{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:46:03Z","timestamp":1792525563386,"version":"4.5.0"},"reference-count":114,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LHDMY23H160001"],"award-info":[{"award-number":["LHDMY23H160001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eosinophils are a type of white blood cell belonging to the granulocyte family. Their cytoplasm contains eosinophilic granules that hold various biologically active substances. They perform diverse functions, participating in inflammatory responses, immune defense, and tissue repair. Eosinophils are implicated in the pathogenesis of multiple diseases, including infectious diseases, allergic disorders, and hematological conditions. Moreover, increasing research in recent years has revealed significant associations between eosinophils and autoimmune diseases, solid tumors, coronary atherosclerotic heart disease, and even Alzheimer's disease. They participate in disease onset and progression through the release of toxic proteins, cytokines, and chemokines, as well as through interactions with other cells. Focusing on the biological characteristics and functions of eosinophils facilitates the elucidation of disease mechanisms associated with related disorders. This, in turn, provides further direction for eosinophil-targeted research and therapeutic strategies, including the research and development of drugs that modulate their function, targeted therapies, immunotherapies, and cell therapies. This paper provides a comprehensive review of the structure, function, and role of eosinophils in related diseases, along with potential future therapeutic strategies. It aims to deepen the understanding of researchers and clinicians, thereby facilitating their application in further research, as well as in clinical disease diagnosis and treatment analysis.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag009","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:33:04Z","timestamp":1768307584000},"source":"Crossref","is-referenced-by-count":3,"title":["Eosinophils: pathological mechanisms and novel targeted therapeutic strategies across multiple disease spectrums"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7445-325X","authenticated-orcid":false,"given":"Yuan","family":"Chen","sequence":"first","affiliation":[{"name":"Hangzhou Normal University School of Clinical Medicine, Hangzhou Normal University Affiliated Hospital , Hangzhou 310015 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Hangzhou Normal University School of Clinical Medicine, Hangzhou Normal University Affiliated Hospital , Hangzhou 310015 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"2026012811053186200_qiag009-B1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3389\/fmed.2017.00115","article-title":"Transcription factors in eosinophil development and as therapeutic targets","volume":"4","author":"Fulkerson","year":"2017","journal-title":"Front Med."},{"key":"2026012811053186200_qiag009-B2","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.2147\/tcrm.S111862","article-title":"Role of biologics in severe eosinophilic asthma\u2014focus on reslizumab","volume":"12","author":"Pelaia","year":"2016","journal-title":"Ther Clin Risk Manag"},{"key":"2026012811053186200_qiag009-B3","doi-asserted-by":"publisher","first-page":"17406","DOI":"10.1074\/jbc.R113.546218","article-title":"Eosinophil granule proteins: form and function","volume":"289","author":"Acharya","year":"2014","journal-title":"J Biol Chem"},{"key":"2026012811053186200_qiag009-B4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000504847","article-title":"The cellular functions of eosinophils: Collegium Internationale Allergologicum (CIA) update 2020","volume":"181","author":"Simon","year":"2020","journal-title":"Int Arch Allergy Immunol"},{"key":"2026012811053186200_qiag009-B5","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/icb.2009.115","article-title":"Eosinophils and th2 immunity: contemporary insights","volume":"88","author":"Spencer","year":"2010","journal-title":"Immunol Cell Biol"},{"key":"2026012811053186200_qiag009-B6","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1111\/j.1365-2222.2008.03037.x","article-title":"Immunoregulatory roles of eosinophils: a new look at a familiar cell","volume":"38","author":"Akuthota","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"2026012811053186200_qiag009-B7","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s12931-023-02504-4","article-title":"Eosinophil extracellular traps in asthma: implications for pathogenesis and therapy","volume":"24","author":"Shen","year":"2023","journal-title":"Respir Res"},{"key":"2026012811053186200_qiag009-B8","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s11882-016-0634-5","article-title":"Eosinophil etosis and DNA traps: a new look at eosinophilic inflammation","volume":"16","author":"Ueki","year":"2016","journal-title":"Curr Allergy Asthma Rep"},{"key":"2026012811053186200_qiag009-B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/microbiolspec.MCHD-0020-2015","article-title":"The regulatory function of eosinophils","volume":"4","author":"Wen","year":"2016","journal-title":"Microbiol Spectr"},{"key":"2026012811053186200_qiag009-B10","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1111\/all.15751","article-title":"Eosinophils from a to z","volume":"78","author":"Gigon","year":"2023","journal-title":"Allergy"},{"key":"2026012811053186200_qiag009-B11","doi-asserted-by":"publisher","first-page":"9095275","DOI":"10.1155\/2018\/9095275","article-title":"Eosinophils from physiology to disease: a comprehensive review","volume":"2018","author":"Ramirez","year":"2018","journal-title":"Biomed Res Int"},{"key":"2026012811053186200_qiag009-B12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41568-024-00787-3","article-title":"Dendritic cell maturation in cancer","volume":"25","author":"Moon","year":"2025","journal-title":"Nat Rev Cancer"},{"key":"2026012811053186200_qiag009-B13","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3389\/fphys.2019.01514","article-title":"Interleukin-5 in the pathophysiology of severe asthma","volume":"10","author":"Pelaia","year":"2019","journal-title":"Front Physiol"},{"key":"2026012811053186200_qiag009-B14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fmed.2017.00139","article-title":"Interleukin-13 in asthma and other eosinophilic disorders","volume":"4","author":"Doran","year":"2017","journal-title":"Front Med"},{"key":"2026012811053186200_qiag009-B15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fmed.2017.00101","article-title":"Homeostatic eosinophils: characteristics and functions","volume":"4","author":"Marichal","year":"2017","journal-title":"Front Med."},{"key":"2026012811053186200_qiag009-B16","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3390\/cells10020426","article-title":"Heterogeneity of intestinal tissue eosinophils: potential considerations for next-generation eosinophil-targeting strategies","volume":"10","author":"Masterson","year":"2021","journal-title":"Cells"},{"key":"2026012811053186200_qiag009-B17","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.jaci.2024.05.029","article-title":"Single-cell rna-sequencing of human eosinophils in allergic inflammation in the esophagus","volume":"154","author":"Ben-Baruch Morgenstern","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"2026012811053186200_qiag009-B18","doi-asserted-by":"publisher","first-page":"1470381","DOI":"10.3389\/fmed.2024.1470381","article-title":"Eosinophils: old cells, new directions","volume":"11","author":"Sanchez Santos","year":"2025","journal-title":"Front Med."},{"key":"2026012811053186200_qiag009-B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1084\/jem.20221435","article-title":"Emerging functions of tissue-resident eosinophils","volume":"220","author":"Gurtner","year":"2023","journal-title":"J Exp Med"},{"key":"2026012811053186200_qiag009-B20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1126\/science.1201475","article-title":"Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis","volume":"332","author":"Wu","year":"2011","journal-title":"Science"},{"key":"2026012811053186200_qiag009-B21","doi-asserted-by":"publisher","first-page":"10454","DOI":"10.1038\/s41467-025-65440-5","article-title":"Epigenetic and transcriptional programming of murine eosinophils in the esophagus","volume":"16","author":"Felton","year":"2025","journal-title":"Nat Commun"},{"key":"2026012811053186200_qiag009-B22","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.pharmthera.2012.06.005","article-title":"Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions","volume":"135","author":"Kiwamoto","year":"2012","journal-title":"Pharmacol Ther"},{"key":"2026012811053186200_qiag009-B23","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1159\/000236985","article-title":"The interleukin-5\/receptor interaction activates lyn and jak2 tyrosine kinases and propagates signals via the ras-raf-1-map kinase and the jak-stat pathways in eosinophils","volume":"107","author":"Alam","year":"1995","journal-title":"Int Arch Allergy Immunol"},{"key":"2026012811053186200_qiag009-B24","doi-asserted-by":"publisher","first-page":"6660","DOI":"10.1038\/sj.onc.1204629","article-title":"Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of stat6, erk and p38 MAPK pathways","volume":"20","author":"David","year":"2001","journal-title":"Oncogene"},{"key":"2026012811053186200_qiag009-B25","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1002\/eji.201847555","article-title":"Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor grb2","volume":"48","author":"Willebrand","year":"2018","journal-title":"Eur J Immunol"},{"key":"2026012811053186200_qiag009-B26","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.3390\/ijms26104662","article-title":"Emerging roles of C-C motif ligand 11 (ccl11) in cancers and liver diseases: mechanisms and therapeutic implications","volume":"26","author":"Wang","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026012811053186200_qiag009-B27","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/0091-6749(86)90341-6","article-title":"The eosinophil and the pathophysiology of asthma","volume":"77","author":"Frigas","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"2026012811053186200_qiag009-B28","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1046\/j.1365-2222.1999.00542.x","article-title":"Eosinophil cationic protein (ECP): molecular and biological properties and the use of ecp as a marker of eosinophil activation in disease","volume":"29","author":"Venge","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"2026012811053186200_qiag009-B29","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3389\/fimmu.2014.00570","article-title":"Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity","volume":"5","author":"Davoine","year":"2014","journal-title":"Front Immunol"},{"key":"2026012811053186200_qiag009-B30","doi-asserted-by":"publisher","first-page":"e0142881","DOI":"10.1371\/journal.pone.0142881","article-title":"Eosinophils from murine lamina propria induce differentiation of na\u00efve t cells into regulatory t cells via TGF-\u03b21 and retinoic acid","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"2026012811053186200_qiag009-B31","doi-asserted-by":"publisher","first-page":"603295","DOI":"10.3389\/fimmu.2020.603295","article-title":"Eosinophils in eosinophilic esophagitis: the road to fibrostenosis is paved with good intentions","volume":"11","author":"Doyle","year":"2020","journal-title":"Front Immunol"},{"key":"2026012811053186200_qiag009-B32","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.3389\/fimmu.2017.00484","article-title":"Eosinophils in autoimmune diseases","volume":"8","author":"Diny","year":"2017","journal-title":"Front Immunol."},{"key":"2026012811053186200_qiag009-B33","doi-asserted-by":"publisher","first-page":"2244330","DOI":"10.1080\/2162402x.2023.2244330","article-title":"L-kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes","volume":"12","author":"Schlichtner","year":"2023","journal-title":"Oncoimmunology"},{"key":"2026012811053186200_qiag009-B34","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41423-025-01261-2","article-title":"Type 2 immunity in allergic diseases","volume":"22","author":"Ogulur","year":"2025","journal-title":"Cell Mol Immunol"},{"key":"2026012811053186200_qiag009-B35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000357004","article-title":"Remodeling and fibrosis in chronic eosinophil inflammation","volume":"32","author":"Aceves","year":"2014","journal-title":"Dig Dis"},{"key":"2026012811053186200_qiag009-B36","doi-asserted-by":"publisher","first-page":"1609509","DOI":"10.3389\/fimmu.2025.1609509","article-title":"Revisiting pulmonary fibrosis: inflammatory dynamics of the lipofibroblast-to-inflammatory lipofibroblast-to-activated myofibroblast reversible switch","volume":"16","author":"Panagiotidis","year":"2025","journal-title":"Front Immunol"},{"key":"2026012811053186200_qiag009-B37","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s13340-016-0290-y","article-title":"M2 macrophages in metabolism","volume":"7","author":"Fujisaka","year":"2016","journal-title":"Diabetol Int"},{"key":"2026012811053186200_qiag009-B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/jci.insight.170772","article-title":"Linking adipose tissue eosinophils, IL-4, and leptin in human obesity and insulin resistance","volume":"9","author":"Hernandez","year":"2024","journal-title":"JCI Insight"},{"key":"2026012811053186200_qiag009-B39","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/jleuko\/qiae100","article-title":"Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma","volume":"116","author":"Haruna","year":"2024","journal-title":"J Leukoc Biol"},{"key":"2026012811053186200_qiag009-B40","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4110\/in.2017.17.1.41","article-title":"Regulatory eosinophils in inflammation and metabolic disorders","volume":"17","author":"Yang","year":"2017","journal-title":"Immune Netw"},{"key":"2026012811053186200_qiag009-B41","doi-asserted-by":"publisher","first-page":"e70018","DOI":"10.1111\/imr.70018","article-title":"Pathobiology and regulation of eosinophils, mast cells, and basophils in allergic asthma","volume":"331","author":"Whetstone","year":"2025","journal-title":"Immunol Rev"},{"key":"2026012811053186200_qiag009-B42","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3390\/biom15040491","article-title":"The role of eosinophils, eosinophil-related cytokines and ai in predicting immunotherapy efficacy in nsclc","volume":"15","author":"Omero","year":"2025","journal-title":"Biomolecules"},{"key":"2026012811053186200_qiag009-B43","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1600-065X.2011.01026.x","article-title":"Eosinophils: multifaceted biological properties and roles in health and disease","volume":"242","author":"Kita","year":"2011","journal-title":"Immunol Rev"},{"key":"2026012811053186200_qiag009-B44","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3345\/cep.2024.01382","article-title":"Eosinophil-derived neurotoxin levels can predict allergic disease development and atopic march in children","volume":"68","author":"Callaway","year":"2025","journal-title":"Clin Exp Pediatr"},{"key":"2026012811053186200_qiag009-B45","doi-asserted-by":"publisher","first-page":"205","DOI":"10.37349\/eaa.2024.00041","article-title":"Eosinophilic gastrointestinal diseases: current perspectives on pathogenesis and management","volume":"2","author":"Papaiakovou","year":"2024","journal-title":"Explor Asthma Allergy."},{"key":"2026012811053186200_qiag009-B46","doi-asserted-by":"publisher","first-page":"210150","DOI":"10.1183\/16000617.0150-2021","article-title":"Eosinophils and eosinophilic immune dysfunction in health and disease","volume":"31","author":"Jackson","year":"2022","journal-title":"Eur Respir Rev"},{"key":"2026012811053186200_qiag009-B47","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.iac.2015.05.004","article-title":"Eosinophilia associated with disorders of immune deficiency or immune dysregulation","volume":"35","author":"Williams","year":"2015","journal-title":"Immunol Allergy Clin North Am"},{"key":"2026012811053186200_qiag009-B48","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1126\/science.ade4177","article-title":"Neuromedin u programs eosinophils to promote mucosal immunity of the small intestine","volume":"381","author":"Li","year":"2023","journal-title":"Science"},{"key":"2026012811053186200_qiag009-B49","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.3390\/diagnostics14212448","article-title":"Integrative cross-talk in asthma: unraveling the complex interactions between eosinophils, immune, and structural cells in the airway microenvironment","volume":"14","author":"Januskevicius","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"2026012811053186200_qiag009-B50","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.21037\/jtd-2024-2092","article-title":"The management of type 2 inflammatory respiratory diseases: a Chinese expert consensus [2024]","volume":"17","author":"Jia","year":"2025","journal-title":"J Thorac Dis"},{"key":"2026012811053186200_qiag009-B51","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/cells13050384","article-title":"Eosinophilic asthma: pathophysiology and therapeutic horizons","volume":"13","author":"Hussain","year":"2024","journal-title":"Cells"},{"key":"2026012811053186200_qiag009-B52","doi-asserted-by":"publisher","first-page":"682","DOI":"10.4049\/jimmunol.1900786","article-title":"Regulation of eosinophil recruitment and allergic airway inflammation by tropomyosin receptor kinase A","volume":"204","author":"Dileepan","year":"2020","journal-title":"J Immunol"},{"key":"2026012811053186200_qiag009-B53","doi-asserted-by":"publisher","first-page":"2040707","DOI":"10.1080\/20018525.2022.2040707","article-title":"Eosinophilic airway diseases: basic science, clinical manifestations and future challenges","volume":"9","author":"Janson","year":"2022","journal-title":"Eur Clin Respir J"},{"key":"2026012811053186200_qiag009-B54","doi-asserted-by":"publisher","first-page":"7254","DOI":"10.3390\/ijms24087254","article-title":"Eosinophilic airway diseases: from pathophysiological mechanisms to clinical practice","volume":"24","author":"Mormile","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026012811053186200_qiag009-B55","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nm.2755","article-title":"IgE and mast cells in allergic disease","volume":"18","author":"Galli","year":"2012","journal-title":"Nat Med"},{"key":"2026012811053186200_qiag009-B56","doi-asserted-by":"publisher","first-page":"1285598","DOI":"10.3389\/fimmu.2024.1285598","article-title":"Exploring the immunopathology of type 2 inflammatory airway diseases","volume":"15","author":"AlBloushi","year":"2024","journal-title":"Front Immunol"},{"key":"2026012811053186200_qiag009-B57","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/all.16459","article-title":"The direct and indirect role of ige on airway epithelium in asthma","volume":"80","author":"Domingo","year":"2025","journal-title":"Allergy"},{"key":"2026012811053186200_qiag009-B58","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1007\/s00018-011-0886-0","article-title":"Deciphering the structure and function of fc\u03b5ri\/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm","volume":"69","author":"Manikandan","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"2026012811053186200_qiag009-B59","doi-asserted-by":"publisher","first-page":"e674","DOI":"10.1002\/hsr2.674","article-title":"Assessing the role of eosinophil-mediated immune response markers in detecting hookworm infection: a case\u2013control study in Kintampo, Ghana","volume":"5","author":"Sakyi","year":"2022","journal-title":"Health Sci Rep"},{"key":"2026012811053186200_qiag009-B60","doi-asserted-by":"publisher","first-page":"1145257","DOI":"10.3389\/fmed.2023.1145257","article-title":"Eosinophilic granulomatosis with polyangiitis\u2014advances in pathogenesis, diagnosis, and treatment","volume":"10","author":"Fijolek","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"2026012811053186200_qiag009-B61","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/s41584-023-00958-w","article-title":"Evidence-based guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis","volume":"19","author":"Emmi","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"2026012811053186200_qiag009-B62","doi-asserted-by":"publisher","first-page":"3","DOI":"10.7555\/jbr.31.20170034","article-title":"Transforming growth factor-\u03b2 signaling in systemic sclerosis","volume":"32","author":"Ayers","year":"2018","journal-title":"J Biomed Res"},{"key":"2026012811053186200_qiag009-B63","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41392-024-01764-w","article-title":"Tgf-\u03b2 signaling in health, disease, and therapeutics","volume":"9","author":"Deng","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"2026012811053186200_qiag009-B64","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.clim.2016.09.010","article-title":"An emerging role for eotaxins in neurodegenerative disease","volume":"189","author":"Huber","year":"2018","journal-title":"Clin Immunol"},{"key":"2026012811053186200_qiag009-B65","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/s41423-023-01043-8","article-title":"Type 2 immunity in the brain and brain borders","volume":"20","author":"Mamuladze","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"2026012811053186200_qiag009-B66","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1034\/j.1398-9995.1999.00170.x","article-title":"Eosinophil activation by eotaxin\u2013eotaxin primes the production of reactive oxygen species from eosinophils","volume":"54","author":"Honda","year":"1999","journal-title":"Allergy"},{"key":"2026012811053186200_qiag009-B67","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3233\/bpl-180078","article-title":"Pathogenic feed-forward mechanisms in Alzheimer's and Parkinson's disease converge on GSK-3","volume":"4","author":"Albeely","year":"2018","journal-title":"Brain Plast"},{"key":"2026012811053186200_qiag009-B68","doi-asserted-by":"publisher","first-page":"151979","DOI":"10.1155\/2015\/151979","article-title":"Tau hyperphosphorylation and oxidative stress, a critical vicious circle in neurodegenerative tauopathies?","volume":"2015","author":"Alavi Naini","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"2026012811053186200_qiag009-B69","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1093\/eurheartj\/ehad262","article-title":"Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis","volume":"44","author":"Meng","year":"2023","journal-title":"Eur Heart J"},{"key":"2026012811053186200_qiag009-B70","doi-asserted-by":"publisher","first-page":"15005","DOI":"10.1038\/boneres.2015.5","article-title":"Tgf-\u03b2\/bmp signaling and other molecular events: regulation of osteoblastogenesis and bone formation","volume":"3","author":"Rahman","year":"2015","journal-title":"Bone Res"},{"key":"2026012811053186200_qiag009-B71","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41422-023-00918-9","article-title":"The roles and regulatory mechanisms of tgf-\u03b2 and bmp signaling in bone and cartilage development, homeostasis and disease","volume":"34","author":"Wu","year":"2024","journal-title":"Cell Res"},{"key":"2026012811053186200_qiag009-B72","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1182\/blood.2019000518","article-title":"Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps","volume":"134","author":"Marx","year":"2019","journal-title":"Blood"},{"key":"2026012811053186200_qiag009-B73","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/bs.apha.2017.08.002","article-title":"Matrix metalloproteinases, vascular remodeling, and vascular disease","volume":"81","author":"Wang","year":"2018","journal-title":"Adv Pharmacol"},{"key":"2026012811053186200_qiag009-B74","doi-asserted-by":"publisher","first-page":"7165","DOI":"10.3390\/ijms21197165","article-title":"Innate immunity effector cells as inflammatory drivers of cardiac fibrosis","volume":"21","author":"Baci","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026012811053186200_qiag009-B75","doi-asserted-by":"publisher","first-page":"12017","DOI":"10.3390\/ijms252212017","article-title":"Vascular extracellular matrix in atherosclerosis","volume":"25","author":"Nubila","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026012811053186200_qiag009-B76","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3389\/fimmu.2019.00062","article-title":"Regulation of type 2 immunity in myocardial infarction","volume":"10","author":"Xu","year":"2019","journal-title":"Front Immunol"},{"key":"2026012811053186200_qiag009-B77","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1186\/s12967-023-04418-7","article-title":"Eosinophils in the tumor microenvironment: implications for cancer immunotherapy","volume":"21","author":"Ghaffari","year":"2023","journal-title":"J Transl Med"},{"key":"2026012811053186200_qiag009-B78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/sciadv.abb5943","article-title":"Eosinophilic inflammation promotes ccl6-dependent metastatic tumor growth","volume":"7","author":"Li","year":"2021","journal-title":"Sci Adv"},{"key":"2026012811053186200_qiag009-B79","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1084\/jem.20160801","article-title":"Pd-l1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits cd8 t cell cytotoxicity","volume":"214","author":"Juneja","year":"2017","journal-title":"J Exp Med"},{"key":"2026012811053186200_qiag009-B80","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1038\/s41590-022-01291-2","article-title":"Eosinophil-lymphocyte interactions in the tumor microenvironment and cancer immunotherapy","volume":"23","author":"Grisaru-Tal","year":"2022","journal-title":"Nat Immunol"},{"key":"2026012811053186200_qiag009-B81","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1016\/j.jaci.2018.10.066","article-title":"Sialic acid-binding immunoglobulin-like lectin (siglec) 8 in patients with eosinophilic disorders: receptor expression and targeting using chimeric antibodies","volume":"143","author":"Legrand","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"2026012811053186200_qiag009-B82","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1365-2222.2008.03173.x","article-title":"Siglec-8 on human eosinophils and mast cells, and siglec-f on murine eosinophils, are functionally related inhibitory receptors","volume":"39","author":"Bochner","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"2026012811053186200_qiag009-B83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2169\/internalmedicine.8417-21","article-title":"Eosinophilic gastrointestinal diseases: the pathogenesis, diagnosis, and treatment","volume":"62","author":"Kinoshita","year":"2023","journal-title":"Intern Med"},{"key":"2026012811053186200_qiag009-B84","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1053\/j.gastro.2022.03.025","article-title":"A clinical severity index for eosinophilic esophagitis: development, consensus, and future directions","volume":"163","author":"Dellon","year":"2022","journal-title":"Gastroenterology"},{"key":"2026012811053186200_qiag009-B85","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1111\/all.13451","article-title":"Immunological and hematological effects of il-5(r\u03b1)-targeted therapy: an overview","volume":"73","author":"Hassani","year":"2018","journal-title":"Allergy"},{"key":"2026012811053186200_qiag009-B86","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1465-9921-12-10","article-title":"Analysing the eosinophil cationic protein\u2014a clue to the function of the eosinophil granulocyte","volume":"12","author":"Bystrom","year":"2011","journal-title":"Respir Res"},{"key":"2026012811053186200_qiag009-B87","doi-asserted-by":"publisher","first-page":"100462","DOI":"10.1016\/j.opresp.2025.100462","article-title":"Long term effectiveness of mepolizumab in the treatment of chronic eosinophilic pneumonia","volume":"7","author":"Long\u00e1s","year":"2025","journal-title":"Open Respir Arch."},{"key":"2026012811053186200_qiag009-B88","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s00535-024-02151-6","article-title":"Advances in omics data for eosinophilic esophagitis: moving towards multi-omics analyses","volume":"59","author":"Matsuyama","year":"2024","journal-title":"J Gastroenterol"},{"key":"2026012811053186200_qiag009-B89","doi-asserted-by":"publisher","first-page":"15775","DOI":"10.1038\/s41598-018-33986-8","article-title":"Identification of novel genes in human airway epithelial cells associated with chronic obstructive pulmonary disease (COPD) using machine-based learning algorithms","volume":"8","author":"Mostafaei","year":"2018","journal-title":"Sci Rep"},{"key":"2026012811053186200_qiag009-B90","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1136\/thoraxjnl-2019-214476","article-title":"Bronchial gene expression signature associated with rate of subsequent FEV(1) decline in individuals with and at risk of COPD","volume":"77","author":"Becker","year":"2022","journal-title":"Thorax"},{"key":"2026012811053186200_qiag009-B91","doi-asserted-by":"publisher","first-page":"2004306","DOI":"10.1183\/13993003.04306-2020","article-title":"Novel mechanisms of action contributing to benralizumab's potent anti-eosinophilic activity","volume":"59","author":"Dagher","year":"2022","journal-title":"Eur Respir J"},{"key":"2026012811053186200_qiag009-B92","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2147\/jaa.S78049","article-title":"Benralizumab: a unique il-5 inhibitor for severe asthma","volume":"9","author":"Tan","year":"2016","journal-title":"J Asthma Allergy"},{"key":"2026012811053186200_qiag009-B93","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/cells10010019","article-title":"Discovery, function, and therapeutic targeting of siglec-8","volume":"10","author":"Youngblood","year":"2021","journal-title":"Cells"},{"key":"2026012811053186200_qiag009-B94","doi-asserted-by":"publisher","first-page":"5014","DOI":"10.1182\/blood-2002-10-3058","article-title":"Ligation of siglec-8: a selective mechanism for induction of human eosinophil apoptosis","volume":"101","author":"Nutku","year":"2003","journal-title":"Blood"},{"key":"2026012811053186200_qiag009-B95","doi-asserted-by":"publisher","first-page":"5333","DOI":"10.4049\/jimmunol.0801421","article-title":"Anti-siglec-f antibody reduces allergen-induced eosinophilic inflammation and airway remodeling","volume":"183","author":"Song","year":"2009","journal-title":"J Immunol"},{"key":"2026012811053186200_qiag009-B96","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/sj.bjp.0702476","article-title":"Adenosine a3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release","volume":"127","author":"Ezeamuzie","year":"1999","journal-title":"Br J Pharmacol"},{"key":"2026012811053186200_qiag009-B97","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.3389\/fimmu.2020.01339","article-title":"Eosinophils and purinergic signaling in health and disease","volume":"11","author":"Ferrari","year":"2020","journal-title":"Front Immunol"},{"key":"2026012811053186200_qiag009-B98","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1517\/14712598.2012.642359","article-title":"Benralizumab \u2013 a humanized mab to il-5r\u03b1 with enhanced antibody-dependent cell-mediated cytotoxicity\u2013a novel approach for the treatment of asthma","volume":"12","author":"Ghazi","year":"2012","journal-title":"Expert Opin Biol Ther"},{"key":"2026012811053186200_qiag009-B99","doi-asserted-by":"publisher","first-page":"593748","DOI":"10.3389\/fimmu.2020.593748","article-title":"Engineering of humanized antibodies against human interleukin 5 receptor alpha subunit that cause potent antibody-dependent cell-mediated cytotoxicity","volume":"11","author":"Kim","year":"2021","journal-title":"Front Immunol"},{"key":"2026012811053186200_qiag009-B100","doi-asserted-by":"publisher","first-page":"101799","DOI":"10.1016\/j.smim.2023.101799","article-title":"Siglecs as potential targets of therapy in human mast cell- and\/or eosinophil-associated diseases","volume":"69","author":"O'Sullivan","year":"2023","journal-title":"Semin Immunol"},{"key":"2026012811053186200_qiag009-B101","doi-asserted-by":"publisher","first-page":"833728","DOI":"10.3389\/fimmu.2022.833728","article-title":"The inhibitory receptor siglec-8 interacts with fc\u03b5ri and globally inhibits intracellular signaling in primary mast cells upon activation","volume":"13","author":"Korver","year":"2022","journal-title":"Front Immunol"},{"key":"2026012811053186200_qiag009-B102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/jci.insight.126219","article-title":"Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis","volume":"4","author":"Youngblood","year":"2019","journal-title":"JCI Insight"},{"key":"2026012811053186200_qiag009-B103","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/aci.0000000000000251","article-title":"Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs","volume":"16","author":"Varricchi","year":"2016","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2026012811053186200_qiag009-B104","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.3390\/biomedicines12071531","article-title":"Insight into IL-5 as a potential target for the treatment of allergic diseases","volume":"12","author":"Antosz","year":"2024","journal-title":"Biomedicines"},{"key":"2026012811053186200_qiag009-B105","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.18553\/jmcp.2023.23034","article-title":"A cost comparison of benralizumab, mepolizumab, and dupilumab in patients with severe asthma: a US third-party payer perspective","volume":"29","author":"Xu","year":"2023","journal-title":"J Manag Care Spec Pharm"},{"key":"2026012811053186200_qiag009-B106","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1080\/02770903.2024.2324855","article-title":"Cost-effectiveness of mepolizumab for severe eosinophilic asthma in China","volume":"61","author":"Chaogang","year":"2024","journal-title":"J Asthma"},{"key":"2026012811053186200_qiag009-B107","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s13312-024-3260-7","article-title":"Global initiative for asthma guidelines 2024: an update","volume":"61","author":"Rajvanshi","year":"2024","journal-title":"Indian Pediatr"},{"key":"2026012811053186200_qiag009-B108","doi-asserted-by":"publisher","first-page":"1900588","DOI":"10.1183\/13993003.00588-2019","article-title":"Management of severe asthma: a European Respiratory Society\/American Thoracic Society guideline","volume":"55","author":"Holguin","year":"2020","journal-title":"Eur Respir J"},{"key":"2026012811053186200_qiag009-B109","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1080\/1744666x.2021.2006635","article-title":"The use of biologics in personalized asthma care","volume":"17","author":"Watchorn","year":"2021","journal-title":"Expert Rev Clin Immunol"},{"key":"2026012811053186200_qiag009-B110","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1136\/ard-2022-223764","article-title":"Eular recommendations for the management of ANCA-associated vasculitis: 2022 update","volume":"83","author":"Hellmich","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"2026012811053186200_qiag009-B111","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1002\/art.41773","article-title":"2021 American college of rheumatology\/vasculitis foundation guideline for the management of antineutrophil cytoplasmic antibody-associated vasculitis","volume":"73","author":"Chung","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"2026012811053186200_qiag009-B112","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3390\/jpm15080370","article-title":"Established and emerging asthma biomarkers with a focus on biologic trials: a narrative review","volume":"15","author":"Lavere","year":"2025","journal-title":"J Pers Med"},{"key":"2026012811053186200_qiag009-B113","doi-asserted-by":"publisher","author":"Gurtner","DOI":"10.1101\/2021.10.27.466053"},{"issue":"6","key":"2026012811053186200_qiag009-B114","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1038\/s41596-024-00967-3","article-title":"Stress-free single-cell transcriptomic profiling and functional genomics of murine eosinophils","volume":"19","author":"Borrelli","year":"2024","journal-title":"Nat Protoc"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiag009\/66405534\/qiag009.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/1\/qiag009\/66405534\/qiag009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/1\/qiag009\/66405534\/qiag009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T16:06:50Z","timestamp":1769616410000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/doi\/10.1093\/jleuko\/qiag009\/8425075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":114,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,26]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiag009","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,12,26]]},"article-number":"qiag009"}}