{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T04:26:51Z","timestamp":1769660811933,"version":"3.49.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"FullHope Biomedical Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Changes in specific immune cell lineages, such as T and B cells, play a central role in the pathogenesis of rheumatoid arthritis (RA). However, a comprehensive evaluation of systemic immune cell changes in RA remains limited. Immune cell proportions of 104 subsets across granulocyte, T-cell, B-cell, and innate lineages were profiled by flow cytometry in 21 new-onset RA patients and 21 healthy controls. Non-parametric tests compared groups, followed by training a logistic regression-based AI model with cross-validation to characterize RA immune profiles and assess each subset's contribution. Among 104 immune cell subsets analyzed, 16 were indicative of RA. Increased proportions of marginal zone B cells, IgMhi B cells, CD11b+lineage\u2212 cells, monocytes, and MHC II+ monocytes, along with decreased eosinophils, reflected activation of innate and humoral immune responses in RA patients. Elevated levels of FoxP3+CD4+ regulatory T cells (FoxP3+ CD4 Treg) and CTLA4+ CD4 Treg cells, as well as increased MHC II+CD4+ and CD8+ T cells, PD-L1+ NK cells, and PD-L1+CD8+ NKT cells, suggested a compensatory immune response. The AI model distinguished immune profiles between RA patients and healthy controls with 100% sensitivity and specificity in this dataset, identifying RA by lower MHC II+ monocytes, higher CTLA4+ CD4 Treg cells, and elevated monocytes. These findings demonstrate the potential of using ICP hallmarks to develop novel diagnostic tools and therapeutic strategies for RA.<\/jats:p>","DOI":"10.1093\/jleuko\/qiaf188","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:44:01Z","timestamp":1767185041000},"source":"Crossref","is-referenced-by-count":0,"title":["Characterizing immune cell profiles of patients with rheumatoid arthritis in Taiwan using artificial intelligence-based cytometric approaches"],"prefix":"10.1093","volume":"118","author":[{"given":"Po-Yu","family":"Li","sequence":"first","affiliation":[{"name":"FullHope Biomedical Co., Ltd , 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City 241405, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Po","family":"Tsao","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veteran General Hospital , No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City 112201, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong St., Beitou Dist., Taipei City 112304, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Syuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veteran General Hospital , No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City 112201, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong St., Beitou Dist., Taipei City 112304, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Cheng","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veteran General Hospital , No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City 112201, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong St., Beitou Dist., Taipei City 112304, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"FullHope Biomedical Co., Ltd , 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City 241405, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Wen","family":"Chan","sequence":"additional","affiliation":[{"name":"FullHope Biomedical Co., Ltd , 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City 241405, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Ying","family":"Chu","sequence":"additional","affiliation":[{"name":"FullHope Biomedical Co., Ltd , 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City 241405, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"FullHope Biomedical Co., Ltd , 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City 241405, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shian-Ren","family":"Lin","sequence":"additional","affiliation":[{"name":"FullHope Biomedical Co., Ltd , 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City 241405, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiu-Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"FullHope Biomedical Co., Ltd , 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City 241405, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Yu","family":"Lai","sequence":"additional","affiliation":[{"name":"FullHope Biomedical Co., Ltd , 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City 241405, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-6465","authenticated-orcid":false,"given":"Jan-Mou","family":"Lee","sequence":"additional","affiliation":[{"name":"FullHope Biomedical Co., Ltd , 10F., No. 10, Ln. 609, Sec. 5, Chongxin Rd., Sanchong Dist., New Taipei City 241405, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veteran General Hospital , No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City 112201, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong St., Beitou Dist., Taipei City 112304, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"2026012811054315600_qiaf188-B1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMra2103726","article-title":"Rheumatoid arthritis\u2014common origins, divergent mechanisms","volume":"388","author":"Gravallese","year":"2023","journal-title":"N Engl J Med"},{"key":"2026012811054315600_qiaf188-B2","doi-asserted-by":"publisher","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","article-title":"Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the global burden of disease study 2021","volume":"5","author":"Collaborators GBDRA","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"2026012811054315600_qiaf188-B3","doi-asserted-by":"publisher","first-page":"1051082","DOI":"10.3389\/fimmu.2022.1051082","article-title":"Systemic complications of rheumatoid arthritis: focus on pathogenesis and treatment","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"key":"2026012811054315600_qiaf188-B4","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1136\/annrheumdis-2019-216243","article-title":"Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era","volume":"79","author":"Hsieh","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2026012811054315600_qiaf188-B5","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"2026012811054315600_qiaf188-B6","doi-asserted-by":"publisher","first-page":"103421","DOI":"10.1016\/j.autrev.2023.103421","article-title":"Should ACR\/EULAR criteria be revised changing the RF and ACPA scores?","volume":"23","author":"Steiner","year":"2024","journal-title":"Autoimmun Rev"},{"key":"2026012811054315600_qiaf188-B7","author":"Tiwari"},{"key":"2026012811054315600_qiaf188-B8","doi-asserted-by":"publisher","first-page":"104233","DOI":"10.1016\/j.ebiom.2022.104233","article-title":"ACPA-negative rheumatoid arthritis: from immune mechanisms to clinical translation","volume":"83","author":"Li","year":"2022","journal-title":"EBioMedicine"},{"key":"2026012811054315600_qiaf188-B9","doi-asserted-by":"publisher","first-page":"e743","DOI":"10.1016\/S2665-9913(23)00242-4","article-title":"Autoantibody-negative rheumatoid arthritis: still a challenge for the rheumatologist","volume":"5","author":"Bugatti","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"2026012811054315600_qiaf188-B10","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1002\/acr.24596","article-title":"2021 American college of rheumatology guideline for the treatment of rheumatoid arthritis","volume":"73","author":"Fraenkel","year":"2021","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2026012811054315600_qiaf188-B11","author":"Benjamin"},{"key":"2026012811054315600_qiaf188-B12","doi-asserted-by":"publisher","first-page":"e0281213","DOI":"10.1371\/journal.pone.0281213","article-title":"Failure and multiple failure for disease modifying antirheumatic drugs in rheumatoid arthritis: real-life evidence from a tertiary referral center in Italy","volume":"18","author":"Conigliaro","year":"2023","journal-title":"PLoS One"},{"key":"2026012811054315600_qiaf188-B13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1136\/annrheumdis-2021-220973","article-title":"EULAR points to consider for the management of difficult-to-treat rheumatoid arthritis","volume":"81","author":"Nagy","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"2026012811054315600_qiaf188-B14","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.55563\/clinexprheumatol\/nyu9er","article-title":"Challenges and insights in managing difficult-to-treat rheumatoid arthritis: real-world clinical perspectives","volume":"42","author":"Alp","year":"2024","journal-title":"Clin Exp Rheumatol"},{"key":"2026012811054315600_qiaf188-B15","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1002\/acr.24042","article-title":"2019 update of the American College of Rheumatology recommended rheumatoid arthritis disease activity measures","volume":"71","author":"England","year":"2019","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2026012811054315600_qiaf188-B16","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/j.immuni.2022.11.009","article-title":"The pathogenesis of rheumatoid arthritis","volume":"55","author":"Alivernini","year":"2022","journal-title":"Immunity"},{"key":"2026012811054315600_qiaf188-B17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jcyt.2021.10.003","article-title":"Rheumatoid arthritis: from synovium biology to cell-based therapy","volume":"24","author":"Debreova","year":"2022","journal-title":"Cytotherapy"},{"key":"2026012811054315600_qiaf188-B18","doi-asserted-by":"publisher","first-page":"e18404","DOI":"10.1111\/jcmm.18404","article-title":"Characterization of unique pattern of immune cell profile in patients with nasopharyngeal carcinoma through flow cytometry and machine learning","volume":"28","author":"Liao","year":"2024","journal-title":"J Cell Mol Med"},{"key":"2026012811054315600_qiaf188-B19","doi-asserted-by":"publisher","first-page":"e000693","DOI":"10.1136\/lupus-2022-000693","article-title":"Novel immunoprofiling method for diagnosing SLE and evaluating therapeutic response","volume":"9","author":"Lee","year":"2022","journal-title":"Lupus Sci Med"},{"key":"2026012811054315600_qiaf188-B20","doi-asserted-by":"publisher","first-page":"1008855","DOI":"10.3389\/fmed.2022.1008855","article-title":"Artificial intelligence-based immunoprofiling serves as a potentially predictive biomarker of nivolumab treatment for advanced hepatocellular carcinoma","volume":"9","author":"Lee","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"2026012811054315600_qiaf188-B21","doi-asserted-by":"publisher","first-page":"4645","DOI":"10.3390\/ijms23094645","article-title":"Innovations in genomics and big data analytics for personalized medicine and health care: a review","volume":"23","author":"Hassan","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026012811054315600_qiaf188-B22","doi-asserted-by":"crossref","DOI":"10.4135\/9781412984997","volume-title":"Meta-analytic procedures for social research","author":"Rosenthal","year":"1991"},{"key":"2026012811054315600_qiaf188-B23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/9780470743386.ch7","volume-title":"Converting among effect sizes. Introduction to meta-analysis","author":"Borenstein","year":"2009"},{"key":"2026012811054315600_qiaf188-B24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol."},{"key":"2026012811054315600_qiaf188-B25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/BOR.0000000000001006","article-title":"Autoantibodies in rheumatoid arthritis\u2014rheumatoid factor, anticitrullinated protein antibodies and beyond","volume":"36","author":"Steiner","year":"2024","journal-title":"Curr Opin Rheumatol"},{"key":"2026012811054315600_qiaf188-B26","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1165\/rcmb.2012-0366MA","article-title":"Identification of myeloid cell subsets in murine lungs using flow cytometry","volume":"49","author":"Zaynagetdinov","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012811054315600_qiaf188-B27","doi-asserted-by":"publisher","first-page":"e185217","DOI":"10.1172\/JCI185217","article-title":"Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis","volume":"135","author":"Inamo","year":"2025","journal-title":"J Clin Invest"},{"key":"2026012811054315600_qiaf188-B28","doi-asserted-by":"publisher","first-page":"1376933","DOI":"10.3389\/fimmu.2024.1376933","article-title":"Comparative single-cell multiplex immunophenotyping of therapy-naive patients with rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus shed light on disease-specific composition of the peripheral immune system","volume":"15","author":"Balog","year":"2024","journal-title":"Front Immunol"},{"key":"2026012811054315600_qiaf188-B29","doi-asserted-by":"publisher","first-page":"10058","DOI":"10.1038\/s41598-023-36999-0","article-title":"Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs","volume":"13","author":"Hedman","year":"2023","journal-title":"Sci Rep"},{"key":"2026012811054315600_qiaf188-B30","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1007\/s10067-022-06315-8","article-title":"Imbalance of Th17, Treg, and helper innate lymphoid cell in the peripheral blood of patients with rheumatoid arthritis","volume":"41","author":"Wang","year":"2022","journal-title":"Clin Rheumatol"},{"key":"2026012811054315600_qiaf188-B31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12865-022-00517-0","article-title":"The proportion and phenotypic changes of CD4(+)CD25(-)foxp3(+) T cells in patients with untreated rheumatoid arthritis","volume":"23","author":"Ju","year":"2022","journal-title":"BMC Immunol"},{"key":"2026012811054315600_qiaf188-B32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.biochi.2020.03.014","article-title":"Regulatory T cells in patients with early untreated rheumatoid arthritis: phenotypic changes in the course of methotrexate treatment","volume":"174","author":"Avdeeva","year":"2020","journal-title":"Biochimie"},{"key":"2026012811054315600_qiaf188-B33","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1002\/art.20499","article-title":"CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid","volume":"50","author":"van Amelsfort","year":"2004","journal-title":"Arthritis Rheum"},{"key":"2026012811054315600_qiaf188-B34","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1023\/a:1023278606036","article-title":"Increased production of a Th2 cytokine profile by activated whole blood cells from rheumatoid arthritis patients","volume":"18","author":"Haddad","year":"1998","journal-title":"J Clin Immunol"},{"key":"2026012811054315600_qiaf188-B35","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.4049\/jimmunol.164.7.3894","article-title":"Activation of the IL-4 STAT pathway in rheumatoid synovium","volume":"164","author":"Muller-Ladner","year":"2000","journal-title":"J Immunol"},{"key":"2026012811054315600_qiaf188-B36","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1006\/bbrc.1994.2219","article-title":"Interleukin-4 acts as a potent stimulator for expression of monocyte chemoattractant JE\/MCP-1 in mouse peritoneal macrophages","volume":"203","author":"Kikuchi","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"2026012811054315600_qiaf188-B37","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1002\/art.1780391012","article-title":"The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis","volume":"39","author":"Isomaki","year":"1996","journal-title":"Arthritis Rheum"},{"key":"2026012811054315600_qiaf188-B38","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1046\/j.1365-2567.1997.00263.x","article-title":"Interleukin-13 selectively induces monocyte chemoattractant protein-1 synthesis and secretion by human endothelial cells. Involvement of IL-4R alpha and Stat6 phosphorylation","volume":"91","author":"Goebeler","year":"1997","journal-title":"Immunology"},{"key":"2026012811054315600_qiaf188-B39","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.bbrc.2018.12.010","article-title":"Eosinophils attenuate arthritis by inducing M2 macrophage polarization via inhibiting the IkappaB\/P38 MAPK signaling pathway","volume":"508","author":"Liu","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"2026012811054315600_qiaf188-B40","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.iac.2015.04.003","article-title":"Eosinophils in gastrointestinal disorders: eosinophilic gastrointestinal diseases, celiac disease, inflammatory bowel diseases, and parasitic infections","volume":"35","author":"Mehta","year":"2015","journal-title":"Immunol Allergy Clin North Am"},{"key":"2026012811054315600_qiaf188-B41","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.cell.2020.03.022","article-title":"How machine learning will transform biomedicine","volume":"181","author":"Goecks","year":"2020","journal-title":"Cell"},{"key":"2026012811054315600_qiaf188-B42","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2478\/rir-2023-0011","article-title":"A survey of artificial intelligence in rheumatoid arthritis","volume":"4","author":"Wang","year":"2023","journal-title":"Rheumatol Immunol Res"},{"key":"2026012811054315600_qiaf188-B43","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1177\/0954411919845747","article-title":"Automatic localization of anatomical regions in medical ultrasound images of rheumatoid arthritis using deep learning","volume":"233","author":"Hemalatha","year":"2019","journal-title":"Proc Inst Mech Eng H"},{"key":"2026012811054315600_qiaf188-B44","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s10278-021-00564-w","article-title":"Automated classification of rheumatoid arthritis, osteoarthritis, and normal hand radiographs with deep learning methods","volume":"35","author":"Ureten","year":"2022","journal-title":"J Digit Imaging"},{"key":"2026012811054315600_qiaf188-B45","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s10067-021-05960-9","article-title":"Machine learning to identify immune-related biomarkers of rheumatoid arthritis based on WGCNA network","volume":"41","author":"Chen","year":"2022","journal-title":"Clin Rheumatol"},{"key":"2026012811054315600_qiaf188-B46","doi-asserted-by":"publisher","first-page":"1238407","DOI":"10.3389\/fgene.2023.1238407","article-title":"Machine learning and bioinformatics analysis to identify autophagy-related biomarkers in peripheral blood for rheumatoid arthritis","volume":"14","author":"Dong","year":"2023","journal-title":"Front Genet"},{"key":"2026012811054315600_qiaf188-B47","doi-asserted-by":"publisher","first-page":"e485","DOI":"10.1016\/S2665-9913(20)30168-5","article-title":"Disease-associated and patient-specific immune cell signatures in juvenile-onset systemic lupus erythematosus: patient stratification using a machine-learning approach","volume":"2","author":"Robinson","year":"2020","journal-title":"Lancet Rheumatol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiaf188\/66192126\/qiaf188.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/1\/qiaf188\/66192126\/qiaf188.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/1\/qiaf188\/66192126\/qiaf188.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T16:06:53Z","timestamp":1769616413000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/doi\/10.1093\/jleuko\/qiaf188\/8408169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,26]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiaf188","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,12,26]]},"article-number":"qiaf188"}}