"},{"key":"2026031813364480600_qiaf171-B43","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/imm.12658","article-title":"Effective antigen presentation to helper T cells by human eosinophils","volume":"149","author":"Farhan","year":"2016","journal-title":"Immunology"},{"key":"2026031813364480600_qiaf171-B44","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12865-016-0153-0","article-title":"Eosinophils may play regionally disparate roles in influencing IgA(+) plasma cell numbers during large and small intestinal inflammation","volume":"17","author":"Forman","year":"2016","journal-title":"BMC Immunol"},{"key":"2026031813364480600_qiaf171-B45","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/mi.2014.123","article-title":"IL-1\u03b2 in eosinophil-mediated small intestinal homeostasis and IgA production","volume":"8","author":"Jung","year":"2015","journal-title":"Mucosal Immunol"},{"key":"2026031813364480600_qiaf171-B46","doi-asserted-by":"publisher","first-page":"3548","DOI":"10.4049\/jimmunol.1302241","article-title":"Eosinophils regulate peripheral B cell numbers in both mice and humans","volume":"192","author":"Wong","year":"2014","journal-title":"J Immunol"},{"key":"2026031813364480600_qiaf171-B47","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.3748\/wjg.v25.i27.3503","article-title":"Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders","volume":"25","author":"Loktionov","year":"2019","journal-title":"World J Gastroenterol"},{"key":"2026031813364480600_qiaf171-B48","doi-asserted-by":"publisher","first-page":"26","DOI":"10.12703\/r\/11-26","article-title":"Recent advances in understanding the role of eosinophils","volume":"11","author":"Constantine","year":"2022","journal-title":"Fac Rev"},{"key":"2026031813364480600_qiaf171-B49","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2174\/157489111796887855","article-title":"Current update on eosinophilic lung diseases and anti-IL-5 treatment","volume":"6","author":"Samitas","year":"2011","journal-title":"Recent Pat Antiinfect Drug Discov"},{"key":"2026031813364480600_qiaf171-B50","doi-asserted-by":"publisher","first-page":"289","DOI":"10.18176\/jiaci.0295","article-title":"Eosinophils: old players in a new game","volume":"28","author":"Sastre","year":"2018","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2026031813364480600_qiaf171-B51","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1067\/mai.2000.105712","article-title":"Mechanisms of eosinophil-associated inflammation","volume":"105","author":"Gleich","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"2026031813364480600_qiaf171-B52","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.crimmu.2022.03.002","article-title":"The emerging roles of eosinophils: implications for the targeted treatment of eosinophilic-associated inflammatory conditions","volume":"3","author":"Lombardi","year":"2022","journal-title":"Curr Res Immunol"},{"key":"2026031813364480600_qiaf171-B53","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1111\/all.14700","article-title":"Monitoring eosinophils to guide therapy with biologics in asthma: does the compartment matter","volume":"76","author":"Koenderman","year":"2021","journal-title":"Allergy"},{"key":"2026031813364480600_qiaf171-B54","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"2026031813364480600_qiaf171-B55","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s12967-020-02454-1","article-title":"Comprehensive analysis and establishment of a prediction model of alternative splicing events reveal the prognostic predictor and immune microenvironment signatures in triple negative breast cancer","volume":"18","author":"Yu","year":"2020","journal-title":"J Transl Med"},{"key":"2026031813364480600_qiaf171-B56","doi-asserted-by":"publisher","first-page":"118199","DOI":"10.1016\/j.ecoenv.2025.118199","article-title":"Residential greenness, genetic susceptibility, and asthma risk: mediating roles of air pollution in UK and Chinese populations","volume":"296","author":"Huang","year":"2025","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026031813364480600_qiaf171-B57","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1183\/20734735.142118","article-title":"Hot topics from the assemblies","volume":"14","year":"2018","journal-title":"Breathe (Sheff)"},{"key":"2026031813364480600_qiaf171-B58","doi-asserted-by":"publisher","first-page":"40","DOI":"10.5414\/ALX02469E","article-title":"Eosinophil granulocytes in chronic inflammatory respiratory diseases and CRSwNP: function, immunological basis, and clinical significance","volume":"8","author":"Klimek","year":"2024","journal-title":"Allergol Select"},{"key":"2026031813364480600_qiaf171-B59","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1080\/00325481.2022.2134624","article-title":"Eosinophilic granulomatosis with polyangiitis","volume":"135","author":"Villa-Forte","year":"2023","journal-title":"Postgrad Med"},{"key":"2026031813364480600_qiaf171-B60","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3760\/cma.j.cn112147-20200618-00721","article-title":"Guidelines for bronchial asthma prevent and management (2020 edition) Asthma group of Chinese Throacic Society","volume":"43","author":"Asthma group of Chinese Throacic Society","year":"2020","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"2026031813364480600_qiaf171-B61","doi-asserted-by":"publisher","first-page":"e18743064279064","DOI":"10.2174\/0118743064279064231227070344","article-title":"Global initiative for chronic obstructive lung disease (GOLD) 2023 guidelines reviewed","volume":"18","author":"Sharma","year":"2024","journal-title":"Open Respir Med J"},{"key":"2026031813364480600_qiaf171-B62","doi-asserted-by":"publisher","first-page":"100676","DOI":"10.1016\/j.waojou.2022.100676","article-title":"Current and emerging biologic therapies targeting eosinophilic disorders","volume":"15","author":"Pitlick","year":"2022","journal-title":"World Allergy Organ J"},{"key":"2026031813364480600_qiaf171-B63","doi-asserted-by":"publisher","first-page":"00576-2021","DOI":"10.1183\/23120541.00576-2021","article-title":"Type 2 inflammation in asthma and other airway diseases","volume":"8","author":"Maspero","year":"2022","journal-title":"ERJ Open Res"},{"key":"2026031813364480600_qiaf171-B64","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12931-021-01746-4","article-title":"Mepolizumab improves clinical outcomes in patients with severe asthma and comorbid conditions","volume":"22","author":"Gibson","year":"2021","journal-title":"Respir Res"},{"key":"2026031813364480600_qiaf171-B65","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S2213-2600(15)00042-9","article-title":"Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials","volume":"3","author":"Castro","year":"2015","journal-title":"Lancet Respir Med"},{"key":"2026031813364480600_qiaf171-B66","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/S0140-6736(16)31322-8","article-title":"Benralizumab, an anti-interleukin-5 receptor \u03b1 monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial","volume":"388","author":"FitzGerald","year":"2016","journal-title":"Lancet"},{"key":"2026031813364480600_qiaf171-B67","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1056\/NEJMoa1804093","article-title":"Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma","volume":"378","author":"Rabe","year":"2018","journal-title":"N Engl J Med"},{"key":"2026031813364480600_qiaf171-B68","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1056\/NEJMoa2034975","article-title":"Tezepelumab in adults and adolescents with severe, uncontrolled asthma","volume":"384","author":"Menzies-Gow","year":"2021","journal-title":"N Engl J Med"},{"key":"2026031813364480600_qiaf171-B69","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1111\/all.15751","article-title":"Eosinophils from A to Z","volume":"78","author":"Gigon","year":"2023","journal-title":"Allergy"},{"key":"2026031813364480600_qiaf171-B70","doi-asserted-by":"publisher","first-page":"688910","DOI":"10.3389\/fimmu.2021.688910","article-title":"Lactylation, a novel metabolic reprogramming code: current status and prospects","volume":"12","author":"Chen","year":"2021","journal-title":"Front Immunol"},{"key":"2026031813364480600_qiaf171-B71","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s12943-022-01645-2","article-title":"The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies","volume":"21","author":"Bai","year":"2022","journal-title":"Mol Cancer"},{"key":"2026031813364480600_qiaf171-B72","doi-asserted-by":"publisher","first-page":"e1445452","DOI":"10.1080\/2162402X.2018.1445452","article-title":"Ph regulators to target the tumor immune microenvironment in human hepatocellular carcinoma","volume":"7","author":"Kuchuk","year":"2018","journal-title":"Oncoimmunology"},{"key":"2026031813364480600_qiaf171-B73","doi-asserted-by":"publisher","first-page":"641883","DOI":"10.3389\/fimmu.2021.641883","article-title":"Metabolites in the tumor microenvironment reprogram functions of immune effector cells through epigenetic modifications","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiaf171\/65768415\/qiaf171.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/3\/qiaf171\/65768415\/qiaf171.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/3\/qiaf171\/65768415\/qiaf171.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:36:48Z","timestamp":1773855408000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/doi\/10.1093\/jleuko\/qiaf171\/8370167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiaf171","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,12,5]]},"article-number":"qiaf171"}}